Gene Gene information from NCBI Gene database.
Entrez ID 5743
Gene name Prostaglandin-endoperoxide synthase 2
Gene symbol PTGS2
Synonyms (NCBI Gene)
COX-2COX2GRIPGHSPGG/HSPGHS-2PHS-2hCox-2
Chromosome 1
Chromosome location 1q31.1
Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, whi
miRNA miRNA information provided by mirtarbase database.
212
miRTarBase ID miRNA Experiments Reference
MIRT004297 hsa-miR-101-3p qRT-PCRLuciferase reporter assayWestern blot 19133256
MIRT004297 hsa-miR-101-3p qRT-PCRLuciferase reporter assayWestern blot 19133256
MIRT004659 hsa-miR-26b-5p Luciferase reporter assayWestern blot 20100477
MIRT004659 hsa-miR-26b-5p Luciferase reporter assayWestern blot 20100477
MIRT004297 hsa-miR-101-3p qRT-PCR 20712078
Transcription factors Transcription factors information provided by TRRUST V2 database.
58
Transcription factor Regulation Reference
APC Repression 10772828;12566320
APC Unknown 11396184
AR Repression 18386814
ATF2 Unknown 11278336;12057991
ATF4 Unknown 21244365
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
80
GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IDA 27642067
GO:0001516 Process Prostaglandin biosynthetic process IEA
GO:0001516 Process Prostaglandin biosynthetic process ISS
GO:0001516 Process Prostaglandin biosynthetic process NAS 20448152
GO:0004601 Function Peroxidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600262 9605 ENSG00000073756
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35354
Protein name Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)
Protein function Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response (Pu
PDB 5F19 , 5F1A , 5IKQ , 5IKR , 5IKT , 5IKV , 5KIR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00008 EGF 21 53 EGF-like domain Domain
PF03098 An_peroxidase 201 560 Animal haem peroxidase Domain
Sequence
Sequence length 604
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Arachidonic acid metabolism
Metabolic pathways
NF-kappa B signaling pathway
Efferocytosis
VEGF signaling pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Retrograde endocannabinoid signaling
Serotonergic synapse
Ovarian steroidogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Leishmaniasis
Human cytomegalovirus infection
Human papillomavirus infection
Kaposi sarcoma-associated herpesvirus infection
Pathways in cancer
Chemical carcinogenesis - DNA adducts
MicroRNAs in cancer
Small cell lung cancer
  Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
127
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AMYOTROPHIC LATERAL SCLEROSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AORTIC ANEURYSM, ABDOMINAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARRHYTHMIAS, CARDIAC CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTERIOSCLEROSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acne Acne BEFREE 28025036
★☆☆☆☆
Found in Text Mining only
Acne Vulgaris Acne BEFREE 28025036
★☆☆☆☆
Found in Text Mining only
Acoustic Neuroma Acoustic Neuroma BEFREE 25616959, 28692590
★☆☆☆☆
Found in Text Mining only
Actinic keratosis Actinic keratosis BEFREE 10417761, 17488409, 17578436, 30618533
★☆☆☆☆
Found in Text Mining only
Acute Cerebrovascular Accidents Stroke CTD_human_DG 20083630
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 18989535, 19485927, 19748095
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome LHGDN 18989535
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 23435965, 29501042
★☆☆☆☆
Found in Text Mining only
Acute Kidney Tubular Necrosis Renal tubular necrosis BEFREE 12865795
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 28270082
★☆☆☆☆
Found in Text Mining only