Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5900
Gene name	Ral guanine nucleotide dissociation stimulator
Gene symbol	RALGDS
Synonyms (NCBI Gene)	RGDSRGFRalGEF
Chromosome	9
Chromosome location	9q34.13-q34.2
Summary	Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]

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Show/Hide all (206)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017310	hsa-miR-335-5p	Microarray	18185580
MIRT047157	hsa-miR-183-5p	CLASH	23622248
MIRT044953	hsa-miR-186-5p	CLASH	23622248
MIRT039756	hsa-miR-615-3p	CLASH	23622248
MIRT439826	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439826	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1289051	hsa-miR-1179	CLIP-seq
MIRT1289052	hsa-miR-1297	CLIP-seq
MIRT1289053	hsa-miR-1915	CLIP-seq
MIRT1289054	hsa-miR-26a	CLIP-seq
MIRT1289055	hsa-miR-26b	CLIP-seq
MIRT1289056	hsa-miR-300	CLIP-seq
MIRT1289057	hsa-miR-3065-5p	CLIP-seq
MIRT1289058	hsa-miR-3194-5p	CLIP-seq
MIRT1289059	hsa-miR-369-3p	CLIP-seq
MIRT1289060	hsa-miR-374a	CLIP-seq
MIRT1289061	hsa-miR-374b	CLIP-seq
MIRT1289062	hsa-miR-381	CLIP-seq
MIRT1289063	hsa-miR-3944-5p	CLIP-seq
MIRT1289064	hsa-miR-4251	CLIP-seq
MIRT1289065	hsa-miR-4272	CLIP-seq
MIRT1289066	hsa-miR-4293	CLIP-seq
MIRT1289067	hsa-miR-4324	CLIP-seq
MIRT1289068	hsa-miR-4446-3p	CLIP-seq
MIRT1289069	hsa-miR-4465	CLIP-seq
MIRT1289070	hsa-miR-4492	CLIP-seq
MIRT1289071	hsa-miR-4498	CLIP-seq
MIRT1289072	hsa-miR-4505	CLIP-seq
MIRT1289073	hsa-miR-4666-3p	CLIP-seq
MIRT1289074	hsa-miR-4699-3p	CLIP-seq
MIRT1289075	hsa-miR-4705	CLIP-seq
MIRT1289076	hsa-miR-4721	CLIP-seq
MIRT1289077	hsa-miR-4725-5p	CLIP-seq
MIRT1289078	hsa-miR-4726-3p	CLIP-seq
MIRT1289079	hsa-miR-4728-5p	CLIP-seq
MIRT1289080	hsa-miR-4731-5p	CLIP-seq
MIRT1289081	hsa-miR-4749-3p	CLIP-seq
MIRT1289082	hsa-miR-4789-5p	CLIP-seq
MIRT1289083	hsa-miR-504	CLIP-seq
MIRT1289084	hsa-miR-520f	CLIP-seq
MIRT1289085	hsa-miR-539	CLIP-seq
MIRT1289086	hsa-miR-634	CLIP-seq
MIRT1289087	hsa-miR-636	CLIP-seq
MIRT1289088	hsa-miR-762	CLIP-seq
MIRT1289089	hsa-miR-767-3p	CLIP-seq
MIRT1289090	hsa-miR-889	CLIP-seq
MIRT1289051	hsa-miR-1179	CLIP-seq
MIRT1289091	hsa-miR-1228	CLIP-seq
MIRT1289092	hsa-miR-1257	CLIP-seq
MIRT1289052	hsa-miR-1297	CLIP-seq
MIRT1289093	hsa-miR-183	CLIP-seq
MIRT1289054	hsa-miR-26a	CLIP-seq
MIRT1289055	hsa-miR-26b	CLIP-seq
MIRT1289094	hsa-miR-302a	CLIP-seq
MIRT1289095	hsa-miR-302b	CLIP-seq
MIRT1289096	hsa-miR-302c	CLIP-seq
MIRT1289097	hsa-miR-302d	CLIP-seq
MIRT1289098	hsa-miR-302e	CLIP-seq
MIRT1289057	hsa-miR-3065-5p	CLIP-seq
MIRT1289058	hsa-miR-3194-5p	CLIP-seq
MIRT1289099	hsa-miR-34a	CLIP-seq
MIRT1289100	hsa-miR-34c-5p	CLIP-seq
MIRT1289101	hsa-miR-372	CLIP-seq
MIRT1289102	hsa-miR-373	CLIP-seq
MIRT1289103	hsa-miR-4257	CLIP-seq
MIRT1289065	hsa-miR-4272	CLIP-seq
MIRT1289069	hsa-miR-4465	CLIP-seq
MIRT1289104	hsa-miR-449a	CLIP-seq
MIRT1289105	hsa-miR-449b	CLIP-seq
MIRT1289106	hsa-miR-4514	CLIP-seq
MIRT1289107	hsa-miR-4532	CLIP-seq
MIRT1289108	hsa-miR-4692	CLIP-seq
MIRT1289074	hsa-miR-4699-3p	CLIP-seq
MIRT1289081	hsa-miR-4749-3p	CLIP-seq
MIRT1289109	hsa-miR-4790-3p	CLIP-seq
MIRT1289110	hsa-miR-4797-5p	CLIP-seq
MIRT1289111	hsa-miR-486-3p	CLIP-seq
MIRT1289112	hsa-miR-520a-3p	CLIP-seq
MIRT1289113	hsa-miR-520b	CLIP-seq
MIRT1289114	hsa-miR-520c-3p	CLIP-seq
MIRT1289115	hsa-miR-520d-3p	CLIP-seq
MIRT1289116	hsa-miR-520e	CLIP-seq
MIRT1289084	hsa-miR-520f	CLIP-seq
MIRT1289117	hsa-miR-552	CLIP-seq
MIRT1289118	hsa-miR-566	CLIP-seq
MIRT1289086	hsa-miR-634	CLIP-seq
MIRT1289087	hsa-miR-636	CLIP-seq
MIRT2085785	hsa-miR-124	CLIP-seq
MIRT1289065	hsa-miR-4272	CLIP-seq
MIRT2085786	hsa-miR-506	CLIP-seq
MIRT2310990	hsa-miR-1207-5p	CLIP-seq
MIRT2085785	hsa-miR-124	CLIP-seq
MIRT2310991	hsa-miR-128	CLIP-seq
MIRT2310992	hsa-miR-27a	CLIP-seq
MIRT2310993	hsa-miR-27b	CLIP-seq
MIRT2310994	hsa-miR-3194-3p	CLIP-seq
MIRT2310995	hsa-miR-3545-5p	CLIP-seq
MIRT2310996	hsa-miR-3622b-5p	CLIP-seq
MIRT2310997	hsa-miR-3907	CLIP-seq
MIRT2310998	hsa-miR-3909	CLIP-seq
MIRT2310999	hsa-miR-421	CLIP-seq
MIRT1289065	hsa-miR-4272	CLIP-seq
MIRT1289066	hsa-miR-4293	CLIP-seq
MIRT1289081	hsa-miR-4749-3p	CLIP-seq
MIRT2311000	hsa-miR-4763-3p	CLIP-seq
MIRT2085786	hsa-miR-506	CLIP-seq
MIRT2607482	hsa-miR-1207-3p	CLIP-seq
MIRT2310990	hsa-miR-1207-5p	CLIP-seq
MIRT1289091	hsa-miR-1228	CLIP-seq
MIRT2085785	hsa-miR-124	CLIP-seq
MIRT2607483	hsa-miR-1271	CLIP-seq
MIRT2607484	hsa-miR-1306	CLIP-seq
MIRT2607485	hsa-miR-182	CLIP-seq
MIRT2607486	hsa-miR-2278	CLIP-seq
MIRT2607487	hsa-miR-2467-3p	CLIP-seq
MIRT2607488	hsa-miR-298	CLIP-seq
MIRT2607489	hsa-miR-3177-5p	CLIP-seq
MIRT2607490	hsa-miR-3180-5p	CLIP-seq
MIRT2607491	hsa-miR-3189-3p	CLIP-seq
MIRT2607492	hsa-miR-3199	CLIP-seq
MIRT2310995	hsa-miR-3545-5p	CLIP-seq
MIRT2310996	hsa-miR-3622b-5p	CLIP-seq
MIRT2607493	hsa-miR-3663-5p	CLIP-seq
MIRT2607494	hsa-miR-3678-3p	CLIP-seq
MIRT2607495	hsa-miR-3714	CLIP-seq
MIRT2310998	hsa-miR-3909	CLIP-seq
MIRT2607496	hsa-miR-3910	CLIP-seq
MIRT2310999	hsa-miR-421	CLIP-seq
MIRT1289103	hsa-miR-4257	CLIP-seq
MIRT2607497	hsa-miR-4268	CLIP-seq
MIRT2607498	hsa-miR-4270	CLIP-seq
MIRT1289065	hsa-miR-4272	CLIP-seq
MIRT1289066	hsa-miR-4293	CLIP-seq
MIRT2607499	hsa-miR-4441	CLIP-seq
MIRT2607500	hsa-miR-4448	CLIP-seq
MIRT2607501	hsa-miR-4468	CLIP-seq
MIRT2607502	hsa-miR-4470	CLIP-seq
MIRT1289106	hsa-miR-4514	CLIP-seq
MIRT1289107	hsa-miR-4532	CLIP-seq
MIRT2607503	hsa-miR-4540	CLIP-seq
MIRT2607504	hsa-miR-4646-5p	CLIP-seq
MIRT2607505	hsa-miR-4659a-5p	CLIP-seq
MIRT2607506	hsa-miR-4659b-5p	CLIP-seq
MIRT1289108	hsa-miR-4692	CLIP-seq
MIRT2607507	hsa-miR-4747-5p	CLIP-seq
MIRT2311000	hsa-miR-4763-3p	CLIP-seq
MIRT1289110	hsa-miR-4797-5p	CLIP-seq
MIRT1289111	hsa-miR-486-3p	CLIP-seq
MIRT2085786	hsa-miR-506	CLIP-seq
MIRT2607508	hsa-miR-512-5p	CLIP-seq
MIRT2607509	hsa-miR-520a-5p	CLIP-seq
MIRT2607510	hsa-miR-525-5p	CLIP-seq
MIRT2607511	hsa-miR-554	CLIP-seq
MIRT1289118	hsa-miR-566	CLIP-seq
MIRT2607512	hsa-miR-767-5p	CLIP-seq
MIRT2607513	hsa-miR-885-3p	CLIP-seq
MIRT2607514	hsa-miR-940	CLIP-seq
MIRT2607515	hsa-miR-96	CLIP-seq
MIRT2607482	hsa-miR-1207-3p	CLIP-seq
MIRT2310990	hsa-miR-1207-5p	CLIP-seq
MIRT1289091	hsa-miR-1228	CLIP-seq
MIRT2085785	hsa-miR-124	CLIP-seq
MIRT2607483	hsa-miR-1271	CLIP-seq
MIRT2607484	hsa-miR-1306	CLIP-seq
MIRT2607485	hsa-miR-182	CLIP-seq
MIRT2607486	hsa-miR-2278	CLIP-seq
MIRT2607488	hsa-miR-298	CLIP-seq
MIRT2607489	hsa-miR-3177-5p	CLIP-seq
MIRT2607490	hsa-miR-3180-5p	CLIP-seq
MIRT2607491	hsa-miR-3189-3p	CLIP-seq
MIRT2607492	hsa-miR-3199	CLIP-seq
MIRT2310995	hsa-miR-3545-5p	CLIP-seq
MIRT2310996	hsa-miR-3622b-5p	CLIP-seq
MIRT2607495	hsa-miR-3714	CLIP-seq
MIRT2310998	hsa-miR-3909	CLIP-seq
MIRT2607496	hsa-miR-3910	CLIP-seq
MIRT2310999	hsa-miR-421	CLIP-seq
MIRT1289103	hsa-miR-4257	CLIP-seq
MIRT2607497	hsa-miR-4268	CLIP-seq
MIRT2607498	hsa-miR-4270	CLIP-seq
MIRT1289065	hsa-miR-4272	CLIP-seq
MIRT2607499	hsa-miR-4441	CLIP-seq
MIRT2607500	hsa-miR-4448	CLIP-seq
MIRT2607501	hsa-miR-4468	CLIP-seq
MIRT2607502	hsa-miR-4470	CLIP-seq
MIRT1289106	hsa-miR-4514	CLIP-seq
MIRT1289107	hsa-miR-4532	CLIP-seq
MIRT2607503	hsa-miR-4540	CLIP-seq
MIRT2607504	hsa-miR-4646-5p	CLIP-seq
MIRT2607505	hsa-miR-4659a-5p	CLIP-seq
MIRT2607506	hsa-miR-4659b-5p	CLIP-seq
MIRT1289108	hsa-miR-4692	CLIP-seq
MIRT2607507	hsa-miR-4747-5p	CLIP-seq
MIRT2311000	hsa-miR-4763-3p	CLIP-seq
MIRT1289110	hsa-miR-4797-5p	CLIP-seq
MIRT1289111	hsa-miR-486-3p	CLIP-seq
MIRT2085786	hsa-miR-506	CLIP-seq
MIRT2607508	hsa-miR-512-5p	CLIP-seq
MIRT2607509	hsa-miR-520a-5p	CLIP-seq
MIRT2607510	hsa-miR-525-5p	CLIP-seq
MIRT2607511	hsa-miR-554	CLIP-seq
MIRT1289118	hsa-miR-566	CLIP-seq
MIRT2607512	hsa-miR-767-5p	CLIP-seq
MIRT2607513	hsa-miR-885-3p	CLIP-seq
MIRT2607514	hsa-miR-940	CLIP-seq
MIRT2607515	hsa-miR-96	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	20936779, 21988832, 22705156, 24441586, 25241761, 32296183, 35512704
GO:0005634	Component	Nucleus	IDA	22797597
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	22797597
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005903	Component	Brush border	IDA	22797597
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0030695	Function	GTPase regulator activity	IDA	7972015
GO:0030695	Function	GTPase regulator activity	NAS	9365783

MIM	HGNC	e!Ensembl
601619	9842	ENSG00000160271

Q12967

Protein name

Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)

Protein function

Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (By similarity). D

PDB

1RAX , 2B3A , 2RGF , 3KH0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00618	RasGEF_N	115 → 227	RasGEF N-terminal motif	Domain
PF00617	RasGEF	389 → 596	RasGEF domain	Family
PF00788	RA	798 → 885	Ras association (RalGDS/AF-6) domain	Domain

Sequence

MVQRMWAEAAGPAGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRP
ESSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGT
LEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCIL
PYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERR
AHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPA
PGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPS
LQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDK
KGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFS
SLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKF
ATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFE
VIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKK
NTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVE
EINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVS
GLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEE
EEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLP
RMKQKGLKIAKGIF

Sequence length

914

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway Pathways in cancer Colorectal cancer Pancreatic cancer Choline metabolism in cancer		p38MAPK events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary breast ovarian cancer syndrome	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	ClinGen	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult Medulloblastoma	Medulloblastoma	BEFREE	31039326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis 4, Juvenile	Amyotrophic lateral sclerosis	BEFREE	11085590		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	24222664		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	31039326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	24222664	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	31039326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21199803, 26222778	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	32075680	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	CTD_human_DG	21937992		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of brain	Brain Neoplasms	BEFREE	31039326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31488180		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15766660, 17568777		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	31039326		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	LHGDN	17992125		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Melanoma	Pubtator	20412563	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mental deficiency	Mental retardation	CTD_human_DG	21937992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15766660, 28032742		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noonan Syndrome	Noonan syndrome	Pubtator	25941399	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	24222664		★★★★★ ★☆☆☆☆ Found in Text Mining only
Profound Mental Retardation	Mental retardation	CTD_human_DG	21937992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31488180		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin Neoplasms	BEFREE	15766660		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	12140761, 21441953		★★★★★ ★☆☆☆☆ Found in Text Mining only

RALGDS (ral guanine nucleotide dissociation stimulator)