Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57530
Gene name	Cingulin
Gene symbol	CGN
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1q21.3

206

Show/Hide all (206)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004994	hsa-miR-125b-5p	Microarray	17891175
MIRT021173	hsa-miR-186-5p	Sequencing	20371350
MIRT031289	hsa-miR-19b-3p	Sequencing	20371350
MIRT724322	hsa-miR-6771-3p	HITS-CLIP	19536157
MIRT724321	hsa-miR-4705	HITS-CLIP	19536157
MIRT724320	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT724319	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT004994	hsa-miR-125b-5p	Western blot	28082316
MIRT004994	hsa-miR-125b-5p	Western blot	28082316
MIRT724322	hsa-miR-6771-3p	HITS-CLIP	19536157
MIRT724321	hsa-miR-4705	HITS-CLIP	19536157
MIRT724320	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT724319	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT888219	hsa-miR-1237	CLIP-seq
MIRT888220	hsa-miR-1245b-5p	CLIP-seq
MIRT888221	hsa-miR-1248	CLIP-seq
MIRT888222	hsa-miR-125a-5p	CLIP-seq
MIRT888223	hsa-miR-125b	CLIP-seq
MIRT888224	hsa-miR-1286	CLIP-seq
MIRT888225	hsa-miR-15a	CLIP-seq
MIRT888226	hsa-miR-15b	CLIP-seq
MIRT888227	hsa-miR-16	CLIP-seq
MIRT888228	hsa-miR-185	CLIP-seq
MIRT888229	hsa-miR-188-5p	CLIP-seq
MIRT888230	hsa-miR-1910	CLIP-seq
MIRT888231	hsa-miR-1915	CLIP-seq
MIRT888232	hsa-miR-195	CLIP-seq
MIRT888233	hsa-miR-202	CLIP-seq
MIRT888234	hsa-miR-2113	CLIP-seq
MIRT888235	hsa-miR-219-1-3p	CLIP-seq
MIRT888236	hsa-miR-2278	CLIP-seq
MIRT888237	hsa-miR-298	CLIP-seq
MIRT888238	hsa-miR-3127-5p	CLIP-seq
MIRT888239	hsa-miR-3142	CLIP-seq
MIRT888240	hsa-miR-3148	CLIP-seq
MIRT888241	hsa-miR-3153	CLIP-seq
MIRT888242	hsa-miR-3199	CLIP-seq
MIRT888243	hsa-miR-337-3p	CLIP-seq
MIRT888244	hsa-miR-339-5p	CLIP-seq
MIRT888245	hsa-miR-362-5p	CLIP-seq
MIRT888246	hsa-miR-3667-3p	CLIP-seq
MIRT888247	hsa-miR-3673	CLIP-seq
MIRT888248	hsa-miR-3689d	CLIP-seq
MIRT888249	hsa-miR-3918	CLIP-seq
MIRT888250	hsa-miR-424	CLIP-seq
MIRT888251	hsa-miR-4256	CLIP-seq
MIRT888252	hsa-miR-4264	CLIP-seq
MIRT888253	hsa-miR-4270	CLIP-seq
MIRT888254	hsa-miR-4303	CLIP-seq
MIRT888255	hsa-miR-4319	CLIP-seq
MIRT888256	hsa-miR-4421	CLIP-seq
MIRT888257	hsa-miR-4441	CLIP-seq
MIRT888258	hsa-miR-4446-5p	CLIP-seq
MIRT888259	hsa-miR-4468	CLIP-seq
MIRT888260	hsa-miR-4470	CLIP-seq
MIRT888261	hsa-miR-4493	CLIP-seq
MIRT888262	hsa-miR-4496	CLIP-seq
MIRT888263	hsa-miR-4513	CLIP-seq
MIRT888264	hsa-miR-455-3p	CLIP-seq
MIRT888265	hsa-miR-4639-3p	CLIP-seq
MIRT888266	hsa-miR-4676-5p	CLIP-seq
MIRT888267	hsa-miR-4682	CLIP-seq
MIRT888268	hsa-miR-4685-5p	CLIP-seq
MIRT888269	hsa-miR-4708-3p	CLIP-seq
MIRT888270	hsa-miR-4714-5p	CLIP-seq
MIRT888271	hsa-miR-4717-3p	CLIP-seq
MIRT888272	hsa-miR-4717-5p	CLIP-seq
MIRT888273	hsa-miR-4722-5p	CLIP-seq
MIRT888274	hsa-miR-4726-3p	CLIP-seq
MIRT888275	hsa-miR-4731-5p	CLIP-seq
MIRT888276	hsa-miR-4732-3p	CLIP-seq
MIRT888277	hsa-miR-4740-5p	CLIP-seq
MIRT888278	hsa-miR-4753-5p	CLIP-seq
MIRT888279	hsa-miR-4755-5p	CLIP-seq
MIRT888280	hsa-miR-4762-3p	CLIP-seq
MIRT888281	hsa-miR-4797-3p	CLIP-seq
MIRT888282	hsa-miR-4802-5p	CLIP-seq
MIRT888283	hsa-miR-4803	CLIP-seq
MIRT888284	hsa-miR-497	CLIP-seq
MIRT888285	hsa-miR-500b	CLIP-seq
MIRT888286	hsa-miR-501-5p	CLIP-seq
MIRT888287	hsa-miR-541	CLIP-seq
MIRT888288	hsa-miR-571	CLIP-seq
MIRT888289	hsa-miR-575	CLIP-seq
MIRT888290	hsa-miR-583	CLIP-seq
MIRT888291	hsa-miR-654-5p	CLIP-seq
MIRT888292	hsa-miR-670	CLIP-seq
MIRT888293	hsa-miR-764	CLIP-seq
MIRT888294	hsa-miR-9	CLIP-seq
MIRT888231	hsa-miR-1915	CLIP-seq
MIRT888234	hsa-miR-2113	CLIP-seq
MIRT888238	hsa-miR-3127-5p	CLIP-seq
MIRT888247	hsa-miR-3673	CLIP-seq
MIRT888249	hsa-miR-3918	CLIP-seq
MIRT888266	hsa-miR-4676-5p	CLIP-seq
MIRT888274	hsa-miR-4726-3p	CLIP-seq
MIRT888289	hsa-miR-575	CLIP-seq
MIRT888293	hsa-miR-764	CLIP-seq
MIRT1963271	hsa-miR-1224-5p	CLIP-seq
MIRT888222	hsa-miR-125a-5p	CLIP-seq
MIRT888223	hsa-miR-125b	CLIP-seq
MIRT1963272	hsa-miR-1284	CLIP-seq
MIRT888224	hsa-miR-1286	CLIP-seq
MIRT1963273	hsa-miR-1291	CLIP-seq
MIRT888228	hsa-miR-185	CLIP-seq
MIRT1963274	hsa-miR-186	CLIP-seq
MIRT888231	hsa-miR-1915	CLIP-seq
MIRT888233	hsa-miR-202	CLIP-seq
MIRT1963275	hsa-miR-203	CLIP-seq
MIRT1963276	hsa-miR-2110	CLIP-seq
MIRT888234	hsa-miR-2113	CLIP-seq
MIRT1963277	hsa-miR-2117	CLIP-seq
MIRT888235	hsa-miR-219-1-3p	CLIP-seq
MIRT1963278	hsa-miR-24	CLIP-seq
MIRT1963279	hsa-miR-300	CLIP-seq
MIRT1963280	hsa-miR-3064-5p	CLIP-seq
MIRT888238	hsa-miR-3127-5p	CLIP-seq
MIRT1963281	hsa-miR-3133	CLIP-seq
MIRT888241	hsa-miR-3153	CLIP-seq
MIRT1963282	hsa-miR-320a	CLIP-seq
MIRT1963283	hsa-miR-320b	CLIP-seq
MIRT1963284	hsa-miR-320c	CLIP-seq
MIRT1963285	hsa-miR-320d	CLIP-seq
MIRT1963286	hsa-miR-320e	CLIP-seq
MIRT1963287	hsa-miR-323-3p	CLIP-seq
MIRT1963288	hsa-miR-3611	CLIP-seq
MIRT1963289	hsa-miR-3614-3p	CLIP-seq
MIRT1963290	hsa-miR-3616-3p	CLIP-seq
MIRT1963291	hsa-miR-3652	CLIP-seq
MIRT888246	hsa-miR-3667-3p	CLIP-seq
MIRT888247	hsa-miR-3673	CLIP-seq
MIRT888248	hsa-miR-3689d	CLIP-seq
MIRT1963292	hsa-miR-381	CLIP-seq
MIRT1963293	hsa-miR-3915	CLIP-seq
MIRT888249	hsa-miR-3918	CLIP-seq
MIRT1963294	hsa-miR-3919	CLIP-seq
MIRT1963295	hsa-miR-3928	CLIP-seq
MIRT1963296	hsa-miR-3929	CLIP-seq
MIRT1963297	hsa-miR-4258	CLIP-seq
MIRT888253	hsa-miR-4270	CLIP-seq
MIRT1963298	hsa-miR-4271	CLIP-seq
MIRT1963299	hsa-miR-4297	CLIP-seq
MIRT888255	hsa-miR-4319	CLIP-seq
MIRT1963300	hsa-miR-4419a	CLIP-seq
MIRT1963301	hsa-miR-4419b	CLIP-seq
MIRT1963302	hsa-miR-4429	CLIP-seq
MIRT1963303	hsa-miR-4430	CLIP-seq
MIRT888257	hsa-miR-4441	CLIP-seq
MIRT888259	hsa-miR-4468	CLIP-seq
MIRT1963304	hsa-miR-4476	CLIP-seq
MIRT1963305	hsa-miR-4478	CLIP-seq
MIRT888262	hsa-miR-4496	CLIP-seq
MIRT1963306	hsa-miR-4505	CLIP-seq
MIRT1963307	hsa-miR-4510	CLIP-seq
MIRT1963308	hsa-miR-4533	CLIP-seq
MIRT1963309	hsa-miR-4666-3p	CLIP-seq
MIRT1963310	hsa-miR-4667-5p	CLIP-seq
MIRT1963311	hsa-miR-4668-5p	CLIP-seq
MIRT888266	hsa-miR-4676-5p	CLIP-seq
MIRT888268	hsa-miR-4685-5p	CLIP-seq
MIRT1963312	hsa-miR-4689	CLIP-seq
MIRT1963313	hsa-miR-4700-5p	CLIP-seq
MIRT1963314	hsa-miR-4704-3p	CLIP-seq
MIRT1963315	hsa-miR-4715-3p	CLIP-seq
MIRT1963316	hsa-miR-4715-5p	CLIP-seq
MIRT1963317	hsa-miR-4721	CLIP-seq
MIRT888273	hsa-miR-4722-5p	CLIP-seq
MIRT1963318	hsa-miR-4725-3p	CLIP-seq
MIRT888274	hsa-miR-4726-3p	CLIP-seq
MIRT888275	hsa-miR-4731-5p	CLIP-seq
MIRT1963319	hsa-miR-4747-5p	CLIP-seq
MIRT1963320	hsa-miR-4753-3p	CLIP-seq
MIRT1963321	hsa-miR-4777-3p	CLIP-seq
MIRT1963322	hsa-miR-4779	CLIP-seq
MIRT888282	hsa-miR-4802-5p	CLIP-seq
MIRT1963323	hsa-miR-570	CLIP-seq
MIRT888288	hsa-miR-571	CLIP-seq
MIRT888289	hsa-miR-575	CLIP-seq
MIRT1963324	hsa-miR-579	CLIP-seq
MIRT1963325	hsa-miR-659	CLIP-seq
MIRT1963326	hsa-miR-758	CLIP-seq
MIRT888293	hsa-miR-764	CLIP-seq
MIRT888294	hsa-miR-9	CLIP-seq
MIRT888224	hsa-miR-1286	CLIP-seq
MIRT888231	hsa-miR-1915	CLIP-seq
MIRT888234	hsa-miR-2113	CLIP-seq
MIRT888237	hsa-miR-298	CLIP-seq
MIRT888242	hsa-miR-3199	CLIP-seq
MIRT1963287	hsa-miR-323-3p	CLIP-seq
MIRT2199779	hsa-miR-34b	CLIP-seq
MIRT1963294	hsa-miR-3919	CLIP-seq
MIRT888259	hsa-miR-4468	CLIP-seq
MIRT888263	hsa-miR-4513	CLIP-seq
MIRT888266	hsa-miR-4676-5p	CLIP-seq
MIRT888270	hsa-miR-4714-5p	CLIP-seq
MIRT888274	hsa-miR-4726-3p	CLIP-seq
MIRT888275	hsa-miR-4731-5p	CLIP-seq
MIRT888277	hsa-miR-4740-5p	CLIP-seq
MIRT888289	hsa-miR-575	CLIP-seq
MIRT888293	hsa-miR-764	CLIP-seq
MIRT888231	hsa-miR-1915	CLIP-seq
MIRT888234	hsa-miR-2113	CLIP-seq
MIRT888265	hsa-miR-4639-3p	CLIP-seq
MIRT888266	hsa-miR-4676-5p	CLIP-seq
MIRT888270	hsa-miR-4714-5p	CLIP-seq
MIRT888289	hsa-miR-575	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0003779	Function	Actin binding	ISS
GO:0005515	Function	Protein binding	IPI	11042084, 12023291, 15161933, 15778465, 28514442, 31473225, 33961781, 35271311, 36931259
GO:0005886	Component	Plasma membrane	IDA
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IDA	22006950
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	NAS	12529927
GO:0008017	Function	Microtubule binding	IBA
GO:0016459	Component	Myosin complex	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030054	Component	Cell junction	TAS
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070161	Component	Anchoring junction	IEA

MIM	HGNC	e!Ensembl
609473	17429	ENSG00000143375

Q9P2M7

Protein name

Cingulin

Protein function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01576	Myosin_tail_1	786 → 1149	Myosin tail	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.

Sequence

MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFV
VLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGA
YWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFD
SQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVG
TSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAA
PPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTR
KVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQN
MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV
EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE
RQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEK
IEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQL
AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLR
ETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE
EEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRL
LDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSG
GLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG
LEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQ
NKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELS
IQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQ
ARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Sequence length

1197

Interactions

View interactions

	KEGG		Reactome
	Tight junction		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	32371920	Stimulate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	20086175	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28617990		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	2012170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dental Caries	Dental caries	Pubtator	25373699	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis Atopic	Atopic dermatitis	Pubtator	39796069	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diarrhea	Diarrhea	Pubtator	28082316	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Enterocolitis Necrotizing	Enterocolitis	Pubtator	29276042	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ichthyosis Bullosa of Siemens	Junctional epidermolysis bullosa	Pubtator	28082316	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	24625834	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	31220450		★★★★★ ★☆☆☆☆ Found in Text Mining only

CGN (cingulin)