Gene Gene information from NCBI Gene database.
Entrez ID 5901
Gene name RAN, member RAS oncogene family
Gene symbol RAN
Synonyms (NCBI Gene)
ARA24Gsp1TC4
Chromosome 12
Chromosome location 12q24.33
Summary RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis an
miRNA miRNA information provided by mirtarbase database.
1090
miRTarBase ID miRNA Experiments Reference
MIRT001196 hsa-miR-29a-3p flowqRT-PCRGFP reporter assay 19818597
MIRT021084 hsa-miR-186-5p Sequencing 20371350
MIRT051173 hsa-miR-16-5p CLASH 23622248
MIRT045558 hsa-miR-149-5p CLASH 23622248
MIRT045558 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
86
GO ID Ontology Definition Evidence Reference
GO:0000054 Process Ribosomal subunit export from nucleus IBA
GO:0000055 Process Ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 Process Ribosomal small subunit export from nucleus IMP 12773398
GO:0000070 Process Mitotic sister chromatid segregation IMP 29040603
GO:0000166 Function Nucleotide binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601179 9846 ENSG00000132341
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62826
Protein name GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Protein function GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:869
PDB 1I2M , 1IBR , 1K5D , 1K5G , 1QBK , 1RRP , 2MMC , 2MMG , 2N1B , 3CH5 , 3EA5 , 3GJ0 , 3GJ3 , 3GJ4 , 3GJ5 , 3GJ6 , 3GJ7 , 3GJ8 , 3GJX , 3NBY , 3NBZ , 3NC0 , 3NC1 , 3ZJY , 4C0Q , 4GMX , 4GPT , 4HAT , 4HAU , 4HAV , 4HAW , 4HAX , 4HAY , 4HAZ , 4HB0 , 4HB2 , 4HB3 , 4HB4 , 4OL0 , 4WVF , 5CIQ , 5CIT , 5CIW , 5CJ2 , 5CLL , 5CLQ , 5DH9 , 5DHA , 5DHF , 5DI9 , 5DIF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 12 170 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of tissues. {ECO:0000269|PubMed:2108320}.
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ribosome biogenesis in eukaryotes
Nucleocytoplasmic transport
Viral life cycle - HIV-1
Human T-cell leukemia virus 1 infection
  Rev-mediated nuclear export of HIV RNA
Regulation of cholesterol biosynthesis by SREBP (SREBF)
NEP/NS2 Interacts with the Cellular Export Machinery
Nuclear import of Rev protein
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
tRNA processing in the nucleus
Postmitotic nuclear pore complex (NPC) reformation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, INSULIN-DEPENDENT Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PANIC DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 12070164
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 23308199 Inhibit
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 23844663, 24248382, 24852074, 25521377, 31358992
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma CTD_human_DG 12376462, 16316942
★☆☆☆☆
Found in Text Mining only
Anorexia Nervosa Anorexia BEFREE 20545463
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 23468463, 29750309, 30560466
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 22090358, 23468463, 27716616, 28163220, 29750309, 30560466, 32600395 Associate
★☆☆☆☆
Found in Text Mining only
Bulbo-Spinal Atrophy, X-Linked Bulbospinal Atrophy, X-Linked BEFREE 11501969
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 26481147, 29706609 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma CTD_human_DG 12376462, 16316942
★★☆☆☆
Found in Text Mining + Unknown/Other Associations