Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57480
Gene name	Pleckstrin homology and RhoGEF domain containing G1
Gene symbol	PLEKHG1
Synonyms (NCBI Gene)	ARHGEF41
Chromosome	6
Chromosome location	6q25.1

Show/Hide all (97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016820	hsa-miR-335-5p	Microarray	18185580
MIRT535163	hsa-miR-498	PAR-CLIP	22012620
MIRT535163	hsa-miR-498	PAR-CLIP	22012620
MIRT1241754	hsa-miR-1908	CLIP-seq
MIRT1241755	hsa-miR-205	CLIP-seq
MIRT1241756	hsa-miR-24	CLIP-seq
MIRT1241757	hsa-miR-3148	CLIP-seq
MIRT1241758	hsa-miR-3157-5p	CLIP-seq
MIRT1241759	hsa-miR-3161	CLIP-seq
MIRT1241760	hsa-miR-3613-3p	CLIP-seq
MIRT1241761	hsa-miR-3934	CLIP-seq
MIRT1241762	hsa-miR-4284	CLIP-seq
MIRT1241763	hsa-miR-4297	CLIP-seq
MIRT1241764	hsa-miR-4662a-5p	CLIP-seq
MIRT1241765	hsa-miR-4676-5p	CLIP-seq
MIRT1241766	hsa-miR-4686	CLIP-seq
MIRT1241767	hsa-miR-4691-3p	CLIP-seq
MIRT1241768	hsa-miR-4743	CLIP-seq
MIRT1241769	hsa-miR-4753-3p	CLIP-seq
MIRT1241770	hsa-miR-4767	CLIP-seq
MIRT1241771	hsa-miR-4768-5p	CLIP-seq
MIRT1241772	hsa-miR-495	CLIP-seq
MIRT1241773	hsa-miR-548aa	CLIP-seq
MIRT1241774	hsa-miR-548ac	CLIP-seq
MIRT1241775	hsa-miR-548d-3p	CLIP-seq
MIRT1241776	hsa-miR-548z	CLIP-seq
MIRT1241777	hsa-miR-566	CLIP-seq
MIRT1241778	hsa-miR-575	CLIP-seq
MIRT1241779	hsa-miR-578	CLIP-seq
MIRT1241780	hsa-miR-579	CLIP-seq
MIRT1241781	hsa-miR-663	CLIP-seq
MIRT1241782	hsa-miR-873	CLIP-seq
MIRT2071180	hsa-miR-129-5p	CLIP-seq
MIRT2071181	hsa-miR-4423-5p	CLIP-seq
MIRT2071182	hsa-miR-4768-3p	CLIP-seq
MIRT2298405	hsa-miR-1305	CLIP-seq
MIRT2298406	hsa-miR-3612	CLIP-seq
MIRT2298407	hsa-miR-3689d	CLIP-seq
MIRT2298408	hsa-miR-421	CLIP-seq
MIRT2298409	hsa-miR-4433	CLIP-seq
MIRT2298410	hsa-miR-4443	CLIP-seq
MIRT2298411	hsa-miR-4459	CLIP-seq
MIRT2298412	hsa-miR-4709-5p	CLIP-seq
MIRT1241768	hsa-miR-4743	CLIP-seq
MIRT2071182	hsa-miR-4768-3p	CLIP-seq
MIRT2298413	hsa-miR-4772-5p	CLIP-seq
MIRT2298414	hsa-miR-485-5p	CLIP-seq
MIRT2298415	hsa-miR-5096	CLIP-seq
MIRT1241779	hsa-miR-578	CLIP-seq
MIRT1241780	hsa-miR-579	CLIP-seq
MIRT2298416	hsa-miR-650	CLIP-seq
MIRT2298417	hsa-miR-656	CLIP-seq
MIRT2298418	hsa-miR-664	CLIP-seq
MIRT2392655	hsa-miR-1827	CLIP-seq
MIRT2392656	hsa-miR-335	CLIP-seq
MIRT2392657	hsa-miR-3929	CLIP-seq
MIRT2392658	hsa-miR-4272	CLIP-seq
MIRT2392659	hsa-miR-4419b	CLIP-seq
MIRT2392660	hsa-miR-4478	CLIP-seq
MIRT2392661	hsa-miR-4649-3p	CLIP-seq
MIRT1241770	hsa-miR-4767	CLIP-seq
MIRT2298414	hsa-miR-485-5p	CLIP-seq
MIRT1241777	hsa-miR-566	CLIP-seq
MIRT2456647	hsa-miR-3140-3p	CLIP-seq
MIRT2456648	hsa-miR-3167	CLIP-seq
MIRT2456649	hsa-miR-3662	CLIP-seq
MIRT2456650	hsa-miR-4328	CLIP-seq
MIRT2456651	hsa-miR-4456	CLIP-seq
MIRT2456652	hsa-miR-4654	CLIP-seq
MIRT2456653	hsa-miR-4698	CLIP-seq
MIRT2456654	hsa-miR-4711-5p	CLIP-seq
MIRT2456655	hsa-miR-4769-5p	CLIP-seq
MIRT2456656	hsa-miR-541	CLIP-seq
MIRT2456657	hsa-miR-544	CLIP-seq
MIRT2456658	hsa-miR-654-5p	CLIP-seq
MIRT2456659	hsa-miR-876-5p	CLIP-seq
MIRT2392655	hsa-miR-1827	CLIP-seq
MIRT2595550	hsa-miR-3192	CLIP-seq
MIRT2595551	hsa-miR-326	CLIP-seq
MIRT2595552	hsa-miR-330-5p	CLIP-seq
MIRT2595553	hsa-miR-3689a-3p	CLIP-seq
MIRT2595554	hsa-miR-3689c	CLIP-seq
MIRT2595555	hsa-miR-4314	CLIP-seq
MIRT2595556	hsa-miR-4646-5p	CLIP-seq
MIRT2595557	hsa-miR-4728-5p	CLIP-seq
MIRT2392655	hsa-miR-1827	CLIP-seq
MIRT2595550	hsa-miR-3192	CLIP-seq
MIRT2595551	hsa-miR-326	CLIP-seq
MIRT2595552	hsa-miR-330-5p	CLIP-seq
MIRT2595553	hsa-miR-3689a-3p	CLIP-seq
MIRT2595554	hsa-miR-3689c	CLIP-seq
MIRT2688088	hsa-miR-410	CLIP-seq
MIRT2595555	hsa-miR-4314	CLIP-seq
MIRT2595556	hsa-miR-4646-5p	CLIP-seq
MIRT2456653	hsa-miR-4698	CLIP-seq
MIRT2688089	hsa-miR-4719	CLIP-seq
MIRT2595557	hsa-miR-4728-5p	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0031267	Function	Small GTPase binding	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

MIM	HGNC	e!Ensembl
620134	20884	ENSG00000120278

Q9ULL1

Protein name

Pleckstrin homology domain-containing family G member 1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	117 → 291	RhoGEF domain	Domain

Sequence

MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPAR
PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE
ILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC
ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLP
LGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHA
VRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTY
KAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHA
AKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLK
TSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQ
ALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSS
SGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHV
YDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGT
LSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDS
LRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWN
DLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALL
TPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPE
NPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAI
LEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGS
GDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPG
SVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPS
DVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQ
IATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT
LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLS
SSSFA

Sequence length

1385

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIVENTRICULAR LEUKOMALACIA	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE POLYP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cardiovascular Diseases	Cardiovascular Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	30659137	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertensive disease	Hypertension	GWASCAT_DG	28498854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukomalacia Periventricular	Periventricular leukomalacia	Pubtator	39202455	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Waldenstrom Macroglobulinemia	Waldenstrom macroglobulinemia	Pubtator	24366360	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1)