Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	58478
Gene name	Enolase-phosphatase 1
Gene symbol	ENOPH1
Synonyms (NCBI Gene)	E1MASAMST145mtnC
Chromosome	4
Chromosome location	4q21.22

265

Show/Hide all (265)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019743	hsa-miR-375	Microarray	20215506
MIRT049352	hsa-miR-92a-3p	CLASH	23622248
MIRT042153	hsa-miR-484	CLASH	23622248
MIRT963647	hsa-miR-1229	CLIP-seq
MIRT963648	hsa-miR-124	CLIP-seq
MIRT963649	hsa-miR-1244	CLIP-seq
MIRT963650	hsa-miR-1252	CLIP-seq
MIRT963651	hsa-miR-1269	CLIP-seq
MIRT963652	hsa-miR-1269b	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT963654	hsa-miR-1288	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT963656	hsa-miR-148a	CLIP-seq
MIRT963657	hsa-miR-148b	CLIP-seq
MIRT963658	hsa-miR-152	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT963661	hsa-miR-2113	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT963664	hsa-miR-298	CLIP-seq
MIRT963665	hsa-miR-3117-5p	CLIP-seq
MIRT963666	hsa-miR-3121-3p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT963669	hsa-miR-3161	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT963671	hsa-miR-3173-3p	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT963675	hsa-miR-331-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963677	hsa-miR-342-3p	CLIP-seq
MIRT963678	hsa-miR-3612	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT963681	hsa-miR-3714	CLIP-seq
MIRT963682	hsa-miR-371-5p	CLIP-seq
MIRT963683	hsa-miR-371b-5p	CLIP-seq
MIRT963684	hsa-miR-3908	CLIP-seq
MIRT963685	hsa-miR-3910	CLIP-seq
MIRT963686	hsa-miR-3913-3p	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT963689	hsa-miR-3942-5p	CLIP-seq
MIRT963690	hsa-miR-409-3p	CLIP-seq
MIRT963691	hsa-miR-410	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT963695	hsa-miR-4305	CLIP-seq
MIRT963696	hsa-miR-4420	CLIP-seq
MIRT963697	hsa-miR-4422	CLIP-seq
MIRT963698	hsa-miR-4428	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT963701	hsa-miR-4490	CLIP-seq
MIRT963702	hsa-miR-4515	CLIP-seq
MIRT963703	hsa-miR-4639-5p	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT963706	hsa-miR-4678	CLIP-seq
MIRT963707	hsa-miR-4695-5p	CLIP-seq
MIRT963708	hsa-miR-4703-5p	CLIP-seq
MIRT963709	hsa-miR-4740-5p	CLIP-seq
MIRT963710	hsa-miR-4760-5p	CLIP-seq
MIRT963711	hsa-miR-4766-3p	CLIP-seq
MIRT963712	hsa-miR-4777-3p	CLIP-seq
MIRT963713	hsa-miR-489	CLIP-seq
MIRT963714	hsa-miR-506	CLIP-seq
MIRT963715	hsa-miR-5096	CLIP-seq
MIRT963716	hsa-miR-513c	CLIP-seq
MIRT963717	hsa-miR-514b-5p	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT963720	hsa-miR-548a-3p	CLIP-seq
MIRT963721	hsa-miR-548an	CLIP-seq
MIRT963722	hsa-miR-548e	CLIP-seq
MIRT963723	hsa-miR-548f	CLIP-seq
MIRT963724	hsa-miR-548g	CLIP-seq
MIRT963725	hsa-miR-562	CLIP-seq
MIRT963726	hsa-miR-576-3p	CLIP-seq
MIRT963727	hsa-miR-599	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT963729	hsa-miR-630	CLIP-seq
MIRT963730	hsa-miR-650	CLIP-seq
MIRT1985656	hsa-miR-1207-5p	CLIP-seq
MIRT963647	hsa-miR-1229	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT1985657	hsa-miR-153	CLIP-seq
MIRT1985658	hsa-miR-2110	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT963665	hsa-miR-3117-5p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT1985659	hsa-miR-3159	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT1985660	hsa-miR-3177-5p	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT1985661	hsa-miR-326	CLIP-seq
MIRT1985662	hsa-miR-330-5p	CLIP-seq
MIRT963677	hsa-miR-342-3p	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT1985663	hsa-miR-4271	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT963695	hsa-miR-4305	CLIP-seq
MIRT1985664	hsa-miR-4307	CLIP-seq
MIRT963696	hsa-miR-4420	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT1985665	hsa-miR-448	CLIP-seq
MIRT1985666	hsa-miR-4643	CLIP-seq
MIRT1985667	hsa-miR-4659a-3p	CLIP-seq
MIRT1985668	hsa-miR-4659b-3p	CLIP-seq
MIRT1985669	hsa-miR-466	CLIP-seq
MIRT1985670	hsa-miR-4667-5p	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT963706	hsa-miR-4678	CLIP-seq
MIRT1985671	hsa-miR-4700-5p	CLIP-seq
MIRT1985672	hsa-miR-4725-3p	CLIP-seq
MIRT1985673	hsa-miR-4736	CLIP-seq
MIRT963710	hsa-miR-4760-5p	CLIP-seq
MIRT1985674	hsa-miR-4763-3p	CLIP-seq
MIRT1985675	hsa-miR-4789-3p	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT1985676	hsa-miR-549	CLIP-seq
MIRT963726	hsa-miR-576-3p	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT1985677	hsa-miR-637	CLIP-seq
MIRT2220101	hsa-miR-1227	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT1985658	hsa-miR-2110	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT2220102	hsa-miR-3064-3p	CLIP-seq
MIRT963665	hsa-miR-3117-5p	CLIP-seq
MIRT963666	hsa-miR-3121-3p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT2220103	hsa-miR-3141	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT1985661	hsa-miR-326	CLIP-seq
MIRT1985662	hsa-miR-330-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963691	hsa-miR-410	CLIP-seq
MIRT1985663	hsa-miR-4271	CLIP-seq
MIRT2220104	hsa-miR-4282	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963695	hsa-miR-4305	CLIP-seq
MIRT2220105	hsa-miR-4329	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT1985670	hsa-miR-4667-5p	CLIP-seq
MIRT1985671	hsa-miR-4700-5p	CLIP-seq
MIRT1985672	hsa-miR-4725-3p	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT1985676	hsa-miR-549	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT1985677	hsa-miR-637	CLIP-seq
MIRT963647	hsa-miR-1229	CLIP-seq
MIRT963650	hsa-miR-1252	CLIP-seq
MIRT963651	hsa-miR-1269	CLIP-seq
MIRT963652	hsa-miR-1269b	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT963654	hsa-miR-1288	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT1985657	hsa-miR-153	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT963664	hsa-miR-298	CLIP-seq
MIRT2523950	hsa-miR-3124-3p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT963671	hsa-miR-3173-3p	CLIP-seq
MIRT2523951	hsa-miR-3174	CLIP-seq
MIRT1985660	hsa-miR-3177-5p	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963677	hsa-miR-342-3p	CLIP-seq
MIRT963678	hsa-miR-3612	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT2523952	hsa-miR-374a	CLIP-seq
MIRT2523953	hsa-miR-374b	CLIP-seq
MIRT963686	hsa-miR-3913-3p	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT963690	hsa-miR-409-3p	CLIP-seq
MIRT963691	hsa-miR-410	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT2220104	hsa-miR-4282	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT1985664	hsa-miR-4307	CLIP-seq
MIRT963698	hsa-miR-4428	CLIP-seq
MIRT2523954	hsa-miR-4432	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT1985665	hsa-miR-448	CLIP-seq
MIRT963702	hsa-miR-4515	CLIP-seq
MIRT2523955	hsa-miR-4517	CLIP-seq
MIRT1985666	hsa-miR-4643	CLIP-seq
MIRT1985669	hsa-miR-466	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT963707	hsa-miR-4695-5p	CLIP-seq
MIRT963709	hsa-miR-4740-5p	CLIP-seq
MIRT1985675	hsa-miR-4789-3p	CLIP-seq
MIRT963713	hsa-miR-489	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT963730	hsa-miR-650	CLIP-seq
MIRT963650	hsa-miR-1252	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT1985657	hsa-miR-153	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963664	hsa-miR-298	CLIP-seq
MIRT2523950	hsa-miR-3124-3p	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT2523951	hsa-miR-3174	CLIP-seq
MIRT1985660	hsa-miR-3177-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT963686	hsa-miR-3913-3p	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT2220104	hsa-miR-4282	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT1985664	hsa-miR-4307	CLIP-seq
MIRT2523954	hsa-miR-4432	CLIP-seq
MIRT1985665	hsa-miR-448	CLIP-seq
MIRT1985666	hsa-miR-4643	CLIP-seq
MIRT1985669	hsa-miR-466	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT1985675	hsa-miR-4789-3p	CLIP-seq
MIRT963713	hsa-miR-489	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008652	Process	Amino acid biosynthetic process	IEA
GO:0009086	Process	Methionine biosynthetic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IBA
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IDA	15843022
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IEA
GO:0043874	Function	Acireductone synthase activity	IBA
GO:0043874	Function	Acireductone synthase activity	IDA	15843022
GO:0043874	Function	Acireductone synthase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9UHY7

Protein name

Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)

Protein function

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the aci

PDB

1YNS , 1ZS9

Family and domains

Sequence

MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLR
KQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRA
AFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHF
DTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTD
DEKTYYSLITSFSELYLPSST

Sequence length

261

Interactions

View interactions

	KEGG		Reactome
	Cysteine and methionine metabolism Metabolic pathways		Methionine salvage pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Agenesis of corpus callosum	Agenesis Of Corpus Callosum	BEFREE	16088863, 8826452	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30066900	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	BEFREE	15662685, 16088863, 8636066	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	BEFREE	15662685	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	8782167, 8826452, 9744477	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31281503	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	30066900	★★★★★ ★☆☆☆☆ Found in Text Mining only
MASA SYNDROME (disorder)	MASA syndrome	BEFREE	15662685, 8809896, 8826452	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	8782167, 8826452, 9744477	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thumb in palm deformity	Adducted thumbs syndrome	BEFREE	16088863, 7762552, 8636066	★★★★★ ★☆☆☆☆ Found in Text Mining only
X-linked hydrocephalus syndrome	Hydrocephalus Syndrome, X-Linked	BEFREE	8636066, 8826452, 9521424	★★★★★ ★☆☆☆☆ Found in Text Mining only

ENOPH1 (enolase-phosphatase 1)