Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57121
Gene name	Lysophosphatidic acid receptor 5
Gene symbol	LPAR5
Synonyms (NCBI Gene)	GPR92GPR93KPG_010LPA5
Chromosome	12
Chromosome location	12p13.31
Summary	This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Ma

Show/Hide all (31)

miRTarBase ID	miRNA	Experiments
MIRT1115475	hsa-miR-1254	CLIP-seq
MIRT1115476	hsa-miR-3116	CLIP-seq
MIRT1115477	hsa-miR-3148	CLIP-seq
MIRT1115478	hsa-miR-4286	CLIP-seq
MIRT1115479	hsa-miR-4290	CLIP-seq
MIRT1115480	hsa-miR-4315	CLIP-seq
MIRT1115481	hsa-miR-4695-5p	CLIP-seq
MIRT1115482	hsa-miR-4764-5p	CLIP-seq
MIRT1115483	hsa-miR-4775	CLIP-seq
MIRT1115484	hsa-miR-4790-5p	CLIP-seq
MIRT1115485	hsa-miR-548c-3p	CLIP-seq
MIRT1115486	hsa-miR-630	CLIP-seq
MIRT1115487	hsa-miR-765	CLIP-seq
MIRT1115488	hsa-miR-875-3p	CLIP-seq
MIRT1115489	hsa-miR-1269	CLIP-seq
MIRT1115490	hsa-miR-1269b	CLIP-seq
MIRT1115491	hsa-miR-3133	CLIP-seq
MIRT1115492	hsa-miR-4520b-3p	CLIP-seq
MIRT1115493	hsa-miR-4529-3p	CLIP-seq
MIRT1115482	hsa-miR-4764-5p	CLIP-seq
MIRT1115494	hsa-miR-653	CLIP-seq
MIRT1115495	hsa-miR-890	CLIP-seq
MIRT2032477	hsa-miR-186	CLIP-seq
MIRT2453224	hsa-miR-1253	CLIP-seq
MIRT2453225	hsa-miR-185	CLIP-seq
MIRT2453226	hsa-miR-3150b-3p	CLIP-seq
MIRT2453227	hsa-miR-4306	CLIP-seq
MIRT2453228	hsa-miR-4434	CLIP-seq
MIRT2453229	hsa-miR-4516	CLIP-seq
MIRT2453230	hsa-miR-4644	CLIP-seq
MIRT2453231	hsa-miR-4784	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0048266	Process	Behavioral response to pain	IBA
GO:0048266	Process	Behavioral response to pain	IEA

MIM	HGNC	e!Ensembl
606926	13307	ENSG00000184574

Q9H1C0

Protein name

Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)

Protein function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	39 → 297	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

Sequence

MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVY
MCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRY
AAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFS
DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANL
VIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFS
AEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSL
SSFTQCPQDSAL

Sequence length

372

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Pathways in cancer		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arrhythmogenic Right Ventricular Dysplasia	Arrhythmogenic right ventricular cardiomyopathy	Pubtator	30664203	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Platelet Disorders	Platelet disorder	Pubtator	21106562	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	31902939	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	28050783		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	24676544		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33408717	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hashimoto Disease	Hashimoto disease	Pubtator	37324256	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	25158955, 29309788		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	18754873	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	25294670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25158955		★★★★★ ★☆☆☆☆ Found in Text Mining only
Niemann-Pick Disease, Type C	Niemann-Pick Disease	BEFREE	25294670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29236751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	24676544		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	36591220	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36806315	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	30872410, 31902939, 32766727, 34115774, 34814333, 37037831, 37324256	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	31902939	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LPAR5 (lysophosphatidic acid receptor 5)