Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57084
Gene name	Solute carrier family 17 member 6
Gene symbol	SLC17A6
Synonyms (NCBI Gene)	DNPIVGLUT2
Chromosome	11
Chromosome location	11p14.3

Show/Hide all (36)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029908	hsa-miR-26b-5p	Microarray	19088304
MIRT1353522	hsa-miR-1193	CLIP-seq
MIRT1353523	hsa-miR-1252	CLIP-seq
MIRT1353524	hsa-miR-2052	CLIP-seq
MIRT1353525	hsa-miR-2116	CLIP-seq
MIRT1353526	hsa-miR-25	CLIP-seq
MIRT1353527	hsa-miR-32	CLIP-seq
MIRT1353528	hsa-miR-331-5p	CLIP-seq
MIRT1353529	hsa-miR-33a	CLIP-seq
MIRT1353530	hsa-miR-33b	CLIP-seq
MIRT1353531	hsa-miR-363	CLIP-seq
MIRT1353532	hsa-miR-367	CLIP-seq
MIRT1353533	hsa-miR-4273	CLIP-seq
MIRT1353534	hsa-miR-4477b	CLIP-seq
MIRT1353535	hsa-miR-4677-5p	CLIP-seq
MIRT1353536	hsa-miR-4694-3p	CLIP-seq
MIRT1353537	hsa-miR-522	CLIP-seq
MIRT1353538	hsa-miR-579	CLIP-seq
MIRT1353539	hsa-miR-629	CLIP-seq
MIRT1353540	hsa-miR-7	CLIP-seq
MIRT1353541	hsa-miR-889	CLIP-seq
MIRT1353542	hsa-miR-92a	CLIP-seq
MIRT1353543	hsa-miR-92b	CLIP-seq
MIRT1353544	hsa-miR-944	CLIP-seq
MIRT2104625	hsa-miR-495	CLIP-seq
MIRT2329069	hsa-miR-19a	CLIP-seq
MIRT2329070	hsa-miR-19b	CLIP-seq
MIRT2329071	hsa-miR-2113	CLIP-seq
MIRT2329072	hsa-miR-2278	CLIP-seq
MIRT2329073	hsa-miR-3065-5p	CLIP-seq
MIRT2329074	hsa-miR-3121-3p	CLIP-seq
MIRT1353533	hsa-miR-4273	CLIP-seq
MIRT2329075	hsa-miR-4282	CLIP-seq
MIRT2329076	hsa-miR-4705	CLIP-seq
MIRT2329077	hsa-miR-576-5p	CLIP-seq
MIRT2329078	hsa-miR-633	CLIP-seq

Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005254	Function	Chloride channel activity	IEA
GO:0005254	Function	Chloride channel activity	ISS
GO:0005313	Function	L-glutamate transmembrane transporter activity	IBA
GO:0005313	Function	L-glutamate transmembrane transporter activity	TAS
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IBA
GO:0005436	Function	Sodium:phosphate symporter activity	IC	33440152
GO:0005436	Function	Sodium:phosphate symporter activity	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006814	Process	Sodium ion transport	IEA
GO:0006817	Process	Phosphate ion transport	IEA
GO:0006817	Process	Phosphate ion transport	ISS
GO:0006821	Process	Chloride transport	IEA
GO:0006836	Process	Neurotransmitter transport	IEA
GO:0015291	Function	Secondary active transmembrane transporter activity	IEA
GO:0015293	Function	Symporter activity	IEA
GO:0015297	Function	Antiporter activity	IEA
GO:0015386	Function	Potassium:proton antiporter activity	ISS
GO:0015813	Process	L-glutamate transmembrane transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030672	Component	Synaptic vesicle membrane	IBA
GO:0030672	Component	Synaptic vesicle membrane	IDA	11698620
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0030672	Component	Synaptic vesicle membrane	TAS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043005	Component	Neuron projection	ISS
GO:0044341	Process	Sodium-dependent phosphate transport	IC	33440152
GO:0044341	Process	Sodium-dependent phosphate transport	ISS
GO:0045202	Component	Synapse	IEA
GO:0050803	Process	Regulation of synapse structure or activity	IBA
GO:0051938	Process	L-glutamate import	IMP	11698620
GO:0055062	Process	Phosphate ion homeostasis	IDA	33440152
GO:0055085	Process	Transmembrane transport	IEA
GO:0060076	Component	Excitatory synapse	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IEA
GO:0098700	Process	Neurotransmitter loading into synaptic vesicle	IBA
GO:0140788	Function	L-glutamate uniporter activity	IDA	11698620
GO:0140788	Function	L-glutamate uniporter activity	ISS
GO:1902476	Process	Chloride transmembrane transport	IEA
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1990384	Process	Hyaloid vascular plexus regression	ISS

MIM	HGNC	e!Ensembl
607563	16703	ENSG00000091664

Q9P2U8

Protein name

Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)

Protein function

Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:11698620, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as a uniporter whic

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07690	MFS_1	76 → 461	Major Facilitator Superfamily	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in adult brain (PubMed:10820226). Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, tempora

Sequence

MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLC
DCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWD
PETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCV
IFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYT
GWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFK
TPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMT
IIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAV
GFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVF
LIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGT
TKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS

Sequence length

582

Interactions

View interactions

	KEGG		Reactome
	Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse Nicotine addiction		Organic anion transporters

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEARNING DISABILITIES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEARNING DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEMORY DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	31705888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Learning Disorders	Learning Disorders	CTD_human_DG	21295146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Age-Related Memory Disorders	Age-Related Memory Disorders	CTD_human_DG	21295146		★★★★★ ★☆☆☆☆ Found in Text Mining only
AICARDI-GOUTIERES SYNDROME	Aicardi Goutieres Syndrome	BEFREE	28738742, 31666356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	38552733, 39650656	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	19770042, 28526579		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	19839996		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	19839996		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37404825	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	LHGDN	17531353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	17711980, 28230208		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33765507	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Learning Disabilities	Learning Disorders	CTD_human_DG	21295146		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Learning Disorders	Learning Disorders	CTD_human_DG	21295146		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Learning Disturbance	Learning Disorders	CTD_human_DG	21295146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	19839996		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	PSYGENET_DG	19839996		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Memory Disorders	Memory Disorders	CTD_human_DG	21295146		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	BEFREE	31780530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Motor neuron atrophy	Motor neuron atrophy	BEFREE	19770042		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30442663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 2	Neurofibromatosis	BEFREE	31165301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	16563567	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	28969383, 30442663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	35258081	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	BEFREE	31705888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	18155679, 19839996, 20541370, 27550734, 31062628		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	19228977, 19839996, 20541370		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Unipolar Depression	Mental Depression	PSYGENET_DG	19839996		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Varicosity	Vulval varices	BEFREE	28337539, 28833113, 28863230, 31118881		★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC17A6 (solute carrier family 17 member 6)