Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57718
Gene name	Protein phosphatase 4 regulatory subunit 4
Gene symbol	PPP4R4
Synonyms (NCBI Gene)	CFAP14KIAA1622PP4R4
Chromosome	14
Chromosome location	14q32.12-q32.13
Summary	The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and app

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miRTarBase ID	miRNA	Experiments
MIRT1258588	hsa-miR-1264	CLIP-seq
MIRT1258589	hsa-miR-361-5p	CLIP-seq
MIRT1258590	hsa-miR-3940-5p	CLIP-seq
MIRT1258591	hsa-miR-4507	CLIP-seq
MIRT1258592	hsa-miR-450b-5p	CLIP-seq
MIRT1258593	hsa-miR-518a-5p	CLIP-seq
MIRT1258594	hsa-miR-527	CLIP-seq
MIRT1258595	hsa-miR-629	CLIP-seq
MIRT1258596	hsa-miR-1229	CLIP-seq
MIRT1258597	hsa-miR-3691-3p	CLIP-seq
MIRT1258598	hsa-miR-4307	CLIP-seq
MIRT2302796	hsa-miR-1279	CLIP-seq
MIRT2302797	hsa-miR-28-3p	CLIP-seq
MIRT2302798	hsa-miR-3074-5p	CLIP-seq
MIRT2302799	hsa-miR-3652	CLIP-seq
MIRT2302800	hsa-miR-4430	CLIP-seq
MIRT2302801	hsa-miR-4505	CLIP-seq
MIRT2302802	hsa-miR-4719	CLIP-seq
MIRT2599477	hsa-miR-1251	CLIP-seq
MIRT2599478	hsa-miR-3163	CLIP-seq
MIRT2599479	hsa-miR-340	CLIP-seq
MIRT2599480	hsa-miR-4496	CLIP-seq
MIRT2599481	hsa-miR-4684-5p	CLIP-seq
MIRT2599477	hsa-miR-1251	CLIP-seq
MIRT2599478	hsa-miR-3163	CLIP-seq
MIRT2599479	hsa-miR-340	CLIP-seq
MIRT2599480	hsa-miR-4496	CLIP-seq
MIRT2599481	hsa-miR-4684-5p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001835	Process	Blastocyst hatching	IEA
GO:0004864	Function	Protein phosphatase inhibitor activity	IDA	18715871
GO:0004865	Function	Protein serine/threonine phosphatase inhibitor activity	IDA	18715871
GO:0005515	Function	Protein binding	IPI	18715871, 27880917, 28514442, 33961781
GO:0005737	Component	Cytoplasm	IDA	18715871
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005929	Component	Cilium	IDA
GO:0008287	Component	Protein serine/threonine phosphatase complex	IBA
GO:0008287	Component	Protein serine/threonine phosphatase complex	IDA	18715871
GO:0019888	Function	Protein phosphatase regulator activity	IBA
GO:0036064	Component	Ciliary basal body	IDA

MIM	HGNC	e!Ensembl
616790	23788	ENSG00000119698

Q6NUP7

Protein name

Serine/threonine-protein phosphatase 4 regulatory subunit 4

Protein function

Putative regulatory subunit of serine/threonine-protein phosphatase 4.

Family and domains

Sequence

MHPPPPAAAMDFSQNSLFGYMEDLQELTIIERPVRRSLKTPEEIERLTVDEDLSDIERAV
YLLSAGQDVQGTSVIANLPFLMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSFLTIL
QDESVSIHAYTHSFLQVILLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSK
AQLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIA
QGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCE
KSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGHNENQIP
PQILEQEKKYISVRKNCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRYTIAICF
YEVSKLLNSGVYLIHKELITLLQDESLEVLDALIDHLPEILELMSTGGESSVQENKLSSL
PDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQRMFTIMMTNNVL
PVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEFIIEIFSKS
FFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCVRKLLCQEK
DKDVLAIVKRTVLELDRMEMSMDAFQKKFYEKDLLDQEKEREELLLLEMEQLEKEKQQND
GRPMSDKMFEKKRRDTKTPTQSLPKNIPISVPGPSSVTPSTSKEIKKSKLIRSQSFNNQA
FHAKYGNLEKCASKSSTTGYTTSVSGLGKTSVLSLADDSFRTRNASSVPSSFSPNTPLPS
TSRGTGNSVDPKSSGSKDTQPRKATLKSRKSNP

Sequence length

873

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	28170284		★★★★★ ★☆☆☆☆ Found in Text Mining only

PPP4R4 (protein phosphatase 4 regulatory subunit 4)