Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57143
Gene name	AarF domain containing kinase 1
Gene symbol	ADCK1
Synonyms (NCBI Gene)	MCP2
Chromosome	14
Chromosome location	14q24.3

183

Show/Hide all (183)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017275	hsa-miR-335-5p	Microarray	18185580
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT767674	hsa-miR-31	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT767676	hsa-miR-3919	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT767679	hsa-miR-4756-3p	CLIP-seq
MIRT767680	hsa-miR-4786-5p	CLIP-seq
MIRT767681	hsa-miR-591	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT1926209	hsa-miR-191	CLIP-seq
MIRT1926210	hsa-miR-3144-5p	CLIP-seq
MIRT1926211	hsa-miR-3191	CLIP-seq
MIRT1926212	hsa-miR-3202	CLIP-seq
MIRT1926213	hsa-miR-4434	CLIP-seq
MIRT1926214	hsa-miR-4516	CLIP-seq
MIRT1926215	hsa-miR-4652-5p	CLIP-seq
MIRT1926216	hsa-miR-4727-3p	CLIP-seq
MIRT1926217	hsa-miR-4747-5p	CLIP-seq
MIRT1926218	hsa-miR-491-5p	CLIP-seq
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT1926209	hsa-miR-191	CLIP-seq
MIRT2167439	hsa-miR-3065-5p	CLIP-seq
MIRT1926210	hsa-miR-3144-5p	CLIP-seq
MIRT1926211	hsa-miR-3191	CLIP-seq
MIRT1926212	hsa-miR-3202	CLIP-seq
MIRT2167440	hsa-miR-326	CLIP-seq
MIRT2167441	hsa-miR-330-5p	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT2167442	hsa-miR-4283	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT2167443	hsa-miR-4489	CLIP-seq
MIRT2167444	hsa-miR-4522	CLIP-seq
MIRT1926215	hsa-miR-4652-5p	CLIP-seq
MIRT2167445	hsa-miR-4667-5p	CLIP-seq
MIRT2167446	hsa-miR-4694-3p	CLIP-seq
MIRT2167447	hsa-miR-4700-5p	CLIP-seq
MIRT1926216	hsa-miR-4727-3p	CLIP-seq
MIRT2167448	hsa-miR-4734	CLIP-seq
MIRT1926217	hsa-miR-4747-5p	CLIP-seq
MIRT2167449	hsa-miR-4767	CLIP-seq
MIRT1926218	hsa-miR-491-5p	CLIP-seq
MIRT2167450	hsa-miR-604	CLIP-seq
MIRT2167451	hsa-miR-637	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT2443178	hsa-miR-125a-5p	CLIP-seq
MIRT2443179	hsa-miR-125b	CLIP-seq
MIRT2443180	hsa-miR-1291	CLIP-seq
MIRT2443181	hsa-miR-296-5p	CLIP-seq
MIRT2443182	hsa-miR-4265	CLIP-seq
MIRT2443183	hsa-miR-4296	CLIP-seq
MIRT2443184	hsa-miR-4319	CLIP-seq
MIRT2443185	hsa-miR-4322	CLIP-seq
MIRT2443186	hsa-miR-4324	CLIP-seq
MIRT2443187	hsa-miR-4329	CLIP-seq
MIRT2443188	hsa-miR-4417	CLIP-seq
MIRT2470035	hsa-miR-1	CLIP-seq
MIRT2470036	hsa-miR-103b	CLIP-seq
MIRT2470037	hsa-miR-1193	CLIP-seq
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT2470038	hsa-miR-1253	CLIP-seq
MIRT2470039	hsa-miR-1270	CLIP-seq
MIRT2470040	hsa-miR-128	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT2470041	hsa-miR-134	CLIP-seq
MIRT2470042	hsa-miR-147b	CLIP-seq
MIRT2470043	hsa-miR-206	CLIP-seq
MIRT2470044	hsa-miR-2277-3p	CLIP-seq
MIRT2470045	hsa-miR-2392	CLIP-seq
MIRT767674	hsa-miR-31	CLIP-seq
MIRT2470046	hsa-miR-3118	CLIP-seq
MIRT2470047	hsa-miR-3150b-3p	CLIP-seq
MIRT2470048	hsa-miR-3164	CLIP-seq
MIRT2470049	hsa-miR-3173-3p	CLIP-seq
MIRT2470050	hsa-miR-3185	CLIP-seq
MIRT2167440	hsa-miR-326	CLIP-seq
MIRT2470051	hsa-miR-328	CLIP-seq
MIRT2167441	hsa-miR-330-5p	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT2470052	hsa-miR-3670	CLIP-seq
MIRT2470053	hsa-miR-3688-5p	CLIP-seq
MIRT2470054	hsa-miR-3929	CLIP-seq
MIRT2167442	hsa-miR-4283	CLIP-seq
MIRT2470055	hsa-miR-4302	CLIP-seq
MIRT2470056	hsa-miR-432	CLIP-seq
MIRT2470057	hsa-miR-4419b	CLIP-seq
MIRT1926213	hsa-miR-4434	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT2470058	hsa-miR-4470	CLIP-seq
MIRT2470059	hsa-miR-4478	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT2167443	hsa-miR-4489	CLIP-seq
MIRT1926214	hsa-miR-4516	CLIP-seq
MIRT2470060	hsa-miR-4519	CLIP-seq
MIRT2470061	hsa-miR-4520a-3p	CLIP-seq
MIRT2167444	hsa-miR-4522	CLIP-seq
MIRT2470062	hsa-miR-4531	CLIP-seq
MIRT2470063	hsa-miR-4653-3p	CLIP-seq
MIRT2470064	hsa-miR-4663	CLIP-seq
MIRT2167445	hsa-miR-4667-5p	CLIP-seq
MIRT2167446	hsa-miR-4694-3p	CLIP-seq
MIRT2167447	hsa-miR-4700-5p	CLIP-seq
MIRT2470065	hsa-miR-4715-5p	CLIP-seq
MIRT2167448	hsa-miR-4734	CLIP-seq
MIRT2167449	hsa-miR-4767	CLIP-seq
MIRT2470066	hsa-miR-4778-3p	CLIP-seq
MIRT2470067	hsa-miR-4784	CLIP-seq
MIRT2470068	hsa-miR-4802-3p	CLIP-seq
MIRT2470069	hsa-miR-516b	CLIP-seq
MIRT2470070	hsa-miR-571	CLIP-seq
MIRT2167450	hsa-miR-604	CLIP-seq
MIRT2470071	hsa-miR-613	CLIP-seq
MIRT2470072	hsa-miR-617	CLIP-seq
MIRT2470073	hsa-miR-620	CLIP-seq
MIRT2470074	hsa-miR-627	CLIP-seq
MIRT2167451	hsa-miR-637	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT2470075	hsa-miR-648	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT2470076	hsa-miR-658	CLIP-seq
MIRT2470077	hsa-miR-720	CLIP-seq
MIRT2470078	hsa-miR-765	CLIP-seq
MIRT2470079	hsa-miR-924	CLIP-seq
MIRT2470035	hsa-miR-1	CLIP-seq
MIRT2470036	hsa-miR-103b	CLIP-seq
MIRT2470037	hsa-miR-1193	CLIP-seq
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT2470040	hsa-miR-128	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT2470042	hsa-miR-147b	CLIP-seq
MIRT1926209	hsa-miR-191	CLIP-seq
MIRT2470043	hsa-miR-206	CLIP-seq
MIRT2470044	hsa-miR-2277-3p	CLIP-seq
MIRT2470045	hsa-miR-2392	CLIP-seq
MIRT767674	hsa-miR-31	CLIP-seq
MIRT2470047	hsa-miR-3150b-3p	CLIP-seq
MIRT2470049	hsa-miR-3173-3p	CLIP-seq
MIRT1926212	hsa-miR-3202	CLIP-seq
MIRT2167440	hsa-miR-326	CLIP-seq
MIRT2470051	hsa-miR-328	CLIP-seq
MIRT2167441	hsa-miR-330-5p	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT2470052	hsa-miR-3670	CLIP-seq
MIRT2470053	hsa-miR-3688-5p	CLIP-seq
MIRT2470054	hsa-miR-3929	CLIP-seq
MIRT2167442	hsa-miR-4283	CLIP-seq
MIRT2470055	hsa-miR-4302	CLIP-seq
MIRT2470057	hsa-miR-4419b	CLIP-seq
MIRT1926213	hsa-miR-4434	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT2470058	hsa-miR-4470	CLIP-seq
MIRT2470059	hsa-miR-4478	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT2167443	hsa-miR-4489	CLIP-seq
MIRT1926214	hsa-miR-4516	CLIP-seq
MIRT2470060	hsa-miR-4519	CLIP-seq
MIRT2470061	hsa-miR-4520a-3p	CLIP-seq
MIRT2167444	hsa-miR-4522	CLIP-seq
MIRT2470063	hsa-miR-4653-3p	CLIP-seq
MIRT2167445	hsa-miR-4667-5p	CLIP-seq
MIRT2167447	hsa-miR-4700-5p	CLIP-seq
MIRT2470065	hsa-miR-4715-5p	CLIP-seq
MIRT1926216	hsa-miR-4727-3p	CLIP-seq
MIRT2167448	hsa-miR-4734	CLIP-seq
MIRT1926217	hsa-miR-4747-5p	CLIP-seq
MIRT2167449	hsa-miR-4767	CLIP-seq
MIRT2470067	hsa-miR-4784	CLIP-seq
MIRT2470068	hsa-miR-4802-3p	CLIP-seq
MIRT2470070	hsa-miR-571	CLIP-seq
MIRT2167450	hsa-miR-604	CLIP-seq
MIRT2470071	hsa-miR-613	CLIP-seq
MIRT2167451	hsa-miR-637	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT2470075	hsa-miR-648	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT2470076	hsa-miR-658	CLIP-seq
MIRT2470078	hsa-miR-765	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	33988507
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0007005	Process	Mitochondrion organization	IBA
GO:0010637	Process	Negative regulation of mitochondrial fusion	IMP	31125351
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0055088	Process	Lipid homeostasis	IBA
GO:1903852	Process	Positive regulation of cristae formation	IMP	31125351

MIM	HGNC	e!Ensembl
620399	19038	ENSG00000063761

Q86TW2

Protein name

AarF domain-containing protein kinase 1 (EC 2.7.-.-)

Protein function

Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03109	ABC1	143 → 259	ABC1 family	Family

Sequence

MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV
PYGSEEYLQLRSKSWPVFLQVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTS
TLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTV
AVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNA
EKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGK
MYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSL
IWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANY
LPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNT
CSFFRRTQISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL

Sequence length

530

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHONDROMALACIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinogenesis	Carcinogenesis	Pubtator	33824271	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33824271	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obsessive-Compulsive Disorder	Obsessive-Compulsive Disorder	GWASCAT_DG	30456828		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Optic Atrophy 1	Optic Atrophy	BEFREE	31125351		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parathyroid Neoplasms	Parathyroid neoplasm	Pubtator	28352668	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	27846195		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	30426252		★★★★★ ★☆☆☆☆ Found in Text Mining only

ADCK1 (aarF domain containing kinase 1)