Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57701
Gene name	NCK associated protein 5 like
Gene symbol	NCKAP5L
Synonyms (NCBI Gene)	Cep169FP1193KIAA1602
Chromosome	12
Chromosome location	12q13.12

Show/Hide all (39)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031503	hsa-miR-16-5p	Sequencing	20371350
MIRT051620	hsa-let-7e-5p	CLASH	23622248
MIRT046593	hsa-miR-222-3p	CLASH	23622248
MIRT037671	hsa-miR-744-5p	CLASH	23622248
MIRT1176518	hsa-miR-1262	CLIP-seq
MIRT1176519	hsa-miR-128	CLIP-seq
MIRT1176520	hsa-miR-1827	CLIP-seq
MIRT1176521	hsa-miR-2114	CLIP-seq
MIRT1176522	hsa-miR-2278	CLIP-seq
MIRT1176523	hsa-miR-3154	CLIP-seq
MIRT1176524	hsa-miR-326	CLIP-seq
MIRT1176525	hsa-miR-330-5p	CLIP-seq
MIRT1176526	hsa-miR-361-3p	CLIP-seq
MIRT1176527	hsa-miR-3664-5p	CLIP-seq
MIRT1176528	hsa-miR-3677-5p	CLIP-seq
MIRT1176529	hsa-miR-4701-3p	CLIP-seq
MIRT1176530	hsa-miR-4714-5p	CLIP-seq
MIRT1176531	hsa-miR-550b	CLIP-seq
MIRT1176532	hsa-miR-665	CLIP-seq
MIRT1176533	hsa-miR-940	CLIP-seq
MIRT1176522	hsa-miR-2278	CLIP-seq
MIRT2051134	hsa-miR-4281	CLIP-seq
MIRT2051135	hsa-miR-4789-3p	CLIP-seq
MIRT2578745	hsa-miR-1321	CLIP-seq
MIRT2578746	hsa-miR-4270	CLIP-seq
MIRT2578747	hsa-miR-4436b-3p	CLIP-seq
MIRT2578748	hsa-miR-4441	CLIP-seq
MIRT2578749	hsa-miR-4685-5p	CLIP-seq
MIRT2578750	hsa-miR-4739	CLIP-seq
MIRT2578751	hsa-miR-4751	CLIP-seq
MIRT2578752	hsa-miR-4756-5p	CLIP-seq
MIRT2578745	hsa-miR-1321	CLIP-seq
MIRT2578746	hsa-miR-4270	CLIP-seq
MIRT2578747	hsa-miR-4436b-3p	CLIP-seq
MIRT2578748	hsa-miR-4441	CLIP-seq
MIRT2578749	hsa-miR-4685-5p	CLIP-seq
MIRT2578750	hsa-miR-4739	CLIP-seq
MIRT2578751	hsa-miR-4751	CLIP-seq
MIRT2578752	hsa-miR-4756-5p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001578	Process	Microtubule bundle formation	IBA
GO:0001578	Process	Microtubule bundle formation	IDA	26485573
GO:0005515	Function	Protein binding	IPI	26485573
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	26485573
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007019	Process	Microtubule depolymerization	IBA
GO:0007019	Process	Microtubule depolymerization	IMP	26485573
GO:0035371	Component	Microtubule plus-end	IBA
GO:0035371	Component	Microtubule plus-end	IDA	26485573

MIM	HGNC	e!Ensembl
615104	29321	ENSG00000167566

Q9HCH0

Protein name

Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169)

Protein function

Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and h

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15246	NCKAP5	875 → 1179	Nck-associated protein 5, Peripheral clock protein	Family

Sequence

MSEAMDQPAGGPGNPRPGEGDDGSMEPGTCQELLHRLRELEAENSALAQANENQRETYER
CLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTTGSLPQIPL
TPLQPPSEPPASPSLSSTEGPAAPLPLGHCAGQREVCWEQQLRPGGPGPPAAPPPALDAL
SPFLRKKAQILEVLRALEETDPLLLCSPATPWRPPGQGPGSPEPINGELCGPPQPEPSPW
APCLLLGPGNLGGLLHWERLLGGLGGEEDTGRPWGPSRGPPQAQGTSSGPNCAPGSSSSS
SSDEAGDPNEAPSPDTLLGALARRQLNLGQLLEDTESYLQAFLAGAAGPLNGDHPGPGQS
SSPDQAPPQLSKSKGLPKSAWGGGTPEAHRPGFGATSEGQGPLPFLSMFMGAGDAPLGSR
PGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPTSEKSPSPGGPQLSPQL
PRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCYTTPDSTQLRPPQS
ALSTTLSPGPVVSPCYENILDLSRSTFRGPSPEPPPSPLQVPTYPQLTLEVPQAPEVLRS
PGVPPSPCLPESYPYGSPQEKSLDKAGSESPHPGRRTPGNSSKKPSQGSGRRPGDPGSTP
LRDRLAALGKLKTGPEGALGSEKNGVPARPGTEKTRGPGKSGESAGDMVPSIHRPLEQLE
AKGGIRGAVALGTNSLKQQEPGLMGDPGARVYSSHSMGARVDLEPVSPRSCLTKVELAKS
RLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPGAPLVTKESP
KPDKGKGPPWADCGSTTAQSTPLVPGPTDPSQGPEGLAPHSAIEEKVMKGIEENVLRLQG
QERAPGAEVKHRNTSSIASWFGLKKSKLPALNRRTEATKNKEGAGGGSPLRREVKMEARK
LEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGPNTGLGQVQGQLAGMYQ
GADTFMQQLLNRVDGKELPSKSWREPKPEYGDFQPVSSDPKSPWPACGPRNGLVGPLQGC
GKPPGKPSSEPGRREETPSEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTP
SKNLPKTKPPRLDPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPA
LLPAAPGHRGHETCPDDPCEDPGPTPPVQLAKNWTFPNTRAAGSSSDPLMCPPRQLEGLP
RTPMALPVDRKRSQEPSRPSPTPQGPPFGGSRTPSTSDMAEEGRVASGGPPGLETSESLS
DSLYDSLSSCGSQG

Sequence length

1334

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autistic Disorder	Autism	Pubtator	22511880	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24455749	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	24455749	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NCKAP5L (NCK associated protein 5 like)