Gene Gene information from NCBI Gene database.
Entrez ID 5757
Gene name Prothymosin alpha
Gene symbol PTMA
Synonyms (NCBI Gene)
TMSA
Chromosome 2
Chromosome location 2q37.1
miRNA miRNA information provided by mirtarbase database.
1021
miRTarBase ID miRNA Experiments Reference
MIRT001343 hsa-miR-1-3p pSILAC 18668040
MIRT001343 hsa-miR-1-3p ImmunoblotImmunofluorescenceImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCRWestern blot 22210864
MIRT001343 hsa-miR-1-3p ImmunoblotImmunofluorescenceImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCRWestern blot 22210864
MIRT001343 hsa-miR-1-3p Luciferase reporter assay 22059741
MIRT001343 hsa-miR-1-3p Luciferase reporter assay 22059741
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
ESR1 Repression 12149645
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15607035, 16478804, 21044950, 25416956, 25556234, 32296183, 32814053
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 8485135, 11897665
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus TAS 10854063
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
188390 9623 ENSG00000187514
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P06454
Protein name Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]
Protein function Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
PDB 2L9I , 2MNQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03247 Prothymosin 2 110 Prothymosin/parathymosin family Family
Sequence
Sequence length 111
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ENDOMETRIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FATTY LIVER CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FATTY LIVER, ALCOHOLIC Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma LHGDN 17046193
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 29541218, 31105795
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma CTD_human_DG 10822126
★☆☆☆☆
Found in Text Mining only
Adenoma, Basal Cell Adenoma CTD_human_DG 10822126
★☆☆☆☆
Found in Text Mining only
Adenoma, Microcystic Adenoma CTD_human_DG 10822126
★☆☆☆☆
Found in Text Mining only
Adenoma, Monomorphic Adenoma CTD_human_DG 10822126
★☆☆☆☆
Found in Text Mining only
Adenoma, Trabecular Adenoma CTD_human_DG 10822126
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety Disorder BEFREE 28122138, 31759625
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety Disorder BEFREE 28122138, 31759625
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 30719818
★☆☆☆☆
Found in Text Mining only