Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57541
Gene name	Zinc finger protein 398
Gene symbol	ZNF398
Synonyms (NCBI Gene)	P51P71ZER6
Chromosome	7
Chromosome location	7q36.1
Summary	This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other

202

Show/Hide all (202)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028302	hsa-miR-32-5p	Sequencing	20371350
MIRT050546	hsa-miR-20a-5p	CLASH	23622248
MIRT048224	hsa-miR-196a-5p	CLASH	23622248
MIRT713003	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT713001	hsa-miR-5695	HITS-CLIP	19536157
MIRT713002	hsa-miR-4720-3p	HITS-CLIP	19536157
MIRT713000	hsa-miR-6792-5p	HITS-CLIP	19536157
MIRT712999	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT712998	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT712997	hsa-miR-4503	HITS-CLIP	19536157
MIRT651128	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT651143	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT651142	hsa-miR-4469	HITS-CLIP	23824327
MIRT651141	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT651140	hsa-miR-4287	HITS-CLIP	23824327
MIRT651138	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT651139	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT651137	hsa-miR-760	HITS-CLIP	23824327
MIRT651136	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT651135	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT651134	hsa-miR-4420	HITS-CLIP	23824327
MIRT651133	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT651132	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT651131	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT409070	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT651130	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT651129	hsa-miR-8057	HITS-CLIP	23824327
MIRT651128	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT651127	hsa-miR-5096	HITS-CLIP	23824327
MIRT651126	hsa-miR-6743-3p	HITS-CLIP	23824327
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT486914	hsa-miR-4257	PAR-CLIP	22012620
MIRT532903	hsa-miR-4504	PAR-CLIP	22012620
MIRT532902	hsa-miR-4474-3p	PAR-CLIP	22012620
MIRT486915	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT486914	hsa-miR-4257	PAR-CLIP	23592263
MIRT486914	hsa-miR-4257	PAR-CLIP	26701625
MIRT486914	hsa-miR-4257	PAR-CLIP	26701625
MIRT486914	hsa-miR-4257	PAR-CLIP	26701625
MIRT532903	hsa-miR-4504	PAR-CLIP	26701625
MIRT532903	hsa-miR-4504	PAR-CLIP	26701625
MIRT532903	hsa-miR-4504	PAR-CLIP	26701625
MIRT486915	hsa-miR-497-3p	PAR-CLIP	26701625
MIRT486915	hsa-miR-497-3p	PAR-CLIP	26701625
MIRT486915	hsa-miR-497-3p	PAR-CLIP	26701625
MIRT713003	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT713001	hsa-miR-5695	HITS-CLIP	19536157
MIRT713002	hsa-miR-4720-3p	HITS-CLIP	19536157
MIRT713000	hsa-miR-6792-5p	HITS-CLIP	19536157
MIRT712999	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT712998	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT712997	hsa-miR-4503	HITS-CLIP	19536157
MIRT651128	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT651143	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT651142	hsa-miR-4469	HITS-CLIP	23824327
MIRT651141	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT651140	hsa-miR-4287	HITS-CLIP	23824327
MIRT651138	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT651139	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT651137	hsa-miR-760	HITS-CLIP	23824327
MIRT651136	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT651135	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT651134	hsa-miR-4420	HITS-CLIP	23824327
MIRT651133	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT651132	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT651131	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT409070	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT651130	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT651129	hsa-miR-8057	HITS-CLIP	23824327
MIRT651128	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT651127	hsa-miR-5096	HITS-CLIP	23824327
MIRT651126	hsa-miR-6743-3p	HITS-CLIP	23824327
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT486914	hsa-miR-4257	PAR-CLIP	22012620
MIRT532903	hsa-miR-4504	PAR-CLIP	22012620
MIRT532902	hsa-miR-4474-3p	PAR-CLIP	22012620
MIRT486915	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT486914	hsa-miR-4257	PAR-CLIP	23592263
MIRT1523893	hsa-miR-1225-3p	CLIP-seq
MIRT1523894	hsa-miR-1228	CLIP-seq
MIRT1523895	hsa-miR-335	CLIP-seq
MIRT1523896	hsa-miR-4323	CLIP-seq
MIRT1523897	hsa-miR-4530	CLIP-seq
MIRT1523898	hsa-miR-4758-3p	CLIP-seq
MIRT1523899	hsa-miR-922	CLIP-seq
MIRT1523900	hsa-miR-1207-5p	CLIP-seq
MIRT1523901	hsa-miR-1271	CLIP-seq
MIRT1523902	hsa-miR-182	CLIP-seq
MIRT1523903	hsa-miR-2053	CLIP-seq
MIRT1523904	hsa-miR-3120-5p	CLIP-seq
MIRT1523905	hsa-miR-3127-5p	CLIP-seq
MIRT1523906	hsa-miR-3153	CLIP-seq
MIRT1523907	hsa-miR-3180-5p	CLIP-seq
MIRT1523908	hsa-miR-320e	CLIP-seq
MIRT1523909	hsa-miR-3650	CLIP-seq
MIRT1523910	hsa-miR-378g	CLIP-seq
MIRT1523911	hsa-miR-3907	CLIP-seq
MIRT1523912	hsa-miR-4270	CLIP-seq
MIRT1523913	hsa-miR-4289	CLIP-seq
MIRT1523914	hsa-miR-4314	CLIP-seq
MIRT1523915	hsa-miR-4437	CLIP-seq
MIRT1523916	hsa-miR-4441	CLIP-seq
MIRT1523917	hsa-miR-4448	CLIP-seq
MIRT1523918	hsa-miR-4475	CLIP-seq
MIRT1523919	hsa-miR-4521	CLIP-seq
MIRT1523920	hsa-miR-4536	CLIP-seq
MIRT1523921	hsa-miR-4674	CLIP-seq
MIRT1523922	hsa-miR-4684-5p	CLIP-seq
MIRT1523923	hsa-miR-4691-3p	CLIP-seq
MIRT1523924	hsa-miR-4698	CLIP-seq
MIRT1523925	hsa-miR-4731-5p	CLIP-seq
MIRT1523926	hsa-miR-4736	CLIP-seq
MIRT1523927	hsa-miR-4763-3p	CLIP-seq
MIRT1523928	hsa-miR-4790-3p	CLIP-seq
MIRT1523929	hsa-miR-578	CLIP-seq
MIRT1523930	hsa-miR-593	CLIP-seq
MIRT1523931	hsa-miR-607	CLIP-seq
MIRT1523932	hsa-miR-616	CLIP-seq
MIRT1523933	hsa-miR-619	CLIP-seq
MIRT1523934	hsa-miR-629	CLIP-seq
MIRT1523935	hsa-miR-630	CLIP-seq
MIRT1523936	hsa-miR-643	CLIP-seq
MIRT1523937	hsa-miR-96	CLIP-seq
MIRT2158366	hsa-miR-1208	CLIP-seq
MIRT2158367	hsa-miR-141	CLIP-seq
MIRT2158368	hsa-miR-200a	CLIP-seq
MIRT2158369	hsa-miR-24	CLIP-seq
MIRT2158370	hsa-miR-2682	CLIP-seq
MIRT2158371	hsa-miR-3065-5p	CLIP-seq
MIRT2158372	hsa-miR-3921	CLIP-seq
MIRT2158373	hsa-miR-4284	CLIP-seq
MIRT2158374	hsa-miR-4468	CLIP-seq
MIRT2158375	hsa-miR-449c	CLIP-seq
MIRT2158376	hsa-miR-4502	CLIP-seq
MIRT2158377	hsa-miR-4528	CLIP-seq
MIRT2158378	hsa-miR-4639-3p	CLIP-seq
MIRT2158379	hsa-miR-4653-5p	CLIP-seq
MIRT2158380	hsa-miR-4686	CLIP-seq
MIRT2158381	hsa-miR-4786-3p	CLIP-seq
MIRT2377836	hsa-miR-127-5p	CLIP-seq
MIRT2377837	hsa-miR-2114	CLIP-seq
MIRT2377838	hsa-miR-31	CLIP-seq
MIRT2377839	hsa-miR-3133	CLIP-seq
MIRT2377840	hsa-miR-370	CLIP-seq
MIRT2377841	hsa-miR-3973	CLIP-seq
MIRT2377842	hsa-miR-3978	CLIP-seq
MIRT2377843	hsa-miR-4426	CLIP-seq
MIRT1523915	hsa-miR-4437	CLIP-seq
MIRT2377844	hsa-miR-4647	CLIP-seq
MIRT2377845	hsa-miR-4662b	CLIP-seq
MIRT2377846	hsa-miR-4742-5p	CLIP-seq
MIRT2377847	hsa-miR-4762-3p	CLIP-seq
MIRT2158381	hsa-miR-4786-3p	CLIP-seq
MIRT2377848	hsa-miR-520g	CLIP-seq
MIRT2377849	hsa-miR-520h	CLIP-seq
MIRT2397548	hsa-miR-3192	CLIP-seq
MIRT2397549	hsa-miR-326	CLIP-seq
MIRT2397550	hsa-miR-330-5p	CLIP-seq
MIRT2377840	hsa-miR-370	CLIP-seq
MIRT1523914	hsa-miR-4314	CLIP-seq
MIRT2397551	hsa-miR-4646-5p	CLIP-seq
MIRT2670199	hsa-miR-1231	CLIP-seq
MIRT2670200	hsa-miR-1245b-3p	CLIP-seq
MIRT2670201	hsa-miR-1827	CLIP-seq
MIRT2670202	hsa-miR-2052	CLIP-seq
MIRT2670203	hsa-miR-3124-3p	CLIP-seq
MIRT2670204	hsa-miR-3127-3p	CLIP-seq
MIRT2670205	hsa-miR-3170	CLIP-seq
MIRT2670206	hsa-miR-337-3p	CLIP-seq
MIRT2670207	hsa-miR-3612	CLIP-seq
MIRT2670208	hsa-miR-3616-5p	CLIP-seq
MIRT2670209	hsa-miR-3647-5p	CLIP-seq
MIRT2670210	hsa-miR-3655	CLIP-seq
MIRT2670211	hsa-miR-3663-5p	CLIP-seq
MIRT2670212	hsa-miR-3679-3p	CLIP-seq
MIRT2670213	hsa-miR-3685	CLIP-seq
MIRT2670214	hsa-miR-384	CLIP-seq
MIRT2670215	hsa-miR-4277	CLIP-seq
MIRT2670216	hsa-miR-4288	CLIP-seq
MIRT1523914	hsa-miR-4314	CLIP-seq
MIRT2670217	hsa-miR-4667-5p	CLIP-seq
MIRT2670218	hsa-miR-4695-5p	CLIP-seq
MIRT2670219	hsa-miR-4700-5p	CLIP-seq
MIRT2670220	hsa-miR-4709-3p	CLIP-seq
MIRT2670221	hsa-miR-4795-5p	CLIP-seq
MIRT2670222	hsa-miR-573	CLIP-seq
MIRT2670223	hsa-miR-632	CLIP-seq
MIRT2670224	hsa-miR-637	CLIP-seq
MIRT2670225	hsa-miR-650	CLIP-seq
MIRT2670201	hsa-miR-1827	CLIP-seq
MIRT2670202	hsa-miR-2052	CLIP-seq
MIRT2670207	hsa-miR-3612	CLIP-seq
MIRT2670218	hsa-miR-4695-5p	CLIP-seq
MIRT2670225	hsa-miR-650	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 28514442, 31403225, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	11779858
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	11779858
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	11779858
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
618593	18373	ENSG00000197024

Q8TD17

Protein name

Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71)

Protein function

Functions as a transcriptional activator.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12417	DUF3669	43 → 113	Zinc finger protein	Family
PF01352	KRAB	142 → 183	KRAB box	Family
PF00096	zf-C2H2	399 → 420	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	427 → 449	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	455 → 477	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	483 → 505	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	511 → 533	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	539 → 561	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	567 → 590	Zinc finger, C2H2 type	Domain

Sequence

MAEAAPAPTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIH
SRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTLLQEYGLLQRRLENLENLL
RNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLI
SMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEEPGISTSDILSWIKQEEEPQ
VGAPPESKESDVYKSTYADEELVIKAEGLARSSLCPEVPVPFSSPPAAAKDAFSDVAFKS
QQSTSMTPFGRPATDLPEASEGQVTFTQLGSYPLPPPVGEQVFSCHHCGKNLSQDMLLTH
QCSHATEHPLPCAQCPKHFTPQADLSSTSQDHASETPPTCPHCARTFTHPSRLTYHLRVH
NSTERPFPCPDCPKRFADQARLTSHRRAHASERPFRCAQCGRSFSLKISLLLHQRGHAQE
RPFSCPQCGIDFNGHSALIRHQMIHTGERPYPCTDCSKSFMRKEHLLNHRRLHTGERPFS
CPHCGKSFIRKHHLMKHQRIHTGERPYPCSYCGRSFRYKQTLKDHLRSGHNGGCGGDSDP
SGQPPNPPGPLITGLETSGLGVNTEGLETNQWYGEGSGGGVL

Sequence length

642

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
RETINAL DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	15365563, 15916980		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	15365563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	10935472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	11179485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31521611		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31521611	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibroadenoma	Fibroadenoma	BEFREE	15365563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	7530025		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	10695992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	10391684, 15365563, 15916980		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	10935472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	11179485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22307076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	11336476		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10203277, 11179485, 11336476, 16832836		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10391684, 11179485, 11336476, 15916980, 16832836		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	10391684		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	11179485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	11340630, 22307076		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	11336476		★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF398 (zinc finger protein 398)