TMCC3 (transmembrane and coiled-coil domain family 3)

Gene

• Entrez ID: 57458
• Gene name: Transmembrane and coiled-coil domain family 3
• Gene symbol: TMCC3
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017797	hsa-miR-335-5p	Microarray	18185580
MIRT050114	hsa-miR-26a-5p	CLASH	23622248
MIRT049619	hsa-miR-92a-3p	CLASH	23622248
MIRT447759	hsa-miR-548ac	PAR-CLIP	22100165
MIRT447758	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT447757	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT447756	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT447755	hsa-miR-548z	PAR-CLIP	22100165
MIRT447754	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT447753	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT447752	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT447751	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT447750	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT447749	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT447747	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT447748	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT447746	hsa-miR-3133	PAR-CLIP	22100165
MIRT447745	hsa-miR-4511	PAR-CLIP	22100165
MIRT447744	hsa-miR-4635	PAR-CLIP	22100165
MIRT447743	hsa-miR-605-3p	PAR-CLIP	22100165
MIRT447742	hsa-miR-4493	PAR-CLIP	22100165
MIRT447741	hsa-miR-6126	PAR-CLIP	22100165
MIRT447740	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT447759	hsa-miR-548ac	PAR-CLIP	22100165
MIRT447758	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT447757	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT447756	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT447755	hsa-miR-548z	PAR-CLIP	22100165
MIRT447754	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT447753	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT447752	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT447751	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT447750	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT447749	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT447747	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT447748	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT447746	hsa-miR-3133	PAR-CLIP	22100165
MIRT447745	hsa-miR-4511	PAR-CLIP	22100165
MIRT447744	hsa-miR-4635	PAR-CLIP	22100165
MIRT447743	hsa-miR-605-3p	PAR-CLIP	22100165
MIRT447742	hsa-miR-4493	PAR-CLIP	22100165
MIRT447741	hsa-miR-6126	PAR-CLIP	22100165
MIRT447740	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT1428358	hsa-miR-103a	CLIP-seq
MIRT1428359	hsa-miR-107	CLIP-seq
MIRT1428360	hsa-miR-1184	CLIP-seq
MIRT1428361	hsa-miR-1208	CLIP-seq
MIRT1428362	hsa-miR-125a-3p	CLIP-seq
MIRT1428363	hsa-miR-128	CLIP-seq
MIRT1428364	hsa-miR-1302	CLIP-seq
MIRT1428365	hsa-miR-1587	CLIP-seq
MIRT1428366	hsa-miR-185	CLIP-seq
MIRT1428367	hsa-miR-1908	CLIP-seq
MIRT1428368	hsa-miR-224	CLIP-seq
MIRT1428369	hsa-miR-27a	CLIP-seq
MIRT1428370	hsa-miR-27b	CLIP-seq
MIRT1428371	hsa-miR-3074-5p	CLIP-seq
MIRT1428372	hsa-miR-3126-5p	CLIP-seq
MIRT1428373	hsa-miR-3165	CLIP-seq
MIRT1428374	hsa-miR-3607-3p	CLIP-seq
MIRT1428375	hsa-miR-378g	CLIP-seq
MIRT1428376	hsa-miR-3919	CLIP-seq
MIRT1428377	hsa-miR-3934	CLIP-seq
MIRT1428378	hsa-miR-4254	CLIP-seq
MIRT1428379	hsa-miR-4282	CLIP-seq
MIRT1428380	hsa-miR-4283	CLIP-seq
MIRT1428381	hsa-miR-4298	CLIP-seq
MIRT1428382	hsa-miR-4306	CLIP-seq
MIRT1428383	hsa-miR-4308	CLIP-seq
MIRT1428384	hsa-miR-4419a	CLIP-seq
MIRT1428385	hsa-miR-4420	CLIP-seq
MIRT1428386	hsa-miR-4492	CLIP-seq
MIRT1428387	hsa-miR-4498	CLIP-seq
MIRT1428388	hsa-miR-4502	CLIP-seq
MIRT1428389	hsa-miR-4510	CLIP-seq
MIRT1428390	hsa-miR-4644	CLIP-seq
MIRT1428391	hsa-miR-4648	CLIP-seq
MIRT1428392	hsa-miR-4656	CLIP-seq
MIRT1428393	hsa-miR-4675	CLIP-seq
MIRT1428394	hsa-miR-4722-3p	CLIP-seq
MIRT1428395	hsa-miR-4741	CLIP-seq
MIRT1428396	hsa-miR-4763-5p	CLIP-seq
MIRT1428397	hsa-miR-541	CLIP-seq
MIRT1428398	hsa-miR-622	CLIP-seq
MIRT1428399	hsa-miR-654-5p	CLIP-seq
MIRT1428400	hsa-miR-663	CLIP-seq
MIRT1428401	hsa-miR-762	CLIP-seq
MIRT1428402	hsa-miR-764	CLIP-seq
MIRT1428403	hsa-miR-922	CLIP-seq
MIRT1428358	hsa-miR-103a	CLIP-seq
MIRT1428359	hsa-miR-107	CLIP-seq
MIRT1428360	hsa-miR-1184	CLIP-seq
MIRT1428371	hsa-miR-3074-5p	CLIP-seq
MIRT2128297	hsa-miR-3611	CLIP-seq
MIRT2128298	hsa-miR-3667-3p	CLIP-seq
MIRT2128299	hsa-miR-3689a-3p	CLIP-seq
MIRT2128300	hsa-miR-3689c	CLIP-seq
MIRT2128301	hsa-miR-3929	CLIP-seq
MIRT2128302	hsa-miR-4297	CLIP-seq
MIRT2128303	hsa-miR-4419b	CLIP-seq
MIRT2128304	hsa-miR-4433	CLIP-seq
MIRT2128305	hsa-miR-4449	CLIP-seq
MIRT2128306	hsa-miR-4459	CLIP-seq
MIRT2128307	hsa-miR-4478	CLIP-seq
MIRT2128308	hsa-miR-4717-3p	CLIP-seq
MIRT1428394	hsa-miR-4722-3p	CLIP-seq
MIRT2128309	hsa-miR-4728-5p	CLIP-seq
MIRT1428396	hsa-miR-4763-5p	CLIP-seq
MIRT2128310	hsa-miR-4768-3p	CLIP-seq
MIRT2128311	hsa-miR-485-5p	CLIP-seq
MIRT2128312	hsa-miR-532-5p	CLIP-seq
MIRT2128313	hsa-miR-550a	CLIP-seq
MIRT2128314	hsa-miR-563	CLIP-seq
MIRT1428403	hsa-miR-922	CLIP-seq
MIRT2349974	hsa-miR-1200	CLIP-seq
MIRT1428362	hsa-miR-125a-3p	CLIP-seq
MIRT2349975	hsa-miR-141	CLIP-seq
MIRT2349976	hsa-miR-188-5p	CLIP-seq
MIRT2349977	hsa-miR-200a	CLIP-seq
MIRT2349978	hsa-miR-205	CLIP-seq
MIRT2349979	hsa-miR-23a	CLIP-seq
MIRT2349980	hsa-miR-23b	CLIP-seq
MIRT2349981	hsa-miR-23c	CLIP-seq
MIRT2349982	hsa-miR-24	CLIP-seq
MIRT1428371	hsa-miR-3074-5p	CLIP-seq
MIRT2349983	hsa-miR-329	CLIP-seq
MIRT2349984	hsa-miR-362-3p	CLIP-seq
MIRT2349985	hsa-miR-3653	CLIP-seq
MIRT2349986	hsa-miR-3654	CLIP-seq
MIRT2128299	hsa-miR-3689a-3p	CLIP-seq
MIRT2128300	hsa-miR-3689c	CLIP-seq
MIRT2349987	hsa-miR-371-5p	CLIP-seq
MIRT2349988	hsa-miR-378	CLIP-seq
MIRT2349989	hsa-miR-378b	CLIP-seq
MIRT2349990	hsa-miR-378c	CLIP-seq
MIRT2349991	hsa-miR-378d	CLIP-seq
MIRT2349992	hsa-miR-378e	CLIP-seq
MIRT2349993	hsa-miR-378f	CLIP-seq
MIRT2349994	hsa-miR-378h	CLIP-seq
MIRT2349995	hsa-miR-378i	CLIP-seq
MIRT2128301	hsa-miR-3929	CLIP-seq
MIRT2349996	hsa-miR-3941	CLIP-seq
MIRT2349997	hsa-miR-421	CLIP-seq
MIRT2349998	hsa-miR-422a	CLIP-seq
MIRT2349999	hsa-miR-4284	CLIP-seq
MIRT2350000	hsa-miR-4324	CLIP-seq
MIRT2128303	hsa-miR-4419b	CLIP-seq
MIRT2128304	hsa-miR-4433	CLIP-seq
MIRT2350001	hsa-miR-4446-5p	CLIP-seq
MIRT2128306	hsa-miR-4459	CLIP-seq
MIRT2128307	hsa-miR-4478	CLIP-seq
MIRT2350002	hsa-miR-450b-5p	CLIP-seq
MIRT2350003	hsa-miR-4661-3p	CLIP-seq
MIRT2128309	hsa-miR-4728-5p	CLIP-seq
MIRT2350004	hsa-miR-4755-5p	CLIP-seq
MIRT2128310	hsa-miR-4768-3p	CLIP-seq
MIRT2350005	hsa-miR-4768-5p	CLIP-seq
MIRT2350006	hsa-miR-4775	CLIP-seq
MIRT2350007	hsa-miR-4778-5p	CLIP-seq
MIRT2350008	hsa-miR-4780	CLIP-seq
MIRT2350009	hsa-miR-4789-5p	CLIP-seq
MIRT2128311	hsa-miR-485-5p	CLIP-seq
MIRT2350010	hsa-miR-518a-5p	CLIP-seq
MIRT2350011	hsa-miR-527	CLIP-seq
MIRT2350012	hsa-miR-543	CLIP-seq
MIRT2350013	hsa-miR-544b	CLIP-seq
MIRT2350014	hsa-miR-548aa	CLIP-seq
MIRT2350015	hsa-miR-587	CLIP-seq
MIRT2350016	hsa-miR-603	CLIP-seq
MIRT2350017	hsa-miR-623	CLIP-seq
MIRT2350018	hsa-miR-942	CLIP-seq
MIRT1428366	hsa-miR-185	CLIP-seq
MIRT2349978	hsa-miR-205	CLIP-seq
MIRT2395896	hsa-miR-342-5p	CLIP-seq
MIRT2395897	hsa-miR-34a	CLIP-seq
MIRT2395898	hsa-miR-34c-5p	CLIP-seq
MIRT1428382	hsa-miR-4306	CLIP-seq
MIRT2395899	hsa-miR-4325	CLIP-seq
MIRT2395900	hsa-miR-449a	CLIP-seq
MIRT2395901	hsa-miR-449b	CLIP-seq
MIRT1428390	hsa-miR-4644	CLIP-seq
MIRT2395902	hsa-miR-4651	CLIP-seq
MIRT2395903	hsa-miR-4664-5p	CLIP-seq
MIRT2350006	hsa-miR-4775	CLIP-seq
MIRT2395904	hsa-miR-608	CLIP-seq
MIRT2434091	hsa-miR-1246	CLIP-seq
MIRT2434092	hsa-miR-1271	CLIP-seq
MIRT2434093	hsa-miR-1290	CLIP-seq
MIRT2434094	hsa-miR-129-5p	CLIP-seq
MIRT2434095	hsa-miR-182	CLIP-seq
MIRT2434096	hsa-miR-3167	CLIP-seq
MIRT2395897	hsa-miR-34a	CLIP-seq
MIRT2395898	hsa-miR-34c-5p	CLIP-seq
MIRT2395900	hsa-miR-449a	CLIP-seq
MIRT2395901	hsa-miR-449b	CLIP-seq
MIRT2350015	hsa-miR-587	CLIP-seq
MIRT2434097	hsa-miR-876-5p	CLIP-seq
MIRT2434098	hsa-miR-96	CLIP-seq
MIRT2434091	hsa-miR-1246	CLIP-seq
MIRT2434092	hsa-miR-1271	CLIP-seq
MIRT2434093	hsa-miR-1290	CLIP-seq
MIRT2434094	hsa-miR-129-5p	CLIP-seq
MIRT2434095	hsa-miR-182	CLIP-seq
MIRT2349978	hsa-miR-205	CLIP-seq
MIRT2349979	hsa-miR-23a	CLIP-seq
MIRT2349980	hsa-miR-23b	CLIP-seq
MIRT2349981	hsa-miR-23c	CLIP-seq
MIRT2434096	hsa-miR-3167	CLIP-seq
MIRT2395897	hsa-miR-34a	CLIP-seq
MIRT2395898	hsa-miR-34c-5p	CLIP-seq
MIRT2349985	hsa-miR-3653	CLIP-seq
MIRT2128304	hsa-miR-4433	CLIP-seq
MIRT2350001	hsa-miR-4446-5p	CLIP-seq
MIRT2128306	hsa-miR-4459	CLIP-seq
MIRT2395900	hsa-miR-449a	CLIP-seq
MIRT2395901	hsa-miR-449b	CLIP-seq
MIRT2350004	hsa-miR-4755-5p	CLIP-seq
MIRT2128310	hsa-miR-4768-3p	CLIP-seq
MIRT2350015	hsa-miR-587	CLIP-seq
MIRT2434097	hsa-miR-876-5p	CLIP-seq
MIRT2434098	hsa-miR-96	CLIP-seq
MIRT2434091	hsa-miR-1246	CLIP-seq
MIRT2434092	hsa-miR-1271	CLIP-seq
MIRT2434093	hsa-miR-1290	CLIP-seq
MIRT2434094	hsa-miR-129-5p	CLIP-seq
MIRT2434095	hsa-miR-182	CLIP-seq
MIRT2434096	hsa-miR-3167	CLIP-seq
MIRT2350015	hsa-miR-587	CLIP-seq
MIRT2434097	hsa-miR-876-5p	CLIP-seq
MIRT2434098	hsa-miR-96	CLIP-seq
MIRT2643468	hsa-miR-1233	CLIP-seq
MIRT2643469	hsa-miR-146b-3p	CLIP-seq
MIRT2643470	hsa-miR-339-5p	CLIP-seq
MIRT2643471	hsa-miR-3613-3p	CLIP-seq
MIRT2349987	hsa-miR-371-5p	CLIP-seq
MIRT2643472	hsa-miR-371b-5p	CLIP-seq
MIRT2643473	hsa-miR-4421	CLIP-seq
MIRT2643474	hsa-miR-4685-5p	CLIP-seq
MIRT2643475	hsa-miR-4691-5p	CLIP-seq
MIRT2643476	hsa-miR-4797-5p	CLIP-seq
MIRT2643477	hsa-miR-501-3p	CLIP-seq
MIRT2643478	hsa-miR-502-3p	CLIP-seq
MIRT2643468	hsa-miR-1233	CLIP-seq
MIRT2643469	hsa-miR-146b-3p	CLIP-seq
MIRT2643470	hsa-miR-339-5p	CLIP-seq
MIRT2643471	hsa-miR-3613-3p	CLIP-seq
MIRT2349987	hsa-miR-371-5p	CLIP-seq
MIRT2643472	hsa-miR-371b-5p	CLIP-seq
MIRT2693266	hsa-miR-4307	CLIP-seq
MIRT2643473	hsa-miR-4421	CLIP-seq
MIRT2643474	hsa-miR-4685-5p	CLIP-seq
MIRT2643475	hsa-miR-4691-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24454821, 28514442, 32296183, 33961781
GO:0005783	Component	Endoplasmic reticulum	IDA	27697108
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0012505	Component	Endomembrane system	IBA
GO:0016020	Component	Membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	27697108
GO:0071889	Function	14-3-3 protein binding	IDA	27697108

Other IDs

• MIM: 617459
• HGNC: 29199
• e!Ensembl: ENSG00000057704

Protein

• UniProt ID: Q9ULS5
• Protein name: Transmembrane and coiled-coil domain protein 3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10267	Tmemb_cc2	65 → 465	Predicted transmembrane and coiled-coil 2 protein	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with highest levels in brain, spinal cord and testis. {ECO:0000269|PubMed:27697108}.
• Sequence:

  MPGSDTALTVDRTYSYPGRHHRCKSRVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILD
  FHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQ
  KSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPHC
  MESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYG
  GSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDT
  QAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELAS
  IEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGRCINVILA
  FMTVILVCVSTIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIPR

• Sequence length: 477

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BASAL CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	29367434		★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	38042639	Associate	★☆☆☆☆ Found in Text Mining only