Gene Gene information from NCBI Gene database.
Entrez ID 57089
Gene name Ectonucleoside triphosphate diphosphohydrolase 7
Gene symbol ENTPD7
Synonyms (NCBI Gene)
LALP1
Chromosome 10
Chromosome location 10q24.2
Summary This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphate
miRNA miRNA information provided by mirtarbase database.
870
miRTarBase ID miRNA Experiments Reference
MIRT024669 hsa-miR-215-5p Microarray 19074876
MIRT026205 hsa-miR-192-5p Microarray 19074876
MIRT028790 hsa-miR-26b-5p Microarray 19088304
MIRT710014 hsa-miR-942-5p HITS-CLIP 19536157
MIRT710013 hsa-miR-4684-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0003924 Function GTPase activity IDA 11278936
GO:0003924 Function GTPase activity IEA
GO:0004382 Function GDP phosphatase activity IBA
GO:0005794 Component Golgi apparatus IBA
GO:0006254 Process CTP catabolic process IDA 11278936
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616753 19745 ENSG00000198018
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NQZ7
Protein name Ectonucleoside triphosphate diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.15) (Lysosomal apyrase-like protein 1)
Protein function Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes ATP and nucleosid
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01150 GDA1_CD39 75 537 GDA1/CD39 (nucleoside phosphatase) family Family
Sequence
Sequence length 604
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Phosphate bond hydrolysis by NTPDase proteins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIGESTIVE SYSTEM DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 1 Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Bipolar Disorder Bipolar disorder Pubtator 37894929 Associate
★☆☆☆☆
Found in Text Mining only