Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57863
Gene name	Cell adhesion molecule 3
Gene symbol	CADM3
Synonyms (NCBI Gene)	BIgRCMT2FFIGSF4BNECL1Necl-1TSLL1synCAM3
Chromosome	1
Chromosome location	1q23.2
Summary	The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is re

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Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT610632	hsa-miR-8485	HITS-CLIP	23313552
MIRT610631	hsa-miR-4643	HITS-CLIP	23313552
MIRT610629	hsa-miR-8064	HITS-CLIP	23313552
MIRT705023	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT624461	hsa-miR-5689	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23313552
MIRT610631	hsa-miR-4643	HITS-CLIP	23313552
MIRT610629	hsa-miR-8064	HITS-CLIP	23313552
MIRT705023	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT624461	hsa-miR-5689	HITS-CLIP	23824327
MIRT610632	hsa-miR-8485	HITS-CLIP	23824327
MIRT610631	hsa-miR-4643	HITS-CLIP	23824327
MIRT610629	hsa-miR-8064	HITS-CLIP	23824327
MIRT858590	hsa-miR-1225-5p	CLIP-seq
MIRT858591	hsa-miR-1267	CLIP-seq
MIRT858592	hsa-miR-1273g	CLIP-seq
MIRT858593	hsa-miR-140-5p	CLIP-seq
MIRT858594	hsa-miR-3148	CLIP-seq
MIRT858595	hsa-miR-3153	CLIP-seq
MIRT858596	hsa-miR-3192	CLIP-seq
MIRT858597	hsa-miR-3194-3p	CLIP-seq
MIRT858598	hsa-miR-323-5p	CLIP-seq
MIRT858599	hsa-miR-3613-5p	CLIP-seq
MIRT858600	hsa-miR-3674	CLIP-seq
MIRT858601	hsa-miR-3680	CLIP-seq
MIRT858602	hsa-miR-3689a-3p	CLIP-seq
MIRT858603	hsa-miR-3689c	CLIP-seq
MIRT858604	hsa-miR-3929	CLIP-seq
MIRT858605	hsa-miR-4314	CLIP-seq
MIRT858606	hsa-miR-4419b	CLIP-seq
MIRT858607	hsa-miR-4478	CLIP-seq
MIRT858608	hsa-miR-4646-5p	CLIP-seq
MIRT858609	hsa-miR-4659a-5p	CLIP-seq
MIRT858610	hsa-miR-4659b-5p	CLIP-seq
MIRT858611	hsa-miR-4668-5p	CLIP-seq
MIRT858612	hsa-miR-4728-5p	CLIP-seq
MIRT858613	hsa-miR-4732-5p	CLIP-seq
MIRT858614	hsa-miR-4747-5p	CLIP-seq
MIRT858615	hsa-miR-485-5p	CLIP-seq
MIRT858616	hsa-miR-765	CLIP-seq
MIRT858617	hsa-miR-876-3p	CLIP-seq
MIRT858618	hsa-miR-1225-3p	CLIP-seq
MIRT858619	hsa-miR-1256	CLIP-seq
MIRT858620	hsa-miR-1275	CLIP-seq
MIRT858621	hsa-miR-138	CLIP-seq
MIRT858622	hsa-miR-2467-3p	CLIP-seq
MIRT858623	hsa-miR-3125	CLIP-seq
MIRT858624	hsa-miR-3173-3p	CLIP-seq
MIRT858625	hsa-miR-320a	CLIP-seq
MIRT858626	hsa-miR-320b	CLIP-seq
MIRT858627	hsa-miR-320c	CLIP-seq
MIRT858628	hsa-miR-320d	CLIP-seq
MIRT858629	hsa-miR-320e	CLIP-seq
MIRT858630	hsa-miR-3916	CLIP-seq
MIRT858631	hsa-miR-3943	CLIP-seq
MIRT858632	hsa-miR-4299	CLIP-seq
MIRT858633	hsa-miR-4300	CLIP-seq
MIRT858634	hsa-miR-4429	CLIP-seq
MIRT858635	hsa-miR-4446-3p	CLIP-seq
MIRT858636	hsa-miR-4492	CLIP-seq
MIRT858637	hsa-miR-4498	CLIP-seq
MIRT858638	hsa-miR-4525	CLIP-seq
MIRT858639	hsa-miR-4651	CLIP-seq
MIRT858640	hsa-miR-4665-5p	CLIP-seq
MIRT858641	hsa-miR-4710	CLIP-seq
MIRT858642	hsa-miR-4721	CLIP-seq
MIRT858643	hsa-miR-4723-5p	CLIP-seq
MIRT858612	hsa-miR-4728-5p	CLIP-seq
MIRT858644	hsa-miR-4731-5p	CLIP-seq
MIRT858645	hsa-miR-4766-5p	CLIP-seq
MIRT858646	hsa-miR-4779	CLIP-seq
MIRT858647	hsa-miR-4792	CLIP-seq
MIRT858648	hsa-miR-488	CLIP-seq
MIRT858649	hsa-miR-608	CLIP-seq
MIRT858650	hsa-miR-625	CLIP-seq
MIRT858651	hsa-miR-637	CLIP-seq
MIRT858652	hsa-miR-762	CLIP-seq
MIRT858653	hsa-miR-920	CLIP-seq
MIRT1954959	hsa-miR-486-3p	CLIP-seq
MIRT2192554	hsa-miR-3184	CLIP-seq
MIRT2192555	hsa-miR-346	CLIP-seq
MIRT2192556	hsa-miR-423-5p	CLIP-seq
MIRT2192557	hsa-miR-4271	CLIP-seq
MIRT2192558	hsa-miR-4288	CLIP-seq
MIRT2192559	hsa-miR-4725-3p	CLIP-seq
MIRT858650	hsa-miR-625	CLIP-seq
MIRT2192560	hsa-miR-632	CLIP-seq
MIRT2192555	hsa-miR-346	CLIP-seq
MIRT2192558	hsa-miR-4288	CLIP-seq
MIRT2192560	hsa-miR-632	CLIP-seq
MIRT2446077	hsa-miR-1254	CLIP-seq
MIRT2446078	hsa-miR-188-3p	CLIP-seq
MIRT2446079	hsa-miR-1908	CLIP-seq
MIRT2446080	hsa-miR-1976	CLIP-seq
MIRT2446081	hsa-miR-3116	CLIP-seq
MIRT2446082	hsa-miR-3197	CLIP-seq
MIRT2446083	hsa-miR-3200-5p	CLIP-seq
MIRT2446084	hsa-miR-3690	CLIP-seq
MIRT2446085	hsa-miR-3925-3p	CLIP-seq
MIRT2446086	hsa-miR-4254	CLIP-seq
MIRT2446087	hsa-miR-4649-3p	CLIP-seq
MIRT2446088	hsa-miR-4722-3p	CLIP-seq
MIRT2446089	hsa-miR-4761-3p	CLIP-seq
MIRT2446090	hsa-miR-4793-5p	CLIP-seq
MIRT2446091	hsa-miR-663	CLIP-seq
MIRT2446092	hsa-miR-766	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	ISS	12826663
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IBA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	ISS	12826663
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS	12826663
GO:0016020	Component	Membrane	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0042803	Function	Protein homodimerization activity	ISS	12826663
GO:0070161	Component	Anchoring junction	IEA

MIM	HGNC	e!Ensembl
609743	17601	ENSG00000162706

Q8N126

Protein name

Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1)

Protein function

Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure

PDB

1Z9M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	35 → 127	Immunoglobulin V-set domain	Domain
PF08205	C2-set_2	133 → 220	CD80-like C2-set immunoglobulin domain	Domain
PF13927	Ig_3	232 → 303		Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. {ECO:0000269|PubMed:11536053, ECO:0000269|Pub

Sequence

MGAPAASLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSL
QWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTA
KSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQ
EDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPD
PPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCT
ATSNMGSYKAYYTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLIMLIFLGHYLIRHKG
TYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI

Sequence length

398

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules		Adherens junctions interactions Nectin/Necl trans heterodimerization

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Charcot-Marie-Tooth disease, axonal, type 2FF	Likely pathogenic	rs2102125471	RCV001678582	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHARCOT-MARIE-TOOTH DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EATING DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	26401960	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	30770760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	Pubtator	30770760	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34497681, 37446311	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Craniocerebral Trauma	Craniocerebral trauma	Pubtator	34969957	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	11536053, 19062177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19062177		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21062931	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	29808799		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	19165527		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CADM3 (cell adhesion molecule 3)