Gene Gene information from NCBI Gene database.
Entrez ID 57721
Gene name Methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
Gene symbol METTL14
Synonyms (NCBI Gene)
hMETTL14
Chromosome 4
Chromosome location 4q26
miRNA miRNA information provided by mirtarbase database.
388
miRTarBase ID miRNA Experiments Reference
MIRT676730 hsa-miR-5571-5p HITS-CLIP 23824327
MIRT656285 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT676729 hsa-miR-4742-5p HITS-CLIP 23824327
MIRT676728 hsa-miR-4269 HITS-CLIP 23824327
MIRT676727 hsa-miR-6715b-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49
GO ID Ontology Definition Evidence Reference
GO:0000398 Process MRNA splicing, via spliceosome IMP 25719671
GO:0001510 Process RNA methylation IEA
GO:0001734 Function MRNA m(6)A methyltransferase activity IDA 27627798
GO:0001734 Function MRNA m(6)A methyltransferase activity IDA 24316715
GO:0003723 Function RNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616504 29330 ENSG00000145388
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HCE5
Protein name N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14)
Protein function The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMe
PDB 5IL0 , 5IL1 , 5IL2 , 5K7M , 5K7U , 5K7W , 5L6D , 5L6E , 5TEY , 6TTP , 6TTT , 6TTV , 6TTW , 6TTX , 6TU1 , 6Y4G , 7ACD , 7NHG , 7NHH , 7NHI , 7NHJ , 7NHV , 7NI7 , 7NI8 , 7NI9 , 7NIA , 7NID , 7O08 , 7O09 , 7O0L , 7O0M , 7O0P , 7O0Q , 7O0R , 7O27 , 7O28 , 7O29 , 7O2E , 7O2F , 7O2H , 7O2I , 7O2X , 7OED , 7OEE , 7OEF , 7OEG , 7OEH , 7OEI , 7OEJ , 7OEK , 7OEL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05063 MT-A70 186 363 MT-A70 Family
Sequence
MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAP
NAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYC
QHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIR
ELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEG
LDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRST
DGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTV
GPT
LTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGG
TSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR
Sequence length 456
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Processing of Capped Intron-Containing Pre-mRNA
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARDIOMYOPATHIES CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EDEMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSULIN RESISTANCE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MULTIPLE MYELOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 31429529
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 31429529
★☆☆☆☆
Found in Text Mining only
Asthenozoospermia Asthenozoospermia Pubtator 27072590 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 35598196 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30953473, 33134390, 33138349, 34349094, 36336884 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 32323801 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 31760940 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 34530916, 34863142 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 31943856, 33159022, 34609072, 36339682, 36354136, 36474147 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 32733931 Stimulate
★☆☆☆☆
Found in Text Mining only