DOLPP1 (dolichyldiphosphatase 1)

Gene

• Entrez ID: 57171
• Gene name: Dolichyldiphosphatase 1
• Gene symbol: DOLPP1
• Synonyms (NCBI Gene): LSFR2
• Chromosome: 9
• Chromosome location: 9q34.11
• Summary: A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023998	hsa-miR-1-3p	Proteomics	18668040
MIRT023998	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT943308	hsa-miR-1206	CLIP-seq
MIRT943309	hsa-miR-1258	CLIP-seq
MIRT943310	hsa-miR-1285	CLIP-seq
MIRT943311	hsa-miR-1291	CLIP-seq
MIRT943312	hsa-miR-1323	CLIP-seq
MIRT943313	hsa-miR-1324	CLIP-seq
MIRT943314	hsa-miR-15a	CLIP-seq
MIRT943315	hsa-miR-15b	CLIP-seq
MIRT943316	hsa-miR-16	CLIP-seq
MIRT943317	hsa-miR-1910	CLIP-seq
MIRT943318	hsa-miR-1913	CLIP-seq
MIRT943319	hsa-miR-195	CLIP-seq
MIRT943320	hsa-miR-1972	CLIP-seq
MIRT943321	hsa-miR-214	CLIP-seq
MIRT943322	hsa-miR-218	CLIP-seq
MIRT943323	hsa-miR-296-5p	CLIP-seq
MIRT943324	hsa-miR-3130-5p	CLIP-seq
MIRT943325	hsa-miR-3132	CLIP-seq
MIRT943326	hsa-miR-3173-5p	CLIP-seq
MIRT943327	hsa-miR-3187-5p	CLIP-seq
MIRT943328	hsa-miR-324-3p	CLIP-seq
MIRT943329	hsa-miR-326	CLIP-seq
MIRT943330	hsa-miR-330-5p	CLIP-seq
MIRT943331	hsa-miR-331-3p	CLIP-seq
MIRT943332	hsa-miR-361-3p	CLIP-seq
MIRT943333	hsa-miR-3619-5p	CLIP-seq
MIRT943334	hsa-miR-3663-5p	CLIP-seq
MIRT943335	hsa-miR-3688-3p	CLIP-seq
MIRT943336	hsa-miR-371b-5p	CLIP-seq
MIRT943337	hsa-miR-378g	CLIP-seq
MIRT943338	hsa-miR-3977	CLIP-seq
MIRT943339	hsa-miR-424	CLIP-seq
MIRT943340	hsa-miR-4251	CLIP-seq
MIRT943341	hsa-miR-4261	CLIP-seq
MIRT943342	hsa-miR-4282	CLIP-seq
MIRT943343	hsa-miR-4289	CLIP-seq
MIRT943344	hsa-miR-4291	CLIP-seq
MIRT943345	hsa-miR-4303	CLIP-seq
MIRT943346	hsa-miR-4313	CLIP-seq
MIRT943347	hsa-miR-4329	CLIP-seq
MIRT943348	hsa-miR-4482	CLIP-seq
MIRT943349	hsa-miR-4486	CLIP-seq
MIRT943350	hsa-miR-4496	CLIP-seq
MIRT943351	hsa-miR-455-3p	CLIP-seq
MIRT943352	hsa-miR-4650-3p	CLIP-seq
MIRT943353	hsa-miR-4693-3p	CLIP-seq
MIRT943354	hsa-miR-4707-5p	CLIP-seq
MIRT943355	hsa-miR-4717-5p	CLIP-seq
MIRT943356	hsa-miR-4724-3p	CLIP-seq
MIRT943357	hsa-miR-4728-5p	CLIP-seq
MIRT943358	hsa-miR-4773	CLIP-seq
MIRT943359	hsa-miR-4802-3p	CLIP-seq
MIRT943360	hsa-miR-494	CLIP-seq
MIRT943361	hsa-miR-497	CLIP-seq
MIRT943362	hsa-miR-548o	CLIP-seq
MIRT943363	hsa-miR-612	CLIP-seq
MIRT943364	hsa-miR-636	CLIP-seq
MIRT943365	hsa-miR-657	CLIP-seq
MIRT943366	hsa-miR-761	CLIP-seq
MIRT943367	hsa-miR-922	CLIP-seq
MIRT943321	hsa-miR-214	CLIP-seq
MIRT943333	hsa-miR-3619-5p	CLIP-seq
MIRT1979326	hsa-miR-3919	CLIP-seq
MIRT943343	hsa-miR-4289	CLIP-seq
MIRT1979327	hsa-miR-4793-5p	CLIP-seq
MIRT943366	hsa-miR-761	CLIP-seq
MIRT943321	hsa-miR-214	CLIP-seq
MIRT1979328	hsa-miR-3151	CLIP-seq
MIRT943333	hsa-miR-3619-5p	CLIP-seq
MIRT1979329	hsa-miR-4447	CLIP-seq
MIRT1979330	hsa-miR-4472	CLIP-seq
MIRT1979331	hsa-miR-491-5p	CLIP-seq
MIRT943366	hsa-miR-761	CLIP-seq
MIRT943321	hsa-miR-214	CLIP-seq
MIRT943333	hsa-miR-3619-5p	CLIP-seq
MIRT1979326	hsa-miR-3919	CLIP-seq
MIRT943366	hsa-miR-761	CLIP-seq
MIRT2214496	hsa-miR-1207-5p	CLIP-seq
MIRT943317	hsa-miR-1910	CLIP-seq
MIRT943321	hsa-miR-214	CLIP-seq
MIRT2214497	hsa-miR-3183	CLIP-seq
MIRT943333	hsa-miR-3619-5p	CLIP-seq
MIRT2214498	hsa-miR-4533	CLIP-seq
MIRT943351	hsa-miR-455-3p	CLIP-seq
MIRT2214499	hsa-miR-4723-3p	CLIP-seq
MIRT2214500	hsa-miR-4736	CLIP-seq
MIRT2214501	hsa-miR-4763-3p	CLIP-seq
MIRT1979331	hsa-miR-491-5p	CLIP-seq
MIRT943366	hsa-miR-761	CLIP-seq
MIRT943321	hsa-miR-214	CLIP-seq
MIRT943333	hsa-miR-3619-5p	CLIP-seq
MIRT943366	hsa-miR-761	CLIP-seq
MIRT2518723	hsa-miR-1193	CLIP-seq
MIRT2214496	hsa-miR-1207-5p	CLIP-seq
MIRT2518724	hsa-miR-1225-3p	CLIP-seq
MIRT2518725	hsa-miR-1229	CLIP-seq
MIRT2518726	hsa-miR-1233	CLIP-seq
MIRT2518727	hsa-miR-1243	CLIP-seq
MIRT2518728	hsa-miR-1273f	CLIP-seq
MIRT2518729	hsa-miR-1276	CLIP-seq
MIRT943310	hsa-miR-1285	CLIP-seq
MIRT2518730	hsa-miR-1286	CLIP-seq
MIRT2518731	hsa-miR-1303	CLIP-seq
MIRT2518732	hsa-miR-1304	CLIP-seq
MIRT2518733	hsa-miR-1343	CLIP-seq
MIRT2518734	hsa-miR-1827	CLIP-seq
MIRT943318	hsa-miR-1913	CLIP-seq
MIRT2518735	hsa-miR-1915	CLIP-seq
MIRT943320	hsa-miR-1972	CLIP-seq
MIRT2518736	hsa-miR-204	CLIP-seq
MIRT2518737	hsa-miR-211	CLIP-seq
MIRT2518738	hsa-miR-2682	CLIP-seq
MIRT2518739	hsa-miR-27a	CLIP-seq
MIRT2518740	hsa-miR-27b	CLIP-seq
MIRT2518741	hsa-miR-2861	CLIP-seq
MIRT2518742	hsa-miR-3121-3p	CLIP-seq
MIRT2518743	hsa-miR-3141	CLIP-seq
MIRT2518744	hsa-miR-3144-5p	CLIP-seq
MIRT2518745	hsa-miR-3177-5p	CLIP-seq
MIRT2518746	hsa-miR-3184	CLIP-seq
MIRT2518747	hsa-miR-3186-5p	CLIP-seq
MIRT943327	hsa-miR-3187-5p	CLIP-seq
MIRT2518748	hsa-miR-3197	CLIP-seq
MIRT943328	hsa-miR-324-3p	CLIP-seq
MIRT943329	hsa-miR-326	CLIP-seq
MIRT943330	hsa-miR-330-5p	CLIP-seq
MIRT2518749	hsa-miR-346	CLIP-seq
MIRT2518750	hsa-miR-3613-3p	CLIP-seq
MIRT2518751	hsa-miR-3654	CLIP-seq
MIRT2518752	hsa-miR-3682-5p	CLIP-seq
MIRT943337	hsa-miR-378g	CLIP-seq
MIRT2518753	hsa-miR-3929	CLIP-seq
MIRT2518754	hsa-miR-3945	CLIP-seq
MIRT2518755	hsa-miR-423-5p	CLIP-seq
MIRT2518756	hsa-miR-4253	CLIP-seq
MIRT2518757	hsa-miR-4270	CLIP-seq
MIRT2518758	hsa-miR-4290	CLIP-seq
MIRT2518759	hsa-miR-4419b	CLIP-seq
MIRT2518760	hsa-miR-4436a	CLIP-seq
MIRT2518761	hsa-miR-4436b-3p	CLIP-seq
MIRT2518762	hsa-miR-4441	CLIP-seq
MIRT2518763	hsa-miR-4464	CLIP-seq
MIRT2518764	hsa-miR-4476	CLIP-seq
MIRT2518765	hsa-miR-4478	CLIP-seq
MIRT943349	hsa-miR-4486	CLIP-seq
MIRT2518766	hsa-miR-449c	CLIP-seq
MIRT2518767	hsa-miR-4512	CLIP-seq
MIRT2518768	hsa-miR-4634	CLIP-seq
MIRT2518769	hsa-miR-4646-5p	CLIP-seq
MIRT2518770	hsa-miR-4667-3p	CLIP-seq
MIRT2518771	hsa-miR-4677-3p	CLIP-seq
MIRT2518772	hsa-miR-4679	CLIP-seq
MIRT2518773	hsa-miR-4687-5p	CLIP-seq
MIRT2518774	hsa-miR-4691-3p	CLIP-seq
MIRT2518775	hsa-miR-4691-5p	CLIP-seq
MIRT943354	hsa-miR-4707-5p	CLIP-seq
MIRT2518776	hsa-miR-4716-3p	CLIP-seq
MIRT943355	hsa-miR-4717-5p	CLIP-seq
MIRT2518777	hsa-miR-4726-3p	CLIP-seq
MIRT2518778	hsa-miR-4727-5p	CLIP-seq
MIRT2214500	hsa-miR-4736	CLIP-seq
MIRT2518779	hsa-miR-4740-3p	CLIP-seq
MIRT2518780	hsa-miR-4747-5p	CLIP-seq
MIRT2518781	hsa-miR-4748	CLIP-seq
MIRT2214501	hsa-miR-4763-3p	CLIP-seq
MIRT2518782	hsa-miR-4786-5p	CLIP-seq
MIRT2518783	hsa-miR-513a-5p	CLIP-seq
MIRT2518784	hsa-miR-532-3p	CLIP-seq
MIRT2518785	hsa-miR-544	CLIP-seq
MIRT2518786	hsa-miR-548aa	CLIP-seq
MIRT943363	hsa-miR-612	CLIP-seq
MIRT2518787	hsa-miR-615-5p	CLIP-seq
MIRT2518788	hsa-miR-619	CLIP-seq
MIRT2518789	hsa-miR-622	CLIP-seq
MIRT2518790	hsa-miR-648	CLIP-seq
MIRT2518791	hsa-miR-651	CLIP-seq
MIRT2518792	hsa-miR-661	CLIP-seq
MIRT2518793	hsa-miR-662	CLIP-seq
MIRT2518794	hsa-miR-764	CLIP-seq
MIRT2679390	hsa-miR-1178	CLIP-seq
MIRT2518723	hsa-miR-1193	CLIP-seq
MIRT2214496	hsa-miR-1207-5p	CLIP-seq
MIRT2518724	hsa-miR-1225-3p	CLIP-seq
MIRT2518725	hsa-miR-1229	CLIP-seq
MIRT2518726	hsa-miR-1233	CLIP-seq
MIRT2518727	hsa-miR-1243	CLIP-seq
MIRT2518728	hsa-miR-1273f	CLIP-seq
MIRT2518729	hsa-miR-1276	CLIP-seq
MIRT943310	hsa-miR-1285	CLIP-seq
MIRT2518730	hsa-miR-1286	CLIP-seq
MIRT2518731	hsa-miR-1303	CLIP-seq
MIRT943312	hsa-miR-1323	CLIP-seq
MIRT2518733	hsa-miR-1343	CLIP-seq
MIRT2518734	hsa-miR-1827	CLIP-seq
MIRT943317	hsa-miR-1910	CLIP-seq
MIRT943318	hsa-miR-1913	CLIP-seq
MIRT2518735	hsa-miR-1915	CLIP-seq
MIRT2679391	hsa-miR-193a-5p	CLIP-seq
MIRT943320	hsa-miR-1972	CLIP-seq
MIRT2518736	hsa-miR-204	CLIP-seq
MIRT2518737	hsa-miR-211	CLIP-seq
MIRT2679392	hsa-miR-2278	CLIP-seq
MIRT2518738	hsa-miR-2682	CLIP-seq
MIRT2518739	hsa-miR-27a	CLIP-seq
MIRT2518740	hsa-miR-27b	CLIP-seq
MIRT2518741	hsa-miR-2861	CLIP-seq
MIRT2679393	hsa-miR-30a	CLIP-seq
MIRT2679394	hsa-miR-30b	CLIP-seq
MIRT2679395	hsa-miR-30c	CLIP-seq
MIRT2679396	hsa-miR-30d	CLIP-seq
MIRT2679397	hsa-miR-30e	CLIP-seq
MIRT2518742	hsa-miR-3121-3p	CLIP-seq
MIRT943324	hsa-miR-3130-5p	CLIP-seq
MIRT2518743	hsa-miR-3141	CLIP-seq
MIRT2518745	hsa-miR-3177-5p	CLIP-seq
MIRT943327	hsa-miR-3187-5p	CLIP-seq
MIRT2518748	hsa-miR-3197	CLIP-seq
MIRT943328	hsa-miR-324-3p	CLIP-seq
MIRT943329	hsa-miR-326	CLIP-seq
MIRT943330	hsa-miR-330-5p	CLIP-seq
MIRT2518749	hsa-miR-346	CLIP-seq
MIRT2679398	hsa-miR-3607-3p	CLIP-seq
MIRT2518750	hsa-miR-3613-3p	CLIP-seq
MIRT2679399	hsa-miR-3616-3p	CLIP-seq
MIRT2518751	hsa-miR-3654	CLIP-seq
MIRT2518752	hsa-miR-3682-5p	CLIP-seq
MIRT943336	hsa-miR-371b-5p	CLIP-seq
MIRT943337	hsa-miR-378g	CLIP-seq
MIRT2518753	hsa-miR-3929	CLIP-seq
MIRT2518754	hsa-miR-3945	CLIP-seq
MIRT943340	hsa-miR-4251	CLIP-seq
MIRT2518756	hsa-miR-4253	CLIP-seq
MIRT2518757	hsa-miR-4270	CLIP-seq
MIRT2518758	hsa-miR-4290	CLIP-seq
MIRT943345	hsa-miR-4303	CLIP-seq
MIRT943347	hsa-miR-4329	CLIP-seq
MIRT2518759	hsa-miR-4419b	CLIP-seq
MIRT2518760	hsa-miR-4436a	CLIP-seq
MIRT2518761	hsa-miR-4436b-3p	CLIP-seq
MIRT2518762	hsa-miR-4441	CLIP-seq
MIRT2679400	hsa-miR-4453	CLIP-seq
MIRT2679401	hsa-miR-4468	CLIP-seq
MIRT2518764	hsa-miR-4476	CLIP-seq
MIRT2518765	hsa-miR-4478	CLIP-seq
MIRT943348	hsa-miR-4482	CLIP-seq
MIRT943349	hsa-miR-4486	CLIP-seq
MIRT2518766	hsa-miR-449c	CLIP-seq
MIRT2518767	hsa-miR-4512	CLIP-seq
MIRT2679402	hsa-miR-4527	CLIP-seq
MIRT2679403	hsa-miR-4538	CLIP-seq
MIRT943351	hsa-miR-455-3p	CLIP-seq
MIRT2518768	hsa-miR-4634	CLIP-seq
MIRT2679404	hsa-miR-4641	CLIP-seq
MIRT2518769	hsa-miR-4646-5p	CLIP-seq
MIRT2518770	hsa-miR-4667-3p	CLIP-seq
MIRT2518771	hsa-miR-4677-3p	CLIP-seq
MIRT2518772	hsa-miR-4679	CLIP-seq
MIRT2518773	hsa-miR-4687-5p	CLIP-seq
MIRT2518774	hsa-miR-4691-3p	CLIP-seq
MIRT2518775	hsa-miR-4691-5p	CLIP-seq
MIRT943353	hsa-miR-4693-3p	CLIP-seq
MIRT943354	hsa-miR-4707-5p	CLIP-seq
MIRT943355	hsa-miR-4717-5p	CLIP-seq
MIRT2518777	hsa-miR-4726-3p	CLIP-seq
MIRT2214500	hsa-miR-4736	CLIP-seq
MIRT2518779	hsa-miR-4740-3p	CLIP-seq
MIRT2518780	hsa-miR-4747-5p	CLIP-seq
MIRT2214501	hsa-miR-4763-3p	CLIP-seq
MIRT2518782	hsa-miR-4786-5p	CLIP-seq
MIRT2518783	hsa-miR-513a-5p	CLIP-seq
MIRT2518784	hsa-miR-532-3p	CLIP-seq
MIRT2518786	hsa-miR-548aa	CLIP-seq
MIRT943362	hsa-miR-548o	CLIP-seq
MIRT943363	hsa-miR-612	CLIP-seq
MIRT2518787	hsa-miR-615-5p	CLIP-seq
MIRT2518788	hsa-miR-619	CLIP-seq
MIRT2518789	hsa-miR-622	CLIP-seq
MIRT2518790	hsa-miR-648	CLIP-seq
MIRT2518791	hsa-miR-651	CLIP-seq
MIRT2518792	hsa-miR-661	CLIP-seq
MIRT2518793	hsa-miR-662	CLIP-seq
MIRT2518794	hsa-miR-764	CLIP-seq
MIRT2679405	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006486	Process	Protein glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	IBA
GO:0006487	Process	Protein N-linked glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	ISS
GO:0006489	Process	Dolichyl diphosphate biosynthetic process	TAS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0047874	Function	Dolichyldiphosphatase activity	IBA
GO:0047874	Function	Dolichyldiphosphatase activity	IEA
GO:0047874	Function	Dolichyldiphosphatase activity	ISS
GO:0047874	Function	Dolichyldiphosphatase activity	TAS

Other IDs

• MIM: 614516
• HGNC: 29565
• e!Ensembl: ENSG00000167130

Protein

• UniProt ID: Q86YN1
• Protein name: Dolichyldiphosphatase 1 (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase 1)
• Protein function: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01569	PAP2	58 → 187	PAP2 superfamily	Family

• Sequence:

  MAADGQCSLPASWRPVTLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTI
  SFLGGLALNEGVNWLIKNVIQEPRPCGGPHTAVGTKYGMPSSHSQFMWFFSVYSFLFLYL
  RMHQTNNARFLDLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWF
  IFTQEVLTPLFPRIAAWPVSEFFLIRDTSLIPNVLWFEYTVTRAEARNRQRKLGTKLQ

• Sequence length: 238

Pathways

KEGG:

N-Glycan biosynthesis
Metabolic pathways

Reactome:

Synthesis of Dolichyl-phosphate

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	31338870		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	31338870	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	31338870		★☆☆☆☆ Found in Text Mining only