Gene Gene information from NCBI Gene database.
Entrez ID 58533
Gene name Sorting nexin 6
Gene symbol SNX6
Synonyms (NCBI Gene)
MSTP010TFAF2
Chromosome 14
Chromosome location 14q13.1
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the lept
miRNA miRNA information provided by mirtarbase database.
450
miRTarBase ID miRNA Experiments Reference
MIRT001331 hsa-miR-1-3p pSILAC 18668040
MIRT020606 hsa-miR-155-5p Proteomics 18668040
MIRT001331 hsa-miR-1-3p Proteomics;Other 18668040
MIRT031491 hsa-miR-16-5p Proteomics 18668040
MIRT052571 hsa-let-7a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11278302, 11279102, 19619496, 19935774, 20354142, 20830743, 21988832, 23524952, 26118995, 28514442, 31413325, 32296183, 32814053, 33961781, 35271311
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 11279102, 20830743
GO:0005737 Component Cytoplasm IEA
GO:0005764 Component Lysosome IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606098 14970 ENSG00000129515
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UNH7
Protein name Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]
Protein function Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00787 PX 56 170 PX domain Domain
PF09325 Vps5 182 399 Vps5 C terminal like Domain
Sequence
Sequence length 406
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Endocytosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Malignant neoplasm of pancreas Pancreatic cancer BEFREE 30307473
★☆☆☆☆
Found in Text Mining only
Pancreatic carcinoma Pancreatic carcinoma BEFREE 30307473
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Pancreatic neoplasm Pubtator 30307473 Associate
★☆☆☆☆
Found in Text Mining only
Parkinson Disease Parkinson disease BEFREE 30640902
★☆☆☆☆
Found in Text Mining only