Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57636
Gene name	Rho GTPase activating protein 23
Gene symbol	ARHGAP23
Synonyms (NCBI Gene)	-
Chromosome	17
Chromosome location	17q12
Summary	The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactiv

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Show/Hide all (194)

miRTarBase ID	miRNA	Experiments
MIRT794102	hsa-miR-101	CLIP-seq
MIRT794103	hsa-miR-1254	CLIP-seq
MIRT794104	hsa-miR-144	CLIP-seq
MIRT794105	hsa-miR-1587	CLIP-seq
MIRT794106	hsa-miR-3116	CLIP-seq
MIRT794107	hsa-miR-3182	CLIP-seq
MIRT794108	hsa-miR-378g	CLIP-seq
MIRT794109	hsa-miR-3944-5p	CLIP-seq
MIRT794110	hsa-miR-4299	CLIP-seq
MIRT794111	hsa-miR-4417	CLIP-seq
MIRT794112	hsa-miR-4492	CLIP-seq
MIRT794113	hsa-miR-4498	CLIP-seq
MIRT794114	hsa-miR-4656	CLIP-seq
MIRT794115	hsa-miR-4675	CLIP-seq
MIRT794116	hsa-miR-4691-3p	CLIP-seq
MIRT794117	hsa-miR-4699-3p	CLIP-seq
MIRT794118	hsa-miR-4741	CLIP-seq
MIRT794119	hsa-miR-509-3p	CLIP-seq
MIRT794120	hsa-miR-519a	CLIP-seq
MIRT794121	hsa-miR-519b-3p	CLIP-seq
MIRT794122	hsa-miR-519c-3p	CLIP-seq
MIRT794123	hsa-miR-541	CLIP-seq
MIRT794124	hsa-miR-550a	CLIP-seq
MIRT794125	hsa-miR-582-5p	CLIP-seq
MIRT794126	hsa-miR-654-5p	CLIP-seq
MIRT794127	hsa-miR-661	CLIP-seq
MIRT794128	hsa-miR-762	CLIP-seq
MIRT1545481	hsa-miR-491-5p	CLIP-seq
MIRT1555978	hsa-miR-3144-5p	CLIP-seq
MIRT1555979	hsa-miR-4716-3p	CLIP-seq
MIRT2174151	hsa-miR-153	CLIP-seq
MIRT794108	hsa-miR-378g	CLIP-seq
MIRT2174152	hsa-miR-3941	CLIP-seq
MIRT2174153	hsa-miR-448	CLIP-seq
MIRT794116	hsa-miR-4691-3p	CLIP-seq
MIRT2426393	hsa-miR-3151	CLIP-seq
MIRT2426394	hsa-miR-4447	CLIP-seq
MIRT2426395	hsa-miR-4472	CLIP-seq
MIRT794117	hsa-miR-4699-3p	CLIP-seq
MIRT1545481	hsa-miR-491-5p	CLIP-seq
MIRT2435471	hsa-miR-1909	CLIP-seq
MIRT2435472	hsa-miR-214	CLIP-seq
MIRT2435473	hsa-miR-3619-5p	CLIP-seq
MIRT2435474	hsa-miR-609	CLIP-seq
MIRT2435475	hsa-miR-761	CLIP-seq
MIRT2435471	hsa-miR-1909	CLIP-seq
MIRT2435472	hsa-miR-214	CLIP-seq
MIRT2435473	hsa-miR-3619-5p	CLIP-seq
MIRT2443907	hsa-miR-4765	CLIP-seq
MIRT2443908	hsa-miR-542-3p	CLIP-seq
MIRT2435474	hsa-miR-609	CLIP-seq
MIRT2435475	hsa-miR-761	CLIP-seq
MIRT2477831	hsa-miR-1	CLIP-seq
MIRT2477832	hsa-miR-1253	CLIP-seq
MIRT2477833	hsa-miR-1321	CLIP-seq
MIRT2477834	hsa-miR-147	CLIP-seq
MIRT2477835	hsa-miR-1470	CLIP-seq
MIRT2477836	hsa-miR-188-5p	CLIP-seq
MIRT2435471	hsa-miR-1909	CLIP-seq
MIRT2477837	hsa-miR-197	CLIP-seq
MIRT2477838	hsa-miR-206	CLIP-seq
MIRT2435472	hsa-miR-214	CLIP-seq
MIRT2477839	hsa-miR-298	CLIP-seq
MIRT2477840	hsa-miR-3126-5p	CLIP-seq
MIRT1555978	hsa-miR-3144-5p	CLIP-seq
MIRT2477841	hsa-miR-3148	CLIP-seq
MIRT2477842	hsa-miR-3150a-3p	CLIP-seq
MIRT2426393	hsa-miR-3151	CLIP-seq
MIRT2477843	hsa-miR-3175	CLIP-seq
MIRT2477844	hsa-miR-3176	CLIP-seq
MIRT794107	hsa-miR-3182	CLIP-seq
MIRT2477845	hsa-miR-3185	CLIP-seq
MIRT2477846	hsa-miR-329	CLIP-seq
MIRT2477847	hsa-miR-3616-3p	CLIP-seq
MIRT2435473	hsa-miR-3619-5p	CLIP-seq
MIRT2477848	hsa-miR-362-3p	CLIP-seq
MIRT2477849	hsa-miR-3650	CLIP-seq
MIRT2477850	hsa-miR-3673	CLIP-seq
MIRT2477851	hsa-miR-3688-3p	CLIP-seq
MIRT2477852	hsa-miR-3689a-3p	CLIP-seq
MIRT2477853	hsa-miR-3689c	CLIP-seq
MIRT794108	hsa-miR-378g	CLIP-seq
MIRT2477854	hsa-miR-3911	CLIP-seq
MIRT2477855	hsa-miR-3922-3p	CLIP-seq
MIRT2477856	hsa-miR-3936	CLIP-seq
MIRT2174152	hsa-miR-3941	CLIP-seq
MIRT2477857	hsa-miR-4271	CLIP-seq
MIRT2477858	hsa-miR-4292	CLIP-seq
MIRT794110	hsa-miR-4299	CLIP-seq
MIRT2477859	hsa-miR-4308	CLIP-seq
MIRT794111	hsa-miR-4417	CLIP-seq
MIRT2477860	hsa-miR-4419a	CLIP-seq
MIRT2477861	hsa-miR-4434	CLIP-seq
MIRT2477862	hsa-miR-4436b-3p	CLIP-seq
MIRT2426394	hsa-miR-4447	CLIP-seq
MIRT2477863	hsa-miR-4455	CLIP-seq
MIRT2426395	hsa-miR-4472	CLIP-seq
MIRT2477864	hsa-miR-4488	CLIP-seq
MIRT794112	hsa-miR-4492	CLIP-seq
MIRT794113	hsa-miR-4498	CLIP-seq
MIRT2477865	hsa-miR-4510	CLIP-seq
MIRT2477866	hsa-miR-4516	CLIP-seq
MIRT2477867	hsa-miR-4667-3p	CLIP-seq
MIRT2477868	hsa-miR-4697-5p	CLIP-seq
MIRT794117	hsa-miR-4699-3p	CLIP-seq
MIRT2477869	hsa-miR-4710	CLIP-seq
MIRT1555979	hsa-miR-4716-3p	CLIP-seq
MIRT2477870	hsa-miR-4725-3p	CLIP-seq
MIRT2477871	hsa-miR-4728-5p	CLIP-seq
MIRT2477872	hsa-miR-4739	CLIP-seq
MIRT2477873	hsa-miR-4756-5p	CLIP-seq
MIRT2443907	hsa-miR-4765	CLIP-seq
MIRT1545481	hsa-miR-491-5p	CLIP-seq
MIRT794119	hsa-miR-509-3p	CLIP-seq
MIRT794123	hsa-miR-541	CLIP-seq
MIRT2477874	hsa-miR-583	CLIP-seq
MIRT2477875	hsa-miR-603	CLIP-seq
MIRT2435474	hsa-miR-609	CLIP-seq
MIRT2477876	hsa-miR-613	CLIP-seq
MIRT2477877	hsa-miR-619	CLIP-seq
MIRT2477878	hsa-miR-634	CLIP-seq
MIRT2477879	hsa-miR-644	CLIP-seq
MIRT794126	hsa-miR-654-5p	CLIP-seq
MIRT2477880	hsa-miR-670	CLIP-seq
MIRT2435475	hsa-miR-761	CLIP-seq
MIRT794128	hsa-miR-762	CLIP-seq
MIRT2477881	hsa-miR-885-3p	CLIP-seq
MIRT2477882	hsa-miR-939	CLIP-seq
MIRT2477831	hsa-miR-1	CLIP-seq
MIRT2477833	hsa-miR-1321	CLIP-seq
MIRT2477834	hsa-miR-147	CLIP-seq
MIRT2477835	hsa-miR-1470	CLIP-seq
MIRT2477836	hsa-miR-188-5p	CLIP-seq
MIRT2435471	hsa-miR-1909	CLIP-seq
MIRT2477837	hsa-miR-197	CLIP-seq
MIRT2477838	hsa-miR-206	CLIP-seq
MIRT2435472	hsa-miR-214	CLIP-seq
MIRT2477840	hsa-miR-3126-5p	CLIP-seq
MIRT1555978	hsa-miR-3144-5p	CLIP-seq
MIRT2477841	hsa-miR-3148	CLIP-seq
MIRT2426393	hsa-miR-3151	CLIP-seq
MIRT2477844	hsa-miR-3176	CLIP-seq
MIRT2477845	hsa-miR-3185	CLIP-seq
MIRT2477846	hsa-miR-329	CLIP-seq
MIRT2477847	hsa-miR-3616-3p	CLIP-seq
MIRT2435473	hsa-miR-3619-5p	CLIP-seq
MIRT2477848	hsa-miR-362-3p	CLIP-seq
MIRT2477849	hsa-miR-3650	CLIP-seq
MIRT2477850	hsa-miR-3673	CLIP-seq
MIRT2477851	hsa-miR-3688-3p	CLIP-seq
MIRT2477852	hsa-miR-3689a-3p	CLIP-seq
MIRT2477853	hsa-miR-3689c	CLIP-seq
MIRT794108	hsa-miR-378g	CLIP-seq
MIRT2477854	hsa-miR-3911	CLIP-seq
MIRT2477855	hsa-miR-3922-3p	CLIP-seq
MIRT2477856	hsa-miR-3936	CLIP-seq
MIRT2174152	hsa-miR-3941	CLIP-seq
MIRT2477857	hsa-miR-4271	CLIP-seq
MIRT2477858	hsa-miR-4292	CLIP-seq
MIRT794110	hsa-miR-4299	CLIP-seq
MIRT2477859	hsa-miR-4308	CLIP-seq
MIRT2477860	hsa-miR-4419a	CLIP-seq
MIRT2426394	hsa-miR-4447	CLIP-seq
MIRT2477863	hsa-miR-4455	CLIP-seq
MIRT2426395	hsa-miR-4472	CLIP-seq
MIRT2477864	hsa-miR-4488	CLIP-seq
MIRT794112	hsa-miR-4492	CLIP-seq
MIRT794113	hsa-miR-4498	CLIP-seq
MIRT2477865	hsa-miR-4510	CLIP-seq
MIRT2477867	hsa-miR-4667-3p	CLIP-seq
MIRT2477868	hsa-miR-4697-5p	CLIP-seq
MIRT2477869	hsa-miR-4710	CLIP-seq
MIRT1555979	hsa-miR-4716-3p	CLIP-seq
MIRT2477870	hsa-miR-4725-3p	CLIP-seq
MIRT2675259	hsa-miR-4725-5p	CLIP-seq
MIRT2477871	hsa-miR-4728-5p	CLIP-seq
MIRT2477872	hsa-miR-4739	CLIP-seq
MIRT2477873	hsa-miR-4756-5p	CLIP-seq
MIRT2443907	hsa-miR-4765	CLIP-seq
MIRT1545481	hsa-miR-491-5p	CLIP-seq
MIRT2675260	hsa-miR-504	CLIP-seq
MIRT794123	hsa-miR-541	CLIP-seq
MIRT2477874	hsa-miR-583	CLIP-seq
MIRT2477875	hsa-miR-603	CLIP-seq
MIRT2435474	hsa-miR-609	CLIP-seq
MIRT2477876	hsa-miR-613	CLIP-seq
MIRT2477877	hsa-miR-619	CLIP-seq
MIRT2477878	hsa-miR-634	CLIP-seq
MIRT2477879	hsa-miR-644	CLIP-seq
MIRT794126	hsa-miR-654-5p	CLIP-seq
MIRT2477880	hsa-miR-670	CLIP-seq
MIRT2435475	hsa-miR-761	CLIP-seq
MIRT794128	hsa-miR-762	CLIP-seq
MIRT2477881	hsa-miR-885-3p	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0070062	Component	Extracellular exosome	HDA	19199708

MIM	HGNC	e!Ensembl
610590	29293	ENSG00000275832

Q9P227

Protein name

Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)

Protein function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17820	PDZ_6	99 → 152	PDZ domain	Domain
PF15410	PH_9	690 → 806	Pleckstrin homology domain	Domain
PF00620	RhoGAP	920 → 1074	RhoGAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor. {ECO:0000269|PubMed:15254754}.

Sequence

MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH
FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL
VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR
SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL
DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA
GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR
SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR
SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP
PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE
DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD
CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL
DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA
ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT
ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA
DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP
RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG
PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL
IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP
DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDS
TTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKP
GAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSV
CSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLAR
RRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRGTA
DDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGARAHS
DNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCL

Sequence length

1491

Interactions

View interactions

	Reactome
			Rho GTPase cycle

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CEREBRAL AMYLOID ANGIOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autistic Disorder	Autism	Pubtator	32108986	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma in Situ	Carcinoma in situ	Pubtator	32192274	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543		★★★★★ ★☆☆☆☆ Found in Text Mining only

ARHGAP23 (Rho GTPase activating protein 23)