Gene Gene information from NCBI Gene database.
Entrez ID 57460
Gene name Protein phosphatase, Mg2+/Mn2+ dependent 1H
Gene symbol PPM1H
Synonyms (NCBI Gene)
ARHCL1NERPP-2CURCC2
Chromosome 12
Chromosome location 12q14.1-q14.2
miRNA miRNA information provided by mirtarbase database.
836
miRTarBase ID miRNA Experiments Reference
MIRT017161 hsa-miR-335-5p Microarray 18185580
MIRT023606 hsa-miR-1-3p Microarray 18668037
MIRT048785 hsa-miR-93-5p CLASH 23622248
MIRT047932 hsa-miR-30c-5p CLASH 23622248
MIRT046778 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004721 Function Phosphoprotein phosphatase activity IMP 22586611
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004741 Function [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
GO:0005515 Function Protein binding IPI 31663853
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616016 18583 ENSG00000111110
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9ULR3
Protein name Protein phosphatase 1H (EC 3.1.3.16)
Protein function Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
PDB 7KPR , 7L4I , 7L4J , 7N0Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00481 PP2C 221 324 Protein phosphatase 2C Family
PF00481 PP2C 365 480 Protein phosphatase 2C Family
Sequence
MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADH
IARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSK
RRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDI
LKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECL
VIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEII
PMSSEFTPETERQRLQYLAFMQPH
LLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAY
KTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYD
LSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARG

VLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS
Sequence length 514
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPEREMESIS GRAVIDARUM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 18059182
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 18059182
★☆☆☆☆
Found in Text Mining only
Attention Deficit Disorder with Hyperactivity Attention deficit hyperactivity disorder Pubtator 20732627 Associate
★☆☆☆☆
Found in Text Mining only
Colon Carcinoma Colon Carcinoma BEFREE 18059182
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 18059182 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 30988394
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 30988394 Associate
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus Systemic Systemic lupus erythematosus Pubtator 20659327, 30685201 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of pancreas Pancreatic cancer BEFREE 27599670
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 18059182, 22586611
★☆☆☆☆
Found in Text Mining only