Gene Gene information from NCBI Gene database.
Entrez ID 57606
Gene name SLAIN motif family member 2
Gene symbol SLAIN2
Synonyms (NCBI Gene)
KIAA1458
Chromosome 4
Chromosome location 4p11
miRNA miRNA information provided by mirtarbase database.
362
miRTarBase ID miRNA Experiments Reference
MIRT030692 hsa-miR-21-5p Microarray 18591254
MIRT093988 hsa-miR-409-3p PAR-CLIP 21572407
MIRT093983 hsa-miR-103a-3p PAR-CLIP 21572407
MIRT093984 hsa-miR-107 PAR-CLIP 21572407
MIRT093990 hsa-miR-944 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21646404, 26496610, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005813 Component Centrosome IDA 21399614
GO:0005829 Component Cytosol IDA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610492 29282 ENSG00000109171
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9P270
Protein name SLAIN motif-containing protein 2
Protein function Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {
PDB 3RDV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15301 SLAIN 130 581 SLAIN motif-containing family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain. {ECO:0000269|PubMed:10819331}.
Sequence
Sequence length 581
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Colorectal Carcinoma Colorectal Cancer BEFREE 30797712
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 30797712 Associate
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease GWASDB_DG 23128233
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease GWASCAT_DG 23128233, 26192919
★☆☆☆☆
Found in Text Mining only
Dementia Dementia Pubtator 28600779 Associate
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Inflammatory Bowel Disease GWASCAT_DG 26192919
★☆☆☆☆
Found in Text Mining only
Intellectual Disability Intellectual developmental disorder Pubtator 28600779 Associate
★☆☆☆☆
Found in Text Mining only
Plexiform leiomyoma Plexiform leiomyoma GWASCAT_DG 30194396
★☆☆☆☆
Found in Text Mining only
Uterine Fibroids Uterine Fibroids GWASCAT_DG 30194396
★☆☆☆☆
Found in Text Mining only