Gene Gene information from NCBI Gene database.
Entrez ID 5737
Gene name Prostaglandin F receptor
Gene symbol PTGFR
Synonyms (NCBI Gene)
FP
Chromosome 1
Chromosome location 1p31.1
Summary The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pre
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs3753380 T>A,C Drug-response Upstream transcript variant
miRNA miRNA information provided by mirtarbase database.
437
miRTarBase ID miRNA Experiments Reference
MIRT031037 hsa-miR-21-5p Microarray 18591254
MIRT654626 hsa-miR-570-3p HITS-CLIP 23824327
MIRT654626 hsa-miR-570-3p HITS-CLIP 23824327
MIRT1272860 hsa-miR-1270 CLIP-seq
MIRT1272861 hsa-miR-1284 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
GATA1 Repression 14746914
NFKB1 Unknown 16855208
RELA Unknown 16855208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004958 Function Prostaglandin F receptor activity IBA
GO:0004958 Function Prostaglandin F receptor activity IDA 18587449
GO:0004958 Function Prostaglandin F receptor activity IEA
GO:0004958 Function Prostaglandin F receptor activity TAS 8300593
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600563 9600 ENSG00000122420
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P43088
Protein name Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor)
Protein function Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms
PDB 8IQ4 , 8IQ6 , 8IUK , 8IUL , 8IUM , 8XJK , 8XJL , 8XJM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 43 304 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Eye. {ECO:0000269|PubMed:18587449}.
Sequence
Sequence length 359
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Calcium signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
  Prostanoid ligand receptors
G alpha (q) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ENDOMETRIOSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma LHGDN 17478553
★☆☆☆☆
Found in Text Mining only
Aniridia Aniridia Pubtator 40570009 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 11295119, 20043119, 26170067
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 31514484, 38188684 Associate
★☆☆☆☆
Found in Text Mining only
Dermatitis Herpetiformis Dermatitis herpetiformis Pubtator 22991566 Associate
★☆☆☆☆
Found in Text Mining only
Developmental Dysplasia of the Hip Developmental dysplasia of the hip Pubtator 34174923 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus GWASCAT_DG 27207532
★☆☆☆☆
Found in Text Mining only
Dissection of aorta Aortic dissection BEFREE 25341845
★☆☆☆☆
Found in Text Mining only
Endometrioma Endometrioma CTD_human_DG 25446850
★☆☆☆☆
Found in Text Mining only
Endometriosis Endometriosis CTD_human_DG 25446850
★★☆☆☆
Found in Text Mining + Unknown/Other Associations