PTN (pleiotrophin)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 5764
Gene name Pleiotrophin
Gene symbol PTN
Synonyms (NCBI Gene)
HARPHB-GAMHBBMHBGF-8HBGF8HBNFHBNF-1NEGF1OSF-1
Chromosome 7
Chromosome location 7q33
Summary The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results
miRNA miRNA information provided by mirtarbase database.
9
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (9)
miRTarBase ID miRNA Experiments Reference
MIRT437648 hsa-miR-155-5p MicroarrayqRT-PCR 22815788
MIRT1273762 hsa-miR-302f CLIP-seq
MIRT1273763 hsa-miR-3143 CLIP-seq
MIRT1273764 hsa-miR-376c CLIP-seq
MIRT1273765 hsa-miR-543 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (3)
Transcription factor Regulation Reference
HOXA5 Activation 15757903
JUN Activation 16199533
SP1 Unknown 10962555
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
82
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (82)
GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IEA
GO:0002232 Process Leukocyte chemotaxis involved in inflammatory response IEA
GO:0002232 Process Leukocyte chemotaxis involved in inflammatory response ISS
GO:0002690 Process Positive regulation of leukocyte chemotaxis IEA
GO:0002690 Process Positive regulation of leukocyte chemotaxis ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
162095 9630 ENSG00000105894
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P21246
Protein name Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promo
Protein function Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:11278720, PubMed:16814777, PubMed:19141530). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) gro
PDB 2N6F , 8VOH , 8VOI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05196 PTN_MK_N 34 → 95 PTN/MK heparin-binding protein family, N-terminal domain Domain
PF01091 PTN_MK_C 96 → 161 PTN/MK heparin-binding protein family, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Osteoblast and brain. {ECO:0000269|PubMed:1701634}.
Sequence
Sequence length 168
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
16
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (16)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BODY WEIGHT — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (144)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 23056589
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 19749796, 23976985
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 29042634 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Anaplastic carcinoma Anaplastic Carcinoma CTD_human_DG 16316942
★★★★★
★☆☆☆☆
Found in Text Mining only
Aneuploidy Aneuploidy Pubtator 17067552 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 19917672
★★★★★
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 14692702, 26645582
★★★★★
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma LHGDN 17443289
★★★★★
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 23349846 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 19917672
★★★★★
★☆☆☆☆
Found in Text Mining only