ZNF248 (zinc finger protein 248)

Gene

• Entrez ID: 57209
• Gene name: Zinc finger protein 248
• Gene symbol: ZNF248
• Synonyms (NCBI Gene): bA162G10.3
• Chromosome: 10
• Chromosome location: 10p11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020559	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT024704	hsa-miR-215-5p	Microarray	19074876
MIRT026187	hsa-miR-192-5p	Microarray	19074876
MIRT020559	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT020559	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1519056	hsa-miR-1208	CLIP-seq
MIRT1519057	hsa-miR-1224-3p	CLIP-seq
MIRT1519058	hsa-miR-1224-5p	CLIP-seq
MIRT1519059	hsa-miR-1260	CLIP-seq
MIRT1519060	hsa-miR-1260b	CLIP-seq
MIRT1519061	hsa-miR-1280	CLIP-seq
MIRT1519062	hsa-miR-1304	CLIP-seq
MIRT1519063	hsa-miR-132	CLIP-seq
MIRT1519064	hsa-miR-135a	CLIP-seq
MIRT1519065	hsa-miR-135b	CLIP-seq
MIRT1519066	hsa-miR-136	CLIP-seq
MIRT1519067	hsa-miR-141	CLIP-seq
MIRT1519068	hsa-miR-149	CLIP-seq
MIRT1519069	hsa-miR-150	CLIP-seq
MIRT1519070	hsa-miR-153	CLIP-seq
MIRT1519071	hsa-miR-154	CLIP-seq
MIRT1519072	hsa-miR-188-3p	CLIP-seq
MIRT1519073	hsa-miR-193a-3p	CLIP-seq
MIRT1519074	hsa-miR-193b	CLIP-seq
MIRT1519075	hsa-miR-200a	CLIP-seq
MIRT1519076	hsa-miR-2053	CLIP-seq
MIRT1519077	hsa-miR-212	CLIP-seq
MIRT1519078	hsa-miR-224	CLIP-seq
MIRT1519079	hsa-miR-24	CLIP-seq
MIRT1519080	hsa-miR-300	CLIP-seq
MIRT1519081	hsa-miR-3074-5p	CLIP-seq
MIRT1519082	hsa-miR-30a	CLIP-seq
MIRT1519083	hsa-miR-30b	CLIP-seq
MIRT1519084	hsa-miR-30c	CLIP-seq
MIRT1519085	hsa-miR-30d	CLIP-seq
MIRT1519086	hsa-miR-30e	CLIP-seq
MIRT1519087	hsa-miR-3119	CLIP-seq
MIRT1519088	hsa-miR-3121-5p	CLIP-seq
MIRT1519089	hsa-miR-3125	CLIP-seq
MIRT1519090	hsa-miR-3150b-3p	CLIP-seq
MIRT1519091	hsa-miR-3156-3p	CLIP-seq
MIRT1519092	hsa-miR-3160-3p	CLIP-seq
MIRT1519093	hsa-miR-325	CLIP-seq
MIRT1519094	hsa-miR-346	CLIP-seq
MIRT1519095	hsa-miR-3614-3p	CLIP-seq
MIRT1519096	hsa-miR-370	CLIP-seq
MIRT1519097	hsa-miR-381	CLIP-seq
MIRT1519098	hsa-miR-3915	CLIP-seq
MIRT1519099	hsa-miR-3916	CLIP-seq
MIRT1519100	hsa-miR-3923	CLIP-seq
MIRT1519101	hsa-miR-3924	CLIP-seq
MIRT1519102	hsa-miR-3926	CLIP-seq
MIRT1519103	hsa-miR-3942-3p	CLIP-seq
MIRT1519104	hsa-miR-411	CLIP-seq
MIRT1519105	hsa-miR-4257	CLIP-seq
MIRT1519106	hsa-miR-4261	CLIP-seq
MIRT1519107	hsa-miR-4263	CLIP-seq
MIRT1519108	hsa-miR-4272	CLIP-seq
MIRT1519109	hsa-miR-4284	CLIP-seq
MIRT1519110	hsa-miR-4301	CLIP-seq
MIRT1519111	hsa-miR-4317	CLIP-seq
MIRT1519112	hsa-miR-4436b-5p	CLIP-seq
MIRT1519113	hsa-miR-4446-5p	CLIP-seq
MIRT1519114	hsa-miR-448	CLIP-seq
MIRT1519115	hsa-miR-4487	CLIP-seq
MIRT1519116	hsa-miR-4491	CLIP-seq
MIRT1519117	hsa-miR-4496	CLIP-seq
MIRT1519118	hsa-miR-4633-3p	CLIP-seq
MIRT1519119	hsa-miR-4646-5p	CLIP-seq
MIRT1519120	hsa-miR-4657	CLIP-seq
MIRT1519121	hsa-miR-4661-5p	CLIP-seq
MIRT1519122	hsa-miR-4689	CLIP-seq
MIRT1519123	hsa-miR-4714-3p	CLIP-seq
MIRT1519124	hsa-miR-4716-5p	CLIP-seq
MIRT1519125	hsa-miR-4719	CLIP-seq
MIRT1519126	hsa-miR-4727-5p	CLIP-seq
MIRT1519127	hsa-miR-4731-3p	CLIP-seq
MIRT1519128	hsa-miR-4747-5p	CLIP-seq
MIRT1519129	hsa-miR-4755-3p	CLIP-seq
MIRT1519130	hsa-miR-4769-3p	CLIP-seq
MIRT1519131	hsa-miR-4784	CLIP-seq
MIRT1519132	hsa-miR-4801	CLIP-seq
MIRT1519133	hsa-miR-516a-3p	CLIP-seq
MIRT1519134	hsa-miR-532-3p	CLIP-seq
MIRT1519135	hsa-miR-548ac	CLIP-seq
MIRT1519136	hsa-miR-548ae	CLIP-seq
MIRT1519137	hsa-miR-548aj	CLIP-seq
MIRT1519138	hsa-miR-548am	CLIP-seq
MIRT1519139	hsa-miR-548d-3p	CLIP-seq
MIRT1519140	hsa-miR-548m	CLIP-seq
MIRT1519141	hsa-miR-548s	CLIP-seq
MIRT1519142	hsa-miR-548x	CLIP-seq
MIRT1519143	hsa-miR-548z	CLIP-seq
MIRT1519144	hsa-miR-558	CLIP-seq
MIRT1519145	hsa-miR-576-5p	CLIP-seq
MIRT1519146	hsa-miR-582-3p	CLIP-seq
MIRT1519147	hsa-miR-587	CLIP-seq
MIRT1519148	hsa-miR-622	CLIP-seq
MIRT1519149	hsa-miR-664	CLIP-seq
MIRT1519150	hsa-miR-892b	CLIP-seq
MIRT2156712	hsa-miR-1226	CLIP-seq
MIRT1519064	hsa-miR-135a	CLIP-seq
MIRT1519065	hsa-miR-135b	CLIP-seq
MIRT1519080	hsa-miR-300	CLIP-seq
MIRT1519081	hsa-miR-3074-5p	CLIP-seq
MIRT2156713	hsa-miR-3126-3p	CLIP-seq
MIRT1519096	hsa-miR-370	CLIP-seq
MIRT1519097	hsa-miR-381	CLIP-seq
MIRT1519115	hsa-miR-4487	CLIP-seq
MIRT1519133	hsa-miR-516a-3p	CLIP-seq
MIRT2376337	hsa-let-7a	CLIP-seq
MIRT2376338	hsa-let-7b	CLIP-seq
MIRT2376339	hsa-let-7c	CLIP-seq
MIRT2376340	hsa-let-7d	CLIP-seq
MIRT2376341	hsa-let-7e	CLIP-seq
MIRT2376342	hsa-let-7f	CLIP-seq
MIRT2376343	hsa-let-7g	CLIP-seq
MIRT2376344	hsa-let-7i	CLIP-seq
MIRT1519056	hsa-miR-1208	CLIP-seq
MIRT1519058	hsa-miR-1224-5p	CLIP-seq
MIRT2376345	hsa-miR-1270	CLIP-seq
MIRT2376346	hsa-miR-1278	CLIP-seq
MIRT2376347	hsa-miR-1283	CLIP-seq
MIRT1519062	hsa-miR-1304	CLIP-seq
MIRT1519063	hsa-miR-132	CLIP-seq
MIRT1519064	hsa-miR-135a	CLIP-seq
MIRT1519065	hsa-miR-135b	CLIP-seq
MIRT1519067	hsa-miR-141	CLIP-seq
MIRT2376348	hsa-miR-1470	CLIP-seq
MIRT1519070	hsa-miR-153	CLIP-seq
MIRT1519071	hsa-miR-154	CLIP-seq
MIRT1519075	hsa-miR-200a	CLIP-seq
MIRT1519077	hsa-miR-212	CLIP-seq
MIRT1519078	hsa-miR-224	CLIP-seq
MIRT1519089	hsa-miR-3125	CLIP-seq
MIRT2376349	hsa-miR-3133	CLIP-seq
MIRT1519090	hsa-miR-3150b-3p	CLIP-seq
MIRT2376350	hsa-miR-3157-3p	CLIP-seq
MIRT2376351	hsa-miR-34c-3p	CLIP-seq
MIRT2376352	hsa-miR-3689a-5p	CLIP-seq
MIRT2376353	hsa-miR-3689b	CLIP-seq
MIRT2376354	hsa-miR-3689e	CLIP-seq
MIRT2376355	hsa-miR-3689f	CLIP-seq
MIRT2376356	hsa-miR-3692	CLIP-seq
MIRT1519098	hsa-miR-3915	CLIP-seq
MIRT1519099	hsa-miR-3916	CLIP-seq
MIRT1519105	hsa-miR-4257	CLIP-seq
MIRT1519106	hsa-miR-4261	CLIP-seq
MIRT2376357	hsa-miR-4434	CLIP-seq
MIRT1519113	hsa-miR-4446-5p	CLIP-seq
MIRT2376358	hsa-miR-4458	CLIP-seq
MIRT2376359	hsa-miR-4476	CLIP-seq
MIRT1519114	hsa-miR-448	CLIP-seq
MIRT1519117	hsa-miR-4496	CLIP-seq
MIRT2376360	hsa-miR-4500	CLIP-seq
MIRT2376361	hsa-miR-4516	CLIP-seq
MIRT2376362	hsa-miR-452	CLIP-seq
MIRT2376363	hsa-miR-4530	CLIP-seq
MIRT2376364	hsa-miR-4531	CLIP-seq
MIRT2376365	hsa-miR-4652-3p	CLIP-seq
MIRT2376366	hsa-miR-4663	CLIP-seq
MIRT2376367	hsa-miR-4667-3p	CLIP-seq
MIRT2376368	hsa-miR-4676-3p	CLIP-seq
MIRT1519122	hsa-miR-4689	CLIP-seq
MIRT2376369	hsa-miR-4718	CLIP-seq
MIRT1519129	hsa-miR-4755-3p	CLIP-seq
MIRT2376370	hsa-miR-4755-5p	CLIP-seq
MIRT2376371	hsa-miR-4778-5p	CLIP-seq
MIRT1519131	hsa-miR-4784	CLIP-seq
MIRT2376372	hsa-miR-4789-5p	CLIP-seq
MIRT2376373	hsa-miR-496	CLIP-seq
MIRT2376374	hsa-miR-499-3p	CLIP-seq
MIRT2376375	hsa-miR-499a-3p	CLIP-seq
MIRT2376376	hsa-miR-502-5p	CLIP-seq
MIRT2376377	hsa-miR-512-3p	CLIP-seq
MIRT1519133	hsa-miR-516a-3p	CLIP-seq
MIRT1519135	hsa-miR-548ac	CLIP-seq
MIRT1519136	hsa-miR-548ae	CLIP-seq
MIRT1519137	hsa-miR-548aj	CLIP-seq
MIRT1519138	hsa-miR-548am	CLIP-seq
MIRT2376378	hsa-miR-548b-3p	CLIP-seq
MIRT1519139	hsa-miR-548d-3p	CLIP-seq
MIRT2376379	hsa-miR-548k	CLIP-seq
MIRT1519140	hsa-miR-548m	CLIP-seq
MIRT2376380	hsa-miR-548n	CLIP-seq
MIRT1519142	hsa-miR-548x	CLIP-seq
MIRT1519143	hsa-miR-548z	CLIP-seq
MIRT1519147	hsa-miR-587	CLIP-seq
MIRT2376381	hsa-miR-620	CLIP-seq
MIRT2376382	hsa-miR-642a	CLIP-seq
MIRT2376383	hsa-miR-874	CLIP-seq
MIRT2376384	hsa-miR-922	CLIP-seq
MIRT2376385	hsa-miR-938	CLIP-seq
MIRT2376386	hsa-miR-98	CLIP-seq
MIRT2376337	hsa-let-7a	CLIP-seq
MIRT2376338	hsa-let-7b	CLIP-seq
MIRT2376339	hsa-let-7c	CLIP-seq
MIRT2376340	hsa-let-7d	CLIP-seq
MIRT2376341	hsa-let-7e	CLIP-seq
MIRT2376342	hsa-let-7f	CLIP-seq
MIRT2376343	hsa-let-7g	CLIP-seq
MIRT2376344	hsa-let-7i	CLIP-seq
MIRT1519057	hsa-miR-1224-3p	CLIP-seq
MIRT2668656	hsa-miR-1236	CLIP-seq
MIRT2376346	hsa-miR-1278	CLIP-seq
MIRT1519066	hsa-miR-136	CLIP-seq
MIRT1519067	hsa-miR-141	CLIP-seq
MIRT2668657	hsa-miR-1912	CLIP-seq
MIRT1519075	hsa-miR-200a	CLIP-seq
MIRT2668658	hsa-miR-3187-3p	CLIP-seq
MIRT2668659	hsa-miR-338-3p	CLIP-seq
MIRT2668660	hsa-miR-3611	CLIP-seq
MIRT2668661	hsa-miR-3616-5p	CLIP-seq
MIRT2668662	hsa-miR-3647-5p	CLIP-seq
MIRT2668663	hsa-miR-378g	CLIP-seq
MIRT2668664	hsa-miR-3925-3p	CLIP-seq
MIRT1519105	hsa-miR-4257	CLIP-seq
MIRT2668665	hsa-miR-4437	CLIP-seq
MIRT2376358	hsa-miR-4458	CLIP-seq
MIRT2376360	hsa-miR-4500	CLIP-seq
MIRT2376362	hsa-miR-452	CLIP-seq
MIRT2668666	hsa-miR-4529-5p	CLIP-seq
MIRT2376363	hsa-miR-4530	CLIP-seq
MIRT2668667	hsa-miR-4635	CLIP-seq
MIRT2668668	hsa-miR-4674	CLIP-seq
MIRT2376368	hsa-miR-4676-3p	CLIP-seq
MIRT2668669	hsa-miR-4724-5p	CLIP-seq
MIRT2668670	hsa-miR-4753-3p	CLIP-seq
MIRT2668671	hsa-miR-4768-5p	CLIP-seq
MIRT2668672	hsa-miR-4795-5p	CLIP-seq
MIRT2668673	hsa-miR-526b	CLIP-seq
MIRT1519135	hsa-miR-548ac	CLIP-seq
MIRT1519139	hsa-miR-548d-3p	CLIP-seq
MIRT2376379	hsa-miR-548k	CLIP-seq
MIRT2376380	hsa-miR-548n	CLIP-seq
MIRT1519143	hsa-miR-548z	CLIP-seq
MIRT2668674	hsa-miR-573	CLIP-seq
MIRT2668675	hsa-miR-578	CLIP-seq
MIRT2668676	hsa-miR-656	CLIP-seq
MIRT2668677	hsa-miR-766	CLIP-seq
MIRT2376384	hsa-miR-922	CLIP-seq
MIRT2668678	hsa-miR-942	CLIP-seq
MIRT2376386	hsa-miR-98	CLIP-seq
MIRT2668656	hsa-miR-1236	CLIP-seq
MIRT1519066	hsa-miR-136	CLIP-seq
MIRT1519067	hsa-miR-141	CLIP-seq
MIRT1519075	hsa-miR-200a	CLIP-seq
MIRT2668660	hsa-miR-3611	CLIP-seq
MIRT2668670	hsa-miR-4753-3p	CLIP-seq
MIRT2668671	hsa-miR-4768-5p	CLIP-seq
MIRT2668676	hsa-miR-656	CLIP-seq
MIRT2668678	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060255	Process	Regulation of macromolecule metabolic process	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: 621128
• HGNC: 13041
• e!Ensembl: ENSG00000198105

Protein

• UniProt ID: Q8NDW4
• Protein name: Zinc finger protein 248
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	7 → 48	KRAB box	Family
  PF00096	zf-C2H2	380 → 402	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	408 → 430	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	436 → 458	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	464 → 486	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	492 → 514	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	520 → 542	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	548 → 570	Zinc finger, C2H2 type	Domain

• Sequence:

  MNKSQEQVSFKDVCVDFTQEEWYLLDPAQKILYRDVILENYSNLVSVGYCITKPEVIFKI
  EQGEEPWILEKGFPSQCHPERKWKVDDVLESSQENEDDHFWELLFHNNKTVSVENGDRGS
  KTFNLGTDPVSLRNYPYKICDSCEMNLKNISGLIISKKNCSRKKPDEFNVCEKLLLDIRH
  EKIPIGEKSYKYDQKRNAINYHQDLSQPSFGQSFEYSKNGQGFHDEAAFFTNKRSQIGET
  VCKYNECGRTFIESLKLNISQRPHLEMEPYGCSICGKSFCMNLRFGHQRALTKDNPYEYN
  EYGEIFCDNSAFIIHQGAYTRKILREYKVSDKTWEKSALLKHQIVHMGGKSYDYNENGSN
  FSKKSHLTQLRRAHTGEKTFECGECGKTFWEKSNLTQHQRTHTGEKPYECTECGKAFCQK
  PHLTNHQRTHTGEKPYECKQCGKTFCVKSNLTEHQRTHTGEKPYECNACGKSFCHRSALT
  VHQRTHTGEKPFICNECGKSFCVKSNLIVHQRTHTGEKPYKCNECGKTFCEKSALTKHQR
  THTGEKPYECNACGKTFSQRSVLTKHQRIHTRVKALSTS

• Sequence length: 579

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	Pubtator	27238579	Associate	★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	12566248		★☆☆☆☆ Found in Text Mining only
Complete hydatidiform mole	Complete Hydatidiform Mole	BEFREE	12566248		★☆☆☆☆ Found in Text Mining only
Gestational Trophoblastic Neoplasms	Gestational Trophoblastic Neoplasms	BEFREE	12566248		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	37254212	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of oropharynx	Malignant Neoplasm Of Oropharynx	BEFREE	21514414		★☆☆☆☆ Found in Text Mining only
Oropharyngeal Carcinoma	Oropharyngeal Carcinoma	BEFREE	21514414		★☆☆☆☆ Found in Text Mining only
Oropharyngeal Neoplasms	Oropharyngeal neoplasm	Pubtator	21514414	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	21514414	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of oropharynx	Oropharyngeal carcinoma	BEFREE	21514414		★☆☆☆☆ Found in Text Mining only