DTWD1 (DTW motif tRNA-uridine aminocarboxypropyltransferase 1)

Gene

• Entrez ID: 56986
• Gene name: DTW motif tRNA-uridine aminocarboxypropyltransferase 1
• Gene symbol: DTWD1
• Synonyms (NCBI Gene): MDS009
• Chromosome: 15
• Chromosome location: 15q21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT946779	hsa-miR-1237	CLIP-seq
MIRT946780	hsa-miR-1298	CLIP-seq
MIRT946781	hsa-miR-2052	CLIP-seq
MIRT946782	hsa-miR-3120-3p	CLIP-seq
MIRT946783	hsa-miR-3124-3p	CLIP-seq
MIRT946784	hsa-miR-3129-3p	CLIP-seq
MIRT946785	hsa-miR-3152-5p	CLIP-seq
MIRT946786	hsa-miR-3156-3p	CLIP-seq
MIRT946787	hsa-miR-3160-5p	CLIP-seq
MIRT946788	hsa-miR-3192	CLIP-seq
MIRT946789	hsa-miR-3607-5p	CLIP-seq
MIRT946790	hsa-miR-361-3p	CLIP-seq
MIRT946791	hsa-miR-3657	CLIP-seq
MIRT946792	hsa-miR-3662	CLIP-seq
MIRT946793	hsa-miR-3679-3p	CLIP-seq
MIRT946794	hsa-miR-3689a-3p	CLIP-seq
MIRT946795	hsa-miR-3689c	CLIP-seq
MIRT946796	hsa-miR-3942-3p	CLIP-seq
MIRT946797	hsa-miR-4261	CLIP-seq
MIRT946798	hsa-miR-4263	CLIP-seq
MIRT946799	hsa-miR-4264	CLIP-seq
MIRT946800	hsa-miR-4275	CLIP-seq
MIRT946801	hsa-miR-4292	CLIP-seq
MIRT946802	hsa-miR-4297	CLIP-seq
MIRT946803	hsa-miR-4301	CLIP-seq
MIRT946804	hsa-miR-4307	CLIP-seq
MIRT946805	hsa-miR-4308	CLIP-seq
MIRT946806	hsa-miR-4427	CLIP-seq
MIRT946807	hsa-miR-4436a	CLIP-seq
MIRT946808	hsa-miR-4517	CLIP-seq
MIRT946809	hsa-miR-4669	CLIP-seq
MIRT946810	hsa-miR-4680-3p	CLIP-seq
MIRT946811	hsa-miR-4680-5p	CLIP-seq
MIRT946812	hsa-miR-4690-5p	CLIP-seq
MIRT946813	hsa-miR-4694-3p	CLIP-seq
MIRT946814	hsa-miR-4701-5p	CLIP-seq
MIRT946815	hsa-miR-4728-5p	CLIP-seq
MIRT946816	hsa-miR-4735-5p	CLIP-seq
MIRT946817	hsa-miR-4753-3p	CLIP-seq
MIRT946818	hsa-miR-4768-5p	CLIP-seq
MIRT946819	hsa-miR-4774-3p	CLIP-seq
MIRT946820	hsa-miR-513b	CLIP-seq
MIRT946821	hsa-miR-545	CLIP-seq
MIRT946822	hsa-miR-588	CLIP-seq
MIRT946823	hsa-miR-617	CLIP-seq
MIRT946824	hsa-miR-622	CLIP-seq
MIRT946825	hsa-miR-639	CLIP-seq
MIRT946826	hsa-miR-7	CLIP-seq
MIRT946827	hsa-miR-873	CLIP-seq
MIRT946828	hsa-miR-889	CLIP-seq
MIRT946829	hsa-miR-944	CLIP-seq
MIRT946830	hsa-miR-1200	CLIP-seq
MIRT946831	hsa-miR-125a-3p	CLIP-seq
MIRT946832	hsa-miR-142-5p	CLIP-seq
MIRT946833	hsa-miR-144	CLIP-seq
MIRT946834	hsa-miR-1911	CLIP-seq
MIRT946835	hsa-miR-203	CLIP-seq
MIRT946836	hsa-miR-3121-3p	CLIP-seq
MIRT946837	hsa-miR-3125	CLIP-seq
MIRT946838	hsa-miR-3159	CLIP-seq
MIRT946839	hsa-miR-3161	CLIP-seq
MIRT946840	hsa-miR-323-5p	CLIP-seq
MIRT946841	hsa-miR-340	CLIP-seq
MIRT946842	hsa-miR-3675-3p	CLIP-seq
MIRT946843	hsa-miR-3916	CLIP-seq
MIRT946844	hsa-miR-3921	CLIP-seq
MIRT946845	hsa-miR-3928	CLIP-seq
MIRT946846	hsa-miR-411	CLIP-seq
MIRT946847	hsa-miR-421	CLIP-seq
MIRT946848	hsa-miR-4502	CLIP-seq
MIRT946849	hsa-miR-4509	CLIP-seq
MIRT946850	hsa-miR-4653-5p	CLIP-seq
MIRT946851	hsa-miR-4709-5p	CLIP-seq
MIRT946852	hsa-miR-4766-5p	CLIP-seq
MIRT946853	hsa-miR-548ag	CLIP-seq
MIRT946854	hsa-miR-548ai	CLIP-seq
MIRT946855	hsa-miR-548m	CLIP-seq
MIRT946856	hsa-miR-552	CLIP-seq
MIRT946857	hsa-miR-653	CLIP-seq
MIRT946858	hsa-miR-877	CLIP-seq
MIRT946833	hsa-miR-144	CLIP-seq
MIRT1980382	hsa-miR-101	CLIP-seq
MIRT1980383	hsa-miR-139-5p	CLIP-seq
MIRT946833	hsa-miR-144	CLIP-seq
MIRT1980384	hsa-miR-150	CLIP-seq
MIRT1980385	hsa-miR-216a	CLIP-seq
MIRT1980386	hsa-miR-216b	CLIP-seq
MIRT1980387	hsa-miR-4468	CLIP-seq
MIRT1980388	hsa-miR-4699-3p	CLIP-seq
MIRT1980389	hsa-miR-4713-5p	CLIP-seq
MIRT1980390	hsa-miR-520d-5p	CLIP-seq
MIRT1980391	hsa-miR-524-5p	CLIP-seq
MIRT1980392	hsa-miR-532-3p	CLIP-seq
MIRT1980393	hsa-miR-576-5p	CLIP-seq
MIRT1980394	hsa-miR-580	CLIP-seq
MIRT2215443	hsa-miR-192	CLIP-seq
MIRT2215444	hsa-miR-196a	CLIP-seq
MIRT2215445	hsa-miR-196b	CLIP-seq
MIRT2215446	hsa-miR-215	CLIP-seq
MIRT2215447	hsa-miR-2278	CLIP-seq
MIRT2215448	hsa-miR-337-3p	CLIP-seq
MIRT1980387	hsa-miR-4468	CLIP-seq
MIRT946813	hsa-miR-4694-3p	CLIP-seq
MIRT2215449	hsa-miR-4703-3p	CLIP-seq
MIRT2215450	hsa-miR-4764-3p	CLIP-seq
MIRT946852	hsa-miR-4766-5p	CLIP-seq
MIRT2215451	hsa-miR-4797-3p	CLIP-seq
MIRT946853	hsa-miR-548ag	CLIP-seq
MIRT946854	hsa-miR-548ai	CLIP-seq
MIRT2215452	hsa-miR-935	CLIP-seq
MIRT2448568	hsa-miR-451b	CLIP-seq
MIRT2519864	hsa-miR-105	CLIP-seq
MIRT2519865	hsa-miR-1305	CLIP-seq
MIRT2215444	hsa-miR-196a	CLIP-seq
MIRT2215445	hsa-miR-196b	CLIP-seq
MIRT2519866	hsa-miR-3117-3p	CLIP-seq
MIRT2519867	hsa-miR-3140-3p	CLIP-seq
MIRT946839	hsa-miR-3161	CLIP-seq
MIRT2519868	hsa-miR-3169	CLIP-seq
MIRT2519869	hsa-miR-3653	CLIP-seq
MIRT2519870	hsa-miR-3658	CLIP-seq
MIRT2519871	hsa-miR-3671	CLIP-seq
MIRT2519872	hsa-miR-3929	CLIP-seq
MIRT946847	hsa-miR-421	CLIP-seq
MIRT2519873	hsa-miR-4419b	CLIP-seq
MIRT2519874	hsa-miR-4420	CLIP-seq
MIRT2519875	hsa-miR-4438	CLIP-seq
MIRT2519876	hsa-miR-4478	CLIP-seq
MIRT2519877	hsa-miR-4528	CLIP-seq
MIRT2519878	hsa-miR-4705	CLIP-seq
MIRT946851	hsa-miR-4709-5p	CLIP-seq
MIRT2519879	hsa-miR-4738-3p	CLIP-seq
MIRT2519880	hsa-miR-4759	CLIP-seq
MIRT2519881	hsa-miR-4760-5p	CLIP-seq
MIRT2519882	hsa-miR-5095	CLIP-seq
MIRT2519883	hsa-miR-520a-5p	CLIP-seq
MIRT2519884	hsa-miR-522	CLIP-seq
MIRT2519885	hsa-miR-525-5p	CLIP-seq
MIRT2519886	hsa-miR-593	CLIP-seq
MIRT2519887	hsa-miR-600	CLIP-seq
MIRT2519888	hsa-miR-607	CLIP-seq
MIRT2679567	hsa-miR-1207-5p	CLIP-seq
MIRT2519865	hsa-miR-1305	CLIP-seq
MIRT946833	hsa-miR-144	CLIP-seq
MIRT2215444	hsa-miR-196a	CLIP-seq
MIRT2215445	hsa-miR-196b	CLIP-seq
MIRT2519867	hsa-miR-3140-3p	CLIP-seq
MIRT946839	hsa-miR-3161	CLIP-seq
MIRT2519872	hsa-miR-3929	CLIP-seq
MIRT946847	hsa-miR-421	CLIP-seq
MIRT2519873	hsa-miR-4419b	CLIP-seq
MIRT2519874	hsa-miR-4420	CLIP-seq
MIRT2519876	hsa-miR-4478	CLIP-seq
MIRT2519878	hsa-miR-4705	CLIP-seq
MIRT946851	hsa-miR-4709-5p	CLIP-seq
MIRT2679568	hsa-miR-4736	CLIP-seq
MIRT2519879	hsa-miR-4738-3p	CLIP-seq
MIRT2519881	hsa-miR-4760-5p	CLIP-seq
MIRT2679569	hsa-miR-4763-3p	CLIP-seq
MIRT2519883	hsa-miR-520a-5p	CLIP-seq
MIRT2519885	hsa-miR-525-5p	CLIP-seq
MIRT2519886	hsa-miR-593	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	31804502
GO:0005634	Component	Nucleus	IEA
GO:0006400	Process	TRNA modification	IBA
GO:0006400	Process	TRNA modification	IDA	31804502
GO:0008033	Process	TRNA processing	IEA
GO:0016432	Function	TRNA-uridine aminocarboxypropyltransferase activity	IBA
GO:0016432	Function	TRNA-uridine aminocarboxypropyltransferase activity	IDA	31804502
GO:0016432	Function	TRNA-uridine aminocarboxypropyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA

Other IDs

• MIM: 621116
• HGNC: 30926
• e!Ensembl: ENSG00000104047

Protein

• UniProt ID: Q8N5C7
• Protein name: tRNA-uridine aminocarboxypropyltransferase 1 (EC 2.5.1.25) (DTW domain-containing protein 1)
• Protein function: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03942	DTW	66 → 289	DTW domain	Domain

• Sequence:

  MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLK
  CGGSRMFYCYTCYVPVENVPIEQIPLVKLPLKIDIIKHPNETDGKSTAIHAKLLAPEFVN
  IYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKR
  TEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQ
  KGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETG
  KLTH

• Sequence length: 304

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BONE FRACTURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-MELANOMA SKIN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ORAL CAVITY CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bipolar Disorder	Bipolar Disorder	BEFREE	30503783		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	30503783	Associate	★☆☆☆☆ Found in Text Mining only