Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57205
Gene name	ATPase phospholipid transporting 10D (putative)
Gene symbol	ATP10D
Synonyms (NCBI Gene)	ATPVD
Chromosome	4
Chromosome location	4p12

124

Show/Hide all (124)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004152	hsa-miR-192-5p	Microarray	16822819
MIRT016855	hsa-miR-335-5p	Microarray	18185580
MIRT447476	hsa-miR-3127-3p	PAR-CLIP	22100165
MIRT447475	hsa-miR-6756-3p	PAR-CLIP	22100165
MIRT447473	hsa-miR-4780	PAR-CLIP	22100165
MIRT447474	hsa-miR-183-3p	PAR-CLIP	22100165
MIRT447472	hsa-miR-4452	PAR-CLIP	22100165
MIRT441157	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT441157	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT447476	hsa-miR-3127-3p	PAR-CLIP	22100165
MIRT447475	hsa-miR-6756-3p	PAR-CLIP	22100165
MIRT447473	hsa-miR-4780	PAR-CLIP	22100165
MIRT447474	hsa-miR-183-3p	PAR-CLIP	22100165
MIRT447472	hsa-miR-4452	PAR-CLIP	22100165
MIRT806307	hsa-miR-1290	CLIP-seq
MIRT806308	hsa-miR-1291	CLIP-seq
MIRT806309	hsa-miR-146b-3p	CLIP-seq
MIRT806310	hsa-miR-194	CLIP-seq
MIRT806311	hsa-miR-3143	CLIP-seq
MIRT806312	hsa-miR-328	CLIP-seq
MIRT806313	hsa-miR-450b-3p	CLIP-seq
MIRT806314	hsa-miR-4797-3p	CLIP-seq
MIRT806315	hsa-miR-543	CLIP-seq
MIRT806316	hsa-miR-635	CLIP-seq
MIRT806317	hsa-miR-663b	CLIP-seq
MIRT806318	hsa-miR-769-3p	CLIP-seq
MIRT1938102	hsa-miR-3124-3p	CLIP-seq
MIRT1938103	hsa-miR-3679-3p	CLIP-seq
MIRT1938104	hsa-miR-4328	CLIP-seq
MIRT1938105	hsa-miR-549	CLIP-seq
MIRT1938106	hsa-miR-642a	CLIP-seq
MIRT2177583	hsa-miR-4503	CLIP-seq
MIRT2177584	hsa-miR-4742-3p	CLIP-seq
MIRT2177585	hsa-miR-944	CLIP-seq
MIRT2435556	hsa-miR-1297	CLIP-seq
MIRT2435557	hsa-miR-1299	CLIP-seq
MIRT2435558	hsa-miR-26a	CLIP-seq
MIRT2435559	hsa-miR-26b	CLIP-seq
MIRT2435560	hsa-miR-326	CLIP-seq
MIRT2435561	hsa-miR-330-5p	CLIP-seq
MIRT2435562	hsa-miR-3545-5p	CLIP-seq
MIRT2435563	hsa-miR-4465	CLIP-seq
MIRT2435564	hsa-miR-593	CLIP-seq
MIRT2435565	hsa-miR-7	CLIP-seq
MIRT2435566	hsa-miR-875-3p	CLIP-seq
MIRT2480996	hsa-miR-125a-5p	CLIP-seq
MIRT2480997	hsa-miR-125b	CLIP-seq
MIRT2480998	hsa-miR-1284	CLIP-seq
MIRT2480999	hsa-miR-1343	CLIP-seq
MIRT2481000	hsa-miR-1827	CLIP-seq
MIRT2481001	hsa-miR-3117-3p	CLIP-seq
MIRT2481002	hsa-miR-3121-3p	CLIP-seq
MIRT1938102	hsa-miR-3124-3p	CLIP-seq
MIRT2481003	hsa-miR-3125	CLIP-seq
MIRT2481004	hsa-miR-3133	CLIP-seq
MIRT2481005	hsa-miR-3169	CLIP-seq
MIRT2481006	hsa-miR-3660	CLIP-seq
MIRT2481007	hsa-miR-3671	CLIP-seq
MIRT1938103	hsa-miR-3679-3p	CLIP-seq
MIRT2481008	hsa-miR-369-3p	CLIP-seq
MIRT2481009	hsa-miR-374a	CLIP-seq
MIRT2481010	hsa-miR-374b	CLIP-seq
MIRT2481011	hsa-miR-3916	CLIP-seq
MIRT2481012	hsa-miR-3976	CLIP-seq
MIRT2481013	hsa-miR-421	CLIP-seq
MIRT2481014	hsa-miR-4281	CLIP-seq
MIRT2481015	hsa-miR-4319	CLIP-seq
MIRT2481016	hsa-miR-4493	CLIP-seq
MIRT2481017	hsa-miR-4502	CLIP-seq
MIRT2481018	hsa-miR-4511	CLIP-seq
MIRT2481019	hsa-miR-4526	CLIP-seq
MIRT2481020	hsa-miR-4695-3p	CLIP-seq
MIRT2481021	hsa-miR-4709-5p	CLIP-seq
MIRT2481022	hsa-miR-4732-3p	CLIP-seq
MIRT2481023	hsa-miR-4753-3p	CLIP-seq
MIRT2481024	hsa-miR-4759	CLIP-seq
MIRT2481025	hsa-miR-4797-5p	CLIP-seq
MIRT2481026	hsa-miR-509-3p	CLIP-seq
MIRT1938105	hsa-miR-549	CLIP-seq
MIRT2481027	hsa-miR-586	CLIP-seq
MIRT2481028	hsa-miR-607	CLIP-seq
MIRT1938106	hsa-miR-642a	CLIP-seq
MIRT2481029	hsa-miR-670	CLIP-seq
MIRT2481030	hsa-miR-942	CLIP-seq
MIRT2480996	hsa-miR-125a-5p	CLIP-seq
MIRT2480997	hsa-miR-125b	CLIP-seq
MIRT2480998	hsa-miR-1284	CLIP-seq
MIRT2480999	hsa-miR-1343	CLIP-seq
MIRT2481000	hsa-miR-1827	CLIP-seq
MIRT2675601	hsa-miR-29a	CLIP-seq
MIRT2675602	hsa-miR-29b	CLIP-seq
MIRT2675603	hsa-miR-29c	CLIP-seq
MIRT2481001	hsa-miR-3117-3p	CLIP-seq
MIRT2481002	hsa-miR-3121-3p	CLIP-seq
MIRT2481003	hsa-miR-3125	CLIP-seq
MIRT2481004	hsa-miR-3133	CLIP-seq
MIRT2481005	hsa-miR-3169	CLIP-seq
MIRT2675604	hsa-miR-3176	CLIP-seq
MIRT2481006	hsa-miR-3660	CLIP-seq
MIRT2481007	hsa-miR-3671	CLIP-seq
MIRT2481008	hsa-miR-369-3p	CLIP-seq
MIRT2481009	hsa-miR-374a	CLIP-seq
MIRT2481010	hsa-miR-374b	CLIP-seq
MIRT2481011	hsa-miR-3916	CLIP-seq
MIRT2675605	hsa-miR-3922-3p	CLIP-seq
MIRT2481012	hsa-miR-3976	CLIP-seq
MIRT2481013	hsa-miR-421	CLIP-seq
MIRT2481014	hsa-miR-4281	CLIP-seq
MIRT2481015	hsa-miR-4319	CLIP-seq
MIRT2481017	hsa-miR-4502	CLIP-seq
MIRT2481018	hsa-miR-4511	CLIP-seq
MIRT2481019	hsa-miR-4526	CLIP-seq
MIRT2481020	hsa-miR-4695-3p	CLIP-seq
MIRT2481021	hsa-miR-4709-5p	CLIP-seq
MIRT2481022	hsa-miR-4732-3p	CLIP-seq
MIRT2481023	hsa-miR-4753-3p	CLIP-seq
MIRT2481024	hsa-miR-4759	CLIP-seq
MIRT2481025	hsa-miR-4797-5p	CLIP-seq
MIRT2481026	hsa-miR-509-3p	CLIP-seq
MIRT1938105	hsa-miR-549	CLIP-seq
MIRT2481027	hsa-miR-586	CLIP-seq
MIRT2481028	hsa-miR-607	CLIP-seq
MIRT2481029	hsa-miR-670	CLIP-seq
MIRT2481030	hsa-miR-942	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000287	Function	Magnesium ion binding	NAS	12532265
GO:0005515	Function	Protein binding	IPI	21914794, 25947375
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	NAS	12532265
GO:0005654	Component	Nucleoplasm	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA	21914794
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	25947375
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006812	Process	Monoatomic cation transport	NAS	12532265
GO:0006869	Process	Lipid transport	IEA
GO:0015914	Process	Phospholipid transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	12532265
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0045332	Process	Phospholipid translocation	IBA
GO:0045332	Process	Phospholipid translocation	NAS	21914794
GO:0046872	Function	Metal ion binding	IEA
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	IBA
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	IEA
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	NAS	12532265
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	TAS
GO:0140351	Function	Glycosylceramide flippase activity	IDA	30530492
GO:0140351	Function	Glycosylceramide flippase activity	IEA
GO:1990531	Component	Phospholipid-translocating ATPase complex	IDA	25947375
GO:1990531	Component	Phospholipid-translocating ATPase complex	IEA
GO:1990531	Component	Phospholipid-translocating ATPase complex	IPI	25947375

MIM	HGNC	e!Ensembl
619815	13549	ENSG00000145246

Q9P241

Protein name

Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D)

Protein function

Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16209	PhoLip_ATPase_N	57 → 124	Phospholipid-translocating ATPase N-terminal	Family
PF13246	Cation_ATPase	685 → 807		Family
PF16212	PhoLip_ATPase_C	1082 → 1327	Phospholipid-translocating P-type ATPase C-terminal	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in placenta and, to a lesser extent, in kidney. {ECO:0000269|PubMed:12532265}.

Sequence

MTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPF
KDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQK
EITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVGDF
IRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFS
SRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKA
MLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDG
HIISPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSIVQC
RALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAVSEDE
DFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVPHSRQAA
FSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAICNTVVVS
APNQPRQKIRHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRL
PLFSRMKPASPVEEEVSQVCESPQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACN
LCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRMS
VVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLR
TLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQE
GVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMST
ILKELQKKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELT
SWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQ
AVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGT
SMTDYWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITL
LDAFYQSLVCFFVPYFTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVII
GSILSYFLFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVL
QGSLFPSPILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPGPS
AVFAMKSASSCAIEQGNLSLCETALDQGYSETKAFEMAGPSKGKES

Sequence length

1426

Interactions

View interactions

	Reactome
			Ion transport by P-type ATPases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEMOLYTIC ANEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atherosclerosis	Atherosclerosis	Pubtator	24125428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bicuspid Aortic Valve Disease	Bicuspid aortic valve	Pubtator	36071494	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Aneurysm	Coronary aneurysm	Pubtator	24125428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	24125428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	24125428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	24125428		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	24125428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	19254779, 28542499		★★★★★ ★☆☆☆☆ Found in Text Mining only

ATP10D (ATPase phospholipid transporting 10D (putative))