Gene Gene information from NCBI Gene database.
Entrez ID 5893
Gene name RAD52 DNA repair protein
Gene symbol RAD52
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12p13.33
Summary The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-
miRNA miRNA information provided by mirtarbase database.
200
miRTarBase ID miRNA Experiments Reference
MIRT000156 hsa-miR-210-3p immunoprecipitaionqRT-PCR 19826008
MIRT000156 hsa-miR-210-3p Luciferase reporter assayqRT-PCRWestern blot 19141645
MIRT000156 hsa-miR-210-3p Luciferase reporter assayqRT-PCRWestern blot 19141645
MIRT003914 hsa-miR-373-3p Luciferase reporter assayqRT-PCRWestern blot 19141645
MIRT717823 hsa-miR-3671 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000724 Process Double-strand break repair via homologous recombination IBA
GO:0000724 Process Double-strand break repair via homologous recombination IEA
GO:0000724 Process Double-strand break repair via homologous recombination IEA
GO:0000730 Process DNA recombinase assembly IEA
GO:0003677 Function DNA binding IDA 19506022
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600392 9824 ENSG00000002016
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P43351
Protein name DNA repair protein RAD52 homolog
Protein function Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. {ECO:0000269|PubMed:12379650, ECO
PDB 1H2I , 1KN0 , 5JRB , 5XRZ , 5XS0 , 8BJM , 8H1P , 8RIL , 8RJ3 , 8RJW , 8TKQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04098 Rad52_Rad22 35 183 Rad52/22 family double-strand break repair protein Family
Sequence
MSGTEEAILGGRDSHPAAGGGSVLCFGQCQYTAEEYQAIQKALRQRLGPEYISSRMAGGG
QKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDGSY
HEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPR
QLP
LEVDLTKAKRQDLEPSVEEARYNSCRPNMALGHPQLQQVTSPSRPSHAVIPADQDCS
SRSLSSSAVESEATHQRKLRQKQLQQQFRERMEKQQVRVSTPSAEKSEAAPPAPPVTHST
PVTVSEPLLEKDFLAGVTQELIKTLEDNSEKWAVTPDAGDGVVKPSSRADPAQTSDTLAL
NNQMVTQNRTPHSVCHQKPQAKSGSWDLQTYSADQRTTGNWESHRKSQDMKKRKYDPS
Sequence length 418
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Homologous recombination   SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, SQUAMOUS CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Congenital myasthenic syndrome 19 Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 29924316
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 29667179, 30069034
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 10463575, 15958648, 23188672, 25566853, 27974172, 31569559
★☆☆☆☆
Found in Text Mining only
Breast Diseases Breast disease Pubtator 33275133 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 10507777, 21148102, 26548611, 26873923, 36107942, 37445737, 37578974 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 23836560, 26784987
★☆☆☆☆
Found in Text Mining only
Carcinoma Mucoepidermoid Mucoepidermoid carcinoma Pubtator 26035306 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 18449888, 22899653, 26013599, 29845285, 29924316
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma GWASCAT_DG 22899653
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 25793373, 29924316, 32401173 Associate
★☆☆☆☆
Found in Text Mining only