PTGDS (prostaglandin D2 synthase)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5730
Gene name Prostaglandin D2 synthase
Gene symbol PTGDS
Synonyms (NCBI Gene)
L-PGDSLPGDSPDSPGD2PGDSPGDS2
Chromosome 9
Chromosome location 9q34.3
Summary The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervou
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT017585 hsa-miR-335-5p Microarray 18185580
MIRT1272594 hsa-miR-1252 CLIP-seq
MIRT1272595 hsa-miR-2278 CLIP-seq
MIRT1272596 hsa-miR-4468 CLIP-seq
MIRT1272597 hsa-miR-4533 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
HES1 Repression 15743775
NFKB1 Activation 19094210
TFAP2B Activation 15743775
USF1 Activation 17574780
USF1 Repression 18817855
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IDA 20347284, 20667974
GO:0001516 Process Prostaglandin biosynthetic process IEA
GO:0001516 Process Prostaglandin biosynthetic process ISS
GO:0004667 Function Prostaglandin-D synthase activity EXP 20667974
GO:0004667 Function Prostaglandin-D synthase activity IDA 20347284, 20667974
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
176803 9592 ENSG00000107317
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P41222
Protein name Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)
Protein function Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and
PDB 2WWP , 3O19 , 3O22 , 3O2Y , 4IMN , 4IMO , 4ORR , 4ORS , 4ORU , 4ORW , 4ORX , 4ORY , 4OS0 , 4OS3 , 4OS8 , 5WY9 , 8HTA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 40 → 184 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, e
Sequence
Sequence length 190
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Arachidonic acid metabolism
Metabolic pathways 		  Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CAROTID ARTERY DISEASES — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (171)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Inflammatory Demyelinating Polyneuropathy Inflammatory Demyelinating Polyneuropathy BEFREE 19049845
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 28928446
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 21271676
★★★★★
★☆☆☆☆
Found in Text Mining only
Alopecia Alopecia BEFREE 29136266
★★★★★
★☆☆☆☆
Found in Text Mining only
Anaplastic astrocytoma Anaplastic Astrocytoma BEFREE 18852145
★★★★★
★☆☆☆☆
Found in Text Mining only
Androgenetic Alopecia Androgenetic Alopecia BEFREE 29439547
★★★★★
★☆☆☆☆
Found in Text Mining only
Angina Pectoris Angina pectoris Pubtator 9405674 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Angina Stable Angina pectoris Pubtator 9405674 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Anorexia Anorexia BEFREE 29936041
★★★★★
★☆☆☆☆
Found in Text Mining only
Aplastic Anemia Aplastic anemia BEFREE 31802424
★★★★★
★☆☆☆☆
Found in Text Mining only