Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57088
Gene name	Phospholipid scramblase 4
Gene symbol	PLSCR4
Synonyms (NCBI Gene)	TRA1
Chromosome	3
Chromosome location	3q24

192

Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017393	hsa-miR-335-5p	Microarray	18185580
MIRT022441	hsa-miR-124-3p	Microarray	18668037
MIRT027128	hsa-miR-103a-3p	Sequencing	20371350
MIRT031585	hsa-miR-16-5p	Sequencing	20371350
MIRT046398	hsa-miR-15b-5p	CLASH	23622248
MIRT407861	hsa-miR-495-5p	PAR-CLIP	22012620
MIRT535125	hsa-miR-382-5p	PAR-CLIP	22012620
MIRT535124	hsa-miR-425-5p	PAR-CLIP	22012620
MIRT305472	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT535123	hsa-miR-3934-3p	PAR-CLIP	22012620
MIRT535121	hsa-miR-6895-3p	PAR-CLIP	22012620
MIRT535122	hsa-miR-593-3p	PAR-CLIP	22012620
MIRT535120	hsa-miR-1178-3p	PAR-CLIP	22012620
MIRT535118	hsa-miR-6818-3p	PAR-CLIP	22012620
MIRT407861	hsa-miR-495-5p	PAR-CLIP	22012620
MIRT535125	hsa-miR-382-5p	PAR-CLIP	22012620
MIRT535124	hsa-miR-425-5p	PAR-CLIP	22012620
MIRT305472	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT535123	hsa-miR-3934-3p	PAR-CLIP	22012620
MIRT535121	hsa-miR-6895-3p	PAR-CLIP	22012620
MIRT535122	hsa-miR-593-3p	PAR-CLIP	22012620
MIRT535120	hsa-miR-1178-3p	PAR-CLIP	22012620
MIRT535118	hsa-miR-6818-3p	PAR-CLIP	22012620
MIRT1243285	hsa-miR-193a-3p	CLIP-seq
MIRT1243286	hsa-miR-193b	CLIP-seq
MIRT1243287	hsa-miR-3146	CLIP-seq
MIRT1243288	hsa-miR-3622b-5p	CLIP-seq
MIRT1243289	hsa-miR-4699-3p	CLIP-seq
MIRT1243290	hsa-miR-4718	CLIP-seq
MIRT1243291	hsa-miR-4720-5p	CLIP-seq
MIRT1243292	hsa-miR-4795-3p	CLIP-seq
MIRT1243293	hsa-miR-4799-3p	CLIP-seq
MIRT1243294	hsa-miR-548c-3p	CLIP-seq
MIRT1243295	hsa-miR-656	CLIP-seq
MIRT1243296	hsa-miR-892b	CLIP-seq
MIRT1243297	hsa-miR-1272	CLIP-seq
MIRT1243298	hsa-miR-1322	CLIP-seq
MIRT1243299	hsa-miR-145	CLIP-seq
MIRT1243300	hsa-miR-2116	CLIP-seq
MIRT1243301	hsa-miR-3925-3p	CLIP-seq
MIRT1243302	hsa-miR-4277	CLIP-seq
MIRT1243303	hsa-miR-4764-3p	CLIP-seq
MIRT1243292	hsa-miR-4795-3p	CLIP-seq
MIRT1243304	hsa-miR-4803	CLIP-seq
MIRT1243305	hsa-miR-508-5p	CLIP-seq
MIRT1243306	hsa-miR-548ac	CLIP-seq
MIRT1243307	hsa-miR-548ae	CLIP-seq
MIRT1243308	hsa-miR-548aj	CLIP-seq
MIRT1243309	hsa-miR-548am	CLIP-seq
MIRT1243310	hsa-miR-548d-3p	CLIP-seq
MIRT1243311	hsa-miR-548x	CLIP-seq
MIRT1243312	hsa-miR-548z	CLIP-seq
MIRT2071878	hsa-miR-1231	CLIP-seq
MIRT2071879	hsa-miR-337-3p	CLIP-seq
MIRT2071880	hsa-miR-3685	CLIP-seq
MIRT2071881	hsa-miR-384	CLIP-seq
MIRT2071882	hsa-miR-3920	CLIP-seq
MIRT2071883	hsa-miR-4288	CLIP-seq
MIRT2071884	hsa-miR-4427	CLIP-seq
MIRT2071885	hsa-miR-4680-3p	CLIP-seq
MIRT1243292	hsa-miR-4795-3p	CLIP-seq
MIRT2071886	hsa-miR-632	CLIP-seq
MIRT1243295	hsa-miR-656	CLIP-seq
MIRT2432167	hsa-miR-124	CLIP-seq
MIRT2432168	hsa-miR-1257	CLIP-seq
MIRT2432169	hsa-miR-3065-5p	CLIP-seq
MIRT2432170	hsa-miR-3121-3p	CLIP-seq
MIRT2432171	hsa-miR-3123	CLIP-seq
MIRT2432172	hsa-miR-3607-5p	CLIP-seq
MIRT1243288	hsa-miR-3622b-5p	CLIP-seq
MIRT2432173	hsa-miR-3653	CLIP-seq
MIRT2432174	hsa-miR-3658	CLIP-seq
MIRT2432175	hsa-miR-3671	CLIP-seq
MIRT2432176	hsa-miR-3714	CLIP-seq
MIRT2432177	hsa-miR-376c	CLIP-seq
MIRT2432178	hsa-miR-3910	CLIP-seq
MIRT2432179	hsa-miR-3925-5p	CLIP-seq
MIRT2432180	hsa-miR-3941	CLIP-seq
MIRT2432181	hsa-miR-3976	CLIP-seq
MIRT2432182	hsa-miR-410	CLIP-seq
MIRT2432183	hsa-miR-466	CLIP-seq
MIRT2432184	hsa-miR-4672	CLIP-seq
MIRT1243290	hsa-miR-4718	CLIP-seq
MIRT2432185	hsa-miR-4731-3p	CLIP-seq
MIRT2432186	hsa-miR-4801	CLIP-seq
MIRT2432187	hsa-miR-494	CLIP-seq
MIRT2432188	hsa-miR-506	CLIP-seq
MIRT2432189	hsa-miR-539	CLIP-seq
MIRT2432190	hsa-miR-590-3p	CLIP-seq
MIRT2432191	hsa-miR-607	CLIP-seq
MIRT2432192	hsa-miR-889	CLIP-seq
MIRT2456709	hsa-miR-1324	CLIP-seq
MIRT2456710	hsa-miR-135a	CLIP-seq
MIRT2456711	hsa-miR-135b	CLIP-seq
MIRT2456712	hsa-miR-3074-3p	CLIP-seq
MIRT2071879	hsa-miR-337-3p	CLIP-seq
MIRT2456713	hsa-miR-361-5p	CLIP-seq
MIRT2071880	hsa-miR-3685	CLIP-seq
MIRT2071881	hsa-miR-384	CLIP-seq
MIRT2456714	hsa-miR-3913-3p	CLIP-seq
MIRT2456709	hsa-miR-1324	CLIP-seq
MIRT2456712	hsa-miR-3074-3p	CLIP-seq
MIRT2071879	hsa-miR-337-3p	CLIP-seq
MIRT2456713	hsa-miR-361-5p	CLIP-seq
MIRT2071880	hsa-miR-3685	CLIP-seq
MIRT2071881	hsa-miR-384	CLIP-seq
MIRT2456714	hsa-miR-3913-3p	CLIP-seq
MIRT2595899	hsa-miR-1178	CLIP-seq
MIRT2432167	hsa-miR-124	CLIP-seq
MIRT2595900	hsa-miR-1291	CLIP-seq
MIRT2595901	hsa-miR-15a	CLIP-seq
MIRT2595902	hsa-miR-15b	CLIP-seq
MIRT2595903	hsa-miR-16	CLIP-seq
MIRT2595904	hsa-miR-195	CLIP-seq
MIRT2595905	hsa-miR-3064-5p	CLIP-seq
MIRT2595906	hsa-miR-3136-5p	CLIP-seq
MIRT2595907	hsa-miR-328	CLIP-seq
MIRT2432175	hsa-miR-3671	CLIP-seq
MIRT2432176	hsa-miR-3714	CLIP-seq
MIRT2595908	hsa-miR-382	CLIP-seq
MIRT2432178	hsa-miR-3910	CLIP-seq
MIRT2595909	hsa-miR-3919	CLIP-seq
MIRT2432182	hsa-miR-410	CLIP-seq
MIRT2595910	hsa-miR-424	CLIP-seq
MIRT2595911	hsa-miR-4267	CLIP-seq
MIRT2595912	hsa-miR-4435	CLIP-seq
MIRT2595913	hsa-miR-4439	CLIP-seq
MIRT2595914	hsa-miR-4448	CLIP-seq
MIRT2595915	hsa-miR-4687-3p	CLIP-seq
MIRT2595916	hsa-miR-4756-3p	CLIP-seq
MIRT2595917	hsa-miR-497	CLIP-seq
MIRT2432188	hsa-miR-506	CLIP-seq
MIRT2432189	hsa-miR-539	CLIP-seq
MIRT2595918	hsa-miR-570	CLIP-seq
MIRT2595919	hsa-miR-593	CLIP-seq
MIRT2432191	hsa-miR-607	CLIP-seq
MIRT2595920	hsa-miR-663b	CLIP-seq
MIRT2432192	hsa-miR-889	CLIP-seq
MIRT1243296	hsa-miR-892b	CLIP-seq
MIRT2595921	hsa-miR-943	CLIP-seq
MIRT2595899	hsa-miR-1178	CLIP-seq
MIRT2688201	hsa-miR-1200	CLIP-seq
MIRT2432167	hsa-miR-124	CLIP-seq
MIRT2595900	hsa-miR-1291	CLIP-seq
MIRT2688202	hsa-miR-2054	CLIP-seq
MIRT2688203	hsa-miR-298	CLIP-seq
MIRT2595905	hsa-miR-3064-5p	CLIP-seq
MIRT2688204	hsa-miR-3074-5p	CLIP-seq
MIRT2688205	hsa-miR-3124-3p	CLIP-seq
MIRT2595906	hsa-miR-3136-5p	CLIP-seq
MIRT2688206	hsa-miR-3143	CLIP-seq
MIRT2688207	hsa-miR-3163	CLIP-seq
MIRT2595907	hsa-miR-328	CLIP-seq
MIRT2688208	hsa-miR-3613-3p	CLIP-seq
MIRT2688209	hsa-miR-3664-5p	CLIP-seq
MIRT2432175	hsa-miR-3671	CLIP-seq
MIRT2688210	hsa-miR-3678-3p	CLIP-seq
MIRT2432176	hsa-miR-3714	CLIP-seq
MIRT2595908	hsa-miR-382	CLIP-seq
MIRT2432178	hsa-miR-3910	CLIP-seq
MIRT2595909	hsa-miR-3919	CLIP-seq
MIRT2071882	hsa-miR-3920	CLIP-seq
MIRT2432182	hsa-miR-410	CLIP-seq
MIRT2595911	hsa-miR-4267	CLIP-seq
MIRT2688211	hsa-miR-4307	CLIP-seq
MIRT2688212	hsa-miR-4318	CLIP-seq
MIRT2595912	hsa-miR-4435	CLIP-seq
MIRT2595913	hsa-miR-4439	CLIP-seq
MIRT2595914	hsa-miR-4448	CLIP-seq
MIRT2688213	hsa-miR-4668-3p	CLIP-seq
MIRT2595915	hsa-miR-4687-3p	CLIP-seq
MIRT2688214	hsa-miR-4693-5p	CLIP-seq
MIRT2688215	hsa-miR-4714-5p	CLIP-seq
MIRT2595916	hsa-miR-4756-3p	CLIP-seq
MIRT1243292	hsa-miR-4795-3p	CLIP-seq
MIRT2432188	hsa-miR-506	CLIP-seq
MIRT2688216	hsa-miR-513a-3p	CLIP-seq
MIRT2432189	hsa-miR-539	CLIP-seq
MIRT2688217	hsa-miR-543	CLIP-seq
MIRT1243307	hsa-miR-548ae	CLIP-seq
MIRT1243308	hsa-miR-548aj	CLIP-seq
MIRT1243309	hsa-miR-548am	CLIP-seq
MIRT1243311	hsa-miR-548x	CLIP-seq
MIRT2688218	hsa-miR-556-3p	CLIP-seq
MIRT2595918	hsa-miR-570	CLIP-seq
MIRT2595919	hsa-miR-593	CLIP-seq
MIRT2432191	hsa-miR-607	CLIP-seq
MIRT2595920	hsa-miR-663b	CLIP-seq
MIRT2432192	hsa-miR-889	CLIP-seq
MIRT2688219	hsa-miR-892a	CLIP-seq
MIRT1243296	hsa-miR-892b	CLIP-seq
MIRT2595921	hsa-miR-943	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	NAS	10930526
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 21690087, 23088713, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IDA	21690087
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	19333378
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0017121	Process	Plasma membrane phospholipid scrambling	IBA
GO:0017121	Process	Plasma membrane phospholipid scrambling	IEA
GO:0017121	Process	Plasma membrane phospholipid scrambling	NAS	10930526
GO:0017124	Function	SH3 domain binding	IEA
GO:0017128	Function	Phospholipid scramblase activity	IBA
GO:0017128	Function	Phospholipid scramblase activity	IDA	23089641
GO:0017128	Function	Phospholipid scramblase activity	IEA
GO:0017128	Function	Phospholipid scramblase activity	NAS	10930526
GO:0019899	Function	Enzyme binding	IPI	19333378
GO:0042609	Function	CD4 receptor binding	IPI	19333378
GO:0061589	Process	Calcium activated phosphatidylserine scrambling	IDA	23089641
GO:0061590	Process	Calcium activated phosphatidylcholine scrambling	IDA	23089641
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA

MIM	HGNC	e!Ensembl
607612	16497	ENSG00000114698

Q9NRQ2

Protein name

Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1)

Protein function

Catalyzes metal ion-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane and participates in the redistribution of

PDB

3Q5U

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03803	Scramblase	100 → 322	Scramblase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes. {ECO:0000269|PubMed:10930526}.

Sequence

MSGVVPTAPEQPAGEMENQTKPPDPRPDAPPEYNSHFLPGPPGTAVPPPTGYPGGLPMGY
YSPQQPSTFPLYQPVGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYLVQLD
NIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTD
CMGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKK
ENVMRVRGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWNGLLSAMADADHFDIHFPLDL
DVKMKAMIFGACFLIDFMYFERSPPQRSR

Sequence length

329

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sensorineural hearing loss disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL CELL LUNG CARCINOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anemia Sickle Cell	Sickle cell anemia	Pubtator	34772994	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arterial Occlusive Diseases	Arterial occlusive disease	Pubtator	34772994	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Choroid Plexus Carcinoma	Choroid Plexus Carcinoma	BEFREE	31409384		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33577029	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	29499950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	22512921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Gastrointestinal neoplasm	Pubtator	38554324	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	29499950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemolysis	Hemolysis	Pubtator	34772994	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hermaphroditism	Hermaphroditism	BEFREE	29493066		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	12200383, 15827139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	30417470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	12200383		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31322545		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papilloma Choroid Plexus	Choroid plexus papilloma	Pubtator	31409384	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	17997842		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	17997842		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	Pubtator	17997842	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Small cell carcinoma of lung	Lung carcinoma	CTD_human_DG	22941189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Teratoma	Teratoma	BEFREE	23050522, 26975546, 27328415, 28545044		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	34772994	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Hormone Resistance Syndrome	Thyroid hormone resistance	Pubtator	33509032	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	40179432	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PLSCR4 (phospholipid scramblase 4)