MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3)

Gene

• Entrez ID: 57553
• Gene name: Microtubule associated monooxygenase, calponin and LIM domain containing 3
• Gene symbol: MICAL3
• Synonyms (NCBI Gene): MICAL-3
• Chromosome: 22
• Chromosome location: 22q11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1148031	hsa-let-7a	CLIP-seq
MIRT1148032	hsa-let-7b	CLIP-seq
MIRT1148033	hsa-let-7c	CLIP-seq
MIRT1148034	hsa-let-7d	CLIP-seq
MIRT1148035	hsa-let-7e	CLIP-seq
MIRT1148036	hsa-let-7f	CLIP-seq
MIRT1148037	hsa-let-7g	CLIP-seq
MIRT1148038	hsa-let-7i	CLIP-seq
MIRT1148039	hsa-miR-1178	CLIP-seq
MIRT1148040	hsa-miR-1193	CLIP-seq
MIRT1148041	hsa-miR-1208	CLIP-seq
MIRT1148042	hsa-miR-122	CLIP-seq
MIRT1148043	hsa-miR-1245b-3p	CLIP-seq
MIRT1148044	hsa-miR-1273f	CLIP-seq
MIRT1148045	hsa-miR-128	CLIP-seq
MIRT1148046	hsa-miR-1302	CLIP-seq
MIRT1148047	hsa-miR-1343	CLIP-seq
MIRT1148048	hsa-miR-1913	CLIP-seq
MIRT1148049	hsa-miR-1976	CLIP-seq
MIRT1148050	hsa-miR-2392	CLIP-seq
MIRT1148051	hsa-miR-27a	CLIP-seq
MIRT1148052	hsa-miR-27b	CLIP-seq
MIRT1148053	hsa-miR-3121-5p	CLIP-seq
MIRT1148054	hsa-miR-3122	CLIP-seq
MIRT1148055	hsa-miR-3135b	CLIP-seq
MIRT1148056	hsa-miR-3152-3p	CLIP-seq
MIRT1148057	hsa-miR-3155	CLIP-seq
MIRT1148058	hsa-miR-3155b	CLIP-seq
MIRT1148059	hsa-miR-3194-3p	CLIP-seq
MIRT1148060	hsa-miR-3199	CLIP-seq
MIRT1148061	hsa-miR-324-3p	CLIP-seq
MIRT1148062	hsa-miR-329	CLIP-seq
MIRT1148063	hsa-miR-339-3p	CLIP-seq
MIRT1148064	hsa-miR-3545-5p	CLIP-seq
MIRT1148065	hsa-miR-362-3p	CLIP-seq
MIRT1148066	hsa-miR-3650	CLIP-seq
MIRT1148067	hsa-miR-3652	CLIP-seq
MIRT1148068	hsa-miR-3674	CLIP-seq
MIRT1148069	hsa-miR-3682-3p	CLIP-seq
MIRT1148070	hsa-miR-3913-5p	CLIP-seq
MIRT1148071	hsa-miR-3927	CLIP-seq
MIRT1148072	hsa-miR-4279	CLIP-seq
MIRT1148073	hsa-miR-4294	CLIP-seq
MIRT1148074	hsa-miR-4298	CLIP-seq
MIRT1148075	hsa-miR-4300	CLIP-seq
MIRT1148076	hsa-miR-4303	CLIP-seq
MIRT1148077	hsa-miR-431	CLIP-seq
MIRT1148078	hsa-miR-4330	CLIP-seq
MIRT1148079	hsa-miR-4420	CLIP-seq
MIRT1148080	hsa-miR-4430	CLIP-seq
MIRT1148081	hsa-miR-4438	CLIP-seq
MIRT1148082	hsa-miR-4451	CLIP-seq
MIRT1148083	hsa-miR-4457	CLIP-seq
MIRT1148084	hsa-miR-4458	CLIP-seq
MIRT1148085	hsa-miR-4500	CLIP-seq
MIRT1148086	hsa-miR-4511	CLIP-seq
MIRT1148087	hsa-miR-4519	CLIP-seq
MIRT1148088	hsa-miR-4662a-5p	CLIP-seq
MIRT1148089	hsa-miR-4676-5p	CLIP-seq
MIRT1148090	hsa-miR-4679	CLIP-seq
MIRT1148091	hsa-miR-4707-3p	CLIP-seq
MIRT1148092	hsa-miR-4719	CLIP-seq
MIRT1148093	hsa-miR-4722-3p	CLIP-seq
MIRT1148094	hsa-miR-4731-3p	CLIP-seq
MIRT1148095	hsa-miR-4732-5p	CLIP-seq
MIRT1148096	hsa-miR-4740-3p	CLIP-seq
MIRT1148097	hsa-miR-4795-5p	CLIP-seq
MIRT1148098	hsa-miR-4796-3p	CLIP-seq
MIRT1148099	hsa-miR-4801	CLIP-seq
MIRT1148100	hsa-miR-483-5p	CLIP-seq
MIRT1148101	hsa-miR-484	CLIP-seq
MIRT1148102	hsa-miR-5095	CLIP-seq
MIRT1148103	hsa-miR-513a-5p	CLIP-seq
MIRT1148104	hsa-miR-548ae	CLIP-seq
MIRT1148105	hsa-miR-548aj	CLIP-seq
MIRT1148106	hsa-miR-548al	CLIP-seq
MIRT1148107	hsa-miR-548am	CLIP-seq
MIRT1148108	hsa-miR-548x	CLIP-seq
MIRT1148109	hsa-miR-575	CLIP-seq
MIRT1148110	hsa-miR-892a	CLIP-seq
MIRT1148111	hsa-miR-920	CLIP-seq
MIRT1148112	hsa-miR-924	CLIP-seq
MIRT1148113	hsa-miR-95	CLIP-seq
MIRT1148114	hsa-miR-98	CLIP-seq
MIRT1148115	hsa-miR-1182	CLIP-seq
MIRT1148116	hsa-miR-1185	CLIP-seq
MIRT1148117	hsa-miR-1202	CLIP-seq
MIRT1148118	hsa-miR-1234	CLIP-seq
MIRT1148043	hsa-miR-1245b-3p	CLIP-seq
MIRT1148119	hsa-miR-127-5p	CLIP-seq
MIRT1148120	hsa-miR-1297	CLIP-seq
MIRT1148121	hsa-miR-1305	CLIP-seq
MIRT1148122	hsa-miR-138	CLIP-seq
MIRT1148123	hsa-miR-19a	CLIP-seq
MIRT1148124	hsa-miR-19b	CLIP-seq
MIRT1148125	hsa-miR-204	CLIP-seq
MIRT1148126	hsa-miR-211	CLIP-seq
MIRT1148127	hsa-miR-214	CLIP-seq
MIRT1148050	hsa-miR-2392	CLIP-seq
MIRT1148128	hsa-miR-26a	CLIP-seq
MIRT1148129	hsa-miR-26b	CLIP-seq
MIRT1148130	hsa-miR-28-5p	CLIP-seq
MIRT1148131	hsa-miR-3120-5p	CLIP-seq
MIRT1148132	hsa-miR-3139	CLIP-seq
MIRT1148133	hsa-miR-3148	CLIP-seq
MIRT1148134	hsa-miR-3151	CLIP-seq
MIRT1148135	hsa-miR-3187-3p	CLIP-seq
MIRT1148136	hsa-miR-323b-5p	CLIP-seq
MIRT1148137	hsa-miR-346	CLIP-seq
MIRT1148138	hsa-miR-3605-5p	CLIP-seq
MIRT1148139	hsa-miR-3619-5p	CLIP-seq
MIRT1148140	hsa-miR-3663-3p	CLIP-seq
MIRT1148141	hsa-miR-3679-5p	CLIP-seq
MIRT1148142	hsa-miR-3682-5p	CLIP-seq
MIRT1148143	hsa-miR-3938	CLIP-seq
MIRT1148144	hsa-miR-3972	CLIP-seq
MIRT1148145	hsa-miR-4265	CLIP-seq
MIRT1148146	hsa-miR-4282	CLIP-seq
MIRT1148147	hsa-miR-4288	CLIP-seq
MIRT1148148	hsa-miR-4296	CLIP-seq
MIRT1148077	hsa-miR-431	CLIP-seq
MIRT1148149	hsa-miR-4317	CLIP-seq
MIRT1148150	hsa-miR-4322	CLIP-seq
MIRT1148151	hsa-miR-4421	CLIP-seq
MIRT1148152	hsa-miR-4435	CLIP-seq
MIRT1148153	hsa-miR-4447	CLIP-seq
MIRT1148154	hsa-miR-4465	CLIP-seq
MIRT1148155	hsa-miR-4472	CLIP-seq
MIRT1148156	hsa-miR-4488	CLIP-seq
MIRT1148157	hsa-miR-4493	CLIP-seq
MIRT1148158	hsa-miR-4530	CLIP-seq
MIRT1148159	hsa-miR-4633-3p	CLIP-seq
MIRT1148160	hsa-miR-4640-5p	CLIP-seq
MIRT1148161	hsa-miR-4645-5p	CLIP-seq
MIRT1148162	hsa-miR-4663	CLIP-seq
MIRT1148163	hsa-miR-4670-3p	CLIP-seq
MIRT1148164	hsa-miR-4673	CLIP-seq
MIRT1148165	hsa-miR-4697-5p	CLIP-seq
MIRT1148166	hsa-miR-4698	CLIP-seq
MIRT1148167	hsa-miR-4701-5p	CLIP-seq
MIRT1148168	hsa-miR-4722-5p	CLIP-seq
MIRT1148169	hsa-miR-4726-5p	CLIP-seq
MIRT1148170	hsa-miR-4727-5p	CLIP-seq
MIRT1148171	hsa-miR-4755-3p	CLIP-seq
MIRT1148172	hsa-miR-4755-5p	CLIP-seq
MIRT1148173	hsa-miR-4769-3p	CLIP-seq
MIRT1148174	hsa-miR-488	CLIP-seq
MIRT1148175	hsa-miR-491-5p	CLIP-seq
MIRT1148176	hsa-miR-498	CLIP-seq
MIRT1148177	hsa-miR-544b	CLIP-seq
MIRT1148178	hsa-miR-548s	CLIP-seq
MIRT1148179	hsa-miR-579	CLIP-seq
MIRT1148180	hsa-miR-588	CLIP-seq
MIRT1148181	hsa-miR-623	CLIP-seq
MIRT1148182	hsa-miR-624	CLIP-seq
MIRT1148183	hsa-miR-632	CLIP-seq
MIRT1148184	hsa-miR-637	CLIP-seq
MIRT1148185	hsa-miR-708	CLIP-seq
MIRT1148186	hsa-miR-761	CLIP-seq
MIRT1148187	hsa-miR-888	CLIP-seq
MIRT1148113	hsa-miR-95	CLIP-seq
MIRT1148115	hsa-miR-1182	CLIP-seq
MIRT1148135	hsa-miR-3187-3p	CLIP-seq
MIRT1148152	hsa-miR-4435	CLIP-seq
MIRT1148161	hsa-miR-4645-5p	CLIP-seq
MIRT1148164	hsa-miR-4673	CLIP-seq
MIRT1148167	hsa-miR-4701-5p	CLIP-seq
MIRT1148178	hsa-miR-548s	CLIP-seq
MIRT1148180	hsa-miR-588	CLIP-seq
MIRT1148040	hsa-miR-1193	CLIP-seq
MIRT1148041	hsa-miR-1208	CLIP-seq
MIRT1148048	hsa-miR-1913	CLIP-seq
MIRT1148049	hsa-miR-1976	CLIP-seq
MIRT1148050	hsa-miR-2392	CLIP-seq
MIRT1148056	hsa-miR-3152-3p	CLIP-seq
MIRT1148061	hsa-miR-324-3p	CLIP-seq
MIRT1921680	hsa-miR-411	CLIP-seq
MIRT1148079	hsa-miR-4420	CLIP-seq
MIRT1148088	hsa-miR-4662a-5p	CLIP-seq
MIRT1148089	hsa-miR-4676-5p	CLIP-seq
MIRT1148091	hsa-miR-4707-3p	CLIP-seq
MIRT1148100	hsa-miR-483-5p	CLIP-seq
MIRT1148109	hsa-miR-575	CLIP-seq
MIRT1148110	hsa-miR-892a	CLIP-seq
MIRT1148040	hsa-miR-1193	CLIP-seq
MIRT1148041	hsa-miR-1208	CLIP-seq
MIRT1922232	hsa-miR-129-5p	CLIP-seq
MIRT1148048	hsa-miR-1913	CLIP-seq
MIRT1148049	hsa-miR-1976	CLIP-seq
MIRT1148050	hsa-miR-2392	CLIP-seq
MIRT1922233	hsa-miR-3149	CLIP-seq
MIRT1148056	hsa-miR-3152-3p	CLIP-seq
MIRT1148061	hsa-miR-324-3p	CLIP-seq
MIRT1921680	hsa-miR-411	CLIP-seq
MIRT1148079	hsa-miR-4420	CLIP-seq
MIRT1148088	hsa-miR-4662a-5p	CLIP-seq
MIRT1148089	hsa-miR-4676-5p	CLIP-seq
MIRT1148091	hsa-miR-4707-3p	CLIP-seq
MIRT1922234	hsa-miR-4775	CLIP-seq
MIRT1148100	hsa-miR-483-5p	CLIP-seq
MIRT1148109	hsa-miR-575	CLIP-seq
MIRT1922235	hsa-miR-590-3p	CLIP-seq
MIRT1148110	hsa-miR-892a	CLIP-seq
MIRT1148040	hsa-miR-1193	CLIP-seq
MIRT1148048	hsa-miR-1913	CLIP-seq
MIRT1148049	hsa-miR-1976	CLIP-seq
MIRT1148050	hsa-miR-2392	CLIP-seq
MIRT1148056	hsa-miR-3152-3p	CLIP-seq
MIRT1148061	hsa-miR-324-3p	CLIP-seq
MIRT1148088	hsa-miR-4662a-5p	CLIP-seq
MIRT1148089	hsa-miR-4676-5p	CLIP-seq
MIRT1148091	hsa-miR-4707-3p	CLIP-seq
MIRT1148109	hsa-miR-575	CLIP-seq
MIRT1148110	hsa-miR-892a	CLIP-seq
MIRT2042153	hsa-miR-1207-3p	CLIP-seq
MIRT2042154	hsa-miR-125a-3p	CLIP-seq
MIRT2042155	hsa-miR-1273g	CLIP-seq
MIRT1148045	hsa-miR-128	CLIP-seq
MIRT1148120	hsa-miR-1297	CLIP-seq
MIRT1148122	hsa-miR-138	CLIP-seq
MIRT2042156	hsa-miR-145	CLIP-seq
MIRT2042157	hsa-miR-1972	CLIP-seq
MIRT1148128	hsa-miR-26a	CLIP-seq
MIRT1148129	hsa-miR-26b	CLIP-seq
MIRT1148138	hsa-miR-3605-5p	CLIP-seq
MIRT2042158	hsa-miR-3665	CLIP-seq
MIRT1148142	hsa-miR-3682-5p	CLIP-seq
MIRT2042159	hsa-miR-383	CLIP-seq
MIRT2042160	hsa-miR-4269	CLIP-seq
MIRT2042161	hsa-miR-4277	CLIP-seq
MIRT2042162	hsa-miR-4302	CLIP-seq
MIRT1148152	hsa-miR-4435	CLIP-seq
MIRT1148154	hsa-miR-4465	CLIP-seq
MIRT2042163	hsa-miR-4474-3p	CLIP-seq
MIRT2042164	hsa-miR-4660	CLIP-seq
MIRT1148163	hsa-miR-4670-3p	CLIP-seq
MIRT2042165	hsa-miR-4685-5p	CLIP-seq
MIRT1148166	hsa-miR-4698	CLIP-seq
MIRT2042166	hsa-miR-4710	CLIP-seq
MIRT2042167	hsa-miR-4772-5p	CLIP-seq
MIRT2042168	hsa-miR-4779	CLIP-seq
MIRT2042169	hsa-miR-601	CLIP-seq
MIRT2042170	hsa-miR-765	CLIP-seq
MIRT1148056	hsa-miR-3152-3p	CLIP-seq
MIRT2271882	hsa-miR-4735-5p	CLIP-seq
MIRT1148110	hsa-miR-892a	CLIP-seq
MIRT2271883	hsa-miR-1226	CLIP-seq
MIRT1148120	hsa-miR-1297	CLIP-seq
MIRT1148121	hsa-miR-1305	CLIP-seq
MIRT1148128	hsa-miR-26a	CLIP-seq
MIRT1148129	hsa-miR-26b	CLIP-seq
MIRT2271884	hsa-miR-3183	CLIP-seq
MIRT1148078	hsa-miR-4330	CLIP-seq
MIRT1148154	hsa-miR-4465	CLIP-seq
MIRT2271885	hsa-miR-4650-5p	CLIP-seq
MIRT2271886	hsa-miR-4723-3p	CLIP-seq
MIRT1148171	hsa-miR-4755-3p	CLIP-seq
MIRT2271887	hsa-miR-642a	CLIP-seq
MIRT2271888	hsa-miR-646	CLIP-seq
MIRT1148042	hsa-miR-122	CLIP-seq
MIRT1148045	hsa-miR-128	CLIP-seq
MIRT2454120	hsa-miR-1289	CLIP-seq
MIRT1922232	hsa-miR-129-5p	CLIP-seq
MIRT1148047	hsa-miR-1343	CLIP-seq
MIRT2454121	hsa-miR-3064-3p	CLIP-seq
MIRT1148055	hsa-miR-3135b	CLIP-seq
MIRT1922233	hsa-miR-3149	CLIP-seq
MIRT1148057	hsa-miR-3155	CLIP-seq
MIRT1148058	hsa-miR-3155b	CLIP-seq
MIRT1148059	hsa-miR-3194-3p	CLIP-seq
MIRT2454122	hsa-miR-3198	CLIP-seq
MIRT1148067	hsa-miR-3652	CLIP-seq
MIRT1921680	hsa-miR-411	CLIP-seq
MIRT2454123	hsa-miR-4292	CLIP-seq
MIRT1148073	hsa-miR-4294	CLIP-seq
MIRT2454124	hsa-miR-4309	CLIP-seq
MIRT1148077	hsa-miR-431	CLIP-seq
MIRT1148080	hsa-miR-4430	CLIP-seq
MIRT1148081	hsa-miR-4438	CLIP-seq
MIRT2454125	hsa-miR-4534	CLIP-seq
MIRT2454126	hsa-miR-4715-3p	CLIP-seq
MIRT2454127	hsa-miR-4725-5p	CLIP-seq
MIRT2271882	hsa-miR-4735-5p	CLIP-seq
MIRT1922234	hsa-miR-4775	CLIP-seq
MIRT1148100	hsa-miR-483-5p	CLIP-seq
MIRT1148101	hsa-miR-484	CLIP-seq
MIRT2454128	hsa-miR-504	CLIP-seq
MIRT1148102	hsa-miR-5095	CLIP-seq
MIRT1922235	hsa-miR-590-3p	CLIP-seq
MIRT1148112	hsa-miR-924	CLIP-seq
MIRT2454129	hsa-miR-941	CLIP-seq
MIRT1922232	hsa-miR-129-5p	CLIP-seq
MIRT1922233	hsa-miR-3149	CLIP-seq
MIRT1921680	hsa-miR-411	CLIP-seq
MIRT2271882	hsa-miR-4735-5p	CLIP-seq
MIRT1922234	hsa-miR-4775	CLIP-seq
MIRT1148100	hsa-miR-483-5p	CLIP-seq
MIRT1922235	hsa-miR-590-3p	CLIP-seq
MIRT2454129	hsa-miR-941	CLIP-seq
MIRT2271883	hsa-miR-1226	CLIP-seq
MIRT1148049	hsa-miR-1976	CLIP-seq
MIRT2570741	hsa-miR-224	CLIP-seq
MIRT2570742	hsa-miR-2861	CLIP-seq
MIRT2570743	hsa-miR-3117-5p	CLIP-seq
MIRT2570744	hsa-miR-3120-3p	CLIP-seq
MIRT2570745	hsa-miR-3176	CLIP-seq
MIRT2570746	hsa-miR-3186-3p	CLIP-seq
MIRT2570747	hsa-miR-3667-3p	CLIP-seq
MIRT2570748	hsa-miR-3689a-3p	CLIP-seq
MIRT2570749	hsa-miR-3689c	CLIP-seq
MIRT2570750	hsa-miR-370	CLIP-seq
MIRT2570751	hsa-miR-378g	CLIP-seq
MIRT2570752	hsa-miR-3922-3p	CLIP-seq
MIRT2570753	hsa-miR-4283	CLIP-seq
MIRT2570754	hsa-miR-4286	CLIP-seq
MIRT2570755	hsa-miR-4437	CLIP-seq
MIRT2570756	hsa-miR-4489	CLIP-seq
MIRT2570757	hsa-miR-4674	CLIP-seq
MIRT1148167	hsa-miR-4701-5p	CLIP-seq
MIRT2570758	hsa-miR-4717-5p	CLIP-seq
MIRT2570759	hsa-miR-4728-5p	CLIP-seq
MIRT2570760	hsa-miR-4733-3p	CLIP-seq
MIRT2570761	hsa-miR-483-3p	CLIP-seq
MIRT2570762	hsa-miR-541	CLIP-seq
MIRT1148180	hsa-miR-588	CLIP-seq
MIRT2570763	hsa-miR-600	CLIP-seq
MIRT2570764	hsa-miR-654-5p	CLIP-seq
MIRT1148187	hsa-miR-888	CLIP-seq
MIRT2570765	hsa-miR-922	CLIP-seq
MIRT2570742	hsa-miR-2861	CLIP-seq
MIRT2570748	hsa-miR-3689a-3p	CLIP-seq
MIRT2570749	hsa-miR-3689c	CLIP-seq
MIRT2570759	hsa-miR-4728-5p	CLIP-seq
MIRT2570762	hsa-miR-541	CLIP-seq
MIRT2570764	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IDA	24440334
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	ISS
GO:0004497	Function	Monooxygenase activity	IEA
GO:0005515	Function	Protein binding	IPI	27528609
GO:0005634	Component	Nucleus	IDA	24440334
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005938	Component	Cell cortex	IEA
GO:0006887	Process	Exocytosis	IEA
GO:0007010	Process	Cytoskeleton organization	IDA	24440334
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016709	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISS
GO:0030042	Process	Actin filament depolymerization	IDA	24440334
GO:0030042	Process	Actin filament depolymerization	IEA
GO:0030042	Process	Actin filament depolymerization	ISS
GO:0030496	Component	Midbody	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045171	Component	Intercellular bridge	IDA
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0060090	Function	Molecular adaptor activity	EXP	27528609
GO:0071949	Function	FAD binding	IEA
GO:0071949	Function	FAD binding	ISS
GO:0090543	Component	Flemming body	IDA
GO:0120501	Function	F-actin monooxygenase activity	IEA

Other IDs

• MIM: 608882
• HGNC: 24694
• e!Ensembl: ENSG00000243156

Protein

• UniProt ID: Q7RTP6
• Protein name: [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
• Protein function: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of acti
• PDB: 2D88, 5SZG, 6ICI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01494	FAD_binding_3	86 → 141	FAD binding domain	Family
  PF00307	CH	519 → 625	Calponin homology (CH) domain	Domain
  PF00412	LIM	764 → 822	LIM domain	Domain
  PF12130	DUF3585	1854 → 1988	Bivalent Mical/EHBP Rab binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15694364}.
• Sequence:

  MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW
  KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA
  FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN
  VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK
  LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV
  MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH
  YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD
  SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR
  PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV
  TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE
  MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT
  ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN
  KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE
  GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE
  AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL
  RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG
  VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG
  NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP
  AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL
  PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE
  PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI
  CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR
  SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL
  KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL
  GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE
  PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP
  LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM
  QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG
  GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW
  KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS
  SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ
  VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE
  LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR
  EREEDKDLEAAMLSKGFSLNWS

• Sequence length: 2002

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	30587593		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	30804561		★☆☆☆☆ Found in Text Mining only
Ciliopathies	Ciliopathies	BEFREE	26485645		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	22385522		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30587593		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30587593		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	22385522	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	GWASCAT_DG	29422604		★★☆☆☆ Found in Text Mining + Unknown/Other Associations