PTGER4 (prostaglandin E receptor 4)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5734
Gene name Prostaglandin E receptor 4
Gene symbol PTGER4
Synonyms (NCBI Gene)
EP4EP4R
Chromosome 5
Chromosome location 5p13.1
Summary The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 indu
miRNA miRNA information provided by mirtarbase database.
34
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (34)
miRTarBase ID miRNA Experiments Reference
MIRT053339 hsa-miR-101-3p ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blotMotility assayCAM assayColony formation assay 22353936
MIRT053339 hsa-miR-101-3p ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCRWestern blotMotility assayCAM assayColony formation assay 22353936
MIRT439876 hsa-miR-106b-5p HITS-CLIP 22473208
MIRT439875 hsa-miR-20a-5p HITS-CLIP 22473208
MIRT439876 hsa-miR-106b-5p HITS-CLIP 22473208
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (3)
Transcription factor Regulation Reference
NFKB1 Unknown 23300802
RELA Unknown 23300802
XBP1 Unknown 23300802
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IDA 1833717
GO:0001818 Process Negative regulation of cytokine production ISS
GO:0001819 Process Positive regulation of cytokine production ISS
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004955 Function Prostaglandin receptor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601586 9596 ENSG00000171522
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35408
Protein name Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
Protein function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal ep
PDB 5YHL , 5YWY , 7D7M , 8GCM , 8GCP , 8GD9 , 8GDA , 8GDB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 34 → 329 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Sequence
Sequence length 488
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Efferocytosis
Inflammatory mediator regulation of TRP channels
Renin secretion
Human cytomegalovirus infection
Human papillomavirus infection
Pathways in cancer 		  Prostanoid ligand receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (11)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANKYLOSING SPONDYLITIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTERIOSCLEROSIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS, EXPERIMENTAL — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHLORACNE — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (132)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 11592775, 19843025, 21589857, 22353936, 28899736
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 16574793
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 19843025
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 16540660, 22551900
★★★★★
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia BEFREE 30948641
★★★★★
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 21743469, 24069348, 31253169
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ankylosing spondylitis Ankylosing Spondylitis CTD_human_DG 21743469
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Aortic Aneurysm Abdominal Aortic aneurysm Pubtator 24133193, 24876670 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Abdominal Aortic Aneurysm BEFREE 22595380
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Psoriatic Psoriatic arthritis Pubtator 31253169 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only