Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57719
Gene name	Anoctamin 8
Gene symbol	ANO8
Synonyms (NCBI Gene)	KIAA1623TMEM16H
Chromosome	19
Chromosome location	19p13.11

Show/Hide all (87)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028358	hsa-miR-32-5p	Sequencing	20371350
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT785886	hsa-miR-1253	CLIP-seq
MIRT785887	hsa-miR-1257	CLIP-seq
MIRT785888	hsa-miR-137	CLIP-seq
MIRT785889	hsa-miR-153	CLIP-seq
MIRT785890	hsa-miR-25	CLIP-seq
MIRT785891	hsa-miR-3145-3p	CLIP-seq
MIRT785892	hsa-miR-32	CLIP-seq
MIRT785893	hsa-miR-33a	CLIP-seq
MIRT785894	hsa-miR-33b	CLIP-seq
MIRT785895	hsa-miR-363	CLIP-seq
MIRT785896	hsa-miR-367	CLIP-seq
MIRT785897	hsa-miR-3714	CLIP-seq
MIRT785898	hsa-miR-448	CLIP-seq
MIRT785899	hsa-miR-4632	CLIP-seq
MIRT785900	hsa-miR-4712-3p	CLIP-seq
MIRT785901	hsa-miR-4727-5p	CLIP-seq
MIRT785902	hsa-miR-520d-5p	CLIP-seq
MIRT785903	hsa-miR-524-5p	CLIP-seq
MIRT785904	hsa-miR-544	CLIP-seq
MIRT785905	hsa-miR-92a	CLIP-seq
MIRT785906	hsa-miR-92b	CLIP-seq
MIRT785901	hsa-miR-4727-5p	CLIP-seq
MIRT785902	hsa-miR-520d-5p	CLIP-seq
MIRT785903	hsa-miR-524-5p	CLIP-seq
MIRT785904	hsa-miR-544	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IDA	21984732, 22178883
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IMP	22946059
GO:0005254	Function	Chloride channel activity	IBA
GO:0005254	Function	Chloride channel activity	TAS
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22946059
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:1902476	Process	Chloride transmembrane transport	IBA
GO:1902476	Process	Chloride transmembrane transport	IMP	22946059

MIM	HGNC	e!Ensembl
610216	29329	ENSG00000074855

Q9HCE9

Protein name

Anoctamin-8 (Transmembrane protein 16H)

Protein function

Does not exhibit calcium-activated chloride channel (CaCC) activity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04547	Anoctamin	237 → 878	Calcium-activated chloride channel	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in embryonic stem cells, fetal brain and neural tissues. {ECO:0000269|PubMed:15647853}.

Sequence

MAEAASGAGGTSLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTV
PTENCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLR
GADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQ
GEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDY
FGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLE
EWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQLLVS
LPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIW
LNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFL
QNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGG
GGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEE
EGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEED
DEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDP
PEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEI
RSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPE
AAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQ
QRRRREEEERQRHAEHHARREHDSGGREEARAEGSGLDPATSSEKASAKAKGSTAGGHGP
ERPKRPGSLLAPNNVMKLKQIIPLQGKFLSSGATSSLAAAGAGATTRPPPAQSPTGSDTR
LPAFLSFKFLKSPETRRDSERSHSPPKAFHAGKLFPFGGTRAEPGSNGAGGQARPDGTPS
SGSSRVQRSGPVDEALAEELEAPRPEEEGSGTALAPVGAPALRTRRSRSPAPPPPMPLPR
PPTPPAGCWQWDGPWGCGGEGAAPRQALAAAECPPCAMAGPPPAPQPLPGDASFYSLPPP
PLPPTSDPLETPAPSPSPSPSPQAVCWPSGWH

Sequence length

1232

Interactions

View interactions

	Reactome
			Stimuli-sensing channels Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANO8-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUMINAL A BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIPLE-NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Intrahepatic Cholestasis of Pregnancy	Intrahepatic cholestasis of pregnancy	Pubtator	32942997	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	27777418		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	GWASDB_DG	20852631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASDB_DG	24390342		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	GWASCAT_DG	24390342		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ANO8 (anoctamin 8)