Gene Gene information from NCBI Gene database.
Entrez ID 57472
Gene name CCR4-NOT transcription complex subunit 6
Gene symbol CNOT6
Synonyms (NCBI Gene)
CCR4Ccr4a
Chromosome 5
Chromosome location 5q35.3
Summary This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3`-5` RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, includin
miRNA miRNA information provided by mirtarbase database.
1403
miRTarBase ID miRNA Experiments Reference
MIRT003851 hsa-miR-1-3p Microarray 15685193
MIRT004074 hsa-miR-373-3p Microarray 15685193
MIRT016605 hsa-miR-193b-3p Microarray 20304954
MIRT020329 hsa-miR-130b-3p Sequencing 20371350
MIRT021485 hsa-miR-9-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0000175 Function 3'-5'-RNA exonuclease activity IBA
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening IEA
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening IMP 20595389
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening NAS 31320642
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608951 14099 ENSG00000113300
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9ULM6
Protein name CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase)
Protein function Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression,
PDB 7AX1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 51 109 Leucine rich repeat Repeat
PF03372 Exo_endo_phos 192 531 Endonuclease/Exonuclease/phosphatase family Domain
Sequence
Sequence length 557
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  RNA degradation  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 28950145
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30233846
★☆☆☆☆
Found in Text Mining only
Adult Hodgkin Lymphoma Hodgkin Lymphoma BEFREE 19377047, 25712215
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 11861261, 15569983, 17205512, 18071306, 19748990, 21242994, 21244576, 21993874, 22493372, 22699226, 23482931, 24970722, 25320373, 25488980, 25613789
View all (15 more)
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia LHGDN 11861261, 15569983, 17071491, 18071306
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia CTD_human_DG 26437031
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 20148806
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 31630801
★☆☆☆☆
Found in Text Mining only
Anemia, Sickle Cell Anemia BEFREE 29697532
★☆☆☆☆
Found in Text Mining only
Angioimmunoblastic Lymphadenopathy Angioimmunoblastic T-cell lymphoma BEFREE 27158755
★☆☆☆☆
Found in Text Mining only