Gene Gene information from NCBI Gene database.
Entrez ID 57600
Gene name Folliculin interacting protein 2
Gene symbol FNIP2
Synonyms (NCBI Gene)
FNIPLMAPO1
Chromosome 4
Chromosome location 4q32.1
Summary This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. Th
miRNA miRNA information provided by mirtarbase database.
401
miRTarBase ID miRNA Experiments Reference
MIRT045302 hsa-miR-186-5p CLASH 23622248
MIRT615007 hsa-miR-6076 HITS-CLIP 23824327
MIRT615006 hsa-miR-6797-3p HITS-CLIP 23824327
MIRT615005 hsa-miR-5011-3p HITS-CLIP 23824327
MIRT615004 hsa-miR-4666b HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 21209915
GO:0005515 Function Protein binding IPI 18403135, 18663353, 19914239, 25126726, 27353360
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 18403135, 18663353, 19137017
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612768 29280 ENSG00000052795
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9P278
Protein name Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein)
Protein function Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:3
PDB 6NZD , 6ULG , 7LSW , 7LT6 , 8DHB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14636 FNIP_N 46 168 Folliculin-interacting protein N-terminus Family
PF14637 FNIP_M 297 531 Folliculin-interacting protein middle domain Family
PF14638 FNIP_C 927 1110 Folliculin-interacting protein C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas (PubMed:18403135, PubMed:18663353, PubMed:27353360). Moderately expressed in the lung, small intestine, kidne
Sequence
MAPTLLQKLFNKRGSSGSSAAASAQGRAPKEGPAFSWSCSEFDLNEIRLIVYQDCDRRGR
QVLFDSKAVQKIEEVTAQKTEDVPIKISAKCCQGSSSVSSSSSSSISSHSSSGGSSHHAK
EQLPKYQYTRPASDVNMLGEMMFGSVAMSYKGSTLKIHYIRSPPQLMI
SKVFSARMGSFC
GSTNNLQDSFEYINQDPNLGKLNTNQNSLGPCRTGSNLAHSTPVDMPSRGQNEDRDSGIA
RSASLSSLLITPFPSPSSSTSSSSSYQRRWLRSQTTSLENGIIPRRSTDETFSLAEETCS
SNPAMVRRKKIAISIIFSLCEKEEAQRNFQDFFFSHFPLFESHMNRLKSAIEKAMISCRK
IAESSLRVQFYVSRLMEALGEFRGTIWNLYSVPRIAEPVWLTMMSGTLEKNQLCQRFLKE
FTLLIEQINKNQFFAALLTAVLTYHLAWVPTVMPVDHPPIKAFSEKRTSQSVNMLAKTHP
YNPLWAQLGDLYGAIGSPVRLTRTVVVGKQKDLVQRILYVLTYFLRCSELQ
ENQLTWSGN
HGEGDQVLNGSKIITALEKGEVEESEYVVITVRNEPALVPPILPPTAAERHNPWPTGFPE
CPEGTDSRDLGLKPDKEANRRPEQGSEACSAGCLGPASDASWKPQNAFCGDEKNKEAPQD
GSSRLPSCEVLGAGMKMDQQAVCELLKVEMPTRLPDRSVAWPCPDRHLREKPSLEKVTFQ
IGSFASPESDFESRMKKMEERVKACGPSLEASEAADVAQDPQVSRSPFKPGFQENVCCPQ
NRLSEGDEGESDKGFAEDRGSRNDMAADIAGQLSHAADLGTASHGAGGTGGRRLEATRGL
YVKAAEGPVLEPVAPRCVQRGPGLVAGANIPCGDDNKKANFRTEGDIPRNESSDSALGDS
DDEACASAMLDLGHGGDRTGGSLEVELPLPRSQSISTQNVRNFGRSLLAGYCPTYMPDLV
LHGTGSDEKLKQCLVADLVHTVHHPVLDEPIAEAVCIIADTDKWSVQVATSQRKVTDNMK
LGQDVLVSSQVSSLLQSILQLYKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVH
VKELGVVLGIESNDLPLLTAIASTHSPYVA
QILL
Sequence length 1114
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  mTOR signaling pathway   Amino acids regulate mTORC1
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Renal Cell Renal cell carcinoma Pubtator 18403135 Associate
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 18403135
★☆☆☆☆
Found in Text Mining only
Fibrofolliculoma Fibrofolliculoma BEFREE 23108783
★☆☆☆☆
Found in Text Mining only
HIP DYSPLASIA, BEUKES TYPE Hip Dysplasia BEFREE 27303042
★☆☆☆☆
Found in Text Mining only
Hurthle Cell Tumor Tumor BEFREE 18403135
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of kidney Kidney Cancer BEFREE 23108783, 26608100, 28039480
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 28039480
★☆☆☆☆
Found in Text Mining only
Multiple fibrofolliculomas Multiple Fibrofolliculomas BEFREE 27303042
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 18403135, 27353360, 28039480
★☆☆☆☆
Found in Text Mining only
Oxyphilic Adenoma Oxyphilic Adenoma BEFREE 18403135
★☆☆☆☆
Found in Text Mining only