HOMEZ (homeobox and leucine zipper encoding)

Gene

• Entrez ID: 57594
• Gene name: Homeobox and leucine zipper encoding
• Gene symbol: HOMEZ
• Synonyms (NCBI Gene): KIAA1443
• Chromosome: 14
• Chromosome location: 14q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT713864	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT713863	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT713862	hsa-miR-3185	HITS-CLIP	19536157
MIRT713864	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT713863	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT713862	hsa-miR-3185	HITS-CLIP	19536157
MIRT529127	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT529126	hsa-miR-4756-3p	PAR-CLIP	22012620
MIRT529125	hsa-miR-203a-3p	PAR-CLIP	22012620
MIRT529124	hsa-miR-5186	PAR-CLIP	22012620
MIRT529123	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT529122	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT529121	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT529124	hsa-miR-5186	PAR-CLIP	27292025
MIRT713864	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT713863	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT713862	hsa-miR-3185	HITS-CLIP	19536157
MIRT713864	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT713863	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT713862	hsa-miR-3185	HITS-CLIP	19536157
MIRT529127	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT529126	hsa-miR-4756-3p	PAR-CLIP	22012620
MIRT529125	hsa-miR-203a-3p	PAR-CLIP	22012620
MIRT529124	hsa-miR-5186	PAR-CLIP	22012620
MIRT529123	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT529122	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT529121	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT1052605	hsa-miR-1179	CLIP-seq
MIRT1052606	hsa-miR-1246	CLIP-seq
MIRT1052607	hsa-miR-1290	CLIP-seq
MIRT1052608	hsa-miR-1296	CLIP-seq
MIRT1052609	hsa-miR-194	CLIP-seq
MIRT1052610	hsa-miR-2053	CLIP-seq
MIRT1052611	hsa-miR-2114	CLIP-seq
MIRT1052612	hsa-miR-2115	CLIP-seq
MIRT1052613	hsa-miR-218	CLIP-seq
MIRT1052614	hsa-miR-223	CLIP-seq
MIRT1052615	hsa-miR-24	CLIP-seq
MIRT1052616	hsa-miR-2909	CLIP-seq
MIRT1052617	hsa-miR-3122	CLIP-seq
MIRT1052618	hsa-miR-3158-3p	CLIP-seq
MIRT1052619	hsa-miR-3167	CLIP-seq
MIRT1052620	hsa-miR-3192	CLIP-seq
MIRT1052621	hsa-miR-33a	CLIP-seq
MIRT1052622	hsa-miR-33b	CLIP-seq
MIRT1052623	hsa-miR-3647-3p	CLIP-seq
MIRT1052624	hsa-miR-382	CLIP-seq
MIRT1052625	hsa-miR-3913-5p	CLIP-seq
MIRT1052626	hsa-miR-3936	CLIP-seq
MIRT1052627	hsa-miR-4284	CLIP-seq
MIRT1052628	hsa-miR-4433	CLIP-seq
MIRT1052629	hsa-miR-4436b-5p	CLIP-seq
MIRT1052630	hsa-miR-4446-3p	CLIP-seq
MIRT1052631	hsa-miR-4459	CLIP-seq
MIRT1052632	hsa-miR-4683	CLIP-seq
MIRT1052633	hsa-miR-4728-5p	CLIP-seq
MIRT1052634	hsa-miR-4760-5p	CLIP-seq
MIRT1052635	hsa-miR-4761-5p	CLIP-seq
MIRT1052636	hsa-miR-4795-3p	CLIP-seq
MIRT1052637	hsa-miR-499a-5p	CLIP-seq
MIRT1052638	hsa-miR-521	CLIP-seq
MIRT1052639	hsa-miR-541	CLIP-seq
MIRT1052640	hsa-miR-548a-5p	CLIP-seq
MIRT1052641	hsa-miR-548ab	CLIP-seq
MIRT1052642	hsa-miR-548ak	CLIP-seq
MIRT1052643	hsa-miR-548b-5p	CLIP-seq
MIRT1052644	hsa-miR-548c-5p	CLIP-seq
MIRT1052645	hsa-miR-548d-5p	CLIP-seq
MIRT1052646	hsa-miR-548h	CLIP-seq
MIRT1052647	hsa-miR-548i	CLIP-seq
MIRT1052648	hsa-miR-548j	CLIP-seq
MIRT1052649	hsa-miR-548n	CLIP-seq
MIRT1052650	hsa-miR-548w	CLIP-seq
MIRT1052651	hsa-miR-548y	CLIP-seq
MIRT1052652	hsa-miR-550a	CLIP-seq
MIRT1052653	hsa-miR-559	CLIP-seq
MIRT1052654	hsa-miR-564	CLIP-seq
MIRT1052655	hsa-miR-569	CLIP-seq
MIRT1052656	hsa-miR-654-5p	CLIP-seq
MIRT1052657	hsa-miR-659	CLIP-seq
MIRT1052658	hsa-miR-764	CLIP-seq
MIRT1052659	hsa-miR-802	CLIP-seq
MIRT1052660	hsa-miR-876-5p	CLIP-seq
MIRT1549592	hsa-miR-4528	CLIP-seq
MIRT1549593	hsa-miR-579	CLIP-seq
MIRT1549594	hsa-miR-590-3p	CLIP-seq
MIRT2011919	hsa-miR-1207-5p	CLIP-seq
MIRT1052609	hsa-miR-194	CLIP-seq
MIRT2011920	hsa-miR-2110	CLIP-seq
MIRT1052611	hsa-miR-2114	CLIP-seq
MIRT1052614	hsa-miR-223	CLIP-seq
MIRT1052615	hsa-miR-24	CLIP-seq
MIRT2011921	hsa-miR-25	CLIP-seq
MIRT1052617	hsa-miR-3122	CLIP-seq
MIRT2011922	hsa-miR-3150a-3p	CLIP-seq
MIRT1052620	hsa-miR-3192	CLIP-seq
MIRT2011923	hsa-miR-32	CLIP-seq
MIRT2011924	hsa-miR-363	CLIP-seq
MIRT2011925	hsa-miR-3656	CLIP-seq
MIRT2011926	hsa-miR-3665	CLIP-seq
MIRT2011927	hsa-miR-367	CLIP-seq
MIRT2011928	hsa-miR-383	CLIP-seq
MIRT1052625	hsa-miR-3913-5p	CLIP-seq
MIRT2011929	hsa-miR-3915	CLIP-seq
MIRT2011930	hsa-miR-3928	CLIP-seq
MIRT1052627	hsa-miR-4284	CLIP-seq
MIRT2011931	hsa-miR-4426	CLIP-seq
MIRT1052628	hsa-miR-4433	CLIP-seq
MIRT2011932	hsa-miR-4450	CLIP-seq
MIRT1052631	hsa-miR-4459	CLIP-seq
MIRT2011933	hsa-miR-4496	CLIP-seq
MIRT2011934	hsa-miR-4647	CLIP-seq
MIRT2011935	hsa-miR-4654	CLIP-seq
MIRT2011936	hsa-miR-4662b	CLIP-seq
MIRT2011937	hsa-miR-4679	CLIP-seq
MIRT1052632	hsa-miR-4683	CLIP-seq
MIRT2011938	hsa-miR-4715-3p	CLIP-seq
MIRT2011939	hsa-miR-4727-5p	CLIP-seq
MIRT1052633	hsa-miR-4728-5p	CLIP-seq
MIRT2011940	hsa-miR-4736	CLIP-seq
MIRT1052635	hsa-miR-4761-5p	CLIP-seq
MIRT2011941	hsa-miR-4763-3p	CLIP-seq
MIRT2011942	hsa-miR-4769-3p	CLIP-seq
MIRT2011943	hsa-miR-4769-5p	CLIP-seq
MIRT2011944	hsa-miR-4772-5p	CLIP-seq
MIRT2011945	hsa-miR-494	CLIP-seq
MIRT1052638	hsa-miR-521	CLIP-seq
MIRT1052639	hsa-miR-541	CLIP-seq
MIRT1052640	hsa-miR-548a-5p	CLIP-seq
MIRT1052641	hsa-miR-548ab	CLIP-seq
MIRT1052642	hsa-miR-548ak	CLIP-seq
MIRT1052643	hsa-miR-548b-5p	CLIP-seq
MIRT1052644	hsa-miR-548c-5p	CLIP-seq
MIRT1052645	hsa-miR-548d-5p	CLIP-seq
MIRT1052646	hsa-miR-548h	CLIP-seq
MIRT1052647	hsa-miR-548i	CLIP-seq
MIRT1052648	hsa-miR-548j	CLIP-seq
MIRT1052649	hsa-miR-548n	CLIP-seq
MIRT1052650	hsa-miR-548w	CLIP-seq
MIRT1052651	hsa-miR-548y	CLIP-seq
MIRT1052652	hsa-miR-550a	CLIP-seq
MIRT1052653	hsa-miR-559	CLIP-seq
MIRT1052654	hsa-miR-564	CLIP-seq
MIRT1052656	hsa-miR-654-5p	CLIP-seq
MIRT1052658	hsa-miR-764	CLIP-seq
MIRT2011946	hsa-miR-92a	CLIP-seq
MIRT2011947	hsa-miR-92b	CLIP-seq
MIRT2011948	hsa-miR-935	CLIP-seq
MIRT2011919	hsa-miR-1207-5p	CLIP-seq
MIRT1052609	hsa-miR-194	CLIP-seq
MIRT1052615	hsa-miR-24	CLIP-seq
MIRT2011921	hsa-miR-25	CLIP-seq
MIRT1052617	hsa-miR-3122	CLIP-seq
MIRT1052620	hsa-miR-3192	CLIP-seq
MIRT2011923	hsa-miR-32	CLIP-seq
MIRT2244221	hsa-miR-3545-5p	CLIP-seq
MIRT2244222	hsa-miR-361-3p	CLIP-seq
MIRT2011924	hsa-miR-363	CLIP-seq
MIRT1052623	hsa-miR-3647-3p	CLIP-seq
MIRT2011925	hsa-miR-3656	CLIP-seq
MIRT2011926	hsa-miR-3665	CLIP-seq
MIRT2011927	hsa-miR-367	CLIP-seq
MIRT1052625	hsa-miR-3913-5p	CLIP-seq
MIRT2244223	hsa-miR-4267	CLIP-seq
MIRT1052627	hsa-miR-4284	CLIP-seq
MIRT1052628	hsa-miR-4433	CLIP-seq
MIRT1052631	hsa-miR-4459	CLIP-seq
MIRT2244224	hsa-miR-4511	CLIP-seq
MIRT2011937	hsa-miR-4679	CLIP-seq
MIRT1052632	hsa-miR-4683	CLIP-seq
MIRT2244225	hsa-miR-4705	CLIP-seq
MIRT2011938	hsa-miR-4715-3p	CLIP-seq
MIRT2011939	hsa-miR-4727-5p	CLIP-seq
MIRT1052633	hsa-miR-4728-5p	CLIP-seq
MIRT2011940	hsa-miR-4736	CLIP-seq
MIRT1052635	hsa-miR-4761-5p	CLIP-seq
MIRT2244226	hsa-miR-4762-5p	CLIP-seq
MIRT2011941	hsa-miR-4763-3p	CLIP-seq
MIRT2011942	hsa-miR-4769-3p	CLIP-seq
MIRT2244227	hsa-miR-4786-3p	CLIP-seq
MIRT2244228	hsa-miR-4793-5p	CLIP-seq
MIRT2244229	hsa-miR-4794	CLIP-seq
MIRT2244230	hsa-miR-4796-3p	CLIP-seq
MIRT2011945	hsa-miR-494	CLIP-seq
MIRT2244231	hsa-miR-520g	CLIP-seq
MIRT2244232	hsa-miR-520h	CLIP-seq
MIRT1052639	hsa-miR-541	CLIP-seq
MIRT2244233	hsa-miR-548b-3p	CLIP-seq
MIRT1052652	hsa-miR-550a	CLIP-seq
MIRT1549594	hsa-miR-590-3p	CLIP-seq
MIRT1052656	hsa-miR-654-5p	CLIP-seq
MIRT1052658	hsa-miR-764	CLIP-seq
MIRT1052659	hsa-miR-802	CLIP-seq
MIRT2011946	hsa-miR-92a	CLIP-seq
MIRT2011947	hsa-miR-92b	CLIP-seq
MIRT1052617	hsa-miR-3122	CLIP-seq
MIRT1052620	hsa-miR-3192	CLIP-seq
MIRT1052625	hsa-miR-3913-5p	CLIP-seq
MIRT1052633	hsa-miR-4728-5p	CLIP-seq
MIRT1052635	hsa-miR-4761-5p	CLIP-seq
MIRT1052639	hsa-miR-541	CLIP-seq
MIRT1052656	hsa-miR-654-5p	CLIP-seq
MIRT2437631	hsa-miR-1185	CLIP-seq
MIRT1052607	hsa-miR-1290	CLIP-seq
MIRT2437632	hsa-miR-3605-5p	CLIP-seq
MIRT2437633	hsa-miR-3679-5p	CLIP-seq
MIRT2437634	hsa-miR-3978	CLIP-seq
MIRT2437635	hsa-miR-4797-5p	CLIP-seq
MIRT2437636	hsa-miR-759	CLIP-seq
MIRT1052617	hsa-miR-3122	CLIP-seq
MIRT1052625	hsa-miR-3913-5p	CLIP-seq
MIRT1052633	hsa-miR-4728-5p	CLIP-seq
MIRT1052635	hsa-miR-4761-5p	CLIP-seq
MIRT1052639	hsa-miR-541	CLIP-seq
MIRT1052656	hsa-miR-654-5p	CLIP-seq
MIRT2547159	hsa-miR-1272	CLIP-seq
MIRT2547160	hsa-miR-1273	CLIP-seq
MIRT2011921	hsa-miR-25	CLIP-seq
MIRT1052617	hsa-miR-3122	CLIP-seq
MIRT2547161	hsa-miR-3133	CLIP-seq
MIRT1052620	hsa-miR-3192	CLIP-seq
MIRT2011923	hsa-miR-32	CLIP-seq
MIRT2547162	hsa-miR-3613-3p	CLIP-seq
MIRT2011924	hsa-miR-363	CLIP-seq
MIRT2011927	hsa-miR-367	CLIP-seq
MIRT2547163	hsa-miR-371b-5p	CLIP-seq
MIRT1052625	hsa-miR-3913-5p	CLIP-seq
MIRT2547164	hsa-miR-4325	CLIP-seq
MIRT2547165	hsa-miR-4432	CLIP-seq
MIRT2547166	hsa-miR-4486	CLIP-seq
MIRT2547167	hsa-miR-4502	CLIP-seq
MIRT2244224	hsa-miR-4511	CLIP-seq
MIRT2547168	hsa-miR-451b	CLIP-seq
MIRT2547169	hsa-miR-4649-5p	CLIP-seq
MIRT2547170	hsa-miR-4684-5p	CLIP-seq
MIRT2547171	hsa-miR-4696	CLIP-seq
MIRT1052633	hsa-miR-4728-5p	CLIP-seq
MIRT2547172	hsa-miR-4733-5p	CLIP-seq
MIRT1052635	hsa-miR-4761-5p	CLIP-seq
MIRT1052639	hsa-miR-541	CLIP-seq
MIRT2547173	hsa-miR-548aa	CLIP-seq
MIRT2547174	hsa-miR-548c-3p	CLIP-seq
MIRT2547175	hsa-miR-570	CLIP-seq
MIRT1052656	hsa-miR-654-5p	CLIP-seq
MIRT2547176	hsa-miR-661	CLIP-seq
MIRT2011946	hsa-miR-92a	CLIP-seq
MIRT2011947	hsa-miR-92b	CLIP-seq
MIRT2547159	hsa-miR-1272	CLIP-seq
MIRT2547160	hsa-miR-1273	CLIP-seq
MIRT2011921	hsa-miR-25	CLIP-seq
MIRT1052617	hsa-miR-3122	CLIP-seq
MIRT2547161	hsa-miR-3133	CLIP-seq
MIRT2011923	hsa-miR-32	CLIP-seq
MIRT2547162	hsa-miR-3613-3p	CLIP-seq
MIRT2011924	hsa-miR-363	CLIP-seq
MIRT2011927	hsa-miR-367	CLIP-seq
MIRT2547163	hsa-miR-371b-5p	CLIP-seq
MIRT1052625	hsa-miR-3913-5p	CLIP-seq
MIRT2547164	hsa-miR-4325	CLIP-seq
MIRT2547165	hsa-miR-4432	CLIP-seq
MIRT2547166	hsa-miR-4486	CLIP-seq
MIRT2547167	hsa-miR-4502	CLIP-seq
MIRT2547168	hsa-miR-451b	CLIP-seq
MIRT2547169	hsa-miR-4649-5p	CLIP-seq
MIRT2547170	hsa-miR-4684-5p	CLIP-seq
MIRT2547171	hsa-miR-4696	CLIP-seq
MIRT1052633	hsa-miR-4728-5p	CLIP-seq
MIRT2547172	hsa-miR-4733-5p	CLIP-seq
MIRT1052635	hsa-miR-4761-5p	CLIP-seq
MIRT1052639	hsa-miR-541	CLIP-seq
MIRT2547175	hsa-miR-570	CLIP-seq
MIRT1052656	hsa-miR-654-5p	CLIP-seq
MIRT2547176	hsa-miR-661	CLIP-seq
MIRT2011946	hsa-miR-92a	CLIP-seq
MIRT2011947	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 36217029
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA

Other IDs

• MIM: 608119
• HGNC: 20164
• e!Ensembl: ENSG00000290292

Protein

• UniProt ID: Q8IX15
• Protein name: Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor)
• Protein function: May function as a transcriptional regulator.
• PDB: 2ECC, 2YS9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05920	Homeobox_KN	69 → 109	Homeobox KN domain	Family
  PF11569	Homez	453 → 509	Homeodomain leucine-zipper encoding, Homez	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney. {ECO:0000269|PubMed:12925734}.
• Sequence:

  MVRGWEPPPGLDCAISEGHKSEGTMPPNKEASGLSSSPAGLICLPPISEELQLVWTQAAQ
  TSELDSNEHLLKTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIE
  ETRARVVYRRDQLHFKSLLSFTHHAGRPPEEVPPPPVPAPEQVGIGIGPPTLSKPTQTKG
  LKVEPEEPSQMPPLPQSHQKLKESLMTPGSGAFPYQSDFWQHLQSSGLSKEQAGRGPNQS
  HGIGTASWNHSTTVPQPQARDKPPPIALIASSCKEESASSVTPSSSSTSSSFQVLANGAT
  AASKPLQPLGCVPQSVSPSEQALPPHLEPAWPQGLRHNSVPGRVGPTEYLSPDMQRQRKT
  KRKTKEQLAILKSFFLQCQWARREDYQKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFR
  DNAVPGAPSFQDPAIPTPPPSTRSLNERAETPPLPIPPPPPDIQPLERYWAAHQQLRETD
  IPQLSQASRLSTQQVLDWFDSRLPQPAEVVVCLDEEEEEEEEELPEDDEEEEEEEEEDDD
  DDDDDVIIQD

• Sequence length: 550

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BRONCHIAL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRONCHITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Coronary heart disease	Coronary Heart Disease	BEFREE	20422016, 23574532		★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	20422016, 23574532	Associate	★☆☆☆☆ Found in Text Mining only
Heart Septal Defects Ventricular	Congenital heart septal defect	Pubtator	23574532	Associate	★☆☆☆☆ Found in Text Mining only
Ventricular Septal Defects	Ventricular septal defect	BEFREE	23574532		★☆☆☆☆ Found in Text Mining only