PXN (paxillin)

Gene

• Entrez ID: 5829
• Gene name: Paxillin
• Gene symbol: PXN
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q24.23
• Summary: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007346	hsa-miR-137	Luciferase reporter assay, qRT-PCR, Western blot	23275153
MIRT007346	hsa-miR-137	Luciferase reporter assay, qRT-PCR, Western blot	23275153
MIRT007346	hsa-miR-137	Luciferase reporter assay, qRT-PCR, Western blot	23275153
MIRT018650	hsa-miR-335-5p	Microarray	18185580
MIRT023030	hsa-miR-124-3p	Microarray	18668037
MIRT049136	hsa-miR-92a-3p	CLASH	23622248
MIRT046850	hsa-miR-221-3p	CLASH	23622248
MIRT732117	hsa-miR-212-3p	Luciferase reporter assay, qRT-PCR, Western blot	26693054
MIRT732117	hsa-miR-212-3p	Luciferase reporter assay, qRT-PCR, Western blot	26693054
MIRT732117	hsa-miR-212-3p	Luciferase reporter assay, qRT-PCR, Western blot	26693054
MIRT732117	hsa-miR-212-3p	Luciferase reporter assay, qRT-PCR, Western blot	26693054
MIRT1279099	hsa-miR-1200	CLIP-seq
MIRT1279100	hsa-miR-1225-3p	CLIP-seq
MIRT1279101	hsa-miR-1226	CLIP-seq
MIRT1279102	hsa-miR-1248	CLIP-seq
MIRT1279103	hsa-miR-1251	CLIP-seq
MIRT1279104	hsa-miR-1253	CLIP-seq
MIRT1279105	hsa-miR-125a-5p	CLIP-seq
MIRT1279106	hsa-miR-125b	CLIP-seq
MIRT1279107	hsa-miR-128	CLIP-seq
MIRT1279108	hsa-miR-132	CLIP-seq
MIRT1279109	hsa-miR-1910	CLIP-seq
MIRT1279110	hsa-miR-2110	CLIP-seq
MIRT1279111	hsa-miR-212	CLIP-seq
MIRT1279112	hsa-miR-24	CLIP-seq
MIRT1279113	hsa-miR-27a	CLIP-seq
MIRT1279114	hsa-miR-27b	CLIP-seq
MIRT1279115	hsa-miR-298	CLIP-seq
MIRT1279116	hsa-miR-299-5p	CLIP-seq
MIRT1279117	hsa-miR-3074-5p	CLIP-seq
MIRT1279118	hsa-miR-3120-3p	CLIP-seq
MIRT1279119	hsa-miR-3124-3p	CLIP-seq
MIRT1279120	hsa-miR-3127-3p	CLIP-seq
MIRT1279121	hsa-miR-3150a-3p	CLIP-seq
MIRT1279122	hsa-miR-3163	CLIP-seq
MIRT1279123	hsa-miR-3180-5p	CLIP-seq
MIRT1279124	hsa-miR-3189-5p	CLIP-seq
MIRT1279125	hsa-miR-340	CLIP-seq
MIRT1279126	hsa-miR-3622a-5p	CLIP-seq
MIRT1279127	hsa-miR-371-3p	CLIP-seq
MIRT1279128	hsa-miR-3714	CLIP-seq
MIRT1279129	hsa-miR-412	CLIP-seq
MIRT1279130	hsa-miR-4251	CLIP-seq
MIRT1279131	hsa-miR-4259	CLIP-seq
MIRT1279132	hsa-miR-4269	CLIP-seq
MIRT1279133	hsa-miR-4276	CLIP-seq
MIRT1279134	hsa-miR-4283	CLIP-seq
MIRT1279135	hsa-miR-4299	CLIP-seq
MIRT1279136	hsa-miR-4319	CLIP-seq
MIRT1279137	hsa-miR-4323	CLIP-seq
MIRT1279138	hsa-miR-4324	CLIP-seq
MIRT1279139	hsa-miR-4437	CLIP-seq
MIRT1279140	hsa-miR-4443	CLIP-seq
MIRT1279141	hsa-miR-4447	CLIP-seq
MIRT1279142	hsa-miR-4449	CLIP-seq
MIRT1279143	hsa-miR-4450	CLIP-seq
MIRT1279144	hsa-miR-4472	CLIP-seq
MIRT1279145	hsa-miR-4488	CLIP-seq
MIRT1279146	hsa-miR-4519	CLIP-seq
MIRT1279147	hsa-miR-4640-3p	CLIP-seq
MIRT1279148	hsa-miR-4645-5p	CLIP-seq
MIRT1279149	hsa-miR-4673	CLIP-seq
MIRT1279150	hsa-miR-4697-5p	CLIP-seq
MIRT1279151	hsa-miR-4710	CLIP-seq
MIRT1279152	hsa-miR-4716-3p	CLIP-seq
MIRT1279153	hsa-miR-4723-5p	CLIP-seq
MIRT1279154	hsa-miR-4792	CLIP-seq
MIRT1279155	hsa-miR-520a-5p	CLIP-seq
MIRT1279156	hsa-miR-525-5p	CLIP-seq
MIRT1279157	hsa-miR-544b	CLIP-seq
MIRT1279158	hsa-miR-558	CLIP-seq
MIRT1279159	hsa-miR-570	CLIP-seq
MIRT1279160	hsa-miR-610	CLIP-seq
MIRT1279161	hsa-miR-629	CLIP-seq
MIRT1279162	hsa-miR-1193	CLIP-seq
MIRT1279099	hsa-miR-1200	CLIP-seq
MIRT1279163	hsa-miR-1207-5p	CLIP-seq
MIRT1279100	hsa-miR-1225-3p	CLIP-seq
MIRT1279101	hsa-miR-1226	CLIP-seq
MIRT1279164	hsa-miR-1228	CLIP-seq
MIRT1279165	hsa-miR-1246	CLIP-seq
MIRT1279104	hsa-miR-1253	CLIP-seq
MIRT1279166	hsa-miR-1255b	CLIP-seq
MIRT1279167	hsa-miR-1256	CLIP-seq
MIRT1279168	hsa-miR-1287	CLIP-seq
MIRT1279169	hsa-miR-1290	CLIP-seq
MIRT1279170	hsa-miR-1292	CLIP-seq
MIRT1279171	hsa-miR-1324	CLIP-seq
MIRT1279172	hsa-miR-142-5p	CLIP-seq
MIRT1279173	hsa-miR-185	CLIP-seq
MIRT1279174	hsa-miR-1909	CLIP-seq
MIRT1279175	hsa-miR-199a-3p	CLIP-seq
MIRT1279176	hsa-miR-199b-3p	CLIP-seq
MIRT1279110	hsa-miR-2110	CLIP-seq
MIRT1279177	hsa-miR-2115	CLIP-seq
MIRT1279178	hsa-miR-2278	CLIP-seq
MIRT1279179	hsa-miR-2355-5p	CLIP-seq
MIRT1279112	hsa-miR-24	CLIP-seq
MIRT1279113	hsa-miR-27a	CLIP-seq
MIRT1279114	hsa-miR-27b	CLIP-seq
MIRT1279115	hsa-miR-298	CLIP-seq
MIRT1279180	hsa-miR-302f	CLIP-seq
MIRT1279181	hsa-miR-3065-5p	CLIP-seq
MIRT1279117	hsa-miR-3074-5p	CLIP-seq
MIRT1279182	hsa-miR-3119	CLIP-seq
MIRT1279119	hsa-miR-3124-3p	CLIP-seq
MIRT1279183	hsa-miR-3125	CLIP-seq
MIRT1279184	hsa-miR-3129-5p	CLIP-seq
MIRT1279185	hsa-miR-3134	CLIP-seq
MIRT1279186	hsa-miR-3135	CLIP-seq
MIRT1279187	hsa-miR-3135b	CLIP-seq
MIRT1279122	hsa-miR-3163	CLIP-seq
MIRT1279188	hsa-miR-3167	CLIP-seq
MIRT1279189	hsa-miR-3188	CLIP-seq
MIRT1279124	hsa-miR-3189-5p	CLIP-seq
MIRT1279190	hsa-miR-3201	CLIP-seq
MIRT1279191	hsa-miR-3202	CLIP-seq
MIRT1279192	hsa-miR-330-3p	CLIP-seq
MIRT1279193	hsa-miR-335	CLIP-seq
MIRT1279194	hsa-miR-34b	CLIP-seq
MIRT1279195	hsa-miR-3616-5p	CLIP-seq
MIRT1279196	hsa-miR-3647-5p	CLIP-seq
MIRT1279128	hsa-miR-3714	CLIP-seq
MIRT1279197	hsa-miR-377	CLIP-seq
MIRT1279198	hsa-miR-3916	CLIP-seq
MIRT1279199	hsa-miR-3926	CLIP-seq
MIRT1279200	hsa-miR-3928	CLIP-seq
MIRT1279201	hsa-miR-3977	CLIP-seq
MIRT1279130	hsa-miR-4251	CLIP-seq
MIRT1279202	hsa-miR-4264	CLIP-seq
MIRT1279203	hsa-miR-4271	CLIP-seq
MIRT1279133	hsa-miR-4276	CLIP-seq
MIRT1279134	hsa-miR-4283	CLIP-seq
MIRT1279204	hsa-miR-4286	CLIP-seq
MIRT1279205	hsa-miR-4306	CLIP-seq
MIRT1279137	hsa-miR-4323	CLIP-seq
MIRT1279138	hsa-miR-4324	CLIP-seq
MIRT1279206	hsa-miR-4436b-3p	CLIP-seq
MIRT1279139	hsa-miR-4437	CLIP-seq
MIRT1279141	hsa-miR-4447	CLIP-seq
MIRT1279142	hsa-miR-4449	CLIP-seq
MIRT1279207	hsa-miR-4468	CLIP-seq
MIRT1279144	hsa-miR-4472	CLIP-seq
MIRT1279145	hsa-miR-4488	CLIP-seq
MIRT1279146	hsa-miR-4519	CLIP-seq
MIRT1279208	hsa-miR-4533	CLIP-seq
MIRT1279209	hsa-miR-4644	CLIP-seq
MIRT1279210	hsa-miR-4650-5p	CLIP-seq
MIRT1279211	hsa-miR-4667-5p	CLIP-seq
MIRT1279212	hsa-miR-4688	CLIP-seq
MIRT1279150	hsa-miR-4697-5p	CLIP-seq
MIRT1279213	hsa-miR-4700-5p	CLIP-seq
MIRT1279152	hsa-miR-4716-3p	CLIP-seq
MIRT1279214	hsa-miR-4720-5p	CLIP-seq
MIRT1279153	hsa-miR-4723-5p	CLIP-seq
MIRT1279215	hsa-miR-4725-3p	CLIP-seq
MIRT1279216	hsa-miR-4728-3p	CLIP-seq
MIRT1279217	hsa-miR-4747-5p	CLIP-seq
MIRT1279218	hsa-miR-4755-3p	CLIP-seq
MIRT1279219	hsa-miR-4761-3p	CLIP-seq
MIRT1279220	hsa-miR-4763-3p	CLIP-seq
MIRT1279221	hsa-miR-4773	CLIP-seq
MIRT1279222	hsa-miR-4787-5p	CLIP-seq
MIRT1279223	hsa-miR-4791	CLIP-seq
MIRT1279224	hsa-miR-4795-5p	CLIP-seq
MIRT1279225	hsa-miR-4797-3p	CLIP-seq
MIRT1279226	hsa-miR-4799-3p	CLIP-seq
MIRT1279227	hsa-miR-486-3p	CLIP-seq
MIRT1279228	hsa-miR-488	CLIP-seq
MIRT1279229	hsa-miR-491-3p	CLIP-seq
MIRT1279230	hsa-miR-513a-5p	CLIP-seq
MIRT1279231	hsa-miR-516a-3p	CLIP-seq
MIRT1279232	hsa-miR-520d-5p	CLIP-seq
MIRT1279233	hsa-miR-524-5p	CLIP-seq
MIRT1279234	hsa-miR-542-3p	CLIP-seq
MIRT1279157	hsa-miR-544b	CLIP-seq
MIRT1279235	hsa-miR-548an	CLIP-seq
MIRT1279236	hsa-miR-548s	CLIP-seq
MIRT1279158	hsa-miR-558	CLIP-seq
MIRT1279237	hsa-miR-561	CLIP-seq
MIRT1279159	hsa-miR-570	CLIP-seq
MIRT1279238	hsa-miR-573	CLIP-seq
MIRT1279239	hsa-miR-577	CLIP-seq
MIRT1279240	hsa-miR-583	CLIP-seq
MIRT1279241	hsa-miR-637	CLIP-seq
MIRT1279242	hsa-miR-765	CLIP-seq
MIRT1279243	hsa-miR-876-5p	CLIP-seq
MIRT1279244	hsa-miR-936	CLIP-seq
MIRT1279245	hsa-miR-940	CLIP-seq
MIRT1279199	hsa-miR-3926	CLIP-seq
MIRT1552821	hsa-miR-4311	CLIP-seq
MIRT1279236	hsa-miR-548s	CLIP-seq
MIRT1552822	hsa-miR-759	CLIP-seq
MIRT1279099	hsa-miR-1200	CLIP-seq
MIRT1279163	hsa-miR-1207-5p	CLIP-seq
MIRT1279100	hsa-miR-1225-3p	CLIP-seq
MIRT1279101	hsa-miR-1226	CLIP-seq
MIRT1279103	hsa-miR-1251	CLIP-seq
MIRT1279104	hsa-miR-1253	CLIP-seq
MIRT1279107	hsa-miR-128	CLIP-seq
MIRT1279168	hsa-miR-1287	CLIP-seq
MIRT2082262	hsa-miR-1587	CLIP-seq
MIRT1279173	hsa-miR-185	CLIP-seq
MIRT1279174	hsa-miR-1909	CLIP-seq
MIRT2082263	hsa-miR-1913	CLIP-seq
MIRT2082264	hsa-miR-1972	CLIP-seq
MIRT1279110	hsa-miR-2110	CLIP-seq
MIRT1279179	hsa-miR-2355-5p	CLIP-seq
MIRT2082265	hsa-miR-2392	CLIP-seq
MIRT1279112	hsa-miR-24	CLIP-seq
MIRT2082266	hsa-miR-2467-3p	CLIP-seq
MIRT1279113	hsa-miR-27a	CLIP-seq
MIRT1279114	hsa-miR-27b	CLIP-seq
MIRT2082267	hsa-miR-296-5p	CLIP-seq
MIRT1279115	hsa-miR-298	CLIP-seq
MIRT2082268	hsa-miR-3064-5p	CLIP-seq
MIRT1279117	hsa-miR-3074-5p	CLIP-seq
MIRT1279182	hsa-miR-3119	CLIP-seq
MIRT1279119	hsa-miR-3124-3p	CLIP-seq
MIRT1279120	hsa-miR-3127-3p	CLIP-seq
MIRT2082269	hsa-miR-3128	CLIP-seq
MIRT1279186	hsa-miR-3135	CLIP-seq
MIRT1279187	hsa-miR-3135b	CLIP-seq
MIRT2082270	hsa-miR-3144-5p	CLIP-seq
MIRT1279121	hsa-miR-3150a-3p	CLIP-seq
MIRT2082271	hsa-miR-3151	CLIP-seq
MIRT2082272	hsa-miR-3179	CLIP-seq
MIRT1279189	hsa-miR-3188	CLIP-seq
MIRT1279124	hsa-miR-3189-5p	CLIP-seq
MIRT2082273	hsa-miR-3191	CLIP-seq
MIRT1279191	hsa-miR-3202	CLIP-seq
MIRT2082274	hsa-miR-324-3p	CLIP-seq
MIRT2082275	hsa-miR-342-5p	CLIP-seq
MIRT2082276	hsa-miR-3605-5p	CLIP-seq
MIRT2082277	hsa-miR-3652	CLIP-seq
MIRT2082278	hsa-miR-3677-3p	CLIP-seq
MIRT2082279	hsa-miR-3684	CLIP-seq
MIRT1279128	hsa-miR-3714	CLIP-seq
MIRT2082280	hsa-miR-3922-5p	CLIP-seq
MIRT2082281	hsa-miR-3925-5p	CLIP-seq
MIRT2082282	hsa-miR-3976	CLIP-seq
MIRT1279129	hsa-miR-412	CLIP-seq
MIRT1279130	hsa-miR-4251	CLIP-seq
MIRT1279131	hsa-miR-4259	CLIP-seq
MIRT1279202	hsa-miR-4264	CLIP-seq
MIRT1279203	hsa-miR-4271	CLIP-seq
MIRT1279133	hsa-miR-4276	CLIP-seq
MIRT2082283	hsa-miR-4279	CLIP-seq
MIRT1279134	hsa-miR-4283	CLIP-seq
MIRT1279205	hsa-miR-4306	CLIP-seq
MIRT1279137	hsa-miR-4323	CLIP-seq
MIRT1279138	hsa-miR-4324	CLIP-seq
MIRT2082284	hsa-miR-4430	CLIP-seq
MIRT2082285	hsa-miR-4433	CLIP-seq
MIRT2082286	hsa-miR-4435	CLIP-seq
MIRT1279139	hsa-miR-4437	CLIP-seq
MIRT1279141	hsa-miR-4447	CLIP-seq
MIRT1279142	hsa-miR-4449	CLIP-seq
MIRT1279143	hsa-miR-4450	CLIP-seq
MIRT2082287	hsa-miR-4459	CLIP-seq
MIRT1279207	hsa-miR-4468	CLIP-seq
MIRT1279144	hsa-miR-4472	CLIP-seq
MIRT2082288	hsa-miR-4481	CLIP-seq
MIRT1279145	hsa-miR-4488	CLIP-seq
MIRT2082289	hsa-miR-4492	CLIP-seq
MIRT2082290	hsa-miR-4498	CLIP-seq
MIRT2082291	hsa-miR-4505	CLIP-seq
MIRT1279146	hsa-miR-4519	CLIP-seq
MIRT2082292	hsa-miR-4534	CLIP-seq
MIRT1279209	hsa-miR-4644	CLIP-seq
MIRT2082293	hsa-miR-4651	CLIP-seq
MIRT2082294	hsa-miR-4652-5p	CLIP-seq
MIRT2082295	hsa-miR-4656	CLIP-seq
MIRT2082296	hsa-miR-4664-5p	CLIP-seq
MIRT1279211	hsa-miR-4667-5p	CLIP-seq
MIRT2082297	hsa-miR-4675	CLIP-seq
MIRT1279212	hsa-miR-4688	CLIP-seq
MIRT2082298	hsa-miR-4693-3p	CLIP-seq
MIRT1279150	hsa-miR-4697-5p	CLIP-seq
MIRT1279213	hsa-miR-4700-5p	CLIP-seq
MIRT1279152	hsa-miR-4716-3p	CLIP-seq
MIRT1279214	hsa-miR-4720-5p	CLIP-seq
MIRT1279215	hsa-miR-4725-3p	CLIP-seq
MIRT2082299	hsa-miR-4731-5p	CLIP-seq
MIRT2082300	hsa-miR-4736	CLIP-seq
MIRT2082301	hsa-miR-4741	CLIP-seq
MIRT2082302	hsa-miR-4745-5p	CLIP-seq
MIRT1279217	hsa-miR-4747-5p	CLIP-seq
MIRT1279218	hsa-miR-4755-3p	CLIP-seq
MIRT1279220	hsa-miR-4763-3p	CLIP-seq
MIRT2082303	hsa-miR-4768-3p	CLIP-seq
MIRT2082304	hsa-miR-4783-3p	CLIP-seq
MIRT1279225	hsa-miR-4797-3p	CLIP-seq
MIRT1279226	hsa-miR-4799-3p	CLIP-seq
MIRT2082305	hsa-miR-4802-3p	CLIP-seq
MIRT1279227	hsa-miR-486-3p	CLIP-seq
MIRT2082306	hsa-miR-491-5p	CLIP-seq
MIRT1279230	hsa-miR-513a-5p	CLIP-seq
MIRT1279157	hsa-miR-544b	CLIP-seq
MIRT1279159	hsa-miR-570	CLIP-seq
MIRT2082307	hsa-miR-608	CLIP-seq
MIRT2082308	hsa-miR-642a	CLIP-seq
MIRT2082309	hsa-miR-762	CLIP-seq
MIRT2082310	hsa-miR-939	CLIP-seq
MIRT1279099	hsa-miR-1200	CLIP-seq
MIRT2082271	hsa-miR-3151	CLIP-seq
MIRT1279138	hsa-miR-4324	CLIP-seq
MIRT1279141	hsa-miR-4447	CLIP-seq
MIRT1279144	hsa-miR-4472	CLIP-seq
MIRT2082306	hsa-miR-491-5p	CLIP-seq
MIRT2307876	hsa-miR-4517	CLIP-seq
MIRT1279108	hsa-miR-132	CLIP-seq
MIRT2082263	hsa-miR-1913	CLIP-seq
MIRT2307877	hsa-miR-203	CLIP-seq
MIRT1279111	hsa-miR-212	CLIP-seq
MIRT1279118	hsa-miR-3120-3p	CLIP-seq
MIRT1279119	hsa-miR-3124-3p	CLIP-seq
MIRT2307878	hsa-miR-3153	CLIP-seq
MIRT1279122	hsa-miR-3163	CLIP-seq
MIRT1279191	hsa-miR-3202	CLIP-seq
MIRT2082274	hsa-miR-324-3p	CLIP-seq
MIRT1279125	hsa-miR-340	CLIP-seq
MIRT1279195	hsa-miR-3616-5p	CLIP-seq
MIRT1279196	hsa-miR-3647-5p	CLIP-seq
MIRT2307879	hsa-miR-3919	CLIP-seq
MIRT1279203	hsa-miR-4271	CLIP-seq
MIRT2307880	hsa-miR-4313	CLIP-seq
MIRT1279141	hsa-miR-4447	CLIP-seq
MIRT2307881	hsa-miR-4453	CLIP-seq
MIRT1279144	hsa-miR-4472	CLIP-seq
MIRT1279146	hsa-miR-4519	CLIP-seq
MIRT2307882	hsa-miR-4538	CLIP-seq
MIRT2307883	hsa-miR-4668-5p	CLIP-seq
MIRT2307884	hsa-miR-4707-5p	CLIP-seq
MIRT1279152	hsa-miR-4716-3p	CLIP-seq
MIRT1279214	hsa-miR-4720-5p	CLIP-seq
MIRT1279153	hsa-miR-4723-5p	CLIP-seq
MIRT1279215	hsa-miR-4725-3p	CLIP-seq
MIRT1279217	hsa-miR-4747-5p	CLIP-seq
MIRT1279218	hsa-miR-4755-3p	CLIP-seq
MIRT1279224	hsa-miR-4795-5p	CLIP-seq
MIRT1279226	hsa-miR-4799-3p	CLIP-seq
MIRT2082306	hsa-miR-491-5p	CLIP-seq
MIRT1279158	hsa-miR-558	CLIP-seq
MIRT1279238	hsa-miR-573	CLIP-seq
MIRT1279240	hsa-miR-583	CLIP-seq
MIRT1279242	hsa-miR-765	CLIP-seq
MIRT1279100	hsa-miR-1225-3p	CLIP-seq
MIRT1279173	hsa-miR-185	CLIP-seq
MIRT2307877	hsa-miR-203	CLIP-seq
MIRT1279113	hsa-miR-27a	CLIP-seq
MIRT1279114	hsa-miR-27b	CLIP-seq
MIRT1279115	hsa-miR-298	CLIP-seq
MIRT1279124	hsa-miR-3189-5p	CLIP-seq
MIRT1279128	hsa-miR-3714	CLIP-seq
MIRT1279133	hsa-miR-4276	CLIP-seq
MIRT1279205	hsa-miR-4306	CLIP-seq
MIRT1279137	hsa-miR-4323	CLIP-seq
MIRT1279209	hsa-miR-4644	CLIP-seq
MIRT1279217	hsa-miR-4747-5p	CLIP-seq
MIRT1279230	hsa-miR-513a-5p	CLIP-seq
MIRT2082310	hsa-miR-939	CLIP-seq
MIRT2082306	hsa-miR-491-5p	CLIP-seq
MIRT1279166	hsa-miR-1255b	CLIP-seq
MIRT2605175	hsa-miR-1276	CLIP-seq
MIRT1279170	hsa-miR-1292	CLIP-seq
MIRT2605176	hsa-miR-149	CLIP-seq
MIRT2082263	hsa-miR-1913	CLIP-seq
MIRT1279110	hsa-miR-2110	CLIP-seq
MIRT2605177	hsa-miR-2114	CLIP-seq
MIRT2605178	hsa-miR-216b	CLIP-seq
MIRT2082267	hsa-miR-296-5p	CLIP-seq
MIRT1279121	hsa-miR-3150a-3p	CLIP-seq
MIRT2082271	hsa-miR-3151	CLIP-seq
MIRT2605179	hsa-miR-3156-5p	CLIP-seq
MIRT2605180	hsa-miR-3189-3p	CLIP-seq
MIRT2082274	hsa-miR-324-3p	CLIP-seq
MIRT2605181	hsa-miR-362-5p	CLIP-seq
MIRT2082279	hsa-miR-3684	CLIP-seq
MIRT2307879	hsa-miR-3919	CLIP-seq
MIRT2082280	hsa-miR-3922-5p	CLIP-seq
MIRT1279200	hsa-miR-3928	CLIP-seq
MIRT2605182	hsa-miR-4268	CLIP-seq
MIRT1279203	hsa-miR-4271	CLIP-seq
MIRT2082283	hsa-miR-4279	CLIP-seq
MIRT1552821	hsa-miR-4311	CLIP-seq
MIRT2307880	hsa-miR-4313	CLIP-seq
MIRT2082285	hsa-miR-4433	CLIP-seq
MIRT2082287	hsa-miR-4459	CLIP-seq
MIRT2307876	hsa-miR-4517	CLIP-seq
MIRT2605183	hsa-miR-4668-3p	CLIP-seq
MIRT2307884	hsa-miR-4707-5p	CLIP-seq
MIRT1279215	hsa-miR-4725-3p	CLIP-seq
MIRT2605184	hsa-miR-4725-5p	CLIP-seq
MIRT2605185	hsa-miR-4756-3p	CLIP-seq
MIRT2605186	hsa-miR-4763-5p	CLIP-seq
MIRT2082303	hsa-miR-4768-3p	CLIP-seq
MIRT2082304	hsa-miR-4783-3p	CLIP-seq
MIRT2605187	hsa-miR-4793-3p	CLIP-seq
MIRT2605188	hsa-miR-4793-5p	CLIP-seq
MIRT2605189	hsa-miR-500b	CLIP-seq
MIRT2605190	hsa-miR-504	CLIP-seq
MIRT1279240	hsa-miR-583	CLIP-seq
MIRT2605191	hsa-miR-635	CLIP-seq
MIRT2082308	hsa-miR-642a	CLIP-seq
MIRT2605192	hsa-miR-670	CLIP-seq
MIRT2605193	hsa-miR-711	CLIP-seq
MIRT2605194	hsa-miR-938	CLIP-seq
MIRT2082263	hsa-miR-1913	CLIP-seq
MIRT2082271	hsa-miR-3151	CLIP-seq
MIRT2082274	hsa-miR-324-3p	CLIP-seq
MIRT1279166	hsa-miR-1255b	CLIP-seq
MIRT2605175	hsa-miR-1276	CLIP-seq
MIRT1279170	hsa-miR-1292	CLIP-seq
MIRT2605176	hsa-miR-149	CLIP-seq
MIRT1279110	hsa-miR-2110	CLIP-seq
MIRT2605177	hsa-miR-2114	CLIP-seq
MIRT1279179	hsa-miR-2355-5p	CLIP-seq
MIRT2082267	hsa-miR-296-5p	CLIP-seq
MIRT1279121	hsa-miR-3150a-3p	CLIP-seq
MIRT2082271	hsa-miR-3151	CLIP-seq
MIRT2605179	hsa-miR-3156-5p	CLIP-seq
MIRT2605180	hsa-miR-3189-3p	CLIP-seq
MIRT2689185	hsa-miR-326	CLIP-seq
MIRT2689186	hsa-miR-330-5p	CLIP-seq
MIRT2605181	hsa-miR-362-5p	CLIP-seq
MIRT2689187	hsa-miR-3679-3p	CLIP-seq
MIRT2082279	hsa-miR-3684	CLIP-seq
MIRT2307879	hsa-miR-3919	CLIP-seq
MIRT2082280	hsa-miR-3922-5p	CLIP-seq
MIRT1279200	hsa-miR-3928	CLIP-seq
MIRT2605182	hsa-miR-4268	CLIP-seq
MIRT1279203	hsa-miR-4271	CLIP-seq
MIRT2082283	hsa-miR-4279	CLIP-seq
MIRT1552821	hsa-miR-4311	CLIP-seq
MIRT2082285	hsa-miR-4433	CLIP-seq
MIRT2082287	hsa-miR-4459	CLIP-seq
MIRT1279211	hsa-miR-4667-5p	CLIP-seq
MIRT1279213	hsa-miR-4700-5p	CLIP-seq
MIRT1279215	hsa-miR-4725-3p	CLIP-seq
MIRT2605185	hsa-miR-4756-3p	CLIP-seq
MIRT2082303	hsa-miR-4768-3p	CLIP-seq
MIRT2082304	hsa-miR-4783-3p	CLIP-seq
MIRT2605188	hsa-miR-4793-5p	CLIP-seq
MIRT2605189	hsa-miR-500b	CLIP-seq
MIRT1279240	hsa-miR-583	CLIP-seq
MIRT2605191	hsa-miR-635	CLIP-seq
MIRT1279241	hsa-miR-637	CLIP-seq
MIRT2082308	hsa-miR-642a	CLIP-seq
MIRT2605193	hsa-miR-711	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IDA	24036928
GO:0005515	Function	Protein binding	IPI	7561682, 9756887, 10604475, 10814581, 11035932, 12861019, 14665621, 14688263, 15572663, 16628223, 17082770, 18940607, 19167335, 19492042, 20489202, 21034468, 21173240, 21741599, 22270917, 22728435, 23393263, 23397142, 24694988, 24863063, 25795725, 26598620, 27880917, 31980649, 32296
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005875	Component	Microtubule associated complex	TAS	10840040
GO:0005886	Component	Plasma membrane	IDA	17449030
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IMP	25753039
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA	12686598, 20086044, 23574715, 24863063
GO:0005925	Component	Focal adhesion	IEA
GO:0005925	Component	Focal adhesion	IMP	25705373
GO:0005938	Component	Cell cortex	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	NAS	10840040
GO:0007165	Process	Signal transduction	TAS	7534286
GO:0007172	Process	Signal complex assembly	TAS	9054445
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IBA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IDA	24036928
GO:0008013	Function	Beta-catenin binding	IPI	17513457
GO:0016477	Process	Cell migration	IMP	23275153, 26693054
GO:0017166	Function	Vinculin binding	IPI	9054445
GO:0019903	Function	Protein phosphatase binding	IPI	28759036
GO:0030027	Component	Lamellipodium	IDA	12686598
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IBA
GO:0034614	Process	Cellular response to reactive oxygen species	IEP	12686598
GO:0038191	Function	Neuropilin binding	IPI	24863063
GO:0043542	Process	Endothelial cell migration	IBA
GO:0043542	Process	Endothelial cell migration	IMP	24863063
GO:0046872	Function	Metal ion binding	IEA
GO:0051496	Process	Positive regulation of stress fiber assembly	IMP	24863063
GO:0060396	Process	Growth hormone receptor signaling pathway	IDA	10925297
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 602505
• HGNC: 9718
• e!Ensembl: ENSG00000089159

Protein

• UniProt ID: P49023
• Protein name: Paxillin
• Protein function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion.
• PDB: 1OW6, 1OW7, 1OW8, 2K2R, 2O9V, 2VZD, 2VZG, 2VZI, 3GM1, 3PY7, 3RQE, 3RQF, 3RQG, 3U3F, 4EDN, 4R32, 4XGZ, 4XH2, 5UWH, 6IUI, 6PW8, 6U4M, 6U4N, 7QB0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03535	Paxillin	44 → 253		Family
  PF00412	LIM	358 → 413	LIM domain	Domain
  PF00412	LIM	417 → 472	LIM domain	Domain
  PF00412	LIM	476 → 531	LIM domain	Domain
  PF00412	LIM	535 → 590	LIM domain	Domain

• Sequence:

  MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG
  TILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF
  PNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPL
  YGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQG
  EMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKIQGLEQRADGERCWAAGWPRDGG
  RSSPGGQDEGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGA
  CKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYC
  NGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCA
  RAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQK
  PITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC

• Sequence length: 591

Pathways

KEGG:

Chemokine signaling pathway
VEGF signaling pathway
Focal adhesion
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Shigellosis
Yersinia infection
Human cytomegalovirus infection
Human papillomavirus infection
Human immunodeficiency virus 1 infection
Viral carcinogenesis
Proteoglycans in cancer

Reactome:

GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations