Gene Gene information from NCBI Gene database.
Entrez ID 57561
Gene name Arrestin domain containing 3
Gene symbol ARRDC3
Synonyms (NCBI Gene)
TLIMP
Chromosome 5
Chromosome location 5q14.3
Summary This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4,
miRNA miRNA information provided by mirtarbase database.
584
miRTarBase ID miRNA Experiments Reference
MIRT017348 hsa-miR-335-5p Microarray 18185580
MIRT020215 hsa-miR-130b-3p Sequencing 20371350
MIRT026009 hsa-miR-148a-3p Sequencing 20371350
MIRT031205 hsa-miR-19b-3p Sequencing 20371350
MIRT052564 hsa-let-7a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0001659 Process Temperature homeostasis IEA
GO:0005515 Function Protein binding IPI 20603614, 23208550, 23236378, 23886940, 25416956, 28514442, 32296183, 33961781, 38270169
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005764 Component Lysosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612464 29263 ENSG00000113369
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96B67
Protein name Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
Protein function Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinatio
PDB 4N7H , 4R7V , 4R7X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00339 Arrestin_N 9 165 Arrestin (or S-antigen), N-terminal domain Domain
PF02752 Arrestin_C 187 314 Arrestin (or S-antigen), C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bl
Sequence
Sequence length 414
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 20603614, 25038754, 28782483, 30545011
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma CTD_human_DG 25038754
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 23319801, 25038754 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 24457910, 29348172 Inhibit
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
cervical cancer Cervical Cancer BEFREE 30412241
★☆☆☆☆
Found in Text Mining only
Cervix carcinoma Cervix carcinoma BEFREE 30412241
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 29416926
★☆☆☆☆
Found in Text Mining only
Fatty Liver Alcoholic Fatty liver, alcoholic Pubtator 31341404 Associate
★☆☆☆☆
Found in Text Mining only
Fatty Liver Disease Fatty Liver BEFREE 31341404
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 20603614, 25038754, 28782483, 30545011
★☆☆☆☆
Found in Text Mining only