PTGIR (prostaglandin I2 receptor)

Gene

• Entrez ID: 5739
• Gene name: Prostaglandin I2 receptor
• Gene symbol: PTGIR
• Synonyms (NCBI Gene): IP, PRIPR
• Chromosome: 19
• Chromosome location: 19q13.32
• Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1273090	hsa-miR-1	CLIP-seq
MIRT1273091	hsa-miR-1207-5p	CLIP-seq
MIRT1273092	hsa-miR-122	CLIP-seq
MIRT1273093	hsa-miR-1266	CLIP-seq
MIRT1273094	hsa-miR-1273g	CLIP-seq
MIRT1273095	hsa-miR-149	CLIP-seq
MIRT1273096	hsa-miR-1972	CLIP-seq
MIRT1273097	hsa-miR-206	CLIP-seq
MIRT1273098	hsa-miR-2113	CLIP-seq
MIRT1273099	hsa-miR-3198	CLIP-seq
MIRT1273100	hsa-miR-323b-3p	CLIP-seq
MIRT1273101	hsa-miR-3664-3p	CLIP-seq
MIRT1273102	hsa-miR-3673	CLIP-seq
MIRT1273103	hsa-miR-4270	CLIP-seq
MIRT1273104	hsa-miR-4300	CLIP-seq
MIRT1273105	hsa-miR-4309	CLIP-seq
MIRT1273106	hsa-miR-4318	CLIP-seq
MIRT1273107	hsa-miR-432	CLIP-seq
MIRT1273108	hsa-miR-4436b-3p	CLIP-seq
MIRT1273109	hsa-miR-4441	CLIP-seq
MIRT1273110	hsa-miR-4468	CLIP-seq
MIRT1273111	hsa-miR-4492	CLIP-seq
MIRT1273112	hsa-miR-4498	CLIP-seq
MIRT1273113	hsa-miR-4518	CLIP-seq
MIRT1273114	hsa-miR-4650-5p	CLIP-seq
MIRT1273115	hsa-miR-4671-5p	CLIP-seq
MIRT1273116	hsa-miR-4752	CLIP-seq
MIRT1273117	hsa-miR-4756-3p	CLIP-seq
MIRT1273118	hsa-miR-4763-3p	CLIP-seq
MIRT1273119	hsa-miR-613	CLIP-seq
MIRT1273120	hsa-miR-760	CLIP-seq
MIRT1273121	hsa-miR-762	CLIP-seq
MIRT1273122	hsa-miR-920	CLIP-seq
MIRT1273123	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU2F1	Activation	19118563
SP1	Activation	19118563
SPI1	Activation	19118563

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005829	Component	Cytosol	IDA	20622039
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20622039
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7512962
GO:0006954	Process	Inflammatory response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7512962
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	20622039
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007267	Process	Cell-cell signaling	TAS	7512962
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	IEA
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	ISS	20622039
GO:0016020	Component	Membrane	IEA
GO:0016501	Function	Prostacyclin receptor activity	IBA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IBA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IDA	20622039
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IEA

Other IDs

• MIM: 600022
• HGNC: 9602
• e!Ensembl: ENSG00000160013

Protein

• UniProt ID: P43119
• Protein name: Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
• Protein function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
• PDB: 8X79, 8X7A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	30 → 292	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
  LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
  LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
  GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
  LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
  QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
  PPTQQSSGSAVGTSSKAEASVACSLC

• Sequence length: 386

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation

Reactome:

Prostanoid ligand receptors
Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA, ASPIRIN-INDUCED	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Megakaryocytic Leukemias	Megakaryocytic Leukemia	BEFREE	7514139		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	14752026, 17691954, 18323528, 22112851		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	17496729		★☆☆☆☆ Found in Text Mining only
Asthma, Aspirin-Induced	Asthma	CTD_human_DG	20485159		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Atherosclerosis	Atherosclerosis	BEFREE	14752026, 17691954, 18323528, 22112851		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	18323528, 24886841	Associate	★☆☆☆☆ Found in Text Mining only
Blood Platelet Disorders	Platelet disorder	Pubtator	18323528, 24886841	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	LHGDN	17704830		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	18323528	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	20522800		★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Cerebral Infarction	BEFREE	23628440		★☆☆☆☆ Found in Text Mining only
Congenital heart disease	Congenital Heart Disease	BEFREE	12598419		★☆☆☆☆ Found in Text Mining only
Coronary Artery Dissection Spontaneous	Spontaneous coronary artery dissection	Pubtator	32531060	Associate	★☆☆☆☆ Found in Text Mining only
Deep Vein Thrombosis	Thrombosis	BEFREE	18551041		★☆☆☆☆ Found in Text Mining only
Dementia Vascular	Vascular dementia	Pubtator	16763535	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	35781537	Associate	★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart Diseases	CTD_human_DG	16154102		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Idiopathic pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	27919660, 28462839, 28494686, 28524738, 28533253, 28597774, 28639216, 28791952, 28891448, 29146573, 29527168, 29720235, 30103548, 30442035, 30671881, 30963265, 31042010, 31391223, 31696306		★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary hypertension	Pulmonary Hypertension	BEFREE	29146573		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	36155972	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	23628440		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	7543911	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22380928		★☆☆☆☆ Found in Text Mining only
Oropharyngeal Neoplasms	Oropharyngeal neoplasm	Pubtator	31969157	Associate	★☆☆☆☆ Found in Text Mining only
Patent ductus arteriosus	Patent ductus arteriosus	BEFREE	12598419		★☆☆☆☆ Found in Text Mining only
Pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	28462839, 28524738, 29720235, 30671881		★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	29720235	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	19880449	Associate	★☆☆☆☆ Found in Text Mining only
Raynaud Phenomenon	Raynaud Phenomenon	BEFREE	29193819		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	31969157	Associate	★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	29193819		★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	7543911	Associate	★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASDB_DG	23128233		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	23128233		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vascular Diseases	Vascular Diseases	BEFREE	18551041		★☆☆☆☆ Found in Text Mining only
Vascular Remodeling	Vascular remodeling	Pubtator	32531060	Associate	★☆☆☆☆ Found in Text Mining only
von Willebrand Disease, Type 1	von Willebrand disorder	BEFREE	26630678		★☆☆☆☆ Found in Text Mining only