Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57448
Gene name	Baculoviral IAP repeat containing 6
Gene symbol	BIRC6
Synonyms (NCBI Gene)	APOLLONBRUCE
Chromosome	2
Chromosome location	2p22.3
Summary	This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005001	hsa-miR-218-5p	Luciferase reporter assayqRT-PCR	19890957
MIRT004956	hsa-let-7b-5p	qRT-PCR	17942906
MIRT052603	hsa-let-7a-5p	CLASH	23622248
MIRT052603	hsa-let-7a-5p	CLASH	23622248
MIRT047374	hsa-miR-34a-5p	CLASH	23622248
MIRT039908	hsa-miR-615-3p	CLASH	23622248
MIRT039908	hsa-miR-615-3p	CLASH	23622248
MIRT437461	ebv-miR-BART15	Luciferase reporter assay	23678170
MIRT437461	ebv-miR-BART15	Luciferase reporter assay	23678170
MIRT437461	ebv-miR-BART15	Luciferase reporter assay	23678170
MIRT047374	hsa-miR-34a-5p	PCR array	28097098
MIRT821651	hsa-miR-1243	CLIP-seq
MIRT821652	hsa-miR-181a	CLIP-seq
MIRT821653	hsa-miR-181b	CLIP-seq
MIRT821654	hsa-miR-181c	CLIP-seq
MIRT821655	hsa-miR-181d	CLIP-seq
MIRT821656	hsa-miR-196a	CLIP-seq
MIRT821657	hsa-miR-196b	CLIP-seq
MIRT821658	hsa-miR-204	CLIP-seq
MIRT821659	hsa-miR-211	CLIP-seq
MIRT821660	hsa-miR-30a	CLIP-seq
MIRT821661	hsa-miR-30b	CLIP-seq
MIRT821662	hsa-miR-30c	CLIP-seq
MIRT821663	hsa-miR-30d	CLIP-seq
MIRT821664	hsa-miR-30e	CLIP-seq
MIRT821665	hsa-miR-3124-3p	CLIP-seq
MIRT821666	hsa-miR-3149	CLIP-seq
MIRT821667	hsa-miR-3685	CLIP-seq
MIRT821668	hsa-miR-384	CLIP-seq
MIRT821669	hsa-miR-3945	CLIP-seq
MIRT821670	hsa-miR-4262	CLIP-seq
MIRT821671	hsa-miR-4274	CLIP-seq
MIRT821672	hsa-miR-4328	CLIP-seq
MIRT821673	hsa-miR-4446-5p	CLIP-seq
MIRT821674	hsa-miR-4452	CLIP-seq
MIRT821675	hsa-miR-4519	CLIP-seq
MIRT821676	hsa-miR-4719	CLIP-seq
MIRT821677	hsa-miR-4731-3p	CLIP-seq
MIRT821678	hsa-miR-4755-5p	CLIP-seq
MIRT821679	hsa-miR-4761-3p	CLIP-seq
MIRT821680	hsa-miR-4789-5p	CLIP-seq
MIRT821681	hsa-miR-4801	CLIP-seq
MIRT821682	hsa-miR-543	CLIP-seq
MIRT821683	hsa-miR-548aa	CLIP-seq
MIRT821684	hsa-miR-548ag	CLIP-seq
MIRT821685	hsa-miR-548ai	CLIP-seq
MIRT821686	hsa-miR-548g	CLIP-seq
MIRT821687	hsa-miR-568	CLIP-seq
MIRT821688	hsa-miR-600	CLIP-seq
MIRT821689	hsa-miR-623	CLIP-seq
MIRT821690	hsa-miR-653	CLIP-seq
MIRT821651	hsa-miR-1243	CLIP-seq
MIRT1942887	hsa-miR-130a	CLIP-seq
MIRT1942888	hsa-miR-130b	CLIP-seq
MIRT1942889	hsa-miR-183	CLIP-seq
MIRT821656	hsa-miR-196a	CLIP-seq
MIRT821657	hsa-miR-196b	CLIP-seq
MIRT821658	hsa-miR-204	CLIP-seq
MIRT821659	hsa-miR-211	CLIP-seq
MIRT1942890	hsa-miR-300	CLIP-seq
MIRT1942891	hsa-miR-301a	CLIP-seq
MIRT1942892	hsa-miR-301b	CLIP-seq
MIRT821665	hsa-miR-3124-3p	CLIP-seq
MIRT821666	hsa-miR-3149	CLIP-seq
MIRT1942893	hsa-miR-3666	CLIP-seq
MIRT821667	hsa-miR-3685	CLIP-seq
MIRT1942894	hsa-miR-381	CLIP-seq
MIRT821668	hsa-miR-384	CLIP-seq
MIRT1942895	hsa-miR-3925-3p	CLIP-seq
MIRT821669	hsa-miR-3945	CLIP-seq
MIRT821671	hsa-miR-4274	CLIP-seq
MIRT1942896	hsa-miR-4295	CLIP-seq
MIRT821672	hsa-miR-4328	CLIP-seq
MIRT821673	hsa-miR-4446-5p	CLIP-seq
MIRT821674	hsa-miR-4452	CLIP-seq
MIRT821675	hsa-miR-4519	CLIP-seq
MIRT1942897	hsa-miR-454	CLIP-seq
MIRT821676	hsa-miR-4719	CLIP-seq
MIRT821677	hsa-miR-4731-3p	CLIP-seq
MIRT821678	hsa-miR-4755-5p	CLIP-seq
MIRT1942898	hsa-miR-4760-3p	CLIP-seq
MIRT821679	hsa-miR-4761-3p	CLIP-seq
MIRT821680	hsa-miR-4789-5p	CLIP-seq
MIRT1942899	hsa-miR-4795-3p	CLIP-seq
MIRT821681	hsa-miR-4801	CLIP-seq
MIRT1942900	hsa-miR-519a	CLIP-seq
MIRT1942901	hsa-miR-519b-3p	CLIP-seq
MIRT1942902	hsa-miR-519c-3p	CLIP-seq
MIRT821684	hsa-miR-548ag	CLIP-seq
MIRT821685	hsa-miR-548ai	CLIP-seq
MIRT821686	hsa-miR-548g	CLIP-seq
MIRT821687	hsa-miR-568	CLIP-seq
MIRT1942903	hsa-miR-586	CLIP-seq
MIRT821689	hsa-miR-623	CLIP-seq
MIRT1942904	hsa-miR-766	CLIP-seq
MIRT2181633	hsa-miR-1207-5p	CLIP-seq
MIRT1942889	hsa-miR-183	CLIP-seq
MIRT2181634	hsa-miR-194	CLIP-seq
MIRT821656	hsa-miR-196a	CLIP-seq
MIRT821657	hsa-miR-196b	CLIP-seq
MIRT821658	hsa-miR-204	CLIP-seq
MIRT2181635	hsa-miR-2053	CLIP-seq
MIRT821659	hsa-miR-211	CLIP-seq
MIRT2181636	hsa-miR-29a	CLIP-seq
MIRT2181637	hsa-miR-29b	CLIP-seq
MIRT2181638	hsa-miR-29c	CLIP-seq
MIRT2181639	hsa-miR-3065-3p	CLIP-seq
MIRT821669	hsa-miR-3945	CLIP-seq
MIRT821671	hsa-miR-4274	CLIP-seq
MIRT821672	hsa-miR-4328	CLIP-seq
MIRT821673	hsa-miR-4446-5p	CLIP-seq
MIRT821675	hsa-miR-4519	CLIP-seq
MIRT2181640	hsa-miR-4736	CLIP-seq
MIRT821678	hsa-miR-4755-5p	CLIP-seq
MIRT2181641	hsa-miR-4763-3p	CLIP-seq
MIRT821689	hsa-miR-623	CLIP-seq
MIRT2485188	hsa-miR-1233	CLIP-seq
MIRT2485189	hsa-miR-129-3p	CLIP-seq
MIRT2485190	hsa-miR-134	CLIP-seq
MIRT2485191	hsa-miR-139-5p	CLIP-seq
MIRT2181634	hsa-miR-194	CLIP-seq
MIRT2181636	hsa-miR-29a	CLIP-seq
MIRT2181637	hsa-miR-29b	CLIP-seq
MIRT2181638	hsa-miR-29c	CLIP-seq
MIRT2181639	hsa-miR-3065-3p	CLIP-seq
MIRT2485192	hsa-miR-3118	CLIP-seq
MIRT2485193	hsa-miR-3148	CLIP-seq
MIRT2485194	hsa-miR-3164	CLIP-seq
MIRT2485195	hsa-miR-3183	CLIP-seq
MIRT2485196	hsa-miR-3607-5p	CLIP-seq
MIRT2485197	hsa-miR-374c	CLIP-seq
MIRT2485198	hsa-miR-4279	CLIP-seq
MIRT2485199	hsa-miR-4501	CLIP-seq
MIRT2485200	hsa-miR-4666-5p	CLIP-seq
MIRT2485201	hsa-miR-4723-3p	CLIP-seq
MIRT2485202	hsa-miR-4797-5p	CLIP-seq
MIRT821683	hsa-miR-548aa	CLIP-seq
MIRT2485203	hsa-miR-655	CLIP-seq
MIRT2485204	hsa-miR-665	CLIP-seq
MIRT2485190	hsa-miR-134	CLIP-seq
MIRT2485191	hsa-miR-139-5p	CLIP-seq
MIRT2181634	hsa-miR-194	CLIP-seq
MIRT2181636	hsa-miR-29a	CLIP-seq
MIRT2181637	hsa-miR-29b	CLIP-seq
MIRT2181638	hsa-miR-29c	CLIP-seq
MIRT2181639	hsa-miR-3065-3p	CLIP-seq
MIRT2485192	hsa-miR-3118	CLIP-seq
MIRT2485193	hsa-miR-3148	CLIP-seq
MIRT2485194	hsa-miR-3164	CLIP-seq
MIRT2485195	hsa-miR-3183	CLIP-seq
MIRT2485196	hsa-miR-3607-5p	CLIP-seq
MIRT2485197	hsa-miR-374c	CLIP-seq
MIRT2485198	hsa-miR-4279	CLIP-seq
MIRT2675973	hsa-miR-4476	CLIP-seq
MIRT2485199	hsa-miR-4501	CLIP-seq
MIRT2485200	hsa-miR-4666-5p	CLIP-seq
MIRT2485201	hsa-miR-4723-3p	CLIP-seq
MIRT2485202	hsa-miR-4797-5p	CLIP-seq
MIRT821683	hsa-miR-548aa	CLIP-seq
MIRT2485203	hsa-miR-655	CLIP-seq
MIRT2485204	hsa-miR-665	CLIP-seq
MIRT2675974	hsa-miR-760	CLIP-seq

Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IDA	18329369
GO:0000922	Component	Spindle pole	IEA
GO:0001890	Process	Placenta development	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	15200957
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0004869	Function	Cysteine-type endopeptidase inhibitor activity	IEA
GO:0004869	Function	Cysteine-type endopeptidase inhibitor activity	IMP	15200957
GO:0005515	Function	Protein binding	IPI	14765125, 15200957, 18329369, 26496610, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IDA	18329369
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0005802	Component	Trans-Golgi network	IDA	18329369
GO:0005813	Component	Centrosome	IEA
GO:0005815	Component	Microtubule organizing center	IDA	18329369
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006468	Process	Protein phosphorylation	TAS	18329369
GO:0006915	Process	Apoptotic process	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	TAS	18329369
GO:0016740	Function	Transferase activity	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0030496	Component	Midbody	IDA	18329369
GO:0032465	Process	Regulation of cytokinesis	IEA
GO:0032465	Process	Regulation of cytokinesis	IMP	18329369
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042127	Process	Regulation of cell population proliferation	TAS	18414036
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	15200957
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10544019
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0060711	Process	Labyrinthine layer development	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IEA
GO:0090543	Component	Flemming body	IEA
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IMP	14765125

MIM	HGNC	e!Ensembl
605638	13516	ENSG00000115760

Q9NR09

Protein name

Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)

Protein function

Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not co

PDB

3CEG , 8ATM , 8ATO , 8ATU , 8ATX , 8AUK , 8AUW , 8E2D , 8E2E , 8E2F , 8E2G , 8E2H , 8E2I , 8E2K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00653	BIR	289 → 359	Inhibitor of Apoptosis domain	Domain
PF12356	BIRC6	3463 → 3618	Baculoviral IAP repeat-containing protein 6	Family
PF00179	UQ_con	4577 → 4735	Ubiquitin-conjugating enzyme	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain cancer cells.

Sequence

MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRD
GCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYI
SAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK
VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELK
KINQNVAALPVASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVG
YRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG
EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKV
HLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLEDS
DSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA
NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGE
SISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDD
GFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL
RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRR
KGELESNLAVVNGANISVIQHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLE
EEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL
GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGE
LHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFTLE
ILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ
TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNI
EVEQNGKPSLVDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGM
LTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA
SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCA
MLQFSEFHEKLVNTLCRKTDDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLLSK
TRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP
AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYS
SPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEGSFTSLTGL
LEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSL
SHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNP
VAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNL
AAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL
LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITV
IGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKGEGESANQPEIDQHLAMMVAL
QEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQL
QLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHA
SNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVL
QELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTE
GVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGS
SSLDRLYSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQ
ATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLL
SMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWG
GAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLETI
DEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTW
YDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAE
LMLKMMSTLEADSILQALTNTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLN
VCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS
ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIH
VLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHILS
TERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSR
SGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREY
SARVSVTTNTTDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGL
CNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY
MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVN
TARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQPAE
VLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVS
VEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLG
LTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANLLQ
TCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLF
GRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSS
TVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKK
AVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ
APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDIS
QDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLC
HSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKL
MAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINAT
SHVIQHPMYGAGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKE
KVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKII
TVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSK
TDSYKRLHPEKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGL
ALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEP
PPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHI
LQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPR
VPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHV
TCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRND
SVLDMARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKM
KTCVDTYTNRLRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQ
EKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYM
SQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTP
YANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEK
WNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAM
LEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH
TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL

Sequence length

4857

Interactions

View interactions

	KEGG
	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (32)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	association	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIRC6-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary breast ovarian cancer syndrome	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOGONADISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (71)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	BEFREE	22085301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	22085301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	22085301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	22085301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aneuploidy	Aneuploidy	Pubtator	36576405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Angle Closure Glaucoma	Angle Closure Glaucoma	BEFREE	25118708		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	33317170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	31674007	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30931701		★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Neoplasm	Benign Neoplasm	CTD_human_DG	18239605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19223905		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19223905, 30987626	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	19759907	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	23301059, 24453032	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	Pubtator	36576405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	24453032	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31091257		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Carotid artery stenosis	Pubtator	33317170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	22085301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	21788403		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25933218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21788403, 25933218, 29575536	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30446354, 31062760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	27432467	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	25118708, 29845210		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma Open Angle	Open angle glaucoma	Pubtator	21655191	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma, Primary Open Angle	Glaucoma	BEFREE	24597656, 25118708		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	27388765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	27388765	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	27388765		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Heart failure	Heart Failure	BEFREE	30446354, 31062760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	29764561, 30982490	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	22085301, 30982490		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30693543, 30931701		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	30693543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of brain	Brain Neoplasms	BEFREE	10544019		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19223905		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	30693543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	23287853		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	10544019, 31091257		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23409057, 25071009		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10544019, 21788403, 22196277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	CTD_human_DG	18239605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	21788403		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	22553342		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Melanoma	Pubtator	22553342	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Diseases	Mitochondrial disease	Pubtator	22553342	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	28520795		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	CTD_human_DG	18239605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21788403, 22788920, 23287853, 25933218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	22788920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	22788920	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	31692446	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	31692446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	23287853, 27768839		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteitis Deformans	Paget disease	BEFREE	30905357		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	31091257		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	31091257		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	29123378, 31091257	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Paget Disease	Paget disease	BEFREE	30905357		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	17912030	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parathyroid Gland Adenocarcinoma	Parathyroid Gland Adenocarcinoma	BEFREE	22198862		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parathyroid Neoplasms	Parathyroid neoplasm	Pubtator	22198862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Kidney Diseases	Polycystic kidney disease	BEFREE	24597656		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary angle-closure glaucoma	Angle closure glaucoma	BEFREE	25118708		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23409057, 25071009		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	23409057, 29429983	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	25216531		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	23287853		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	38438090	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	33317170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

BIRC6 (baculoviral IAP repeat containing 6)