LYRM4 (LYR motif containing 4)

Gene

• Entrez ID: 57128
• Gene name: LYR motif containing 4
• Gene symbol: LYRM4
• Synonyms (NCBI Gene): C6orf149, CGI-203, COXPD19, ISD11
• Chromosome: 6
• Chromosome location: 6p25.1
• Summary: The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT710697	hsa-miR-4459	HITS-CLIP	19536157
MIRT710696	hsa-miR-665	HITS-CLIP	19536157
MIRT710695	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT710694	hsa-miR-6134	HITS-CLIP	19536157
MIRT458154	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT458153	hsa-miR-6086	HITS-CLIP	19536157
MIRT458172	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT710693	hsa-miR-3689d	HITS-CLIP	19536157
MIRT710692	hsa-miR-6851-5p	HITS-CLIP	19536157
MIRT710691	hsa-miR-6880-5p	HITS-CLIP	19536157
MIRT710690	hsa-miR-7847-3p	HITS-CLIP	19536157
MIRT458168	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT458167	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT458165	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT702181	hsa-miR-1273e	HITS-CLIP	19536157
MIRT458164	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT458168	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT458167	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT458165	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT458163	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT458162	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT458161	hsa-miR-3174	HITS-CLIP	23313552
MIRT458159	hsa-miR-4257	HITS-CLIP	23313552
MIRT458160	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT458158	hsa-miR-3160-3p	HITS-CLIP	23313552
MIRT458157	hsa-miR-558	HITS-CLIP	23313552
MIRT458155	hsa-miR-4487	HITS-CLIP	23313552
MIRT458156	hsa-miR-1827	HITS-CLIP	23313552
MIRT458154	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT458153	hsa-miR-6086	HITS-CLIP	23313552
MIRT458152	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT458151	hsa-miR-3612	HITS-CLIP	23313552
MIRT458150	hsa-miR-650	HITS-CLIP	23313552
MIRT458149	hsa-miR-6073	HITS-CLIP	23313552
MIRT458148	hsa-miR-142-3p	HITS-CLIP	23313552
MIRT458147	hsa-miR-921	HITS-CLIP	23313552
MIRT702181	hsa-miR-1273e	HITS-CLIP	23313552
MIRT702180	hsa-miR-2681-3p	HITS-CLIP	23313552
MIRT702179	hsa-miR-4645-5p	HITS-CLIP	23313552
MIRT702178	hsa-miR-4673	HITS-CLIP	23313552
MIRT702177	hsa-miR-215-3p	HITS-CLIP	23313552
MIRT458172	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT702176	hsa-miR-3135b	HITS-CLIP	23313552
MIRT702175	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT702174	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT702173	hsa-miR-3652	HITS-CLIP	23313552
MIRT702172	hsa-miR-4430	HITS-CLIP	23313552
MIRT702171	hsa-miR-4466	HITS-CLIP	23313552
MIRT702170	hsa-miR-675-5p	HITS-CLIP	23313552
MIRT702169	hsa-miR-143-5p	HITS-CLIP	23313552
MIRT702168	hsa-miR-5698	HITS-CLIP	23313552
MIRT687620	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT458176	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT687619	hsa-miR-151a-5p	HITS-CLIP	23313552
MIRT687618	hsa-miR-151b	HITS-CLIP	23313552
MIRT687617	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT687616	hsa-miR-3926	HITS-CLIP	23313552
MIRT687615	hsa-miR-3606-5p	HITS-CLIP	23313552
MIRT219209	hsa-miR-548s	HITS-CLIP	23313552
MIRT458163	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT458162	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT458161	hsa-miR-3174	HITS-CLIP	23706177
MIRT458159	hsa-miR-4257	HITS-CLIP	23706177
MIRT458160	hsa-miR-1247-3p	HITS-CLIP	23706177
MIRT681419	hsa-miR-5186	HITS-CLIP	23706177
MIRT458158	hsa-miR-3160-3p	HITS-CLIP	23706177
MIRT458157	hsa-miR-558	HITS-CLIP	23706177
MIRT458155	hsa-miR-4487	HITS-CLIP	23706177
MIRT458156	hsa-miR-1827	HITS-CLIP	23706177
MIRT458154	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT458153	hsa-miR-6086	HITS-CLIP	23706177
MIRT458152	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT458151	hsa-miR-3612	HITS-CLIP	23706177
MIRT458150	hsa-miR-650	HITS-CLIP	23706177
MIRT458149	hsa-miR-6073	HITS-CLIP	23706177
MIRT458148	hsa-miR-142-3p	HITS-CLIP	23706177
MIRT458147	hsa-miR-921	HITS-CLIP	23706177
MIRT670506	hsa-miR-4787-5p	HITS-CLIP	23824327
MIRT670505	hsa-miR-4284	HITS-CLIP	23824327
MIRT670504	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670503	hsa-miR-3180	HITS-CLIP	23824327
MIRT670502	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT670501	hsa-miR-3196	HITS-CLIP	23824327
MIRT670500	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT670499	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT670498	hsa-miR-4488	HITS-CLIP	23824327
MIRT670497	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT670496	hsa-miR-7977	HITS-CLIP	23824327
MIRT458177	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT458176	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT458175	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT458174	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT458173	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT542118	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT458171	hsa-miR-661	PAR-CLIP	21572407
MIRT542117	hsa-miR-542-3p	PAR-CLIP	21572407
MIRT458170	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT458169	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT458166	hsa-miR-7703	PAR-CLIP	21572407
MIRT542116	hsa-miR-1262	PAR-CLIP	21572407
MIRT542115	hsa-miR-4701-3p	PAR-CLIP	21572407
MIRT542114	hsa-miR-6736-5p	PAR-CLIP	21572407
MIRT458164	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT495154	hsa-miR-1224-3p	PAR-CLIP	23708386
MIRT495153	hsa-miR-4286	PAR-CLIP	23708386
MIRT495152	hsa-miR-377-3p	PAR-CLIP	23708386
MIRT458177	hsa-miR-508-5p	PAR-CLIP	23592263
MIRT458176	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT458175	hsa-miR-6742-3p	PAR-CLIP	23592263
MIRT458174	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT458173	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT458172	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458171	hsa-miR-661	PAR-CLIP	23592263
MIRT458170	hsa-miR-6512-3p	PAR-CLIP	23592263
MIRT458169	hsa-miR-6720-5p	PAR-CLIP	23592263
MIRT458168	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT458166	hsa-miR-7703	PAR-CLIP	23592263
MIRT458167	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458165	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT458164	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT458163	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT458162	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT458161	hsa-miR-3174	PAR-CLIP	23592263
MIRT458159	hsa-miR-4257	PAR-CLIP	23592263
MIRT458160	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT458158	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT458157	hsa-miR-558	PAR-CLIP	23592263
MIRT458155	hsa-miR-4487	PAR-CLIP	23592263
MIRT458156	hsa-miR-1827	PAR-CLIP	23592263
MIRT458154	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT458153	hsa-miR-6086	PAR-CLIP	23592263
MIRT458152	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT458151	hsa-miR-3612	PAR-CLIP	23592263
MIRT458150	hsa-miR-650	PAR-CLIP	23592263
MIRT458149	hsa-miR-6073	PAR-CLIP	23592263
MIRT458148	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT458147	hsa-miR-921	PAR-CLIP	23592263
MIRT458160	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT458160	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT458148	hsa-miR-142-3p	PAR-CLIP	26701625
MIRT458148	hsa-miR-142-3p	PAR-CLIP	26701625
MIRT458156	hsa-miR-1827	PAR-CLIP	26701625
MIRT458156	hsa-miR-1827	PAR-CLIP	26701625
MIRT458163	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT458163	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT458152	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT458152	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT458158	hsa-miR-3160-3p	PAR-CLIP	26701625
MIRT458158	hsa-miR-3160-3p	PAR-CLIP	26701625
MIRT458161	hsa-miR-3174	PAR-CLIP	26701625
MIRT458161	hsa-miR-3174	PAR-CLIP	26701625
MIRT458151	hsa-miR-3612	PAR-CLIP	26701625
MIRT458151	hsa-miR-3612	PAR-CLIP	26701625
MIRT458154	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT458154	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT458159	hsa-miR-4257	PAR-CLIP	26701625
MIRT458159	hsa-miR-4257	PAR-CLIP	26701625
MIRT458155	hsa-miR-4487	PAR-CLIP	26701625
MIRT458155	hsa-miR-4487	PAR-CLIP	26701625
MIRT458157	hsa-miR-558	PAR-CLIP	26701625
MIRT458157	hsa-miR-558	PAR-CLIP	26701625
MIRT458149	hsa-miR-6073	PAR-CLIP	26701625
MIRT458149	hsa-miR-6073	PAR-CLIP	26701625
MIRT458153	hsa-miR-6086	PAR-CLIP	26701625
MIRT458153	hsa-miR-6086	PAR-CLIP	26701625
MIRT458150	hsa-miR-650	PAR-CLIP	26701625
MIRT458150	hsa-miR-650	PAR-CLIP	26701625
MIRT458162	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT458162	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT458147	hsa-miR-921	PAR-CLIP	26701625
MIRT458147	hsa-miR-921	PAR-CLIP	26701625
MIRT702181	hsa-miR-1273e	PAR-CLIP	27292025
MIRT710693	hsa-miR-3689d	PAR-CLIP	27292025
MIRT458154	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT710697	hsa-miR-4459	PAR-CLIP	27292025
MIRT458167	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT458153	hsa-miR-6086	PAR-CLIP	27292025
MIRT710694	hsa-miR-6134	PAR-CLIP	27292025
MIRT458172	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT458165	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT710696	hsa-miR-665	PAR-CLIP	27292025
MIRT458168	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT710695	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT710692	hsa-miR-6851-5p	PAR-CLIP	27292025
MIRT710691	hsa-miR-6880-5p	PAR-CLIP	27292025
MIRT710690	hsa-miR-7847-3p	PAR-CLIP	27292025
MIRT710697	hsa-miR-4459	HITS-CLIP	19536157
MIRT710696	hsa-miR-665	HITS-CLIP	19536157
MIRT710695	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT710694	hsa-miR-6134	HITS-CLIP	19536157
MIRT458154	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT458153	hsa-miR-6086	HITS-CLIP	19536157
MIRT458172	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT710693	hsa-miR-3689d	HITS-CLIP	19536157
MIRT710692	hsa-miR-6851-5p	HITS-CLIP	19536157
MIRT710691	hsa-miR-6880-5p	HITS-CLIP	19536157
MIRT710690	hsa-miR-7847-3p	HITS-CLIP	19536157
MIRT458168	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT458167	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT458165	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT702181	hsa-miR-1273e	HITS-CLIP	19536157
MIRT458164	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT458168	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT458167	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT458165	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT458163	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT458162	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT458161	hsa-miR-3174	HITS-CLIP	23313552
MIRT458159	hsa-miR-4257	HITS-CLIP	23313552
MIRT458160	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT458158	hsa-miR-3160-3p	HITS-CLIP	23313552
MIRT458157	hsa-miR-558	HITS-CLIP	23313552
MIRT458155	hsa-miR-4487	HITS-CLIP	23313552
MIRT458156	hsa-miR-1827	HITS-CLIP	23313552
MIRT458154	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT458153	hsa-miR-6086	HITS-CLIP	23313552
MIRT458152	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT458151	hsa-miR-3612	HITS-CLIP	23313552
MIRT458150	hsa-miR-650	HITS-CLIP	23313552
MIRT458149	hsa-miR-6073	HITS-CLIP	23313552
MIRT458148	hsa-miR-142-3p	HITS-CLIP	23313552
MIRT458147	hsa-miR-921	HITS-CLIP	23313552
MIRT702181	hsa-miR-1273e	HITS-CLIP	23313552
MIRT702180	hsa-miR-2681-3p	HITS-CLIP	23313552
MIRT702179	hsa-miR-4645-5p	HITS-CLIP	23313552
MIRT702178	hsa-miR-4673	HITS-CLIP	23313552
MIRT702177	hsa-miR-215-3p	HITS-CLIP	23313552
MIRT458172	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT702176	hsa-miR-3135b	HITS-CLIP	23313552
MIRT702175	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT702174	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT702173	hsa-miR-3652	HITS-CLIP	23313552
MIRT702172	hsa-miR-4430	HITS-CLIP	23313552
MIRT702171	hsa-miR-4466	HITS-CLIP	23313552
MIRT702170	hsa-miR-675-5p	HITS-CLIP	23313552
MIRT702169	hsa-miR-143-5p	HITS-CLIP	23313552
MIRT702168	hsa-miR-5698	HITS-CLIP	23313552
MIRT687620	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT458176	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT687619	hsa-miR-151a-5p	HITS-CLIP	23313552
MIRT687618	hsa-miR-151b	HITS-CLIP	23313552
MIRT687617	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT687616	hsa-miR-3926	HITS-CLIP	23313552
MIRT687615	hsa-miR-3606-5p	HITS-CLIP	23313552
MIRT219209	hsa-miR-548s	HITS-CLIP	23313552
MIRT458163	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT458162	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT458161	hsa-miR-3174	HITS-CLIP	23706177
MIRT458159	hsa-miR-4257	HITS-CLIP	23706177
MIRT458160	hsa-miR-1247-3p	HITS-CLIP	23706177
MIRT681419	hsa-miR-5186	HITS-CLIP	23706177
MIRT458158	hsa-miR-3160-3p	HITS-CLIP	23706177
MIRT458157	hsa-miR-558	HITS-CLIP	23706177
MIRT458155	hsa-miR-4487	HITS-CLIP	23706177
MIRT458156	hsa-miR-1827	HITS-CLIP	23706177
MIRT458154	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT458153	hsa-miR-6086	HITS-CLIP	23706177
MIRT458152	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT458151	hsa-miR-3612	HITS-CLIP	23706177
MIRT458150	hsa-miR-650	HITS-CLIP	23706177
MIRT458149	hsa-miR-6073	HITS-CLIP	23706177
MIRT458148	hsa-miR-142-3p	HITS-CLIP	23706177
MIRT458147	hsa-miR-921	HITS-CLIP	23706177
MIRT670506	hsa-miR-4787-5p	HITS-CLIP	23824327
MIRT670505	hsa-miR-4284	HITS-CLIP	23824327
MIRT670504	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670503	hsa-miR-3180	HITS-CLIP	23824327
MIRT670502	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT670501	hsa-miR-3196	HITS-CLIP	23824327
MIRT670500	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT670499	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT670498	hsa-miR-4488	HITS-CLIP	23824327
MIRT670497	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT670496	hsa-miR-7977	HITS-CLIP	23824327
MIRT458177	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT458176	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT458175	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT458174	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT458173	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT542118	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT458171	hsa-miR-661	PAR-CLIP	21572407
MIRT542117	hsa-miR-542-3p	PAR-CLIP	21572407
MIRT458170	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT458169	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT458166	hsa-miR-7703	PAR-CLIP	21572407
MIRT542116	hsa-miR-1262	PAR-CLIP	21572407
MIRT542115	hsa-miR-4701-3p	PAR-CLIP	21572407
MIRT542114	hsa-miR-6736-5p	PAR-CLIP	21572407
MIRT458164	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT495154	hsa-miR-1224-3p	PAR-CLIP	23708386
MIRT495153	hsa-miR-4286	PAR-CLIP	23708386
MIRT495152	hsa-miR-377-3p	PAR-CLIP	23708386
MIRT458177	hsa-miR-508-5p	PAR-CLIP	23592263
MIRT458176	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT458175	hsa-miR-6742-3p	PAR-CLIP	23592263
MIRT458174	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT458173	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT458172	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458171	hsa-miR-661	PAR-CLIP	23592263
MIRT458170	hsa-miR-6512-3p	PAR-CLIP	23592263
MIRT458169	hsa-miR-6720-5p	PAR-CLIP	23592263
MIRT458168	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT458166	hsa-miR-7703	PAR-CLIP	23592263
MIRT458167	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458165	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT458164	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT458163	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT458162	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT458161	hsa-miR-3174	PAR-CLIP	23592263
MIRT458159	hsa-miR-4257	PAR-CLIP	23592263
MIRT458160	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT458158	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT458157	hsa-miR-558	PAR-CLIP	23592263
MIRT458155	hsa-miR-4487	PAR-CLIP	23592263
MIRT458156	hsa-miR-1827	PAR-CLIP	23592263
MIRT458154	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT458153	hsa-miR-6086	PAR-CLIP	23592263
MIRT458152	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT458151	hsa-miR-3612	PAR-CLIP	23592263
MIRT458150	hsa-miR-650	PAR-CLIP	23592263
MIRT458149	hsa-miR-6073	PAR-CLIP	23592263
MIRT458148	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT458147	hsa-miR-921	PAR-CLIP	23592263
MIRT1123782	hsa-miR-3122	CLIP-seq
MIRT1123783	hsa-miR-3165	CLIP-seq
MIRT1123784	hsa-miR-3614-5p	CLIP-seq
MIRT1123785	hsa-miR-3665	CLIP-seq
MIRT1123786	hsa-miR-3689a-3p	CLIP-seq
MIRT1123787	hsa-miR-3689c	CLIP-seq
MIRT1123788	hsa-miR-3913-5p	CLIP-seq
MIRT1123789	hsa-miR-3929	CLIP-seq
MIRT1123790	hsa-miR-4419b	CLIP-seq
MIRT1123791	hsa-miR-4436a	CLIP-seq
MIRT1123792	hsa-miR-4478	CLIP-seq
MIRT1123793	hsa-miR-4649-3p	CLIP-seq
MIRT1123794	hsa-miR-4728-5p	CLIP-seq
MIRT1123795	hsa-miR-4736	CLIP-seq
MIRT1123796	hsa-miR-4786-5p	CLIP-seq
MIRT1123797	hsa-miR-485-5p	CLIP-seq
MIRT1123798	hsa-miR-940	CLIP-seq
MIRT1123799	hsa-miR-1225-3p	CLIP-seq
MIRT1123800	hsa-miR-323-5p	CLIP-seq
MIRT1123801	hsa-miR-3681	CLIP-seq
MIRT1123802	hsa-miR-3691-5p	CLIP-seq
MIRT1123803	hsa-miR-371-5p	CLIP-seq
MIRT1123804	hsa-miR-371b-5p	CLIP-seq
MIRT1123805	hsa-miR-3943	CLIP-seq
MIRT1123806	hsa-miR-4281	CLIP-seq
MIRT1123807	hsa-miR-4292	CLIP-seq
MIRT1123808	hsa-miR-4308	CLIP-seq
MIRT1123809	hsa-miR-4693-3p	CLIP-seq
MIRT1123810	hsa-miR-4728-3p	CLIP-seq
MIRT1123811	hsa-miR-493	CLIP-seq
MIRT2035005	hsa-miR-134	CLIP-seq
MIRT2035006	hsa-miR-3118	CLIP-seq
MIRT2035007	hsa-miR-3164	CLIP-seq
MIRT2035008	hsa-miR-4501	CLIP-seq
MIRT2035009	hsa-miR-570	CLIP-seq
MIRT2265438	hsa-miR-188-3p	CLIP-seq
MIRT2265439	hsa-miR-1909	CLIP-seq
MIRT2265440	hsa-miR-361-5p	CLIP-seq
MIRT1123791	hsa-miR-4436a	CLIP-seq
MIRT2265441	hsa-miR-4514	CLIP-seq
MIRT2265442	hsa-miR-4692	CLIP-seq
MIRT2265443	hsa-miR-4700-3p	CLIP-seq
MIRT2265444	hsa-miR-4778-5p	CLIP-seq
MIRT2265445	hsa-miR-532-3p	CLIP-seq
MIRT2265446	hsa-miR-885-3p	CLIP-seq
MIRT2390421	hsa-miR-1228	CLIP-seq
MIRT2390422	hsa-miR-128	CLIP-seq
MIRT1123782	hsa-miR-3122	CLIP-seq
MIRT1123783	hsa-miR-3165	CLIP-seq
MIRT1123785	hsa-miR-3665	CLIP-seq
MIRT1123786	hsa-miR-3689a-3p	CLIP-seq
MIRT1123787	hsa-miR-3689c	CLIP-seq
MIRT2390423	hsa-miR-377	CLIP-seq
MIRT1123788	hsa-miR-3913-5p	CLIP-seq
MIRT1123789	hsa-miR-3929	CLIP-seq
MIRT1123790	hsa-miR-4419b	CLIP-seq
MIRT1123791	hsa-miR-4436a	CLIP-seq
MIRT1123792	hsa-miR-4478	CLIP-seq
MIRT1123793	hsa-miR-4649-3p	CLIP-seq
MIRT1123794	hsa-miR-4728-5p	CLIP-seq
MIRT1123795	hsa-miR-4736	CLIP-seq
MIRT1123797	hsa-miR-485-5p	CLIP-seq
MIRT1123798	hsa-miR-940	CLIP-seq
MIRT2390421	hsa-miR-1228	CLIP-seq
MIRT1123782	hsa-miR-3122	CLIP-seq
MIRT1123783	hsa-miR-3165	CLIP-seq
MIRT1123784	hsa-miR-3614-5p	CLIP-seq
MIRT1123785	hsa-miR-3665	CLIP-seq
MIRT1123786	hsa-miR-3689a-3p	CLIP-seq
MIRT1123787	hsa-miR-3689c	CLIP-seq
MIRT1123788	hsa-miR-3913-5p	CLIP-seq
MIRT1123789	hsa-miR-3929	CLIP-seq
MIRT1123790	hsa-miR-4419b	CLIP-seq
MIRT1123791	hsa-miR-4436a	CLIP-seq
MIRT1123792	hsa-miR-4478	CLIP-seq
MIRT1123793	hsa-miR-4649-3p	CLIP-seq
MIRT1123794	hsa-miR-4728-5p	CLIP-seq
MIRT1123795	hsa-miR-4736	CLIP-seq
MIRT1123797	hsa-miR-485-5p	CLIP-seq
MIRT1123798	hsa-miR-940	CLIP-seq
MIRT2390421	hsa-miR-1228	CLIP-seq
MIRT1123782	hsa-miR-3122	CLIP-seq
MIRT1123783	hsa-miR-3165	CLIP-seq
MIRT1123784	hsa-miR-3614-5p	CLIP-seq
MIRT1123785	hsa-miR-3665	CLIP-seq
MIRT1123786	hsa-miR-3689a-3p	CLIP-seq
MIRT1123787	hsa-miR-3689c	CLIP-seq
MIRT1123788	hsa-miR-3913-5p	CLIP-seq
MIRT1123789	hsa-miR-3929	CLIP-seq
MIRT1123790	hsa-miR-4419b	CLIP-seq
MIRT1123792	hsa-miR-4478	CLIP-seq
MIRT1123793	hsa-miR-4649-3p	CLIP-seq
MIRT1123794	hsa-miR-4728-5p	CLIP-seq
MIRT1123795	hsa-miR-4736	CLIP-seq
MIRT1123797	hsa-miR-485-5p	CLIP-seq
MIRT1123798	hsa-miR-940	CLIP-seq
MIRT1123799	hsa-miR-1225-3p	CLIP-seq
MIRT2564639	hsa-miR-1226	CLIP-seq
MIRT2564640	hsa-miR-1250	CLIP-seq
MIRT2035005	hsa-miR-134	CLIP-seq
MIRT2564641	hsa-miR-141	CLIP-seq
MIRT2265438	hsa-miR-188-3p	CLIP-seq
MIRT2564642	hsa-miR-1910	CLIP-seq
MIRT2564643	hsa-miR-200a	CLIP-seq
MIRT2564644	hsa-miR-299-5p	CLIP-seq
MIRT2035006	hsa-miR-3118	CLIP-seq
MIRT1123782	hsa-miR-3122	CLIP-seq
MIRT2564645	hsa-miR-3127-5p	CLIP-seq
MIRT2035007	hsa-miR-3164	CLIP-seq
MIRT2564646	hsa-miR-3182	CLIP-seq
MIRT2564647	hsa-miR-3189-5p	CLIP-seq
MIRT2564648	hsa-miR-320e	CLIP-seq
MIRT2564649	hsa-miR-338-3p	CLIP-seq
MIRT2265440	hsa-miR-361-5p	CLIP-seq
MIRT1123786	hsa-miR-3689a-3p	CLIP-seq
MIRT1123787	hsa-miR-3689c	CLIP-seq
MIRT1123803	hsa-miR-371-5p	CLIP-seq
MIRT1123804	hsa-miR-371b-5p	CLIP-seq
MIRT1123788	hsa-miR-3913-5p	CLIP-seq
MIRT2564650	hsa-miR-3925-3p	CLIP-seq
MIRT1123805	hsa-miR-3943	CLIP-seq
MIRT2564651	hsa-miR-4274	CLIP-seq
MIRT2564652	hsa-miR-4300	CLIP-seq
MIRT1123791	hsa-miR-4436a	CLIP-seq
MIRT2035008	hsa-miR-4501	CLIP-seq
MIRT2265441	hsa-miR-4514	CLIP-seq
MIRT2265442	hsa-miR-4692	CLIP-seq
MIRT2265443	hsa-miR-4700-3p	CLIP-seq
MIRT2564653	hsa-miR-4758-3p	CLIP-seq
MIRT2564654	hsa-miR-4772-3p	CLIP-seq
MIRT2564655	hsa-miR-5096	CLIP-seq
MIRT2564656	hsa-miR-511	CLIP-seq
MIRT2564657	hsa-miR-515-5p	CLIP-seq
MIRT2265445	hsa-miR-532-3p	CLIP-seq
MIRT2564658	hsa-miR-596	CLIP-seq
MIRT2564659	hsa-miR-764	CLIP-seq
MIRT2564660	hsa-miR-766	CLIP-seq
MIRT2265446	hsa-miR-885-3p	CLIP-seq
MIRT2564661	hsa-miR-920	CLIP-seq
MIRT2564639	hsa-miR-1226	CLIP-seq
MIRT2564640	hsa-miR-1250	CLIP-seq
MIRT2035005	hsa-miR-134	CLIP-seq
MIRT2564641	hsa-miR-141	CLIP-seq
MIRT2265438	hsa-miR-188-3p	CLIP-seq
MIRT2564642	hsa-miR-1910	CLIP-seq
MIRT2564643	hsa-miR-200a	CLIP-seq
MIRT2564644	hsa-miR-299-5p	CLIP-seq
MIRT2035006	hsa-miR-3118	CLIP-seq
MIRT1123782	hsa-miR-3122	CLIP-seq
MIRT2035007	hsa-miR-3164	CLIP-seq
MIRT2564646	hsa-miR-3182	CLIP-seq
MIRT2564648	hsa-miR-320e	CLIP-seq
MIRT2265440	hsa-miR-361-5p	CLIP-seq
MIRT1123786	hsa-miR-3689a-3p	CLIP-seq
MIRT1123787	hsa-miR-3689c	CLIP-seq
MIRT1123788	hsa-miR-3913-5p	CLIP-seq
MIRT2564650	hsa-miR-3925-3p	CLIP-seq
MIRT2564651	hsa-miR-4274	CLIP-seq
MIRT2564652	hsa-miR-4300	CLIP-seq
MIRT1123791	hsa-miR-4436a	CLIP-seq
MIRT2035008	hsa-miR-4501	CLIP-seq
MIRT2265441	hsa-miR-4514	CLIP-seq
MIRT2265442	hsa-miR-4692	CLIP-seq
MIRT2265443	hsa-miR-4700-3p	CLIP-seq
MIRT2564654	hsa-miR-4772-3p	CLIP-seq
MIRT2564655	hsa-miR-5096	CLIP-seq
MIRT2564656	hsa-miR-511	CLIP-seq
MIRT2564657	hsa-miR-515-5p	CLIP-seq
MIRT2265445	hsa-miR-532-3p	CLIP-seq
MIRT2564658	hsa-miR-596	CLIP-seq
MIRT2564659	hsa-miR-764	CLIP-seq
MIRT2564660	hsa-miR-766	CLIP-seq
MIRT2265446	hsa-miR-885-3p	CLIP-seq
MIRT2564661	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005198	Function	Structural molecule activity	IDA	28634302
GO:0005515	Function	Protein binding	IPI	18650437, 26342079, 27499296, 29097656, 31664822, 33961781
GO:0005634	Component	Nucleus	IDA	23593335
GO:0005634	Component	Nucleus	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	17331979, 23593335
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	27519411
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0016226	Process	Iron-sulfur cluster assembly	IBA
GO:0016226	Process	Iron-sulfur cluster assembly	IEA
GO:0016226	Process	Iron-sulfur cluster assembly	NAS	29097656
GO:0016604	Component	Nuclear body	IDA
GO:0042803	Function	Protein homodimerization activity	IDA	29097656, 34824239
GO:0044571	Process	[2Fe-2S] cluster assembly	IDA	17331979, 31664822
GO:0044572	Process	[4Fe-4S] cluster assembly	IEA
GO:0044572	Process	[4Fe-4S] cluster assembly	ISS
GO:0099128	Component	Mitochondrial [2Fe-2S] assembly complex	IDA	21298097, 31101807
GO:0099128	Component	Mitochondrial [2Fe-2S] assembly complex	IEA
GO:1990221	Component	L-cysteine desulfurase complex	IBA
GO:1990229	Component	Iron-sulfur cluster assembly complex	NAS	29097656

Other IDs

• MIM: 613311
• HGNC: 21365
• e!Ensembl: ENSG00000214113

Protein

• UniProt ID: Q9HD34
• Protein name: LYR motif-containing protein 4
• Protein function: Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffo
• PDB: 5USR, 5WGB, 5WKP, 5WLW, 6NZU, 6ODD, 6UXE, 6W1D, 6WI2, 6WIH, 7RTK, 8PK8, 8PK9, 8PKA, 8RMC, 8RMD, 8RME, 8RMF, 8RMG, 8TVT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05347	Complex1_LYR	7 → 65	Complex 1 protein (LYR family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Reduced mRNA levels in Friedreich ataxia patients. {ECO:0000269|PubMed:17331979}.
• Sequence:

  MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAK
  RDLGVIRRQVHIGQLYSTDKLIIENRDMPRT

• Sequence length: 91

Pathways

Reactome:

Mitochondrial iron-sulfur cluster biogenesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Combined oxidative phosphorylation deficiency 19	Pathogenic	rs587777218	RCV000088687	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LYRM4-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adamantinous Craniopharyngioma	Adamantinous Craniopharyngioma	BEFREE	30031876		★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	19068216	Associate	★☆☆☆☆ Found in Text Mining only
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19	Combined Oxidative Phosphorylation Deficiency	GENOMICS_ENGLAND_DG	23814038		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19	Combined Oxidative Phosphorylation Deficiency	UNIPROT_DG	23814038		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19	Combined Oxidative Phosphorylation Deficiency	CLINVAR_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19	Combined Oxidative Phosphorylation Deficiency	CTD_human_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Crohn Disease	Crohn Disease	GWASDB_DG	18587394		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	19068216	Associate	★☆☆☆☆ Found in Text Mining only
Cytochrome c Oxidase Deficiency	Cytochrome c oxidase deficiency	Pubtator	23814038	Associate	★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	HPO_DG			★☆☆☆☆ Found in Text Mining only
FRIEDREICH ATAXIA 1	Friedreich Ataxia	BEFREE	17331979		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37810780	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial complex I deficiency	Mitochondrial complex deficiency	Pubtator	23814038	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	23814038, 26342079	Associate	★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only
Neonatal Hypotonia	Hypotonia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	20398431		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	21968932, 23069351		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	21968932		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency	Lactic Acidosis	ORPHANET_DG	23814038		★☆☆☆☆ Found in Text Mining only
Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency	Lactic Acidosis	Orphanet			★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	19068216		★☆☆☆☆ Found in Text Mining only