Gene Gene information from NCBI Gene database.
Entrez ID 5899
Gene name RAS like proto-oncogene B
Gene symbol RALB
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2q14.2
Summary This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Ju
miRNA miRNA information provided by mirtarbase database.
572
miRTarBase ID miRNA Experiments Reference
MIRT023622 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT025261 hsa-miR-34a-5p Proteomics 21566225
MIRT052235 hsa-let-7b-5p CLASH 23622248
MIRT1288664 hsa-miR-103b CLIP-seq
MIRT1288665 hsa-miR-1200 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001928 Process Regulation of exocyst assembly ISS
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 19166349
GO:0003924 Function GTPase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
179551 9840 ENSG00000144118
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11234
Protein name Ras-related protein Ral-B (EC 3.6.5.2)
Protein function Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes
PDB 2KE5 , 2KWI , 6ZQT , 6ZRN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 16 178 Ras family Domain
Sequence
Sequence length 206
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Ras signaling pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Pathways in cancer
Colorectal cancer
Pancreatic cancer
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Bladder Neoplasm Bladder Neoplasm LHGDN 17606711
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30320548, 39587695 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 26152517, 33122623 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 20801877, 22331470 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 21199803, 33122623 Associate
★☆☆☆☆
Found in Text Mining only
Leukemia, Myelocytic, Acute Leukemia BEFREE 27991934
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung neoplasms Pubtator 31433161 Associate
★☆☆☆☆
Found in Text Mining only
Melanoma Melanoma Pubtator 20562921 Associate
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasm Pancreatic Neoplasm LHGDN 17174914
★☆☆☆☆
Found in Text Mining only
Polycystic Ovary Syndrome Polycystic ovary syndrome Pubtator 39587695 Associate
★☆☆☆☆
Found in Text Mining only