Gene Gene information from NCBI Gene database.
Entrez ID 56980
Gene name PR/SET domain 10
Gene symbol PRDM10
Synonyms (NCBI Gene)
BHD2PFM7TRIS
Chromosome 11
Chromosome location 11q24.3
Summary The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell diff
miRNA miRNA information provided by mirtarbase database.
201
miRTarBase ID miRNA Experiments Reference
MIRT619472 hsa-miR-6826-5p HITS-CLIP 19536157
MIRT619471 hsa-miR-7110-3p HITS-CLIP 19536157
MIRT619470 hsa-miR-6817-3p HITS-CLIP 19536157
MIRT619469 hsa-miR-6873-3p HITS-CLIP 19536157
MIRT713839 hsa-miR-4768-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 36440963
GO:0000785 Component Chromatin IDA 31143550
GO:0003677 Function DNA binding IEA
GO:0003700 Function DNA-binding transcription factor activity IDA 36440963
GO:0005515 Function Protein binding IPI 25416956
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618319 13995 ENSG00000170325
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NQV6
Protein name PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin)
Protein function Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the tr
PDB 3IHX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12171 zf-C2H2_jaz 354 378 Zinc-finger double-stranded RNA-binding Family
PF16638 Tristanin_u2 380 510 Disordered
PF12874 zf-met 560 580 Domain
PF00096 zf-C2H2 644 666 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 672 695 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 772 795 Zinc finger, C2H2 type Domain
Sequence
MDSKDESSHVWPTSAEHEQNAAQVHFVPDTGTVAQIVYTDDQVRPPQQVVYTADGASYTS
VDGPEHTLVYIHPVEAAQTLFTDPGQVAYVQQDATAQQASLPVHNQVLPSIESVDGSDPL
ATLQTPLGRLEAKEEEDEDEDEDTEEDEEEDGEDTDLDDWEPDPPRPFDPHDLWCEECNN
AHASVCPKHGPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFSKRRIPKRTQFGPVEGPL
VRGSELKDCYIHLKVSLDKGDRKERDLHEDLWFELSDETLCNWMMFVRPAQNHLEQNLVA
YQYGHHVYYTTIKNVEPKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKNWPCYEC
NRRFISSEQLQQHLNSHD
EKLDVFSRTRGRGRGRGKRRFGPGRRPGRPPKFIRLEITSEN
GEKSDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQTTIPIPQLPQETQSSLEHEPETHT
LHLQPQHEESVVPTQSTLTADDMRRAKRIR
LELQNAALQHLFIRKSFRPFKCLQCGKAFR
EKDKLDQHLRFHGREGNCPLTCDLCNKGFISSTSLESHMKLHSDQKTYSCIFCPESFDRL
DLLKDHVAIHINDGYFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQCTECDKAFCRPDKLR
LHMLRH
SDRKDFLCSTCGKQFKRKDKLREHMQRMHNPEREAKKADRISRSKTFKPRITST
DYDSFTFKCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPELTLPIIKPNRDYFCQYCDKV
YKSASKRKAHILKNH
PGAELPPSIRKLRPAGPGEPDPMLSTHTQLTGTIATPPVCCPHCS
KQYSSKTKMVQHIRKKHPEFAQLSNTIHTPLTTAVISATPAVLTTDSATGETVVTTDLLT
QAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQ
STVDVGQLHDPQPYPQHAIQVQHIQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQ
QQQQQQNSSVQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTS
GHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTNGNGSS
EVHITKP
Sequence length 1147
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIRT-HOGG-DUBE SYNDROME Disgenet, Orphanet
Disgenet, Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Birt-Hogg-Dube syndrome 2 Uncertain significance ClinVar
ClinVar, Disgenet, GenCC, HPO
ClinVar, Disgenet, GenCC, HPO
ClinVar, Disgenet, GenCC, HPO
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 29257233
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma Pubtator 36734437 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 29843214 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 36440963, 37331486 Associate
★☆☆☆☆
Found in Text Mining only
Coronary Arteriosclerosis Coronary Arteriosclerosis BEFREE 22951892
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease BEFREE 22951892
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease Pubtator 22951892 Associate
★☆☆☆☆
Found in Text Mining only
Coronary heart disease Coronary Heart Disease BEFREE 22951892
★☆☆☆☆
Found in Text Mining only
Craniocerebral Trauma Craniocerebral trauma Pubtator 34969957 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 1 Diabetes mellitus, type 1 Pubtator 22951892 Associate
★☆☆☆☆
Found in Text Mining only