Gene Gene information from NCBI Gene database.
Entrez ID 57645
Gene name Pogo transposable element derived with KRAB domain
Gene symbol POGK
Synonyms (NCBI Gene)
BASS2KRBOX2LST003
Chromosome 1
Chromosome location 1q24.1
Summary The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it ma
miRNA miRNA information provided by mirtarbase database.
598
miRTarBase ID miRNA Experiments Reference
MIRT002759 hsa-miR-1-3p Luciferase reporter assayMicroarray 15685193
MIRT020150 hsa-miR-130b-3p Sequencing 20371350
MIRT002759 hsa-miR-1-3p Microarray;Other 15685193
MIRT024246 hsa-miR-218-5p Sequencing 20371350
MIRT028075 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 22939624
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620039 18800 ENSG00000143157
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9P215
Protein name Pogo transposable element with KRAB domain
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 46 87 KRAB box Family
PF09607 BrkDBD 195 247 Brinker DNA-binding domain Domain
PF03221 HTH_Tnp_Tc5 259 323 Tc5 transposase DNA-binding domain Domain
PF03184 DDE_1 395 567 DDE superfamily endonuclease Family
Sequence
MESTAYPLNLSLKEEEEEEEIQSRELEDGPADMQKVRICSEGGWVPALFDEVAIYFSDEE
WEVLTEQQKALYREVMRMNYETVLSLE
FPFPKPDMITRLEGEEESQNSDEWQLQGGTSAE
NEESDVKPPDWPNPMNATSQFPQPQHFDSFGLRLPRDITELPEWSEGYPFYMAMGFPGYD
LSADDIAGKFQFSRGMRRSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQ
LQNAHAM
RRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPE
KGFKASLGWCRRMMRRYDLSLRH
KVPVPQHLPEDLTEKLVTYQRSVLALRRAHDYEVAQM
GNADETPICLEVPSRVTVDNQGEKPVLVKTPGREKLKITAMLGVLADGRKLPPYIILRGT
YIPPGKFPSGMEIRCHRYGWMTEDLMQDWLEVVWRRRTGAVPKQRGMLILNGFRGHATDS
VKNSMESMNTDMVIIPGGLTSQLQVLDVVVYKPLNDSVRAQYSNWLLAGNLALSPTGNAK
KPPLGLFLEWVMVAWNSISSESIVQGF
KKCHISSNLEEEDDVLWEIESELPGGGEPPKDC
DTESMAESN
Sequence length 609
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations