Gene Gene information from NCBI Gene database.
Entrez ID 57446
Gene name NDRG family member 3
Gene symbol NDRG3
Synonyms (NCBI Gene)
-
Chromosome 20
Chromosome location 20q11.23
miRNA miRNA information provided by mirtarbase database.
737
miRTarBase ID miRNA Experiments Reference
MIRT049545 hsa-miR-92a-3p CLASH 23622248
MIRT036450 hsa-miR-1226-3p CLASH 23622248
MIRT627992 hsa-miR-6808-5p HITS-CLIP 23824327
MIRT627991 hsa-miR-6893-5p HITS-CLIP 23824327
MIRT627990 hsa-miR-940 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 11936845
GO:0007165 Process Signal transduction IBA
GO:0007283 Process Spermatogenesis NAS 11406283
GO:0030154 Process Cell differentiation NAS 11406283
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605273 14462 ENSG00000101079
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UGV2
Protein name Protein NDRG3 (N-myc downstream-regulated gene 3 protein)
PDB 6L4B , 6L4G , 6L4H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03096 Ndr 32 317 Ndr family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Highly expressed in brain. {ECO:0000269|PubMed:11352569}.
Sequence
Sequence length 375
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MELANOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NON-MELANOMA SKIN CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 18975380
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 28326836
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 31935861 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 30413609, 33256802 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 31072445 Stimulate
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Cerebral Infarction BEFREE 27812761
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 29844682, 30033230
★☆☆☆☆
Found in Text Mining only
Hypoxia Hypoxia Pubtator 29760417, 31935861 Associate
★☆☆☆☆
Found in Text Mining only
Ischemic stroke Ischemic Stroke BEFREE 27812761
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 21725618, 28269758, 30413609
★☆☆☆☆
Found in Text Mining only