Gene Gene information from NCBI Gene database.
Entrez ID 57727
Gene name Nuclear receptor coactivator 5
Gene symbol NCOA5
Synonyms (NCBI Gene)
CIAbA465L10.6
Chromosome 20
Chromosome location 20q13.12
Summary This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptor
miRNA miRNA information provided by mirtarbase database.
266
miRTarBase ID miRNA Experiments Reference
MIRT051979 hsa-let-7b-5p CLASH 23622248
MIRT499974 hsa-miR-6813-3p PAR-CLIP 24398324
MIRT499973 hsa-miR-3919 PAR-CLIP 24398324
MIRT499972 hsa-miR-4756-3p PAR-CLIP 24398324
MIRT499971 hsa-miR-212-5p PAR-CLIP 24398324
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II NAS 25755249
GO:0003682 Function Chromatin binding IEA
GO:0003714 Function Transcription corepressor activity NAS 25755249
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 11113208
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616825 15909 ENSG00000124160
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HCD5
Protein name Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)
Protein function Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuc
PDB 1V95 , 2J7X , 2J7Y , 4ZI1
Family and domains
Tissue specificity TISSUE SPECIFICITY: Widely expressed.
Sequence
MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDL
RDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPM
YRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREEL
YRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQ
ALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNE
CREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEET
DKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPT
PSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQAS
GNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSV
QKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY
Sequence length 579
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
20
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Agranulocytosis Agranulocytosis BEFREE 21483481
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 30566627, 31161461
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 12483744, 23341540, 24836681, 26947206, 27460490, 28013195, 28249243, 28539269, 28957555, 29268189, 29361119, 30344681, 30649471, 30755337, 30800133
View all (5 more)
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 21645569
★☆☆☆☆
Found in Text Mining only
Behcet Syndrome Behcet Syndrome BEFREE 28694762
★☆☆☆☆
Found in Text Mining only
Bone Diseases Bone Disease BEFREE 22884682
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 27847318
★☆☆☆☆
Found in Text Mining only
cervical cancer Cervical Cancer BEFREE 30335900
★☆☆☆☆
Found in Text Mining only
Cervix carcinoma Cervix carcinoma BEFREE 30335900
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 29296214
★☆☆☆☆
Found in Text Mining only