VAT1L (vesicle amine transport 1 like)

Gene

• Entrez ID: 57687
• Gene name: Vesicle amine transport 1 like
• Gene symbol: VAT1L
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018808	hsa-miR-335-5p	Microarray	18185580
MIRT443597	hsa-miR-6792-5p	PAR-CLIP	22100165
MIRT443596	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT443595	hsa-miR-4503	PAR-CLIP	22100165
MIRT439311	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439312	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT439311	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439312	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT443597	hsa-miR-6792-5p	PAR-CLIP	22100165
MIRT443596	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT443595	hsa-miR-4503	PAR-CLIP	22100165
MIRT1482965	hsa-miR-1256	CLIP-seq
MIRT1482966	hsa-miR-1322	CLIP-seq
MIRT1482967	hsa-miR-138	CLIP-seq
MIRT1482968	hsa-miR-2861	CLIP-seq
MIRT1482969	hsa-miR-3150b-3p	CLIP-seq
MIRT1482970	hsa-miR-3169	CLIP-seq
MIRT1482971	hsa-miR-3199	CLIP-seq
MIRT1482972	hsa-miR-3909	CLIP-seq
MIRT1482973	hsa-miR-3942-3p	CLIP-seq
MIRT1482974	hsa-miR-4263	CLIP-seq
MIRT1482975	hsa-miR-4265	CLIP-seq
MIRT1482976	hsa-miR-4277	CLIP-seq
MIRT1482977	hsa-miR-4296	CLIP-seq
MIRT1482978	hsa-miR-4322	CLIP-seq
MIRT1482979	hsa-miR-4417	CLIP-seq
MIRT1482980	hsa-miR-4423-3p	CLIP-seq
MIRT1482981	hsa-miR-4437	CLIP-seq
MIRT1482982	hsa-miR-4674	CLIP-seq
MIRT1482983	hsa-miR-4784	CLIP-seq
MIRT1482984	hsa-miR-4799-5p	CLIP-seq
MIRT1482985	hsa-miR-513a-3p	CLIP-seq
MIRT1482986	hsa-miR-576-5p	CLIP-seq
MIRT1482987	hsa-miR-616	CLIP-seq
MIRT1482988	hsa-miR-643	CLIP-seq
MIRT1482989	hsa-miR-661	CLIP-seq
MIRT2145402	hsa-miR-1255a	CLIP-seq
MIRT2145403	hsa-miR-1255b	CLIP-seq
MIRT2145404	hsa-miR-3613-3p	CLIP-seq
MIRT2145405	hsa-miR-3614-5p	CLIP-seq
MIRT1482976	hsa-miR-4277	CLIP-seq
MIRT2145406	hsa-miR-4645-3p	CLIP-seq
MIRT2145407	hsa-miR-890	CLIP-seq
MIRT2365615	hsa-miR-18a	CLIP-seq
MIRT2365616	hsa-miR-18b	CLIP-seq
MIRT2365617	hsa-miR-205	CLIP-seq
MIRT2365618	hsa-miR-3622b-5p	CLIP-seq
MIRT2365619	hsa-miR-3662	CLIP-seq
MIRT2365620	hsa-miR-375	CLIP-seq
MIRT2365621	hsa-miR-3926	CLIP-seq
MIRT1482976	hsa-miR-4277	CLIP-seq
MIRT2365622	hsa-miR-4420	CLIP-seq
MIRT2365623	hsa-miR-4720-3p	CLIP-seq
MIRT2365624	hsa-miR-4735-3p	CLIP-seq
MIRT2365625	hsa-miR-4753-3p	CLIP-seq
MIRT2365626	hsa-miR-4804-3p	CLIP-seq
MIRT2365627	hsa-miR-486-3p	CLIP-seq
MIRT2365628	hsa-miR-544	CLIP-seq
MIRT2365629	hsa-miR-548s	CLIP-seq
MIRT2396804	hsa-miR-4427	CLIP-seq
MIRT2694939	hsa-miR-1243	CLIP-seq
MIRT2694940	hsa-miR-1275	CLIP-seq
MIRT2694941	hsa-miR-1293	CLIP-seq
MIRT2694942	hsa-miR-3175	CLIP-seq
MIRT2694943	hsa-miR-3654	CLIP-seq
MIRT2694944	hsa-miR-4447	CLIP-seq
MIRT2694945	hsa-miR-4472	CLIP-seq
MIRT2694946	hsa-miR-4483	CLIP-seq
MIRT2694947	hsa-miR-4525	CLIP-seq
MIRT2694948	hsa-miR-4651	CLIP-seq
MIRT2694949	hsa-miR-4665-5p	CLIP-seq
MIRT2694950	hsa-miR-4723-5p	CLIP-seq
MIRT2694951	hsa-miR-541	CLIP-seq
MIRT2694952	hsa-miR-608	CLIP-seq
MIRT2694953	hsa-miR-625	CLIP-seq
MIRT2694954	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32814053, 33961781
GO:0008270	Function	Zinc ion binding	IEA
GO:0016491	Function	Oxidoreductase activity	IEA

Other IDs

• MIM: 620202
• HGNC: 29315
• e!Ensembl: ENSG00000171724

Protein

• UniProt ID: Q9HCJ6
• Protein name: Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-)
• PDB: 4A27
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08240	ADH_N	68 → 144	Alcohol dehydrogenase GroES-like domain	Domain
  PF13602	ADH_zinc_N_2	218 → 378		Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in skin fibroblasts. {ECO:0000269|PubMed:19844255}.
• Sequence:

  MAKEGVEKAEETEQMIEKEAGKEPAEGGGGDGSHRLGDAQEMRAVVLAGFGGLNKLRLFR
  KAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGY
  EIGDRVMAFVNYNAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLRE
  GMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIKDSVTHLFDRNADYVQEVK
  RISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEK
  VNPIKLYEENKVIAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEV
  KEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEEEDHEGDSENKERMPFIQ

• Sequence length: 419

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HASHIMOTO'S THYROIDITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	36776048	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	23535033		★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASDB_DG	23535033		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	37564657	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	33562295	Associate	★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	40243895	Stimulate	★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	40243895	Stimulate	★☆☆☆☆ Found in Text Mining only