Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57109
Gene name	REX4 homolog, 3'-5' exonuclease
Gene symbol	REXO4
Synonyms (NCBI Gene)	REX4XPMC2XPMC2H
Chromosome	9
Chromosome location	9q34.2

111

Show/Hide all (111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028599	hsa-miR-30a-5p	Proteomics	18668040
MIRT041926	hsa-miR-484	CLASH	23622248
MIRT040143	hsa-miR-615-3p	CLASH	23622248
MIRT1301451	hsa-miR-1286	CLIP-seq
MIRT1301452	hsa-miR-1343	CLIP-seq
MIRT1301453	hsa-miR-149	CLIP-seq
MIRT1301454	hsa-miR-15a	CLIP-seq
MIRT1301455	hsa-miR-15b	CLIP-seq
MIRT1301456	hsa-miR-16	CLIP-seq
MIRT1301457	hsa-miR-194	CLIP-seq
MIRT1301458	hsa-miR-195	CLIP-seq
MIRT1301459	hsa-miR-214	CLIP-seq
MIRT1301460	hsa-miR-3064-5p	CLIP-seq
MIRT1301461	hsa-miR-30a	CLIP-seq
MIRT1301462	hsa-miR-30b	CLIP-seq
MIRT1301463	hsa-miR-30c	CLIP-seq
MIRT1301464	hsa-miR-30d	CLIP-seq
MIRT1301465	hsa-miR-30e	CLIP-seq
MIRT1301466	hsa-miR-3169	CLIP-seq
MIRT1301467	hsa-miR-3171	CLIP-seq
MIRT1301468	hsa-miR-3180	CLIP-seq
MIRT1301469	hsa-miR-3180-3p	CLIP-seq
MIRT1301470	hsa-miR-3196	CLIP-seq
MIRT1301471	hsa-miR-3591-3p	CLIP-seq
MIRT1301472	hsa-miR-3619-5p	CLIP-seq
MIRT1301473	hsa-miR-3691-3p	CLIP-seq
MIRT1301474	hsa-miR-424	CLIP-seq
MIRT1301475	hsa-miR-4326	CLIP-seq
MIRT1301476	hsa-miR-4436b-3p	CLIP-seq
MIRT1301477	hsa-miR-4687-3p	CLIP-seq
MIRT1301478	hsa-miR-4729	CLIP-seq
MIRT1301479	hsa-miR-4781-5p	CLIP-seq
MIRT1301480	hsa-miR-497	CLIP-seq
MIRT1301481	hsa-miR-621	CLIP-seq
MIRT1301482	hsa-miR-744	CLIP-seq
MIRT1301483	hsa-miR-760	CLIP-seq
MIRT1301484	hsa-miR-761	CLIP-seq
MIRT1301485	hsa-miR-892b	CLIP-seq
MIRT2089479	hsa-miR-1269	CLIP-seq
MIRT2089480	hsa-miR-1269b	CLIP-seq
MIRT2089481	hsa-miR-1288	CLIP-seq
MIRT2089482	hsa-miR-1915	CLIP-seq
MIRT2089483	hsa-miR-2277-3p	CLIP-seq
MIRT2089484	hsa-miR-3065-3p	CLIP-seq
MIRT2089485	hsa-miR-34a	CLIP-seq
MIRT2089486	hsa-miR-34c-5p	CLIP-seq
MIRT2089487	hsa-miR-4267	CLIP-seq
MIRT2089488	hsa-miR-4426	CLIP-seq
MIRT2089489	hsa-miR-4467	CLIP-seq
MIRT2089490	hsa-miR-449a	CLIP-seq
MIRT2089491	hsa-miR-449b	CLIP-seq
MIRT2089492	hsa-miR-4515	CLIP-seq
MIRT2089493	hsa-miR-4647	CLIP-seq
MIRT2089494	hsa-miR-4662b	CLIP-seq
MIRT2089495	hsa-miR-4671-5p	CLIP-seq
MIRT2089496	hsa-miR-4740-5p	CLIP-seq
MIRT2089497	hsa-miR-4749-3p	CLIP-seq
MIRT2089498	hsa-miR-542-3p	CLIP-seq
MIRT2089499	hsa-miR-597	CLIP-seq
MIRT2314412	hsa-miR-125a-3p	CLIP-seq
MIRT2314413	hsa-miR-1266	CLIP-seq
MIRT1301451	hsa-miR-1286	CLIP-seq
MIRT1301454	hsa-miR-15a	CLIP-seq
MIRT1301455	hsa-miR-15b	CLIP-seq
MIRT1301456	hsa-miR-16	CLIP-seq
MIRT2314414	hsa-miR-1913	CLIP-seq
MIRT2089482	hsa-miR-1915	CLIP-seq
MIRT1301458	hsa-miR-195	CLIP-seq
MIRT2314415	hsa-miR-198	CLIP-seq
MIRT1301459	hsa-miR-214	CLIP-seq
MIRT2314416	hsa-miR-28-5p	CLIP-seq
MIRT2314417	hsa-miR-3125	CLIP-seq
MIRT2314418	hsa-miR-3136-3p	CLIP-seq
MIRT2314419	hsa-miR-3139	CLIP-seq
MIRT1301466	hsa-miR-3169	CLIP-seq
MIRT1301468	hsa-miR-3180	CLIP-seq
MIRT1301469	hsa-miR-3180-3p	CLIP-seq
MIRT1301470	hsa-miR-3196	CLIP-seq
MIRT2314420	hsa-miR-324-3p	CLIP-seq
MIRT2314421	hsa-miR-346	CLIP-seq
MIRT1301472	hsa-miR-3619-5p	CLIP-seq
MIRT2314422	hsa-miR-3622a-3p	CLIP-seq
MIRT2314423	hsa-miR-3622b-3p	CLIP-seq
MIRT2314424	hsa-miR-3650	CLIP-seq
MIRT2314425	hsa-miR-3664-3p	CLIP-seq
MIRT2314426	hsa-miR-3916	CLIP-seq
MIRT2314427	hsa-miR-3934	CLIP-seq
MIRT1301474	hsa-miR-424	CLIP-seq
MIRT2089487	hsa-miR-4267	CLIP-seq
MIRT2314428	hsa-miR-4274	CLIP-seq
MIRT2314429	hsa-miR-4288	CLIP-seq
MIRT2314430	hsa-miR-4291	CLIP-seq
MIRT2314431	hsa-miR-4433	CLIP-seq
MIRT1301476	hsa-miR-4436b-3p	CLIP-seq
MIRT2314432	hsa-miR-4459	CLIP-seq
MIRT2314433	hsa-miR-4518	CLIP-seq
MIRT2314434	hsa-miR-4652-3p	CLIP-seq
MIRT2314435	hsa-miR-4711-3p	CLIP-seq
MIRT2089497	hsa-miR-4749-3p	CLIP-seq
MIRT2314436	hsa-miR-4768-3p	CLIP-seq
MIRT1301479	hsa-miR-4781-5p	CLIP-seq
MIRT1301480	hsa-miR-497	CLIP-seq
MIRT2314437	hsa-miR-614	CLIP-seq
MIRT2314438	hsa-miR-632	CLIP-seq
MIRT2314439	hsa-miR-663b	CLIP-seq
MIRT2314440	hsa-miR-708	CLIP-seq
MIRT1301482	hsa-miR-744	CLIP-seq
MIRT1301484	hsa-miR-761	CLIP-seq
MIRT2314441	hsa-miR-764	CLIP-seq
MIRT2314442	hsa-miR-922	CLIP-seq
MIRT2393632	hsa-miR-4641	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IDA	21602889
GO:0003697	Function	Single-stranded DNA binding	IDA	21602889
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IDA	21602889
GO:0004527	Function	Exonuclease activity	IBA
GO:0004527	Function	Exonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	10908561
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006259	Process	DNA metabolic process	IEA
GO:0006281	Process	DNA repair	IDA	21602889
GO:0006308	Process	DNA catabolic process	IBA
GO:0006308	Process	DNA catabolic process	IDA	21602889
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	10908561
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IBA
GO:0008408	Function	3'-5' exonuclease activity	IDA	21602889
GO:0008408	Function	3'-5' exonuclease activity	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016787	Function	Hydrolase activity	IEA

MIM	HGNC	e!Ensembl
602930	12820	ENSG00000148300

Q9GZR2

Protein name

RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00929	RNase_T	244 → 394	Exonuclease	Family

Sequence

MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPP
KAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMP
AGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRK
AKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGL
TRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPEN
LKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSG
RPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSD
DA

Sequence length

422

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Recurrent spontaneous abortion	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	25849309	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25849309	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	GWASCAT_DG	28604730	★★★★★ ★☆☆☆☆ Found in Text Mining only

REXO4 (REX4 homolog, 3'-5' exonuclease)