Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57477
Gene name	Shroom family member 4
Gene symbol	SHROOM4
Synonyms (NCBI Gene)	MRXSSDSSHAPshrm4
Chromosome	X
Chromosome location	Xp11.22
Summary	This gene encodes a member of the APX/Shroom family, which contain an N-terminal PDZ domain and a C-terminal ASD2 motif. The encoded protein may play a role in cytoskeletal architecture. Mutations in this gene have been linked to the X-linked Stocco dos S

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121434620	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant, genic downstream transcript variant
rs886041718	G>A	Pathogenic	Stop gained, non coding transcript variant, genic downstream transcript variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018002	hsa-miR-335-5p	Microarray	18185580
MIRT712200	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT712199	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT712198	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT712197	hsa-miR-6072	HITS-CLIP	19536157
MIRT712196	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT712195	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT712194	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT712193	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT676813	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT653827	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT653828	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676812	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT676811	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT676810	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676809	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT676808	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT676807	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT676806	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT679129	hsa-miR-4279	HITS-CLIP	23824327
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT676813	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676812	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT676811	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT676810	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT676809	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT676808	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT676807	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT676806	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT653827	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT653828	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT674601	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT653826	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT653825	hsa-miR-1976	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT653827	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT653828	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT653826	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT653825	hsa-miR-1976	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT521131	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT521129	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT521130	hsa-miR-575	PAR-CLIP	23446348
MIRT521128	hsa-miR-2392	PAR-CLIP	23446348
MIRT521127	hsa-miR-296-3p	PAR-CLIP	23446348
MIRT521126	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT521125	hsa-miR-3152-3p	PAR-CLIP	23446348
MIRT521124	hsa-miR-4662a-5p	PAR-CLIP	23446348
MIRT521123	hsa-miR-5096	PAR-CLIP	23446348
MIRT712200	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT712199	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT712198	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT712197	hsa-miR-6072	HITS-CLIP	19536157
MIRT712196	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT712195	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT712194	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT712193	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT676813	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT653827	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT653828	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676812	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT676811	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT676810	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676809	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT676808	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT676807	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT676806	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT679129	hsa-miR-4279	HITS-CLIP	23824327
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT676813	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT676812	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT676811	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT676810	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT676809	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT676808	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT676807	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT676806	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT653827	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT653828	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT674601	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT653826	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT653825	hsa-miR-1976	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT653827	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT653828	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT653826	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT653825	hsa-miR-1976	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632423	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT632422	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT632421	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT521131	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT521129	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT521130	hsa-miR-575	PAR-CLIP	23446348
MIRT521128	hsa-miR-2392	PAR-CLIP	23446348
MIRT521127	hsa-miR-296-3p	PAR-CLIP	23446348
MIRT521126	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT521125	hsa-miR-3152-3p	PAR-CLIP	23446348
MIRT521124	hsa-miR-4662a-5p	PAR-CLIP	23446348
MIRT521123	hsa-miR-5096	PAR-CLIP	23446348
MIRT1347996	hsa-miR-105	CLIP-seq
MIRT1347997	hsa-miR-1193	CLIP-seq
MIRT1347998	hsa-miR-1197	CLIP-seq
MIRT1347999	hsa-miR-1233	CLIP-seq
MIRT1348000	hsa-miR-1267	CLIP-seq
MIRT1348001	hsa-miR-1271	CLIP-seq
MIRT1348002	hsa-miR-1303	CLIP-seq
MIRT1348003	hsa-miR-145	CLIP-seq
MIRT1348004	hsa-miR-15a	CLIP-seq
MIRT1348005	hsa-miR-15b	CLIP-seq
MIRT1348006	hsa-miR-16	CLIP-seq
MIRT1348007	hsa-miR-182	CLIP-seq
MIRT1348008	hsa-miR-185	CLIP-seq
MIRT1348009	hsa-miR-190	CLIP-seq
MIRT1348010	hsa-miR-190b	CLIP-seq
MIRT1348011	hsa-miR-193a-3p	CLIP-seq
MIRT1348012	hsa-miR-193b	CLIP-seq
MIRT1348013	hsa-miR-195	CLIP-seq
MIRT1348014	hsa-miR-216b	CLIP-seq
MIRT1348015	hsa-miR-217	CLIP-seq
MIRT1348016	hsa-miR-2278	CLIP-seq
MIRT1348017	hsa-miR-298	CLIP-seq
MIRT1348018	hsa-miR-3119	CLIP-seq
MIRT1348019	hsa-miR-3120-5p	CLIP-seq
MIRT1348020	hsa-miR-3125	CLIP-seq
MIRT1348021	hsa-miR-3165	CLIP-seq
MIRT1348022	hsa-miR-3175	CLIP-seq
MIRT1348023	hsa-miR-3180-5p	CLIP-seq
MIRT1348024	hsa-miR-3187-3p	CLIP-seq
MIRT1348025	hsa-miR-3192	CLIP-seq
MIRT1348026	hsa-miR-3199	CLIP-seq
MIRT1348027	hsa-miR-330-3p	CLIP-seq
MIRT1348028	hsa-miR-3652	CLIP-seq
MIRT1348029	hsa-miR-3677-5p	CLIP-seq
MIRT1348030	hsa-miR-3682-3p	CLIP-seq
MIRT1348031	hsa-miR-3689a-3p	CLIP-seq
MIRT1348032	hsa-miR-3689c	CLIP-seq
MIRT1348033	hsa-miR-3689d	CLIP-seq
MIRT1348034	hsa-miR-3916	CLIP-seq
MIRT1348035	hsa-miR-424	CLIP-seq
MIRT1348036	hsa-miR-4270	CLIP-seq
MIRT1348037	hsa-miR-4275	CLIP-seq
MIRT1348038	hsa-miR-4292	CLIP-seq
MIRT1348039	hsa-miR-4297	CLIP-seq
MIRT1348040	hsa-miR-4306	CLIP-seq
MIRT1348041	hsa-miR-432	CLIP-seq
MIRT1348042	hsa-miR-4430	CLIP-seq
MIRT1348043	hsa-miR-4441	CLIP-seq
MIRT1348044	hsa-miR-4445	CLIP-seq
MIRT1348045	hsa-miR-4460	CLIP-seq
MIRT1348046	hsa-miR-4466	CLIP-seq
MIRT1348047	hsa-miR-4504	CLIP-seq
MIRT1348048	hsa-miR-4505	CLIP-seq
MIRT1348049	hsa-miR-4529-5p	CLIP-seq
MIRT1348050	hsa-miR-4644	CLIP-seq
MIRT1348051	hsa-miR-4687-3p	CLIP-seq
MIRT1348052	hsa-miR-4694-3p	CLIP-seq
MIRT1348053	hsa-miR-4695-3p	CLIP-seq
MIRT1348054	hsa-miR-4704-5p	CLIP-seq
MIRT1348055	hsa-miR-4712-5p	CLIP-seq
MIRT1348056	hsa-miR-4719	CLIP-seq
MIRT1348057	hsa-miR-4727-3p	CLIP-seq
MIRT1348058	hsa-miR-4728-5p	CLIP-seq
MIRT1348059	hsa-miR-4740-3p	CLIP-seq
MIRT1348060	hsa-miR-4778-5p	CLIP-seq
MIRT1348061	hsa-miR-4795-3p	CLIP-seq
MIRT1348062	hsa-miR-485-5p	CLIP-seq
MIRT1348063	hsa-miR-497	CLIP-seq
MIRT1348064	hsa-miR-498	CLIP-seq
MIRT1348065	hsa-miR-513c	CLIP-seq
MIRT1348066	hsa-miR-514b-5p	CLIP-seq
MIRT1348067	hsa-miR-520a-5p	CLIP-seq
MIRT1348068	hsa-miR-520d-5p	CLIP-seq
MIRT1348069	hsa-miR-524-5p	CLIP-seq
MIRT1348070	hsa-miR-525-5p	CLIP-seq
MIRT1348071	hsa-miR-548ae	CLIP-seq
MIRT1348072	hsa-miR-548aj	CLIP-seq
MIRT1348073	hsa-miR-548am	CLIP-seq
MIRT1348074	hsa-miR-548q	CLIP-seq
MIRT1348075	hsa-miR-548x	CLIP-seq
MIRT1348076	hsa-miR-563	CLIP-seq
MIRT1348077	hsa-miR-581	CLIP-seq
MIRT1348078	hsa-miR-593	CLIP-seq
MIRT1348079	hsa-miR-640	CLIP-seq
MIRT1348080	hsa-miR-647	CLIP-seq
MIRT1348081	hsa-miR-659	CLIP-seq
MIRT1348082	hsa-miR-671-5p	CLIP-seq
MIRT1348083	hsa-miR-675	CLIP-seq
MIRT1348084	hsa-miR-676	CLIP-seq
MIRT1348085	hsa-miR-765	CLIP-seq
MIRT1348086	hsa-miR-770-5p	CLIP-seq
MIRT1348087	hsa-miR-877	CLIP-seq
MIRT1348088	hsa-miR-891b	CLIP-seq
MIRT1348089	hsa-miR-892b	CLIP-seq
MIRT1348090	hsa-miR-9	CLIP-seq
MIRT1348091	hsa-miR-96	CLIP-seq
MIRT1553691	hsa-miR-1207-5p	CLIP-seq
MIRT1553692	hsa-miR-4763-3p	CLIP-seq
MIRT2103117	hsa-miR-106a	CLIP-seq
MIRT2103118	hsa-miR-106b	CLIP-seq
MIRT2103119	hsa-miR-122	CLIP-seq
MIRT2103120	hsa-miR-1234	CLIP-seq
MIRT2103121	hsa-miR-1285	CLIP-seq
MIRT2103122	hsa-miR-1305	CLIP-seq
MIRT2103123	hsa-miR-150	CLIP-seq
MIRT2103124	hsa-miR-17	CLIP-seq
MIRT1348007	hsa-miR-182	CLIP-seq
MIRT1348011	hsa-miR-193a-3p	CLIP-seq
MIRT1348012	hsa-miR-193b	CLIP-seq
MIRT2103125	hsa-miR-20a	CLIP-seq
MIRT2103126	hsa-miR-20b	CLIP-seq
MIRT1348014	hsa-miR-216b	CLIP-seq
MIRT1348016	hsa-miR-2278	CLIP-seq
MIRT2103127	hsa-miR-302a	CLIP-seq
MIRT2103128	hsa-miR-302b	CLIP-seq
MIRT2103129	hsa-miR-302c	CLIP-seq
MIRT2103130	hsa-miR-302d	CLIP-seq
MIRT2103131	hsa-miR-302e	CLIP-seq
MIRT2103132	hsa-miR-3167	CLIP-seq
MIRT1348022	hsa-miR-3175	CLIP-seq
MIRT2103133	hsa-miR-3187-5p	CLIP-seq
MIRT1348026	hsa-miR-3199	CLIP-seq
MIRT2103134	hsa-miR-3650	CLIP-seq
MIRT1348028	hsa-miR-3652	CLIP-seq
MIRT2103135	hsa-miR-372	CLIP-seq
MIRT2103136	hsa-miR-373	CLIP-seq
MIRT1348039	hsa-miR-4297	CLIP-seq
MIRT2103137	hsa-miR-4423-5p	CLIP-seq
MIRT1348042	hsa-miR-4430	CLIP-seq
MIRT2103138	hsa-miR-4436b-5p	CLIP-seq
MIRT1348048	hsa-miR-4505	CLIP-seq
MIRT2103139	hsa-miR-4534	CLIP-seq
MIRT1348053	hsa-miR-4695-3p	CLIP-seq
MIRT2103140	hsa-miR-4731-5p	CLIP-seq
MIRT2103141	hsa-miR-4738-3p	CLIP-seq
MIRT1348059	hsa-miR-4740-3p	CLIP-seq
MIRT1348064	hsa-miR-498	CLIP-seq
MIRT2103142	hsa-miR-512-3p	CLIP-seq
MIRT2103143	hsa-miR-519d	CLIP-seq
MIRT2103144	hsa-miR-520a-3p	CLIP-seq
MIRT2103145	hsa-miR-520b	CLIP-seq
MIRT2103146	hsa-miR-520c-3p	CLIP-seq
MIRT2103147	hsa-miR-520d-3p	CLIP-seq
MIRT2103148	hsa-miR-520e	CLIP-seq
MIRT2103149	hsa-miR-520g	CLIP-seq
MIRT2103150	hsa-miR-520h	CLIP-seq
MIRT2103151	hsa-miR-607	CLIP-seq
MIRT2103152	hsa-miR-612	CLIP-seq
MIRT1348079	hsa-miR-640	CLIP-seq
MIRT2103153	hsa-miR-876-5p	CLIP-seq
MIRT1348089	hsa-miR-892b	CLIP-seq
MIRT2103154	hsa-miR-93	CLIP-seq
MIRT1347997	hsa-miR-1193	CLIP-seq
MIRT1553691	hsa-miR-1207-5p	CLIP-seq
MIRT2103119	hsa-miR-122	CLIP-seq
MIRT2103120	hsa-miR-1234	CLIP-seq
MIRT2103123	hsa-miR-150	CLIP-seq
MIRT1348004	hsa-miR-15a	CLIP-seq
MIRT1348005	hsa-miR-15b	CLIP-seq
MIRT1348006	hsa-miR-16	CLIP-seq
MIRT1348007	hsa-miR-182	CLIP-seq
MIRT2327419	hsa-miR-1912	CLIP-seq
MIRT1348013	hsa-miR-195	CLIP-seq
MIRT1348014	hsa-miR-216b	CLIP-seq
MIRT2327420	hsa-miR-223	CLIP-seq
MIRT2327421	hsa-miR-2355-3p	CLIP-seq
MIRT2327422	hsa-miR-3124-3p	CLIP-seq
MIRT1348022	hsa-miR-3175	CLIP-seq
MIRT1348026	hsa-miR-3199	CLIP-seq
MIRT2327423	hsa-miR-331-3p	CLIP-seq
MIRT2103134	hsa-miR-3650	CLIP-seq
MIRT2327424	hsa-miR-3685	CLIP-seq
MIRT2327425	hsa-miR-384	CLIP-seq
MIRT2327426	hsa-miR-411	CLIP-seq
MIRT1348035	hsa-miR-424	CLIP-seq
MIRT2327427	hsa-miR-4328	CLIP-seq
MIRT2103137	hsa-miR-4423-5p	CLIP-seq
MIRT2103138	hsa-miR-4436b-5p	CLIP-seq
MIRT2103139	hsa-miR-4534	CLIP-seq
MIRT2327428	hsa-miR-4646-3p	CLIP-seq
MIRT1348052	hsa-miR-4694-3p	CLIP-seq
MIRT1348053	hsa-miR-4695-3p	CLIP-seq
MIRT1348059	hsa-miR-4740-3p	CLIP-seq
MIRT1553692	hsa-miR-4763-3p	CLIP-seq
MIRT1348063	hsa-miR-497	CLIP-seq
MIRT1348064	hsa-miR-498	CLIP-seq
MIRT2103149	hsa-miR-520g	CLIP-seq
MIRT2103150	hsa-miR-520h	CLIP-seq
MIRT1348079	hsa-miR-640	CLIP-seq
MIRT1348081	hsa-miR-659	CLIP-seq
MIRT1348084	hsa-miR-676	CLIP-seq
MIRT1348088	hsa-miR-891b	CLIP-seq
MIRT1348090	hsa-miR-9	CLIP-seq
MIRT1347997	hsa-miR-1193	CLIP-seq
MIRT2103119	hsa-miR-122	CLIP-seq
MIRT1348014	hsa-miR-216b	CLIP-seq
MIRT2103134	hsa-miR-3650	CLIP-seq
MIRT1348039	hsa-miR-4297	CLIP-seq
MIRT2103137	hsa-miR-4423-5p	CLIP-seq
MIRT2103139	hsa-miR-4534	CLIP-seq
MIRT1348053	hsa-miR-4695-3p	CLIP-seq
MIRT1348064	hsa-miR-498	CLIP-seq
MIRT1348079	hsa-miR-640	CLIP-seq
MIRT2459334	hsa-miR-1228	CLIP-seq
MIRT2459335	hsa-miR-1253	CLIP-seq
MIRT1348000	hsa-miR-1267	CLIP-seq
MIRT2459336	hsa-miR-129-5p	CLIP-seq
MIRT1348014	hsa-miR-216b	CLIP-seq
MIRT2459337	hsa-miR-3149	CLIP-seq
MIRT2459338	hsa-miR-3664-5p	CLIP-seq
MIRT2327426	hsa-miR-411	CLIP-seq
MIRT1348039	hsa-miR-4297	CLIP-seq
MIRT2103137	hsa-miR-4423-5p	CLIP-seq
MIRT2459339	hsa-miR-451b	CLIP-seq
MIRT2459340	hsa-miR-4639-3p	CLIP-seq
MIRT2459341	hsa-miR-4715-3p	CLIP-seq
MIRT2459342	hsa-miR-4735-5p	CLIP-seq
MIRT2459343	hsa-miR-4775	CLIP-seq
MIRT2459344	hsa-miR-4794	CLIP-seq
MIRT1348064	hsa-miR-498	CLIP-seq
MIRT2459345	hsa-miR-590-3p	CLIP-seq
MIRT2459334	hsa-miR-1228	CLIP-seq
MIRT2459335	hsa-miR-1253	CLIP-seq
MIRT1348000	hsa-miR-1267	CLIP-seq
MIRT2459336	hsa-miR-129-5p	CLIP-seq
MIRT2459337	hsa-miR-3149	CLIP-seq
MIRT2459338	hsa-miR-3664-5p	CLIP-seq
MIRT2327426	hsa-miR-411	CLIP-seq
MIRT2103137	hsa-miR-4423-5p	CLIP-seq
MIRT2459339	hsa-miR-451b	CLIP-seq
MIRT2459340	hsa-miR-4639-3p	CLIP-seq
MIRT2459341	hsa-miR-4715-3p	CLIP-seq
MIRT2459342	hsa-miR-4735-5p	CLIP-seq
MIRT2459343	hsa-miR-4775	CLIP-seq
MIRT2459344	hsa-miR-4794	CLIP-seq
MIRT2459345	hsa-miR-590-3p	CLIP-seq
MIRT2459334	hsa-miR-1228	CLIP-seq
MIRT2459336	hsa-miR-129-5p	CLIP-seq
MIRT1348014	hsa-miR-216b	CLIP-seq
MIRT2459337	hsa-miR-3149	CLIP-seq
MIRT2327426	hsa-miR-411	CLIP-seq
MIRT1348039	hsa-miR-4297	CLIP-seq
MIRT2459341	hsa-miR-4715-3p	CLIP-seq
MIRT2459342	hsa-miR-4735-5p	CLIP-seq
MIRT2459343	hsa-miR-4775	CLIP-seq
MIRT2459344	hsa-miR-4794	CLIP-seq
MIRT1348064	hsa-miR-498	CLIP-seq
MIRT2459345	hsa-miR-590-3p	CLIP-seq
MIRT2459334	hsa-miR-1228	CLIP-seq
MIRT2459336	hsa-miR-129-5p	CLIP-seq
MIRT1348014	hsa-miR-216b	CLIP-seq
MIRT2459337	hsa-miR-3149	CLIP-seq
MIRT2327426	hsa-miR-411	CLIP-seq
MIRT1348039	hsa-miR-4297	CLIP-seq
MIRT2459341	hsa-miR-4715-3p	CLIP-seq
MIRT2459342	hsa-miR-4735-5p	CLIP-seq
MIRT2459343	hsa-miR-4775	CLIP-seq
MIRT2459344	hsa-miR-4794	CLIP-seq
MIRT1348064	hsa-miR-498	CLIP-seq
MIRT2459345	hsa-miR-590-3p	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IDA	16684770
GO:0001725	Component	Stress fiber	IEA
GO:0001725	Component	Stress fiber	ISS
GO:0003779	Function	Actin binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005884	Component	Actin filament	IDA	16249884, 16684770
GO:0005912	Component	Adherens junction	IBA
GO:0005925	Component	Focal adhesion	IDA
GO:0007015	Process	Actin filament organization	IBA
GO:0007015	Process	Actin filament organization	IEA
GO:0007015	Process	Actin filament organization	ISS
GO:0007420	Process	Brain development	IDA	16249884
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	16249884
GO:0009925	Component	Basal plasma membrane	IEA
GO:0009925	Component	Basal plasma membrane	ISS
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	ISS
GO:0016324	Component	Apical plasma membrane	IBA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0030036	Process	Actin cytoskeleton organization	NAS	16684770
GO:0030864	Component	Cortical actin cytoskeleton	IBA
GO:0030864	Component	Cortical actin cytoskeleton	IEA
GO:0030864	Component	Cortical actin cytoskeleton	ISS
GO:0043296	Component	Apical junction complex	IBA
GO:0045159	Function	Myosin II binding	IEA
GO:0045159	Function	Myosin II binding	ISS
GO:0050890	Process	Cognition	IDA	16249884
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051015	Function	Actin filament binding	ISS
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099072	Process	Regulation of postsynaptic membrane neurotransmitter receptor levels	IEA

MIM	HGNC	e!Ensembl
300579	29215	ENSG00000158352

Q9ULL8

Protein name

Protein Shroom4 (Second homolog of apical protein)

Protein function

Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMe

PDB

2EDP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	11 → 89	PDZ domain	Domain
PF08687	ASD2	1212 → 1486	Apx/Shroom domain ASD2	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in all fetal and adult tissues investigated. Expressed in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. In brain regions detected in cerebellum, cerebral cortex, medulla, spinal cord, occipi

Sequence

MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
KLTVQEFPGDKWNPITGNRKTSQSGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISS
LDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRREL
FSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQKQQEEEEEEEEE
EEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQS
VPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHF
SPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIES
ISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLL
SLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVS
RYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF

Sequence length

1493

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
X-linked intellectual disability, Stocco dos Santos type	Likely pathogenic	rs2147209054	RCV001779386	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL ANOMALY OF KIDNEY AND URINARY TRACT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
History of neurodevelopmental disorder	Likely benign; Benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC GENERALIZED EPILEPSY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SHROOM4-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
X-LINKED COMPLEX NEURODEVELOPMENTAL DISORDER	—	ClinGen	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
X-LINKED INTELLECTUAL DISABILITY STOCCO DOS SANTOS TYPE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (38)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	31654185		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bilateral congenital dislocation of hip	Congenital Hip dislocation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37652516	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	25167861, 28262662		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	25167861	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	28161704		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital clubfoot	Congenital Clubfoot	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Dent Disease	Dent disease	Pubtator	30630535	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	26740508	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	25425167, 28262662		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroesophageal reflux disease	Gastroesophageal Reflux Disease	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	30630535	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	16249884, 25425167, 28262662, 30630535		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	20613765		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intellectual Disability	Intellectual developmental disorder	Pubtator	23871722, 30630535	Associate	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Malignant neoplasm of breast	Breast Cancer	GWASDB_DG	20852631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	16249884		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked	Mental retardation	BEFREE	16249884		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	30630535	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	26740508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychomotor Disorders	Psychiatric disorders	Pubtator	30630535	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett syndrome	Pubtator	26740508	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	BEFREE	26692240		★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Stocco dos Santos syndrome	Stocco Dos Santos Syndrome	ORPHANET_DG	16249884		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stocco dos Santos syndrome	Stocco Dos Santos Syndrome	UNIPROT_DG	16249884		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stocco dos Santos syndrome	Stocco Dos Santos Syndrome	GENOMICS_ENGLAND_DG	20613765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stocco dos Santos syndrome	Stocco Dos Santos Syndrome	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Stocco dos Santos syndrome	Stocco Dos Santos Syndrome	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Trichohepatoenteric Syndrome	Trichohepatoenteric Syndrome	BEFREE	25425167		★★★★★ ★☆☆☆☆ Found in Text Mining only
X-linked intellectual disability, Stocco Dos Santos type	Mental Retardation, X-Linked	Orphanet			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

SHROOM4 (shroom family member 4)