SPRYD7 (SPRY domain containing 7)

Gene

• Entrez ID: 57213
• Gene name: SPRY domain containing 7
• Gene symbol: SPRYD7
• Synonyms (NCBI Gene): C13orf1, CLLD6
• Chromosome: 13
• Chromosome location: 13q14.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019508	hsa-miR-151a-3p	Sequencing	20371350
MIRT032435	hsa-let-7b-5p	Proteomics	18668040
MIRT1386401	hsa-let-7a	CLIP-seq
MIRT1386402	hsa-let-7b	CLIP-seq
MIRT1386403	hsa-let-7c	CLIP-seq
MIRT1386404	hsa-let-7d	CLIP-seq
MIRT1386405	hsa-let-7e	CLIP-seq
MIRT1386406	hsa-let-7f	CLIP-seq
MIRT1386407	hsa-let-7g	CLIP-seq
MIRT1386408	hsa-let-7i	CLIP-seq
MIRT1386409	hsa-miR-1254	CLIP-seq
MIRT1386410	hsa-miR-197	CLIP-seq
MIRT1386411	hsa-miR-1976	CLIP-seq
MIRT1386412	hsa-miR-202	CLIP-seq
MIRT1386413	hsa-miR-3065-5p	CLIP-seq
MIRT1386414	hsa-miR-3116	CLIP-seq
MIRT1386415	hsa-miR-3122	CLIP-seq
MIRT1386416	hsa-miR-3144-3p	CLIP-seq
MIRT1386417	hsa-miR-3194-3p	CLIP-seq
MIRT1386418	hsa-miR-3660	CLIP-seq
MIRT1386419	hsa-miR-3664-5p	CLIP-seq
MIRT1386420	hsa-miR-3690	CLIP-seq
MIRT1386421	hsa-miR-3913-5p	CLIP-seq
MIRT1386422	hsa-miR-3927	CLIP-seq
MIRT1386423	hsa-miR-3934	CLIP-seq
MIRT1386424	hsa-miR-4251	CLIP-seq
MIRT1386425	hsa-miR-4257	CLIP-seq
MIRT1386426	hsa-miR-4258	CLIP-seq
MIRT1386427	hsa-miR-4275	CLIP-seq
MIRT1386428	hsa-miR-4279	CLIP-seq
MIRT1386429	hsa-miR-4293	CLIP-seq
MIRT1386430	hsa-miR-4303	CLIP-seq
MIRT1386431	hsa-miR-4329	CLIP-seq
MIRT1386432	hsa-miR-4458	CLIP-seq
MIRT1386433	hsa-miR-4500	CLIP-seq
MIRT1386434	hsa-miR-450b-3p	CLIP-seq
MIRT1386435	hsa-miR-4526	CLIP-seq
MIRT1386436	hsa-miR-4638-3p	CLIP-seq
MIRT1386437	hsa-miR-4650-3p	CLIP-seq
MIRT1386438	hsa-miR-4662a-5p	CLIP-seq
MIRT1386439	hsa-miR-4693-3p	CLIP-seq
MIRT1386440	hsa-miR-4698	CLIP-seq
MIRT1386441	hsa-miR-4714-5p	CLIP-seq
MIRT1386442	hsa-miR-4716-5p	CLIP-seq
MIRT1386443	hsa-miR-4722-3p	CLIP-seq
MIRT1386444	hsa-miR-4724-3p	CLIP-seq
MIRT1386445	hsa-miR-4724-5p	CLIP-seq
MIRT1386446	hsa-miR-4766-5p	CLIP-seq
MIRT1386447	hsa-miR-4786-5p	CLIP-seq
MIRT1386448	hsa-miR-498	CLIP-seq
MIRT1386449	hsa-miR-5095	CLIP-seq
MIRT1386450	hsa-miR-5096	CLIP-seq
MIRT1386451	hsa-miR-520a-5p	CLIP-seq
MIRT1386452	hsa-miR-525-5p	CLIP-seq
MIRT1386453	hsa-miR-550b	CLIP-seq
MIRT1386454	hsa-miR-552	CLIP-seq
MIRT1386455	hsa-miR-769-3p	CLIP-seq
MIRT1386456	hsa-miR-769-5p	CLIP-seq
MIRT1386457	hsa-miR-875-5p	CLIP-seq
MIRT1386458	hsa-miR-98	CLIP-seq
MIRT1386459	hsa-miR-1200	CLIP-seq
MIRT1386460	hsa-miR-122	CLIP-seq
MIRT1386461	hsa-miR-1227	CLIP-seq
MIRT1386462	hsa-miR-1251	CLIP-seq
MIRT1386409	hsa-miR-1254	CLIP-seq
MIRT1386463	hsa-miR-1262	CLIP-seq
MIRT1386464	hsa-miR-1307	CLIP-seq
MIRT1386465	hsa-miR-132	CLIP-seq
MIRT1386466	hsa-miR-1321	CLIP-seq
MIRT1386467	hsa-miR-1323	CLIP-seq
MIRT1386468	hsa-miR-141	CLIP-seq
MIRT1386469	hsa-miR-148a	CLIP-seq
MIRT1386470	hsa-miR-148b	CLIP-seq
MIRT1386471	hsa-miR-151-3p	CLIP-seq
MIRT1386472	hsa-miR-152	CLIP-seq
MIRT1386473	hsa-miR-15a	CLIP-seq
MIRT1386474	hsa-miR-15b	CLIP-seq
MIRT1386475	hsa-miR-16	CLIP-seq
MIRT1386476	hsa-miR-186	CLIP-seq
MIRT1386477	hsa-miR-195	CLIP-seq
MIRT1386411	hsa-miR-1976	CLIP-seq
MIRT1386478	hsa-miR-200a	CLIP-seq
MIRT1386479	hsa-miR-204	CLIP-seq
MIRT1386480	hsa-miR-211	CLIP-seq
MIRT1386481	hsa-miR-212	CLIP-seq
MIRT1386482	hsa-miR-298	CLIP-seq
MIRT1386483	hsa-miR-300	CLIP-seq
MIRT1386484	hsa-miR-3074-5p	CLIP-seq
MIRT1386414	hsa-miR-3116	CLIP-seq
MIRT1386485	hsa-miR-3121-3p	CLIP-seq
MIRT1386486	hsa-miR-3126-5p	CLIP-seq
MIRT1386487	hsa-miR-3135b	CLIP-seq
MIRT1386488	hsa-miR-3140-5p	CLIP-seq
MIRT1386489	hsa-miR-3151	CLIP-seq
MIRT1386490	hsa-miR-3165	CLIP-seq
MIRT1386491	hsa-miR-3646	CLIP-seq
MIRT1386492	hsa-miR-3662	CLIP-seq
MIRT1386493	hsa-miR-3672	CLIP-seq
MIRT1386494	hsa-miR-3675-3p	CLIP-seq
MIRT1386495	hsa-miR-3689d	CLIP-seq
MIRT1386420	hsa-miR-3690	CLIP-seq
MIRT1386496	hsa-miR-380	CLIP-seq
MIRT1386497	hsa-miR-381	CLIP-seq
MIRT1386498	hsa-miR-3924	CLIP-seq
MIRT1386499	hsa-miR-3938	CLIP-seq
MIRT1386500	hsa-miR-424	CLIP-seq
MIRT1386501	hsa-miR-4252	CLIP-seq
MIRT1386426	hsa-miR-4258	CLIP-seq
MIRT1386502	hsa-miR-4284	CLIP-seq
MIRT1386429	hsa-miR-4293	CLIP-seq
MIRT1386503	hsa-miR-4307	CLIP-seq
MIRT1386504	hsa-miR-4419a	CLIP-seq
MIRT1386505	hsa-miR-4433	CLIP-seq
MIRT1386506	hsa-miR-4459	CLIP-seq
MIRT1386507	hsa-miR-4463	CLIP-seq
MIRT1386508	hsa-miR-4495	CLIP-seq
MIRT1386509	hsa-miR-4499	CLIP-seq
MIRT1386510	hsa-miR-4504	CLIP-seq
MIRT1386511	hsa-miR-4510	CLIP-seq
MIRT1386436	hsa-miR-4638-3p	CLIP-seq
MIRT1386512	hsa-miR-4638-5p	CLIP-seq
MIRT1386513	hsa-miR-4684-5p	CLIP-seq
MIRT1386514	hsa-miR-4701-3p	CLIP-seq
MIRT1386515	hsa-miR-4735-5p	CLIP-seq
MIRT1386516	hsa-miR-4739	CLIP-seq
MIRT1386517	hsa-miR-4755-5p	CLIP-seq
MIRT1386518	hsa-miR-4756-5p	CLIP-seq
MIRT1386519	hsa-miR-4765	CLIP-seq
MIRT1386520	hsa-miR-4768-3p	CLIP-seq
MIRT1386447	hsa-miR-4786-5p	CLIP-seq
MIRT1386521	hsa-miR-4793-3p	CLIP-seq
MIRT1386522	hsa-miR-486-3p	CLIP-seq
MIRT1386523	hsa-miR-497	CLIP-seq
MIRT1386524	hsa-miR-509-3p	CLIP-seq
MIRT1386525	hsa-miR-513a-5p	CLIP-seq
MIRT1386526	hsa-miR-545	CLIP-seq
MIRT1386527	hsa-miR-548o	CLIP-seq
MIRT1386528	hsa-miR-548p	CLIP-seq
MIRT1386529	hsa-miR-576-5p	CLIP-seq
MIRT1386530	hsa-miR-596	CLIP-seq
MIRT1386531	hsa-miR-623	CLIP-seq
MIRT1386532	hsa-miR-624	CLIP-seq
MIRT1386533	hsa-miR-659	CLIP-seq
MIRT1386534	hsa-miR-661	CLIP-seq
MIRT1386456	hsa-miR-769-5p	CLIP-seq
MIRT1386466	hsa-miR-1321	CLIP-seq
MIRT1386411	hsa-miR-1976	CLIP-seq
MIRT1386415	hsa-miR-3122	CLIP-seq
MIRT1386486	hsa-miR-3126-5p	CLIP-seq
MIRT2115682	hsa-miR-3689a-3p	CLIP-seq
MIRT2115683	hsa-miR-3689c	CLIP-seq
MIRT1386421	hsa-miR-3913-5p	CLIP-seq
MIRT2115684	hsa-miR-3929	CLIP-seq
MIRT1386504	hsa-miR-4419a	CLIP-seq
MIRT2115685	hsa-miR-4419b	CLIP-seq
MIRT2115686	hsa-miR-4478	CLIP-seq
MIRT1386511	hsa-miR-4510	CLIP-seq
MIRT2115687	hsa-miR-4728-5p	CLIP-seq
MIRT1386516	hsa-miR-4739	CLIP-seq
MIRT1386518	hsa-miR-4756-5p	CLIP-seq
MIRT2115688	hsa-miR-485-5p	CLIP-seq
MIRT1386440	hsa-miR-4698	CLIP-seq
MIRT2338275	hsa-miR-106a	CLIP-seq
MIRT2338276	hsa-miR-106b	CLIP-seq
MIRT2338277	hsa-miR-1255a	CLIP-seq
MIRT2338278	hsa-miR-1255b	CLIP-seq
MIRT2338279	hsa-miR-1265	CLIP-seq
MIRT1386466	hsa-miR-1321	CLIP-seq
MIRT1386467	hsa-miR-1323	CLIP-seq
MIRT2338280	hsa-miR-149	CLIP-seq
MIRT2338281	hsa-miR-150	CLIP-seq
MIRT1386473	hsa-miR-15a	CLIP-seq
MIRT1386474	hsa-miR-15b	CLIP-seq
MIRT1386475	hsa-miR-16	CLIP-seq
MIRT2338282	hsa-miR-17	CLIP-seq
MIRT2338283	hsa-miR-1827	CLIP-seq
MIRT1386477	hsa-miR-195	CLIP-seq
MIRT1386411	hsa-miR-1976	CLIP-seq
MIRT2338284	hsa-miR-20a	CLIP-seq
MIRT2338285	hsa-miR-20b	CLIP-seq
MIRT2338286	hsa-miR-2392	CLIP-seq
MIRT2338287	hsa-miR-2467-3p	CLIP-seq
MIRT2338288	hsa-miR-302a	CLIP-seq
MIRT2338289	hsa-miR-302b	CLIP-seq
MIRT2338290	hsa-miR-302c	CLIP-seq
MIRT2338291	hsa-miR-302d	CLIP-seq
MIRT2338292	hsa-miR-302e	CLIP-seq
MIRT2338293	hsa-miR-3064-5p	CLIP-seq
MIRT2338294	hsa-miR-31	CLIP-seq
MIRT1386415	hsa-miR-3122	CLIP-seq
MIRT1386486	hsa-miR-3126-5p	CLIP-seq
MIRT1386490	hsa-miR-3165	CLIP-seq
MIRT2338295	hsa-miR-338-3p	CLIP-seq
MIRT2338296	hsa-miR-3652	CLIP-seq
MIRT1386419	hsa-miR-3664-5p	CLIP-seq
MIRT2115682	hsa-miR-3689a-3p	CLIP-seq
MIRT2115683	hsa-miR-3689c	CLIP-seq
MIRT1386495	hsa-miR-3689d	CLIP-seq
MIRT2338297	hsa-miR-372	CLIP-seq
MIRT2338298	hsa-miR-373	CLIP-seq
MIRT1386421	hsa-miR-3913-5p	CLIP-seq
MIRT2115684	hsa-miR-3929	CLIP-seq
MIRT1386500	hsa-miR-424	CLIP-seq
MIRT1386425	hsa-miR-4257	CLIP-seq
MIRT1386426	hsa-miR-4258	CLIP-seq
MIRT1386428	hsa-miR-4279	CLIP-seq
MIRT1386429	hsa-miR-4293	CLIP-seq
MIRT1386504	hsa-miR-4419a	CLIP-seq
MIRT2115685	hsa-miR-4419b	CLIP-seq
MIRT2338299	hsa-miR-4430	CLIP-seq
MIRT2338300	hsa-miR-4455	CLIP-seq
MIRT2338301	hsa-miR-4468	CLIP-seq
MIRT2115686	hsa-miR-4478	CLIP-seq
MIRT2338302	hsa-miR-4505	CLIP-seq
MIRT1386511	hsa-miR-4510	CLIP-seq
MIRT2338303	hsa-miR-4530	CLIP-seq
MIRT2338304	hsa-miR-4532	CLIP-seq
MIRT2338305	hsa-miR-4646-5p	CLIP-seq
MIRT2338306	hsa-miR-4649-3p	CLIP-seq
MIRT1386443	hsa-miR-4722-3p	CLIP-seq
MIRT2115687	hsa-miR-4728-5p	CLIP-seq
MIRT2338307	hsa-miR-4731-5p	CLIP-seq
MIRT1386516	hsa-miR-4739	CLIP-seq
MIRT2338308	hsa-miR-4747-5p	CLIP-seq
MIRT1386518	hsa-miR-4756-5p	CLIP-seq
MIRT2338309	hsa-miR-4775	CLIP-seq
MIRT2338310	hsa-miR-4794	CLIP-seq
MIRT2115688	hsa-miR-485-5p	CLIP-seq
MIRT2338311	hsa-miR-490-3p	CLIP-seq
MIRT1386523	hsa-miR-497	CLIP-seq
MIRT1386448	hsa-miR-498	CLIP-seq
MIRT1386449	hsa-miR-5095	CLIP-seq
MIRT2338312	hsa-miR-512-3p	CLIP-seq
MIRT2338313	hsa-miR-519d	CLIP-seq
MIRT2338314	hsa-miR-520a-3p	CLIP-seq
MIRT2338315	hsa-miR-520b	CLIP-seq
MIRT2338316	hsa-miR-520c-3p	CLIP-seq
MIRT2338317	hsa-miR-520d-3p	CLIP-seq
MIRT2338318	hsa-miR-520e	CLIP-seq
MIRT2338319	hsa-miR-520g	CLIP-seq
MIRT2338320	hsa-miR-520h	CLIP-seq
MIRT1386526	hsa-miR-545	CLIP-seq
MIRT1386527	hsa-miR-548o	CLIP-seq
MIRT1386528	hsa-miR-548p	CLIP-seq
MIRT1386454	hsa-miR-552	CLIP-seq
MIRT2338321	hsa-miR-590-3p	CLIP-seq
MIRT2338322	hsa-miR-609	CLIP-seq
MIRT2338323	hsa-miR-93	CLIP-seq
MIRT2631891	hsa-miR-1228	CLIP-seq
MIRT2631892	hsa-miR-129-5p	CLIP-seq
MIRT1386467	hsa-miR-1323	CLIP-seq
MIRT2631893	hsa-miR-3120-5p	CLIP-seq
MIRT1386415	hsa-miR-3122	CLIP-seq
MIRT2631894	hsa-miR-3149	CLIP-seq
MIRT2338295	hsa-miR-338-3p	CLIP-seq
MIRT2631895	hsa-miR-3613-3p	CLIP-seq
MIRT1386419	hsa-miR-3664-5p	CLIP-seq
MIRT1386493	hsa-miR-3672	CLIP-seq
MIRT1386494	hsa-miR-3675-3p	CLIP-seq
MIRT2115682	hsa-miR-3689a-3p	CLIP-seq
MIRT2115683	hsa-miR-3689c	CLIP-seq
MIRT2631896	hsa-miR-371-5p	CLIP-seq
MIRT2631897	hsa-miR-371b-5p	CLIP-seq
MIRT1386496	hsa-miR-380	CLIP-seq
MIRT1386421	hsa-miR-3913-5p	CLIP-seq
MIRT1386498	hsa-miR-3924	CLIP-seq
MIRT1386508	hsa-miR-4495	CLIP-seq
MIRT2631898	hsa-miR-452	CLIP-seq
MIRT2631899	hsa-miR-4522	CLIP-seq
MIRT2338303	hsa-miR-4530	CLIP-seq
MIRT2631900	hsa-miR-4676-3p	CLIP-seq
MIRT2115687	hsa-miR-4728-5p	CLIP-seq
MIRT1386515	hsa-miR-4735-5p	CLIP-seq
MIRT2631901	hsa-miR-4761-5p	CLIP-seq
MIRT2338309	hsa-miR-4775	CLIP-seq
MIRT2338310	hsa-miR-4794	CLIP-seq
MIRT1386527	hsa-miR-548o	CLIP-seq
MIRT2338321	hsa-miR-590-3p	CLIP-seq
MIRT2631902	hsa-miR-618	CLIP-seq
MIRT1386532	hsa-miR-624	CLIP-seq
MIRT2631903	hsa-miR-656	CLIP-seq
MIRT2631893	hsa-miR-3120-5p	CLIP-seq
MIRT2631895	hsa-miR-3613-3p	CLIP-seq
MIRT1386419	hsa-miR-3664-5p	CLIP-seq
MIRT1386493	hsa-miR-3672	CLIP-seq
MIRT1386494	hsa-miR-3675-3p	CLIP-seq
MIRT2631896	hsa-miR-371-5p	CLIP-seq
MIRT2631897	hsa-miR-371b-5p	CLIP-seq
MIRT2631899	hsa-miR-4522	CLIP-seq
MIRT2631901	hsa-miR-4761-5p	CLIP-seq
MIRT2631902	hsa-miR-618	CLIP-seq
MIRT1386532	hsa-miR-624	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 29892012, 32296183, 32814053

Other IDs

• MIM: 607866
• HGNC: 14297
• e!Ensembl: ENSG00000123178

Protein

• UniProt ID: Q5W111
• Protein name: SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein) (CLL deletion region gene 6 protein)
• PDB: 7CCB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	64 → 177	SPRY domain	Family

• Sequence:

  MATSVLCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPL
  HQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPA
  NSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYH
  TPPPGFEKILFEQQIF

• Sequence length: 196

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
B-CELL MALIGNANCY, LOW-GRADE	Lymphocytic Leukemia	BEFREE	14499696		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	14499696		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37947626	Stimulate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21563233		★☆☆☆☆ Found in Text Mining only